| Definition | Tropheryma whipplei TW08/27, complete genome. |
|---|---|
| Accession | NC_004551 |
| Length | 925,938 |
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The map label for this gene is uvrA [H]
Identifier: 28572625
GI number: 28572625
Start: 510167
End: 513013
Strand: Reverse
Name: uvrA [H]
Synonym: TW476
Alternate gene names: 28572625
Gene position: 513013-510167 (Counterclockwise)
Preceding gene: 28572626
Following gene: 28572624
Centisome position: 55.4
GC content: 42.57
Gene sequence:
>2847_bases GTGTCAAGTCGCAGGTCATTTTTGCGCGTTAAAAACGCGCGGGTTCACAATTTAAAAAACCTTAATGTGCGGATTCCGAG AAATTCAATGACTGTTTTTACAGGCCTTTCCGGCTCCGGAAAGTCAAGTCTTGCATTTGACACTATTTTTGCTGAGGGGC AGAGGCGGTACATAGAGTCTCTTTCTGCATATGCAAGACAGTTTTTAGAAAGACTTGATAGGCCGGAGGTGGATTCTATC GACGGACTCAGCCCATCAGTGGCGATTGACCAAAAAACCACAAGTAGAAATCCGCGCTCTACCGTCGGTACGGTCACGGA AATATTTGATTATTTGCGGCTTCTGTGGGCACGTGTTGGGGTTTTGCACTGTCCGGAATGTGATTTACCCGTACAAAAAC AGACTATTCAGCAGATAGTAGATTCAATTGCCAAGATTCCACACGGTGAAAGATTCATGCTCTTATCACCACTTGTACGA CAAAAAAAGGGGGAATTTGTTGATCTTTTCTCGAGGCTTACCACATCTGGTTTTTCGCGAGTTGTTGTTGATGAAGAAAT TTATTTACTAACAGAAGTTCCGAAACTTAAAAAAAATTCGCGCCACACAATAAAAGTTGTTGTAGATAGGCTTGTTTCTG AGGATAATATGCTAACTCGGCTGACAGATTCAATTGAAACCGCATTTGGCCTTTCGAATATTTGTGAAGTTCAAACCTTC AAAGGTGACGTATTTCGCTTTTCTATAAACTCAGCATGCCCGAATTTACACTTTCTGAACTTTGACAAAATAGAGCCGAG AACCTTCTCGTTTAATTCACCTGTCGGCGCATGTCCTGACTGTGACGGGATCGGCACAGTTCGATCTGTTAATATGACCA CATTAGTGCCTGATACACAGCTTTCAGTTGAGAAGATAGCGCTAGACCTTATAGATAAAAAAATTGTTTCAAAAAACTTC ATGCGCGAGATGTCGGCCCTTGCTAGGAATCTTAAATTCACCCTCAATACCCCGTGGAGTGATCTTACAGATTACGTACA AAACACAATACTGCACGCAAAAAATTTTCTATTACACAACACTAGAGTGCGGTATTACACGGGTCTTGTAAGAAAGATAG AAAGGGATGTATCAGAAAACTCTGGAGGATCTCTTTCGGGTTATTTATACAACTCACCGTGTCGTTCGTGCTCTGGAAAG CGCCTTAGGGCATCGTCACTCTGCGTCAAAGTGTCTAACAAAAATATTATTGATGTTTGTGATATGCCTCTTGACGGAAT ACTCCACTTTTTTAAAGCATTGGATATTCCAAGAAAATTTGAGAAAATATCCTCTCCAATACTCAGAGAAATTATCTCAA GACTGGAGTTTCTGATTGAACTCGGTCTTGGGTATTTAACTTTGTCACGAAGTATTACAACAATTTCTGGAGGTGAGTCC CAAAGAATAAGATTGGCAACTCAAATCGGCTCAGGTCTCACGGAGGTGCTTTATGTTCTGGACGAACCGAGCATTGGTCT ACACAAGAGAGATAACGAGAAGCTTATAAAGCTATTGCTGAATCTTAGGAACCGCGGGAATACGCTTATCGTTGTTGAGC ATGATGAAGAGACGATTAGATCTTCGGATTGGATAGTTGATATAGGGCCTGGTGCGGGGAGAATGGGCGGGCAGGTCGTT TATTCTGGTCCAGTCGGTAAAATGCCCAGTCGTAGTCTTACAGGAAAATACCTCTCGGGTGAACTTATGGTCTCTACACC GAAGAAGCGCCGAGTTTCTTCGTGTGGAATTACCCTCTCGGGTGCAAAAGAAAATAATCTAAAAAATATAACGGTTTTCT TTCCATTAAAAACCTTTATAGTCATTACAGGTGTTTCTGGCTCTGGGAAATCAACCTTAGTAAACTCTGTTTTGTGCAAA GCGCTCTCGAATATTTGCAAGGGGAATACGCCTTCCGAGAATAATTGTCAGGATGCAGATTGTACTGATGCTTGTACGGT ACGCAATGGGATGCAGCACAATGAACAGACTGTTCGTTTGGCACCTGCACTGGATGGTGCGGAGAATATCTCAAAAGTTG TTCATATAGACCAGAAGCCTATCGGACGAACTCCGAGGTCAAATTTGGCGACTTATACCGGGGTGTTTGACAAAATAAGG GATATTTTTTCTAAAACACCAACAGCTCGTGCGAGGGGGTATTCACCAGGTCGATTTAGTTTTAATCTCAAAGGTGGACG ATGTGAAAAATGTAAGGGTGATGGATGCATAAAGATTGAAATGAATTTTTTGCCCGATGTTTATGTGGATTGCGAGGATT GCAATGGAATGCGGTACAACAGAGACACGCTCCAGGTTCTCTACAACAATATGAGTATACATGATGTATTAACAATGCCG GTTTGTGAAGCTGTTGAGTTTTTTAGGGCTATTCCATCTATACATCAACCATTGAAACTCATGGATGAAATAGGGCTCGG CTACATGACTTTAGGTCAACCCGCGCCCACACTGTCCGGTGGGGAAGCTCAAAGGATAAAGCTTGCCGCGCAACTTCAAA AACGCACTGCACAGGATGTTCTGTATGTTCTGGATGAACCAACAACCGGGTTACATTTTCATGATGTTAGGCAGTTGCTT GAGATACTTCATAGACTGGTTGATAACGGCAACACAGTTATCGTAATTGAGCATAATCTGGATGTTATAAAAACAGCAGA CCACGTAATAGATATGGGCCCTGAAGGGGGTAATGCTGGTGGGTCAGTGGTTGCTTGCGGTACACCAGAAGAAGTTGCAC TCCATCCCGACAGTGCAACAGGTTATTTCCTTAAAAAATGCTTGTGA
Upstream 100 bases:
>100_bases AAGAAGCCGCAGAATTACGTGATGAAATACAGTCCCTCAAGGAGAAGTTCCTAAAACCGCGAGGCAGTGGCGGGAAAATT AGACAGTAATCAGAGTAGAA
Downstream 100 bases:
>100_bases GGTAGCTTATGTACCCACCAAGGAGGATAGAGATACCCTGCAAACCGGGGGTTTATAGATTTGAAGATGAAAATGGACGT ATTCTCTATGTTGGTAAGGC
Product: excinuclease ABC subunit A
Products: NA
Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]
Number of amino acids: Translated: 948; Mature: 947
Protein sequence:
>948_residues MSSRRSFLRVKNARVHNLKNLNVRIPRNSMTVFTGLSGSGKSSLAFDTIFAEGQRRYIESLSAYARQFLERLDRPEVDSI DGLSPSVAIDQKTTSRNPRSTVGTVTEIFDYLRLLWARVGVLHCPECDLPVQKQTIQQIVDSIAKIPHGERFMLLSPLVR QKKGEFVDLFSRLTTSGFSRVVVDEEIYLLTEVPKLKKNSRHTIKVVVDRLVSEDNMLTRLTDSIETAFGLSNICEVQTF KGDVFRFSINSACPNLHFLNFDKIEPRTFSFNSPVGACPDCDGIGTVRSVNMTTLVPDTQLSVEKIALDLIDKKIVSKNF MREMSALARNLKFTLNTPWSDLTDYVQNTILHAKNFLLHNTRVRYYTGLVRKIERDVSENSGGSLSGYLYNSPCRSCSGK RLRASSLCVKVSNKNIIDVCDMPLDGILHFFKALDIPRKFEKISSPILREIISRLEFLIELGLGYLTLSRSITTISGGES QRIRLATQIGSGLTEVLYVLDEPSIGLHKRDNEKLIKLLLNLRNRGNTLIVVEHDEETIRSSDWIVDIGPGAGRMGGQVV YSGPVGKMPSRSLTGKYLSGELMVSTPKKRRVSSCGITLSGAKENNLKNITVFFPLKTFIVITGVSGSGKSTLVNSVLCK ALSNICKGNTPSENNCQDADCTDACTVRNGMQHNEQTVRLAPALDGAENISKVVHIDQKPIGRTPRSNLATYTGVFDKIR DIFSKTPTARARGYSPGRFSFNLKGGRCEKCKGDGCIKIEMNFLPDVYVDCEDCNGMRYNRDTLQVLYNNMSIHDVLTMP VCEAVEFFRAIPSIHQPLKLMDEIGLGYMTLGQPAPTLSGGEAQRIKLAAQLQKRTAQDVLYVLDEPTTGLHFHDVRQLL EILHRLVDNGNTVIVIEHNLDVIKTADHVIDMGPEGGNAGGSVVACGTPEEVALHPDSATGYFLKKCL
Sequences:
>Translated_948_residues MSSRRSFLRVKNARVHNLKNLNVRIPRNSMTVFTGLSGSGKSSLAFDTIFAEGQRRYIESLSAYARQFLERLDRPEVDSI DGLSPSVAIDQKTTSRNPRSTVGTVTEIFDYLRLLWARVGVLHCPECDLPVQKQTIQQIVDSIAKIPHGERFMLLSPLVR QKKGEFVDLFSRLTTSGFSRVVVDEEIYLLTEVPKLKKNSRHTIKVVVDRLVSEDNMLTRLTDSIETAFGLSNICEVQTF KGDVFRFSINSACPNLHFLNFDKIEPRTFSFNSPVGACPDCDGIGTVRSVNMTTLVPDTQLSVEKIALDLIDKKIVSKNF MREMSALARNLKFTLNTPWSDLTDYVQNTILHAKNFLLHNTRVRYYTGLVRKIERDVSENSGGSLSGYLYNSPCRSCSGK RLRASSLCVKVSNKNIIDVCDMPLDGILHFFKALDIPRKFEKISSPILREIISRLEFLIELGLGYLTLSRSITTISGGES QRIRLATQIGSGLTEVLYVLDEPSIGLHKRDNEKLIKLLLNLRNRGNTLIVVEHDEETIRSSDWIVDIGPGAGRMGGQVV YSGPVGKMPSRSLTGKYLSGELMVSTPKKRRVSSCGITLSGAKENNLKNITVFFPLKTFIVITGVSGSGKSTLVNSVLCK ALSNICKGNTPSENNCQDADCTDACTVRNGMQHNEQTVRLAPALDGAENISKVVHIDQKPIGRTPRSNLATYTGVFDKIR DIFSKTPTARARGYSPGRFSFNLKGGRCEKCKGDGCIKIEMNFLPDVYVDCEDCNGMRYNRDTLQVLYNNMSIHDVLTMP VCEAVEFFRAIPSIHQPLKLMDEIGLGYMTLGQPAPTLSGGEAQRIKLAAQLQKRTAQDVLYVLDEPTTGLHFHDVRQLL EILHRLVDNGNTVIVIEHNLDVIKTADHVIDMGPEGGNAGGSVVACGTPEEVALHPDSATGYFLKKCL >Mature_947_residues SSRRSFLRVKNARVHNLKNLNVRIPRNSMTVFTGLSGSGKSSLAFDTIFAEGQRRYIESLSAYARQFLERLDRPEVDSID GLSPSVAIDQKTTSRNPRSTVGTVTEIFDYLRLLWARVGVLHCPECDLPVQKQTIQQIVDSIAKIPHGERFMLLSPLVRQ KKGEFVDLFSRLTTSGFSRVVVDEEIYLLTEVPKLKKNSRHTIKVVVDRLVSEDNMLTRLTDSIETAFGLSNICEVQTFK GDVFRFSINSACPNLHFLNFDKIEPRTFSFNSPVGACPDCDGIGTVRSVNMTTLVPDTQLSVEKIALDLIDKKIVSKNFM REMSALARNLKFTLNTPWSDLTDYVQNTILHAKNFLLHNTRVRYYTGLVRKIERDVSENSGGSLSGYLYNSPCRSCSGKR LRASSLCVKVSNKNIIDVCDMPLDGILHFFKALDIPRKFEKISSPILREIISRLEFLIELGLGYLTLSRSITTISGGESQ RIRLATQIGSGLTEVLYVLDEPSIGLHKRDNEKLIKLLLNLRNRGNTLIVVEHDEETIRSSDWIVDIGPGAGRMGGQVVY SGPVGKMPSRSLTGKYLSGELMVSTPKKRRVSSCGITLSGAKENNLKNITVFFPLKTFIVITGVSGSGKSTLVNSVLCKA LSNICKGNTPSENNCQDADCTDACTVRNGMQHNEQTVRLAPALDGAENISKVVHIDQKPIGRTPRSNLATYTGVFDKIRD IFSKTPTARARGYSPGRFSFNLKGGRCEKCKGDGCIKIEMNFLPDVYVDCEDCNGMRYNRDTLQVLYNNMSIHDVLTMPV CEAVEFFRAIPSIHQPLKLMDEIGLGYMTLGQPAPTLSGGEAQRIKLAAQLQKRTAQDVLYVLDEPTTGLHFHDVRQLLE ILHRLVDNGNTVIVIEHNLDVIKTADHVIDMGPEGGNAGGSVVACGTPEEVALHPDSATGYFLKKCL
Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h
COG id: COG0178
COG function: function code L; Excinuclease ATPase subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ABC transporter domains [H]
Homologues:
Organism=Escherichia coli, GI2367343, Length=966, Percent_Identity=48.343685300207, Blast_Score=898, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR013815 - InterPro: IPR003593 - InterPro: IPR004602 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 105201; Mature: 105070
Theoretical pI: Translated: 8.68; Mature: 8.68
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.5 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 4.5 %Cys+Met (Translated Protein) 2.5 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 4.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSSRRSFLRVKNARVHNLKNLNVRIPRNSMTVFTGLSGSGKSSLAFDTIFAEGQRRYIES CCCCHHHHHHCCCHHCCCCCCEEEECCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHH LSAYARQFLERLDRPEVDSIDGLSPSVAIDQKTTSRNPRSTVGTVTEIFDYLRLLWARVG HHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC VLHCPECDLPVQKQTIQQIVDSIAKIPHGERFMLLSPLVRQKKGEFVDLFSRLTTSGFSR EEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCCCEE VVVDEEIYLLTEVPKLKKNSRHTIKVVVDRLVSEDNMLTRLTDSIETAFGLSNICEVQTF EEECCCEEEEECCCHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHEEEC KGDVFRFSINSACPNLHFLNFDKIEPRTFSFNSPVGACPDCDGIGTVRSVNMTTLVPDTQ CCCEEEEEECCCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCCCCEEECCEEEECCCCC LSVEKIALDLIDKKIVSKNFMREMSALARNLKFTLNTPWSDLTDYVQNTILHAKNFLLHN HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC TRVRYYTGLVRKIERDVSENSGGSLSGYLYNSPCRSCSGKRLRASSLCVKVSNKNIIDVC CHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEECCEEEEEECCCCEEEEC DMPLDGILHFFKALDIPRKFEKISSPILREIISRLEFLIELGLGYLTLSRSITTISGGES CCCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCCC QRIRLATQIGSGLTEVLYVLDEPSIGLHKRDNEKLIKLLLNLRNRGNTLIVVEHDEETIR CEEEEHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHC SSDWIVDIGPGAGRMGGQVVYSGPVGKMPSRSLTGKYLSGELMVSTPKKRRVSSCGITLS CCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEECCEEEEECCHHHHHHHCCEEEE GAKENNLKNITVFFPLKTFIVITGVSGSGKSTLVNSVLCKALSNICKGNTPSENNCQDAD CCCCCCCCEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC CTDACTVRNGMQHNEQTVRLAPALDGAENISKVVHIDQKPIGRTPRSNLATYTGVFDKIR CCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHH DIFSKTPTARARGYSPGRFSFNLKGGRCEKCKGDGCIKIEMNFLPDVYVDCEDCNGMRYN HHHHCCCCCHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCEEC RDTLQVLYNNMSIHDVLTMPVCEAVEFFRAIPSIHQPLKLMDEIGLGYMTLGQPAPTLSG HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCC GEAQRIKLAAQLQKRTAQDVLYVLDEPTTGLHFHDVRQLLEILHRLVDNGNTVIVIEHNL CCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCC DVIKTADHVIDMGPEGGNAGGSVVACGTPEEVALHPDSATGYFLKKCL CHHHCCCHHEECCCCCCCCCCCEEECCCCCCEEECCCCCCHHHHHHCC >Mature Secondary Structure SSRRSFLRVKNARVHNLKNLNVRIPRNSMTVFTGLSGSGKSSLAFDTIFAEGQRRYIES CCCHHHHHHCCCHHCCCCCCEEEECCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHH LSAYARQFLERLDRPEVDSIDGLSPSVAIDQKTTSRNPRSTVGTVTEIFDYLRLLWARVG HHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC VLHCPECDLPVQKQTIQQIVDSIAKIPHGERFMLLSPLVRQKKGEFVDLFSRLTTSGFSR EEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCCCEE VVVDEEIYLLTEVPKLKKNSRHTIKVVVDRLVSEDNMLTRLTDSIETAFGLSNICEVQTF EEECCCEEEEECCCHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHEEEC KGDVFRFSINSACPNLHFLNFDKIEPRTFSFNSPVGACPDCDGIGTVRSVNMTTLVPDTQ CCCEEEEEECCCCCCCEEECCCCCCCCEEECCCCCCCCCCCCCCCCEEECCEEEECCCCC LSVEKIALDLIDKKIVSKNFMREMSALARNLKFTLNTPWSDLTDYVQNTILHAKNFLLHN HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC TRVRYYTGLVRKIERDVSENSGGSLSGYLYNSPCRSCSGKRLRASSLCVKVSNKNIIDVC CHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEECCEEEEEECCCCEEEEC DMPLDGILHFFKALDIPRKFEKISSPILREIISRLEFLIELGLGYLTLSRSITTISGGES CCCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCCC QRIRLATQIGSGLTEVLYVLDEPSIGLHKRDNEKLIKLLLNLRNRGNTLIVVEHDEETIR CEEEEHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHC SSDWIVDIGPGAGRMGGQVVYSGPVGKMPSRSLTGKYLSGELMVSTPKKRRVSSCGITLS CCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEECCEEEEECCHHHHHHHCCEEEE GAKENNLKNITVFFPLKTFIVITGVSGSGKSTLVNSVLCKALSNICKGNTPSENNCQDAD CCCCCCCCEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC CTDACTVRNGMQHNEQTVRLAPALDGAENISKVVHIDQKPIGRTPRSNLATYTGVFDKIR CCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHH DIFSKTPTARARGYSPGRFSFNLKGGRCEKCKGDGCIKIEMNFLPDVYVDCEDCNGMRYN HHHHCCCCCHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCEEC RDTLQVLYNNMSIHDVLTMPVCEAVEFFRAIPSIHQPLKLMDEIGLGYMTLGQPAPTLSG HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCC GEAQRIKLAAQLQKRTAQDVLYVLDEPTTGLHFHDVRQLLEILHRLVDNGNTVIVIEHNL CCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCC DVIKTADHVIDMGPEGGNAGGSVVACGTPEEVALHPDSATGYFLKKCL CHHHCCCHHEECCCCCCCCCCCEEECCCCCCEEECCCCCCHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: DNA [C]
Specific reaction: Protein + DNA = Protein-DNA [C]
General reaction: Hydrolase; Acting on ester bonds [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2549377 [H]