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The map label for this gene is fabH [H]

Identifier: 161501889

GI number: 161501889

Start: 557122

End: 558141

Strand: Direct

Name: fabH [H]

Synonym: TW517

Alternate gene names: 161501889

Gene position: 557122-558141 (Clockwise)

Preceding gene: 28572665

Following gene: 28572667

Centisome position: 60.17

GC content: 47.75

Gene sequence:

>1020_bases
ATGACCTTGAAGAAGCTTCCTGCTGTTTTCTTTTGTAGAATTCTGCCTAGAGTGCGATATTCAAAGATAGTTTCCCTAGG
TGCTTACAGGGGCGAGCGGGATGTGTACAATGATGAATTAATCGGTCCGATTAATTCAAGTGACGAGTGGATAAGGCGCA
GAACTGGAATAATTTCAAGAAAGCGCGCGCTTTCAGGTACAACTGTCGTTGACATGGCATACGCAGCCTCAAAGGAGGCC
CTGAATGATGCGCAAATGCGTCCTGAGGATATCGATCTTATTCTGGTGGCAACTATAACTCACTTCGGGCATACTCCTTC
CGTTGCCGCACATGTCGGATTCAGAATAGGGGTGCAGGACGCAATACTGCTTGATATAAACGCTGCATGTGCAGGGTTCT
CCTACGCTATTTTCCAGGCAGACCTCATGATAAAAAGTGGGGTTGCATCCAGAGCGCTTGTTATAGGGGTGGACAAACTC
TCCGAGTTTATTGACCCGCTCGATAGAACCATCTCTTTTCTTTTGGCGGATGGTGCGGGTGCAGCAATCCTGGTTGGGAG
CACATCAATGGGCATCGGGAAAACAGTGTGTGGTGGAAACCCCGGACAGCTTGAATCAGTGGGTCTAACAGGCTCAACAA
CAGATGTAAAAAGCGGCTCGGCATGGCCAACCTTAAGACAAGAGGGGTCATCCATTTTTCGATGGGCGGTTTGGCAAATG
GCCAAGGTTGCAAAGCAGATCTTGGACATAAACCAGGTGCAACCGGGGGATTTAAACGCGTTTATTCCTCATCAGGCAAA
TATACGGATAATAGATGAGCTGGCAAAACAGATTGGACTTGAGGAAAATGTCCTGATTGCACAAGACATATGCAAAACTG
GCAATACGAGTTCTGCATCAATCCCACTGGCGATGCATTCACTCATCAAGGGCAATCCATCACTCTCTGGGGAACTTGCA
CTACAAATAGGTTTTGGTGCGGGGTTAGTGTACGCCGGACAAACAGTTGTAATGCCGTAA

Upstream 100 bases:

>100_bases
AATATTGATTATCTAATTGAACTCCCCCCAGCAGGAACCCTCACAGGCCTCGCAAGGCGGAGTCTTCCGAAAGTCAAGGG
GATTCCTATCAATACAATTG

Downstream 100 bases:

>100_bases
CATATTCCCGATGATTTTGTCCATTCACAGTGTCAGCCGTAAAATTGGTTTTGTTTTAGTCTAGAGAGGTGTTTGCGTGT
CTTTATCAAGGGAGAAAGTT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTLKKLPAVFFCRILPRVRYSKIVSLGAYRGERDVYNDELIGPINSSDEWIRRRTGIISRKRALSGTTVVDMAYAASKEA
LNDAQMRPEDIDLILVATITHFGHTPSVAAHVGFRIGVQDAILLDINAACAGFSYAIFQADLMIKSGVASRALVIGVDKL
SEFIDPLDRTISFLLADGAGAAILVGSTSMGIGKTVCGGNPGQLESVGLTGSTTDVKSGSAWPTLRQEGSSIFRWAVWQM
AKVAKQILDINQVQPGDLNAFIPHQANIRIIDELAKQIGLEENVLIAQDICKTGNTSSASIPLAMHSLIKGNPSLSGELA
LQIGFGAGLVYAGQTVVMP

Sequences:

>Translated_339_residues
MTLKKLPAVFFCRILPRVRYSKIVSLGAYRGERDVYNDELIGPINSSDEWIRRRTGIISRKRALSGTTVVDMAYAASKEA
LNDAQMRPEDIDLILVATITHFGHTPSVAAHVGFRIGVQDAILLDINAACAGFSYAIFQADLMIKSGVASRALVIGVDKL
SEFIDPLDRTISFLLADGAGAAILVGSTSMGIGKTVCGGNPGQLESVGLTGSTTDVKSGSAWPTLRQEGSSIFRWAVWQM
AKVAKQILDINQVQPGDLNAFIPHQANIRIIDELAKQIGLEENVLIAQDICKTGNTSSASIPLAMHSLIKGNPSLSGELA
LQIGFGAGLVYAGQTVVMP
>Mature_338_residues
TLKKLPAVFFCRILPRVRYSKIVSLGAYRGERDVYNDELIGPINSSDEWIRRRTGIISRKRALSGTTVVDMAYAASKEAL
NDAQMRPEDIDLILVATITHFGHTPSVAAHVGFRIGVQDAILLDINAACAGFSYAIFQADLMIKSGVASRALVIGVDKLS
EFIDPLDRTISFLLADGAGAAILVGSTSMGIGKTVCGGNPGQLESVGLTGSTTDVKSGSAWPTLRQEGSSIFRWAVWQMA
KVAKQILDINQVQPGDLNAFIPHQANIRIIDELAKQIGLEENVLIAQDICKTGNTSSASIPLAMHSLIKGNPSLSGELAL
QIGFGAGLVYAGQTVVMP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=315, Percent_Identity=35.8730158730159, Blast_Score=179, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 36195; Mature: 36064

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKKLPAVFFCRILPRVRYSKIVSLGAYRGERDVYNDELIGPINSSDEWIRRRTGIISR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KRALSGTTVVDMAYAASKEALNDAQMRPEDIDLILVATITHFGHTPSVAAHVGFRIGVQD
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCCCCHHHHCCEEECCCC
AILLDINAACAGFSYAIFQADLMIKSGVASRALVIGVDKLSEFIDPLDRTISFLLADGAG
EEEEEECHHHCCCEEEEHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEECCCC
AAILVGSTSMGIGKTVCGGNPGQLESVGLTGSTTDVKSGSAWPTLRQEGSSIFRWAVWQM
CEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHH
AKVAKQILDINQVQPGDLNAFIPHQANIRIIDELAKQIGLEENVLIAQDICKTGNTSSAS
HHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCC
IPLAMHSLIKGNPSLSGELALQIGFGAGLVYAGQTVVMP
CHHHHHHHHCCCCCCCCEEEEEEECCCCEEECCCEEECC
>Mature Secondary Structure 
TLKKLPAVFFCRILPRVRYSKIVSLGAYRGERDVYNDELIGPINSSDEWIRRRTGIISR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KRALSGTTVVDMAYAASKEALNDAQMRPEDIDLILVATITHFGHTPSVAAHVGFRIGVQD
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCCCCHHHHCCEEECCCC
AILLDINAACAGFSYAIFQADLMIKSGVASRALVIGVDKLSEFIDPLDRTISFLLADGAG
EEEEEECHHHCCCEEEEHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEECCCC
AAILVGSTSMGIGKTVCGGNPGQLESVGLTGSTTDVKSGSAWPTLRQEGSSIFRWAVWQM
CEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHH
AKVAKQILDINQVQPGDLNAFIPHQANIRIIDELAKQIGLEENVLIAQDICKTGNTSSAS
HHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCC
IPLAMHSLIKGNPSLSGELALQIGFGAGLVYAGQTVVMP
CHHHHHHHHCCCCCCCCEEEEEEECCCCEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174 [H]