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The map label for this gene is fabD [H]

Identifier: 28572665

GI number: 28572665

Start: 556140

End: 557159

Strand: Direct

Name: fabD [H]

Synonym: TW516

Alternate gene names: 28572665

Gene position: 556140-557159 (Clockwise)

Preceding gene: 28572664

Following gene: 161501889

Centisome position: 60.06

GC content: 44.41

Gene sequence:

>1020_bases
ATGGCATCCATCTGTGATACCATCCCTGAAGAGTGTGCAGCCGCAGGGAATGCGGTTATCACGTGTCCAGGACAAGGCGC
TCAGAAGTCGGGCCTTCTGAACGAGTGGCTGGACCTTCCGGGCTCCTTAGAATTCTTCCAGGCCCAGAGTGATTTTCTAA
AAATAGACCTGATAAAACATGGAACCATCTCTGACACTGATATTTTGCGGGATACACGGATAGCTCAACCTCTTATTGTT
GCATTGGGTATTTTTGTAATTCGCACACTGCAACAAAAGGCGAAAATTATTCAATCCATGCCAGAAGAGGCCCTGAACGG
AGCCAACCCTACTGAACGGATTATGCGATGTGTAGGACTTGCTGGACACTCGGTTGGTGAGATAACAGCAGCTTTCGGTG
CCGGGGTATTGACAGAAAAAAATGCAATGAGACTTGTAAAACATCGCGCAAATCAGATGTATAAATCAACACAAATCTTC
GATACAGGTATGGTTGCTGTTCTTGGGCAATCAGAAAACCTGGAAGAATACATTACCCAGCGGTACAAATTATTTCCAGC
AAATTACAATTGCCCCGGTCAGATTGTATTTGCCGGCCTTAGAGAGAACCTCGATGTCCTGTTGGCCAATCCTCCTGAAA
AAATAAAAGTGATACCCCTCCAGGTTGCCGGAGCTTTTCACACGAGATTTATGCGACCCGCGGTGCAGAATTTAAAAAAA
CTCAAATTTGTAACTGATAAATCTTTTGCAAAAGATCCCGACAAACGTATATGGACGAATTATGACGGGTCAGAGATATT
TTCTGGATCCGAATATGTACAGCTTCTTATTGACCAGATAGCAAGACCCGTCCGTTGGGATCTCTGTCAAAAAAATTTTG
AAAATATTGATTATCTAATTGAACTCCCCCCAGCAGGAACCCTCACAGGCCTCGCAAGGCGGAGTCTTCCGAAAGTCAAG
GGGATTCCTATCAATACAATTGATGACCTTGAAGAAGCTTCCTGCTGTTTTCTTTTGTAG

Upstream 100 bases:

>100_bases
AGCAGTATCGTAATAGCCGTTTTGTCACGGTTGGCAAAAAACGGTCTTGTTGACAAAGACATGCTTAAGCGTGAACTGAT
CCAATACAGAAGCAACAGGC

Downstream 100 bases:

>100_bases
AATTCTGCCTAGAGTGCGATATTCAAAGATAGTTTCCCTAGGTGCTTACAGGGGCGAGCGGGATGTGTACAATGATGAAT
TAATCGGTCCGATTAATTCA

Product: acyl-carrier-protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MASICDTIPEECAAAGNAVITCPGQGAQKSGLLNEWLDLPGSLEFFQAQSDFLKIDLIKHGTISDTDILRDTRIAQPLIV
ALGIFVIRTLQQKAKIIQSMPEEALNGANPTERIMRCVGLAGHSVGEITAAFGAGVLTEKNAMRLVKHRANQMYKSTQIF
DTGMVAVLGQSENLEEYITQRYKLFPANYNCPGQIVFAGLRENLDVLLANPPEKIKVIPLQVAGAFHTRFMRPAVQNLKK
LKFVTDKSFAKDPDKRIWTNYDGSEIFSGSEYVQLLIDQIARPVRWDLCQKNFENIDYLIELPPAGTLTGLARRSLPKVK
GIPINTIDDLEEASCCFLL

Sequences:

>Translated_339_residues
MASICDTIPEECAAAGNAVITCPGQGAQKSGLLNEWLDLPGSLEFFQAQSDFLKIDLIKHGTISDTDILRDTRIAQPLIV
ALGIFVIRTLQQKAKIIQSMPEEALNGANPTERIMRCVGLAGHSVGEITAAFGAGVLTEKNAMRLVKHRANQMYKSTQIF
DTGMVAVLGQSENLEEYITQRYKLFPANYNCPGQIVFAGLRENLDVLLANPPEKIKVIPLQVAGAFHTRFMRPAVQNLKK
LKFVTDKSFAKDPDKRIWTNYDGSEIFSGSEYVQLLIDQIARPVRWDLCQKNFENIDYLIELPPAGTLTGLARRSLPKVK
GIPINTIDDLEEASCCFLL
>Mature_338_residues
ASICDTIPEECAAAGNAVITCPGQGAQKSGLLNEWLDLPGSLEFFQAQSDFLKIDLIKHGTISDTDILRDTRIAQPLIVA
LGIFVIRTLQQKAKIIQSMPEEALNGANPTERIMRCVGLAGHSVGEITAAFGAGVLTEKNAMRLVKHRANQMYKSTQIFD
TGMVAVLGQSENLEEYITQRYKLFPANYNCPGQIVFAGLRENLDVLLANPPEKIKVIPLQVAGAFHTRFMRPAVQNLKKL
KFVTDKSFAKDPDKRIWTNYDGSEIFSGSEYVQLLIDQIARPVRWDLCQKNFENIDYLIELPPAGTLTGLARRSLPKVKG
IPINTIDDLEEASCCFLL

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=296, Percent_Identity=26.6891891891892, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1787334, Length=301, Percent_Identity=26.2458471760797, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71984332, Length=291, Percent_Identity=27.8350515463918, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24665753, Length=287, Percent_Identity=31.3588850174216, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 37526; Mature: 37395

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASICDTIPEECAAAGNAVITCPGQGAQKSGLLNEWLDLPGSLEFFQAQSDFLKIDLIKH
CCCHHHCCHHHHHHCCCEEEECCCCCCCCCCCHHHHHCCCCCHHHHHCCCCEEEEEEEEC
GTISDTDILRDTRIAQPLIVALGIFVIRTLQQKAKIIQSMPEEALNGANPTERIMRCVGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHH
AGHSVGEITAAFGAGVLTEKNAMRLVKHRANQMYKSTQIFDTGMVAVLGQSENLEEYITQ
CCCCHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
RYKLFPANYNCPGQIVFAGLRENLDVLLANPPEKIKVIPLQVAGAFHTRFMRPAVQNLKK
HHEECCCCCCCCCCEEEEECCCCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
LKFVTDKSFAKDPDKRIWTNYDGSEIFSGSEYVQLLIDQIARPVRWDLCQKNFENIDYLI
HHHHHCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEE
ELPPAGTLTGLARRSLPKVKGIPINTIDDLEEASCCFLL
ECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEECC
>Mature Secondary Structure 
ASICDTIPEECAAAGNAVITCPGQGAQKSGLLNEWLDLPGSLEFFQAQSDFLKIDLIKH
CCHHHCCHHHHHHCCCEEEECCCCCCCCCCCHHHHHCCCCCHHHHHCCCCEEEEEEEEC
GTISDTDILRDTRIAQPLIVALGIFVIRTLQQKAKIIQSMPEEALNGANPTERIMRCVGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHH
AGHSVGEITAAFGAGVLTEKNAMRLVKHRANQMYKSTQIFDTGMVAVLGQSENLEEYITQ
CCCCHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
RYKLFPANYNCPGQIVFAGLRENLDVLLANPPEKIKVIPLQVAGAFHTRFMRPAVQNLKK
HHEECCCCCCCCCCEEEEECCCCCEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
LKFVTDKSFAKDPDKRIWTNYDGSEIFSGSEYVQLLIDQIARPVRWDLCQKNFENIDYLI
HHHHHCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEE
ELPPAGTLTGLARRSLPKVKGIPINTIDDLEEASCCFLL
ECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]