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The map label for this gene is uvrB

Identifier: 28572626

GI number: 28572626

Start: 513025

End: 515058

Strand: Reverse

Name: uvrB

Synonym: TW477

Alternate gene names: 28572626

Gene position: 515058-513025 (Counterclockwise)

Preceding gene: 28572627

Following gene: 28572625

Centisome position: 55.63

GC content: 41.79

Gene sequence:

>2034_bases
GTGTATAAAAACTTACATCCAAAATATTTTAGGCTCGCTGCCGAATATGATCCATCTGGCGATCAACCGAAGGCGATTGG
GGAGCTGTCAGACAGAATAGAATCTGGTGAGACTGACATTGTGCTTCTTGGAGCTACGGGTACGGGAAAATCTGCAACAA
TTGCGTGGCTTATAGAAAAACTTGCAAGACCTACGCTTATCATTGCCCACAACAAGACTCTTGCAGCCCAGTTGGCAAAT
GAGTTTCGTAAGTTTTTTCCCGATAATGCGGTTGAATACTTTGTGTCTTATTACGATTACTACCAGCCAGAGGCATATGT
TCCTAAAACTGACACTTTTATTGAAAAAGATGCTTCTGTCAATTCTGAGGTAGAAAGATTGCGACATAGGGCGACAACCT
CTCTTTTGACCAGGCGTGACGTTATTGTTGTCGCCACCGTATCTTGCATATATGGTCTTGGTGCACCGTCTGAATATCTA
AAAGCAGGCTTTAGGCTTGAGGTTGGTCAAAAGATTTCGCAACGAGTTCTTTTGGAAAGATTTACACAGCTTCAATACAA
CAGGAATGATGTCGGATTTGAAAGGGGCAATTTTCGGGTTCGTGGCGACACGATTGAGATAATTCCAGTCTACGAAGAAT
ATACAGTTCGCATTGAAATGTGGGGCGATGAAATTGAAAGGGTTCTCTGTTTGCATCCAGTTACGGGAAATTTACTCTCG
GAACAGAGAGGTGTTCTAATATTTCCGGCCTCGCACTATGTTACAAGTTCAGAGAATCTAAAAAGAGCAATTGTGGATAT
ACGAAAAGAACTGCAGCAGCGACTCCGATATTTTAAGCGAAACAATAGCTTACTTGAAGCACAGAGACTTGAAACGCGCA
CAGAATACGATATAGAACTTATGGAACAGTTGGGTTTCTGCTCGGGGATAGAAAATTACTCAAGACATATTGATGGTAGA
GCGCCCGGCGAACCGCCATTTTGTCTATTAGATTATTTTGATGATGATTTTTTAACCGTCATTGATGAGTCCCATGTTAC
TGTTCCGCAGATAGGAAGCATGCATGCGGGTGACTTTTCAAGAAAAAAGGCCCTCGTTGAAAATGGATTTCGCTTACCCA
GTGCAATTGACAATCGTCCTCTATGTTTTGATGAATTTCGTCAGAGAGTGGGGCAGGTGATATATCTATCAGCCACACCA
GGTAAATATGAGCTGAGTAAATCAGATGGTGTGGTTGAACAAATAATTAGACCAACAGGACTGGTTGATCCAAAGATTAC
GGTAAAACCAATAAAAGGTCAGATAGATGATCTTTTGGAAGAAATTCGAAAACGTAAATTGCTCTCAGAAAGAGTTCTTG
TAACAACACTTACTAAGCGCATGGCTGAAGAATTAACAGATTTTCTATCTGAGGCTGGTGTGAATGTCAGTTATTTGCAC
TCGGATATTGATACGCTGCATCGCGTGGAGCTCTTGACGAGTTTACGCATGGGGAGAATTGATGTTCTTGTTGGGATAAA
TTTACTTCGCGAAGGTTTGGATTTACCCGAAGTAAGTCTTGTTGCAATTTTAGATGCGGATAAAGAAGGGTTTCTGCGTT
CAACAACATCATTTATTCAAACAATCGGACGTGCAGCTCGGCATGTGTCGGGCGAAGTGCATATGTACGCTGATAATATG
ACCGAGTCAATGCAGAAAAGTATTGATGAAACAAATCGACGCAGGCGAATCCAGCAGGATTACAATCGCAAGATGGGCGT
AACACCTGTTCCGATAAAAAAAACAGTAAGTGACATAACAGAGGTATTGTCAAGACCTTCGCGAAAAATAGATTGCACAA
TTCTTGACAGCTTGCCTGATCCAAAGATAGATGGAAAGCAGATAAAGTCTCATATAAAGAGTCTTGAGGCAAAAATGTAT
ATGGCAGCCGAGAGTTTAATGTTCGAAGAAGCCGCAGAATTACGTGATGAAATACAGTCCCTCAAGGAGAAGTTCCTAAA
ACCGCGAGGCAGTGGCGGGAAAATTAGACAGTAA

Upstream 100 bases:

>100_bases
GTTTCAAAAACGCTGTGCATGATACAGAATACATCTGATTTTTCTCATTTGAGGCAGTGTGTTGCCTCGGTCTTCCAAAT
TATGAAAACAATAGACCGAA

Downstream 100 bases:

>100_bases
TCAGAGTAGAAGTGTCAAGTCGCAGGTCATTTTTGCGCGTTAAAAACGCGCGGGTTCACAATTTAAAAAACCTTAATGTG
CGGATTCCGAGAAATTCAAT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 677; Mature: 677

Protein sequence:

>677_residues
MYKNLHPKYFRLAAEYDPSGDQPKAIGELSDRIESGETDIVLLGATGTGKSATIAWLIEKLARPTLIIAHNKTLAAQLAN
EFRKFFPDNAVEYFVSYYDYYQPEAYVPKTDTFIEKDASVNSEVERLRHRATTSLLTRRDVIVVATVSCIYGLGAPSEYL
KAGFRLEVGQKISQRVLLERFTQLQYNRNDVGFERGNFRVRGDTIEIIPVYEEYTVRIEMWGDEIERVLCLHPVTGNLLS
EQRGVLIFPASHYVTSSENLKRAIVDIRKELQQRLRYFKRNNSLLEAQRLETRTEYDIELMEQLGFCSGIENYSRHIDGR
APGEPPFCLLDYFDDDFLTVIDESHVTVPQIGSMHAGDFSRKKALVENGFRLPSAIDNRPLCFDEFRQRVGQVIYLSATP
GKYELSKSDGVVEQIIRPTGLVDPKITVKPIKGQIDDLLEEIRKRKLLSERVLVTTLTKRMAEELTDFLSEAGVNVSYLH
SDIDTLHRVELLTSLRMGRIDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSFIQTIGRAARHVSGEVHMYADNM
TESMQKSIDETNRRRRIQQDYNRKMGVTPVPIKKTVSDITEVLSRPSRKIDCTILDSLPDPKIDGKQIKSHIKSLEAKMY
MAAESLMFEEAAELRDEIQSLKEKFLKPRGSGGKIRQ

Sequences:

>Translated_677_residues
MYKNLHPKYFRLAAEYDPSGDQPKAIGELSDRIESGETDIVLLGATGTGKSATIAWLIEKLARPTLIIAHNKTLAAQLAN
EFRKFFPDNAVEYFVSYYDYYQPEAYVPKTDTFIEKDASVNSEVERLRHRATTSLLTRRDVIVVATVSCIYGLGAPSEYL
KAGFRLEVGQKISQRVLLERFTQLQYNRNDVGFERGNFRVRGDTIEIIPVYEEYTVRIEMWGDEIERVLCLHPVTGNLLS
EQRGVLIFPASHYVTSSENLKRAIVDIRKELQQRLRYFKRNNSLLEAQRLETRTEYDIELMEQLGFCSGIENYSRHIDGR
APGEPPFCLLDYFDDDFLTVIDESHVTVPQIGSMHAGDFSRKKALVENGFRLPSAIDNRPLCFDEFRQRVGQVIYLSATP
GKYELSKSDGVVEQIIRPTGLVDPKITVKPIKGQIDDLLEEIRKRKLLSERVLVTTLTKRMAEELTDFLSEAGVNVSYLH
SDIDTLHRVELLTSLRMGRIDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSFIQTIGRAARHVSGEVHMYADNM
TESMQKSIDETNRRRRIQQDYNRKMGVTPVPIKKTVSDITEVLSRPSRKIDCTILDSLPDPKIDGKQIKSHIKSLEAKMY
MAAESLMFEEAAELRDEIQSLKEKFLKPRGSGGKIRQ
>Mature_677_residues
MYKNLHPKYFRLAAEYDPSGDQPKAIGELSDRIESGETDIVLLGATGTGKSATIAWLIEKLARPTLIIAHNKTLAAQLAN
EFRKFFPDNAVEYFVSYYDYYQPEAYVPKTDTFIEKDASVNSEVERLRHRATTSLLTRRDVIVVATVSCIYGLGAPSEYL
KAGFRLEVGQKISQRVLLERFTQLQYNRNDVGFERGNFRVRGDTIEIIPVYEEYTVRIEMWGDEIERVLCLHPVTGNLLS
EQRGVLIFPASHYVTSSENLKRAIVDIRKELQQRLRYFKRNNSLLEAQRLETRTEYDIELMEQLGFCSGIENYSRHIDGR
APGEPPFCLLDYFDDDFLTVIDESHVTVPQIGSMHAGDFSRKKALVENGFRLPSAIDNRPLCFDEFRQRVGQVIYLSATP
GKYELSKSDGVVEQIIRPTGLVDPKITVKPIKGQIDDLLEEIRKRKLLSERVLVTTLTKRMAEELTDFLSEAGVNVSYLH
SDIDTLHRVELLTSLRMGRIDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSFIQTIGRAARHVSGEVHMYADNM
TESMQKSIDETNRRRRIQQDYNRKMGVTPVPIKKTVSDITEVLSRPSRKIDCTILDSLPDPKIDGKQIKSHIKSLEAKMY
MAAESLMFEEAAELRDEIQSLKEKFLKPRGSGGKIRQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=674, Percent_Identity=55.1928783382789, Blast_Score=721, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_TROW8 (Q83NI7)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789406.1
- ProteinModelPortal:   Q83NI7
- STRING:   Q83NI7
- GeneID:   1064317
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW477
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   TWHI218496:TW0451-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 77102; Mature: 77102

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKNLHPKYFRLAAEYDPSGDQPKAIGELSDRIESGETDIVLLGATGTGKSATIAWLIEK
CCCCCCCHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
LARPTLIIAHNKTLAAQLANEFRKFFPDNAVEYFVSYYDYYQPEAYVPKTDTFIEKDASV
HCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
NSEVERLRHRATTSLLTRRDVIVVATVSCIYGLGAPSEYLKAGFRLEVGQKISQRVLLER
CHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCHHHHHCCCEEHHHHHHHHHHHHHH
FTQLQYNRNDVGFERGNFRVRGDTIEIIPVYEEYTVRIEMWGDEIERVLCLHPVTGNLLS
HHHHHCCCCCCCEECCCEEEECCEEEEEEECCCEEEEEEECCHHHHHEEEECCCCCCHHH
EQRGVLIFPASHYVTSSENLKRAIVDIRKELQQRLRYFKRNNSLLEAQRLETRTEYDIEL
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHH
MEQLGFCSGIENYSRHIDGRAPGEPPFCLLDYFDDDFLTVIDESHVTVPQIGSMHAGDFS
HHHHHHHCCHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHH
RKKALVENGFRLPSAIDNRPLCFDEFRQRVGQVIYLSATPGKYELSKSDGVVEQIIRPTG
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCEEECCCCCHHHHHHCCCC
LVDPKITVKPIKGQIDDLLEEIRKRKLLSERVLVTTLTKRMAEELTDFLSEAGVNVSYLH
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHH
SDIDTLHRVELLTSLRMGRIDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSFIQ
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
TIGRAARHVSGEVHMYADNMTESMQKSIDETNRRRRIQQDYNRKMGVTPVPIKKTVSDIT
HHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
EVLSRPSRKIDCTILDSLPDPKIDGKQIKSHIKSLEAKMYMAAESLMFEEAAELRDEIQS
HHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKEKFLKPRGSGGKIRQ
HHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MYKNLHPKYFRLAAEYDPSGDQPKAIGELSDRIESGETDIVLLGATGTGKSATIAWLIEK
CCCCCCCHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
LARPTLIIAHNKTLAAQLANEFRKFFPDNAVEYFVSYYDYYQPEAYVPKTDTFIEKDASV
HCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
NSEVERLRHRATTSLLTRRDVIVVATVSCIYGLGAPSEYLKAGFRLEVGQKISQRVLLER
CHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCHHHHHCCCEEHHHHHHHHHHHHHH
FTQLQYNRNDVGFERGNFRVRGDTIEIIPVYEEYTVRIEMWGDEIERVLCLHPVTGNLLS
HHHHHCCCCCCCEECCCEEEECCEEEEEEECCCEEEEEEECCHHHHHEEEECCCCCCHHH
EQRGVLIFPASHYVTSSENLKRAIVDIRKELQQRLRYFKRNNSLLEAQRLETRTEYDIEL
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHH
MEQLGFCSGIENYSRHIDGRAPGEPPFCLLDYFDDDFLTVIDESHVTVPQIGSMHAGDFS
HHHHHHHCCHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHH
RKKALVENGFRLPSAIDNRPLCFDEFRQRVGQVIYLSATPGKYELSKSDGVVEQIIRPTG
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCEEECCCCCHHHHHHCCCC
LVDPKITVKPIKGQIDDLLEEIRKRKLLSERVLVTTLTKRMAEELTDFLSEAGVNVSYLH
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHH
SDIDTLHRVELLTSLRMGRIDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSFIQ
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
TIGRAARHVSGEVHMYADNMTESMQKSIDETNRRRRIQQDYNRKMGVTPVPIKKTVSDIT
HHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
EVLSRPSRKIDCTILDSLPDPKIDGKQIKSHIKSLEAKMYMAAESLMFEEAAELRDEIQS
HHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKEKFLKPRGSGGKIRQ
HHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174