Click here to switch to the map view.

The map label for this gene is pyrD [H]

Identifier: 28572681

GI number: 28572681

Start: 570529

End: 571521

Strand: Reverse

Name: pyrD [H]

Synonym: TW532

Alternate gene names: 28572681

Gene position: 571521-570529 (Counterclockwise)

Preceding gene: 28572682

Following gene: 28572678

Centisome position: 61.72

GC content: 43.5

Gene sequence:

>993_bases
TTGAATTTTCTAAAGTGTGTGGATCCAGAACTGGCACACAGAATTGCCGCGGTTGCTCTAAAGTCTGGATTGGGCATGTT
TGTGCCGCAGAGATTTCATATACATCTGGGGACCACATCTATGGGGCTTTATTTTGATACCCCACTCGGCATTGCTGCTG
GGTTTGACAAATTTGCTGATCTTGTTATTCCGCTGTACAGTCTCGGCTTTGGGCATGTTGAGGTTGGAACGGTTACTTTG
CACCCACAACCGGGTAATAAAAAACCAAGAATTCATCGGGTTATGTCCCAGAAGGCGCTTATAAACAGTATGGGATTCAA
TAATCCCGGTGCACAAAAAATGCGTGAAAATATCTTAAAAGTTAGAAAAAGCGGTAGGCGTCTTCCAATAATAGGTGTGA
ATATAGGAAAGAGCAAGGTGTGCCCTCTTGAGGAATCGGCGAAGGACTATGTTAAATCCTTTGAGCTATTAGCAGATGTG
TCAGATTACTTGGTGATAAATGTCTCATCCCCTAACACAGAGGGCCTGCGCACCCTGCAGAGTGTCGGAAATTTAAACAA
AATACTACGTTCGGTGAAACCTATTGCCGACAGGTTTAAAAGGCCTGTTCTGATAAAAATATCTCCAGATCTGAGTAATA
GTGATGTAACAAACATTGCGCTGCTCGTGAAAGAATTCGGACTTGCGGGTGTTGTTGCTTCTAATACAACTACCAAGCGA
ACCGGTCTTCCGAATGAATTTTCAAGTCTTCATGGTGGTTTGTCAGGCCCCATGCTAAAAGAAAGATCGCTTGAGATGTT
AAAAATACTTCGTCGTGACCTTCCAAAGAATAAGTTTTGTATTATCTCAGTCGGTGGCGTATGGGATTATACCGATGTCC
TAGAGAGGCTCGAGTACGGCGCTGATCTTGTGCAGGGATACACAGCTTTTGTGTATAACGGTCCATATTGGGCGTCAAAT
ATAAATCGCGATCTTAGTCGTCTCAGGTCTTAA

Upstream 100 bases:

>100_bases
AAGGTTTGCTAGTGTATATCAAGATTTTGACTCTCTGGAAGATTTTTCCAGGGCTGTAGAGAGGCTGAAAAATCAGTAAG
ATCGAGTGTATTCATATTTT

Downstream 100 bases:

>100_bases
TCGCATTTATTGTGTTGCCCTGTTATACCGTGTCGCCCCGTTATGCGATTTATTGATGGCTGTGAGAGTAATGTTTCTTC
TGGCTACGCCATGGCGTTTA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNFLKCVDPELAHRIAAVALKSGLGMFVPQRFHIHLGTTSMGLYFDTPLGIAAGFDKFADLVIPLYSLGFGHVEVGTVTL
HPQPGNKKPRIHRVMSQKALINSMGFNNPGAQKMRENILKVRKSGRRLPIIGVNIGKSKVCPLEESAKDYVKSFELLADV
SDYLVINVSSPNTEGLRTLQSVGNLNKILRSVKPIADRFKRPVLIKISPDLSNSDVTNIALLVKEFGLAGVVASNTTTKR
TGLPNEFSSLHGGLSGPMLKERSLEMLKILRRDLPKNKFCIISVGGVWDYTDVLERLEYGADLVQGYTAFVYNGPYWASN
INRDLSRLRS

Sequences:

>Translated_330_residues
MNFLKCVDPELAHRIAAVALKSGLGMFVPQRFHIHLGTTSMGLYFDTPLGIAAGFDKFADLVIPLYSLGFGHVEVGTVTL
HPQPGNKKPRIHRVMSQKALINSMGFNNPGAQKMRENILKVRKSGRRLPIIGVNIGKSKVCPLEESAKDYVKSFELLADV
SDYLVINVSSPNTEGLRTLQSVGNLNKILRSVKPIADRFKRPVLIKISPDLSNSDVTNIALLVKEFGLAGVVASNTTTKR
TGLPNEFSSLHGGLSGPMLKERSLEMLKILRRDLPKNKFCIISVGGVWDYTDVLERLEYGADLVQGYTAFVYNGPYWASN
INRDLSRLRS
>Mature_330_residues
MNFLKCVDPELAHRIAAVALKSGLGMFVPQRFHIHLGTTSMGLYFDTPLGIAAGFDKFADLVIPLYSLGFGHVEVGTVTL
HPQPGNKKPRIHRVMSQKALINSMGFNNPGAQKMRENILKVRKSGRRLPIIGVNIGKSKVCPLEESAKDYVKSFELLADV
SDYLVINVSSPNTEGLRTLQSVGNLNKILRSVKPIADRFKRPVLIKISPDLSNSDVTNIALLVKEFGLAGVVASNTTTKR
TGLPNEFSSLHGGLSGPMLKERSLEMLKILRRDLPKNKFCIISVGGVWDYTDVLERLEYGADLVQGYTAFVYNGPYWASN
INRDLSRLRS

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=336, Percent_Identity=41.6666666666667, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI1787177, Length=326, Percent_Identity=37.4233128834356, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17509475, Length=339, Percent_Identity=37.7581120943953, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI281361352, Length=337, Percent_Identity=41.2462908011869, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI17137316, Length=337, Percent_Identity=41.2462908011869, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36423; Mature: 36423

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLKCVDPELAHRIAAVALKSGLGMFVPQRFHIHLGTTSMGLYFDTPLGIAAGFDKFAD
CCCHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEECEEEECCCHHHHHHHHHHH
LVIPLYSLGFGHVEVGTVTLHPQPGNKKPRIHRVMSQKALINSMGFNNPGAQKMRENILK
HHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VRKSGRRLPIIGVNIGKSKVCPLEESAKDYVKSFELLADVSDYLVINVSSPNTEGLRTLQ
HHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHH
SVGNLNKILRSVKPIADRFKRPVLIKISPDLSNSDVTNIALLVKEFGLAGVVASNTTTKR
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCC
TGLPNEFSSLHGGLSGPMLKERSLEMLKILRRDLPKNKFCIISVGGVWDYTDVLERLEYG
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHH
ADLVQGYTAFVYNGPYWASNINRDLSRLRS
HHHHCCCEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNFLKCVDPELAHRIAAVALKSGLGMFVPQRFHIHLGTTSMGLYFDTPLGIAAGFDKFAD
CCCHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEECEEEECCCHHHHHHHHHHH
LVIPLYSLGFGHVEVGTVTLHPQPGNKKPRIHRVMSQKALINSMGFNNPGAQKMRENILK
HHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VRKSGRRLPIIGVNIGKSKVCPLEESAKDYVKSFELLADVSDYLVINVSSPNTEGLRTLQ
HHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHH
SVGNLNKILRSVKPIADRFKRPVLIKISPDLSNSDVTNIALLVKEFGLAGVVASNTTTKR
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCC
TGLPNEFSSLHGGLSGPMLKERSLEMLKILRRDLPKNKFCIISVGGVWDYTDVLERLEYG
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHH
ADLVQGYTAFVYNGPYWASNINRDLSRLRS
HHHHCCCEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA