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The map label for this gene is gap [H]

Identifier: 28572621

GI number: 28572621

Start: 505638

End: 506651

Strand: Reverse

Name: gap [H]

Synonym: TW472

Alternate gene names: 28572621

Gene position: 506651-505638 (Counterclockwise)

Preceding gene: 28572622

Following gene: 28572620

Centisome position: 54.72

GC content: 48.42

Gene sequence:

>1014_bases
GTGACGGTCAAAATAGCAATTAATGGCTTTGGAAGAATTGGTCGTGGCTTTTTCAGGGCTTTATCTTCTCCCTCGTGCAT
TGATGGTCCTGAGATAGATGTTGTTGCAATTAATGACCTGACCTCGCCTGAAGTGTTGGCGCATCTTCTAAGACGGGACA
CAATTTTTGGGCGCTTCCCTGAAAGTGTTTGCCATGATGGCACCAAGTTACTTGTTGGAAAAAGGGAGGTCGCAGTTTTT
TCCGAAAAAGACCCCTCTTCAATTCCATGGAATGGTGTTGATATCGTCATAGAGTCAACGGGTTTATTTACAGATGCAAA
TATCGCGTCTGGACATATAACTGCCGGCAGTAAGCGGGTTATAATTTCCGCACCGGCAAAGAACGAGGATGCCACCTTCG
TCGTTGGTGTCAACCATACAGACTATGATCCAAACAAGCACAGCATAGTGTCTAATGCTTCGTGTACTACAAATTGCCTG
GCGCCCCTGGCAAAGGTTTTTGATGATACGTTCGGCATAGAGCGTGGCCTGATGACAACCGTCCACGCATACACGGCTGA
TCAGAGGTTGCAGGACGCACCGCATAGTGATTTGCGGCGTGCGCGAGCAGCGGCAATGAACCTCGTTCCGACATCCACCG
GCGCGGCGTGCGCGATAGGATTGGTTCTCCCAAATCTCAAGGGGAAGCTTGATGGGTTTGCCATCAGAGTTCCTGTTATA
ACGGGATCAATAACAGATCTCTCACTTGTGTCAAAAACAGATGTTTCCGCTCCGGAGGTCAATGAGGCCTATAGACGAGC
GGCATTGGGCCCCCTGAAAGGGATCCTCTGTTATTCAGAGGATCCGCTTGTTTCAAGTGATATAGTCGCTGACGGTCATT
CTTGTATATATGATGCCAATCTTTTGCGGATTTCTGGCAATATGGTCAAGCTATCTGCCTGGTATGACAATGAATGGGCA
TATTCTCGGCGGCTGGTTGATTTGGCCAAATATATGGCGTCTGTTGGGCTCTGA

Upstream 100 bases:

>100_bases
AAAGGCTTTTTGGAGTATAGTCAATTGGCATGGCGTTACAGATAAGTTTTTGAAAATTGCCGGCAGGTCTGTCGTTTAGA
TAATTTTATAAAGGGGTTGT

Downstream 100 bases:

>100_bases
GTTGCCTTGAGAACTCTTGGCGGTTTCACCTTTCCTTGTGATGCTCCTGTTTTTGTCCGGGTTGATTTCAATGTGCCTAT
GGATGAGGTCGGCACAATAA

Product: glyceraldehyde 3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTVKIAINGFGRIGRGFFRALSSPSCIDGPEIDVVAINDLTSPEVLAHLLRRDTIFGRFPESVCHDGTKLLVGKREVAVF
SEKDPSSIPWNGVDIVIESTGLFTDANIASGHITAGSKRVIISAPAKNEDATFVVGVNHTDYDPNKHSIVSNASCTTNCL
APLAKVFDDTFGIERGLMTTVHAYTADQRLQDAPHSDLRRARAAAMNLVPTSTGAACAIGLVLPNLKGKLDGFAIRVPVI
TGSITDLSLVSKTDVSAPEVNEAYRRAALGPLKGILCYSEDPLVSSDIVADGHSCIYDANLLRISGNMVKLSAWYDNEWA
YSRRLVDLAKYMASVGL

Sequences:

>Translated_337_residues
MTVKIAINGFGRIGRGFFRALSSPSCIDGPEIDVVAINDLTSPEVLAHLLRRDTIFGRFPESVCHDGTKLLVGKREVAVF
SEKDPSSIPWNGVDIVIESTGLFTDANIASGHITAGSKRVIISAPAKNEDATFVVGVNHTDYDPNKHSIVSNASCTTNCL
APLAKVFDDTFGIERGLMTTVHAYTADQRLQDAPHSDLRRARAAAMNLVPTSTGAACAIGLVLPNLKGKLDGFAIRVPVI
TGSITDLSLVSKTDVSAPEVNEAYRRAALGPLKGILCYSEDPLVSSDIVADGHSCIYDANLLRISGNMVKLSAWYDNEWA
YSRRLVDLAKYMASVGL
>Mature_336_residues
TVKIAINGFGRIGRGFFRALSSPSCIDGPEIDVVAINDLTSPEVLAHLLRRDTIFGRFPESVCHDGTKLLVGKREVAVFS
EKDPSSIPWNGVDIVIESTGLFTDANIASGHITAGSKRVIISAPAKNEDATFVVGVNHTDYDPNKHSIVSNASCTTNCLA
PLAKVFDDTFGIERGLMTTVHAYTADQRLQDAPHSDLRRARAAAMNLVPTSTGAACAIGLVLPNLKGKLDGFAIRVPVIT
GSITDLSLVSKTDVSAPEVNEAYRRAALGPLKGILCYSEDPLVSSDIVADGHSCIYDANLLRISGNMVKLSAWYDNEWAY
SRRLVDLAKYMASVGL

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=335, Percent_Identity=47.1641791044776, Blast_Score=294, Evalue=8e-80,
Organism=Homo sapiens, GI7669492, Length=337, Percent_Identity=45.9940652818991, Blast_Score=288, Evalue=4e-78,
Organism=Escherichia coli, GI1788079, Length=338, Percent_Identity=45.2662721893491, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1789295, Length=341, Percent_Identity=43.9882697947214, Blast_Score=275, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17534677, Length=342, Percent_Identity=47.3684210526316, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17534679, Length=342, Percent_Identity=46.7836257309941, Blast_Score=300, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI32566163, Length=340, Percent_Identity=47.0588235294118, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17568413, Length=340, Percent_Identity=47.0588235294118, Blast_Score=296, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6322409, Length=336, Percent_Identity=47.3214285714286, Blast_Score=318, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6321631, Length=337, Percent_Identity=47.4777448071217, Blast_Score=307, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6322468, Length=336, Percent_Identity=46.4285714285714, Blast_Score=299, Evalue=4e-82,
Organism=Drosophila melanogaster, GI17933600, Length=336, Percent_Identity=47.6190476190476, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI18110149, Length=336, Percent_Identity=47.6190476190476, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI85725000, Length=336, Percent_Identity=47.0238095238095, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI22023983, Length=336, Percent_Identity=47.0238095238095, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI19922412, Length=332, Percent_Identity=43.6746987951807, Blast_Score=255, Evalue=2e-68,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 36134; Mature: 36002

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKIAINGFGRIGRGFFRALSSPSCIDGPEIDVVAINDLTSPEVLAHLLRRDTIFGRFP
CEEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHCCCC
ESVCHDGTKLLVGKREVAVFSEKDPSSIPWNGVDIVIESTGLFTDANIASGHITAGSKRV
HHHHCCCCEEEEECCEEEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCEEECCCCEE
IISAPAKNEDATFVVGVNHTDYDPNKHSIVSNASCTTNCLAPLAKVFDDTFGIERGLMTT
EEECCCCCCCCEEEEECCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCHHHCHHHH
VHAYTADQRLQDAPHSDLRRARAAAMNLVPTSTGAACAIGLVLPNLKGKLDGFAIRVPVI
HHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEEE
TGSITDLSLVSKTDVSAPEVNEAYRRAALGPLKGILCYSEDPLVSSDIVADGHSCIYDAN
ECCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHEEEEECCCCCCCCCEEECCCCEEEECE
LLRISGNMVKLSAWYDNEWAYSRRLVDLAKYMASVGL
EEEEECCEEEEEEEECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVKIAINGFGRIGRGFFRALSSPSCIDGPEIDVVAINDLTSPEVLAHLLRRDTIFGRFP
EEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHCCCC
ESVCHDGTKLLVGKREVAVFSEKDPSSIPWNGVDIVIESTGLFTDANIASGHITAGSKRV
HHHHCCCCEEEEECCEEEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCEEECCCCEE
IISAPAKNEDATFVVGVNHTDYDPNKHSIVSNASCTTNCLAPLAKVFDDTFGIERGLMTT
EEECCCCCCCCEEEEECCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCHHHCHHHH
VHAYTADQRLQDAPHSDLRRARAAAMNLVPTSTGAACAIGLVLPNLKGKLDGFAIRVPVI
HHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEEE
TGSITDLSLVSKTDVSAPEVNEAYRRAALGPLKGILCYSEDPLVSSDIVADGHSCIYDAN
ECCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHEEEEECCCCCCCCCEEECCCCEEEECE
LLRISGNMVKLSAWYDNEWAYSRRLVDLAKYMASVGL
EEEEECCEEEEEEEECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400158; 12948626 [H]