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The map label for this gene is uvrC

Identifier: 28572624

GI number: 28572624

Start: 508335

End: 510158

Strand: Reverse

Name: uvrC

Synonym: TW475

Alternate gene names: 28572624

Gene position: 510158-508335 (Counterclockwise)

Preceding gene: 28572625

Following gene: 28572623

Centisome position: 55.1

GC content: 42.16

Gene sequence:

>1824_bases
ATGTACCCACCAAGGAGGATAGAGATACCCTGCAAACCGGGGGTTTATAGATTTGAAGATGAAAATGGACGTATTCTCTA
TGTTGGTAAGGCAAAAAATCTTCGCAATCGCTTGGGAAGTTACTTCACGAATGCAAGGCGAGGGCGCCGTATTTCGTATA
TGCTGTCTATTTCCAAAAAGGTTGGGTGGACGTGCGTCGCAGACGATATAGAGGCACTGAGACTTGAATATTCATGGATA
AAAGAATTTGCCCCGCCTTGTAACGTGAAATTGAAAGATGATAAAGCCTATCCGTTCTTGGCTGTGACAATAGGCGAACA
GGTGCCTAGACTTTTGATTACCAGAAGAAAAATTCAGTACGCTACGCATTTTGGTCCATATCCAAAAGTGTTTCATCTTC
GGGAAACAGTTAGCTTGTTGCACAAGATATTTCAAATAAGGACCTGTTCTCCGACAAACTATAAAAGGGCAATTGCCTCT
GGGATGCCGTGTTTTGAAGGGCAGATTAATAAGTGTTTCGGGCCATGTTCTTTAAAAACAACCCATCTTCAATATCAGAA
AAGAATAAAAAATCTCATGGCTTTTCTAGAGGGTCAATCTTCTTCTCTTTTAGAATCTCTGAAGAAAAAAATGCTCAAGG
CATCTAAGAACAAAGAATACGAAGAGGCGGCAATTTTGCGAGATAAGATACAAGCCGCACAAACGGTTTTATCCAGGAGC
GCGGTTCTGCTAGATGAAACAGTGTCGGCAGACTTTATCGCCGTCGTATCCGATAATTCTATCGCTTCAGTACAGTGCTT
TCGAGTAATTGCTGGTCGCATAAAATCTGTGTATTCATGGCATTTTGAACAACAGGAAGATCAGTCAGCTTCTGAGCTTT
TGTCCCAGTCGATTATTCAGGTGTATGACAAACTAAGCCTTCCGAAAAGGATTGTTCTTTTTGACAAACCGAGTTATCTT
AGTGCACTCTCGGCTCATTTGAACGACAAAAATATTGACAGGTCGCTCGAAATAGAAATTGTATATCACCCGAATGAGCA
GGAAAGGAGACTTTTAGAGACTGTAAAAGATAATGCGCTTTCGGAATTGGAAAGACACAGATTGAGGCGTTCTTCTGATT
ACACCGAGAGGCATAGATCTCTCTTTGAGTTACAAAAATATTTGAACTTGAATTCATTGCCGGTGCGCATTGAATGTTTT
GACATTTCTCATCTCTCGGGCACAAACACCTCGGGAAGCATGGTGGTTTTCGAGAACGGAGAGCCAAAGAAATCGGCGTA
TCGCCACTTTAATATACATATTGATCAGAACAATGACACTGCTTCGATGTTCTCGCTTATATGTCGTAGGTTAAGGTCCC
TCGAGTCAGTTGCACAAGATTCGCCGGATTATCCACACTTGATGATTATCGATGGTGGTAAGCCTCAGCTATCAGCAGCT
GTGGGGGCATTACAAGAGGTGGGTTTAAAGATTCCTGTTTTTGCACTATCAAAAAGACTTGAAGAGCTCTGGTCGCCAGG
GGTCAAAACCTCACTTATTCTTCCACCTAACAGCGAATCGCTGTTCTTATTACAGAAGATTAGAGATGAATCTCACAGGT
TTGCGCTAAAACAACAGACAAGACGGCGTGAGGCATATTTGACAAGTGAGCTCTTCCGCATTCCGGGCCTTGGTAAACAG
AAAGTTATGCAGCTTTTGCGAAGATTTTCTTCATTTGCTGAAATTCGGCAGGCTTCCATTGAAGATATATCTGCATTGCC
AGGGTTTGGTGTAAAAACCGCCGAGAAAATCAAGGAATGTGCAGAAGCATTCTCTTTGAAATAA

Upstream 100 bases:

>100_bases
CTGGTGGGTCAGTGGTTGCTTGCGGTACACCAGAAGAAGTTGCACTCCATCCCGACAGTGCAACAGGTTATTTCCTTAAA
AAATGCTTGTGAGGTAGCTT

Downstream 100 bases:

>100_bases
AATGAACCCGTGAATTCCCTGTTGCAAGCCCTTCACCTCTTGAGATGTGATTTACTCTCTCTTCCGATAGGGGATGCTCA
AACAAGATCAGCTGAACTAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MYPPRRIEIPCKPGVYRFEDENGRILYVGKAKNLRNRLGSYFTNARRGRRISYMLSISKKVGWTCVADDIEALRLEYSWI
KEFAPPCNVKLKDDKAYPFLAVTIGEQVPRLLITRRKIQYATHFGPYPKVFHLRETVSLLHKIFQIRTCSPTNYKRAIAS
GMPCFEGQINKCFGPCSLKTTHLQYQKRIKNLMAFLEGQSSSLLESLKKKMLKASKNKEYEEAAILRDKIQAAQTVLSRS
AVLLDETVSADFIAVVSDNSIASVQCFRVIAGRIKSVYSWHFEQQEDQSASELLSQSIIQVYDKLSLPKRIVLFDKPSYL
SALSAHLNDKNIDRSLEIEIVYHPNEQERRLLETVKDNALSELERHRLRRSSDYTERHRSLFELQKYLNLNSLPVRIECF
DISHLSGTNTSGSMVVFENGEPKKSAYRHFNIHIDQNNDTASMFSLICRRLRSLESVAQDSPDYPHLMIIDGGKPQLSAA
VGALQEVGLKIPVFALSKRLEELWSPGVKTSLILPPNSESLFLLQKIRDESHRFALKQQTRRREAYLTSELFRIPGLGKQ
KVMQLLRRFSSFAEIRQASIEDISALPGFGVKTAEKIKECAEAFSLK

Sequences:

>Translated_607_residues
MYPPRRIEIPCKPGVYRFEDENGRILYVGKAKNLRNRLGSYFTNARRGRRISYMLSISKKVGWTCVADDIEALRLEYSWI
KEFAPPCNVKLKDDKAYPFLAVTIGEQVPRLLITRRKIQYATHFGPYPKVFHLRETVSLLHKIFQIRTCSPTNYKRAIAS
GMPCFEGQINKCFGPCSLKTTHLQYQKRIKNLMAFLEGQSSSLLESLKKKMLKASKNKEYEEAAILRDKIQAAQTVLSRS
AVLLDETVSADFIAVVSDNSIASVQCFRVIAGRIKSVYSWHFEQQEDQSASELLSQSIIQVYDKLSLPKRIVLFDKPSYL
SALSAHLNDKNIDRSLEIEIVYHPNEQERRLLETVKDNALSELERHRLRRSSDYTERHRSLFELQKYLNLNSLPVRIECF
DISHLSGTNTSGSMVVFENGEPKKSAYRHFNIHIDQNNDTASMFSLICRRLRSLESVAQDSPDYPHLMIIDGGKPQLSAA
VGALQEVGLKIPVFALSKRLEELWSPGVKTSLILPPNSESLFLLQKIRDESHRFALKQQTRRREAYLTSELFRIPGLGKQ
KVMQLLRRFSSFAEIRQASIEDISALPGFGVKTAEKIKECAEAFSLK
>Mature_607_residues
MYPPRRIEIPCKPGVYRFEDENGRILYVGKAKNLRNRLGSYFTNARRGRRISYMLSISKKVGWTCVADDIEALRLEYSWI
KEFAPPCNVKLKDDKAYPFLAVTIGEQVPRLLITRRKIQYATHFGPYPKVFHLRETVSLLHKIFQIRTCSPTNYKRAIAS
GMPCFEGQINKCFGPCSLKTTHLQYQKRIKNLMAFLEGQSSSLLESLKKKMLKASKNKEYEEAAILRDKIQAAQTVLSRS
AVLLDETVSADFIAVVSDNSIASVQCFRVIAGRIKSVYSWHFEQQEDQSASELLSQSIIQVYDKLSLPKRIVLFDKPSYL
SALSAHLNDKNIDRSLEIEIVYHPNEQERRLLETVKDNALSELERHRLRRSSDYTERHRSLFELQKYLNLNSLPVRIECF
DISHLSGTNTSGSMVVFENGEPKKSAYRHFNIHIDQNNDTASMFSLICRRLRSLESVAQDSPDYPHLMIIDGGKPQLSAA
VGALQEVGLKIPVFALSKRLEELWSPGVKTSLILPPNSESLFLLQKIRDESHRFALKQQTRRREAYLTSELFRIPGLGKQ
KVMQLLRRFSSFAEIRQASIEDISALPGFGVKTAEKIKECAEAFSLK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=32.7302631578947, Blast_Score=279, Evalue=5e-76,
Organism=Escherichia coli, GI1788037, Length=191, Percent_Identity=28.7958115183246, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_TROW8 (Q83NI9)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789404.1
- ProteinModelPortal:   Q83NI9
- STRING:   Q83NI9
- GeneID:   1064315
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW475
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q83NI9
- ProtClustDB:   PRK00558
- BioCyc:   TWHI218496:TW0449-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69465; Mature: 69465

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPPRRIEIPCKPGVYRFEDENGRILYVGKAKNLRNRLGSYFTNARRGRRISYMLSISKK
CCCCCEEECCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEHHH
VGWTCVADDIEALRLEYSWIKEFAPPCNVKLKDDKAYPFLAVTIGEQVPRLLITRRKIQY
CCCEEECCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHH
ATHFGPYPKVFHLRETVSLLHKIFQIRTCSPTNYKRAIASGMPCFEGQINKCFGPCSLKT
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCHHHCCCCCCCCH
THLQYQKRIKNLMAFLEGQSSSLLESLKKKMLKASKNKEYEEAAILRDKIQAAQTVLSRS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AVLLDETVSADFIAVVSDNSIASVQCFRVIAGRIKSVYSWHFEQQEDQSASELLSQSIIQ
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VYDKLSLPKRIVLFDKPSYLSALSAHLNDKNIDRSLEIEIVYHPNEQERRLLETVKDNAL
HHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
SELERHRLRRSSDYTERHRSLFELQKYLNLNSLPVRIECFDISHLSGTNTSGSMVVFENG
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECC
EPKKSAYRHFNIHIDQNNDTASMFSLICRRLRSLESVAQDSPDYPHLMIIDGGKPQLSAA
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
VGALQEVGLKIPVFALSKRLEELWSPGVKTSLILPPNSESLFLLQKIRDESHRFALKQQT
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
RRREAYLTSELFRIPGLGKQKVMQLLRRFSSFAEIRQASIEDISALPGFGVKTAEKIKEC
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
AEAFSLK
HHHHCCC
>Mature Secondary Structure
MYPPRRIEIPCKPGVYRFEDENGRILYVGKAKNLRNRLGSYFTNARRGRRISYMLSISKK
CCCCCEEECCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEHHH
VGWTCVADDIEALRLEYSWIKEFAPPCNVKLKDDKAYPFLAVTIGEQVPRLLITRRKIQY
CCCEEECCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHH
ATHFGPYPKVFHLRETVSLLHKIFQIRTCSPTNYKRAIASGMPCFEGQINKCFGPCSLKT
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCHHHCCCCCCCCH
THLQYQKRIKNLMAFLEGQSSSLLESLKKKMLKASKNKEYEEAAILRDKIQAAQTVLSRS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AVLLDETVSADFIAVVSDNSIASVQCFRVIAGRIKSVYSWHFEQQEDQSASELLSQSIIQ
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VYDKLSLPKRIVLFDKPSYLSALSAHLNDKNIDRSLEIEIVYHPNEQERRLLETVKDNAL
HHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
SELERHRLRRSSDYTERHRSLFELQKYLNLNSLPVRIECFDISHLSGTNTSGSMVVFENG
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECC
EPKKSAYRHFNIHIDQNNDTASMFSLICRRLRSLESVAQDSPDYPHLMIIDGGKPQLSAA
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
VGALQEVGLKIPVFALSKRLEELWSPGVKTSLILPPNSESLFLLQKIRDESHRFALKQQT
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
RRREAYLTSELFRIPGLGKQKVMQLLRRFSSFAEIRQASIEDISALPGFGVKTAEKIKEC
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
AEAFSLK
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174