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The map label for this gene is fmt [H]

Identifier: 28572564

GI number: 28572564

Start: 449695

End: 450654

Strand: Direct

Name: fmt [H]

Synonym: TW411

Alternate gene names: 28572564

Gene position: 449695-450654 (Clockwise)

Preceding gene: 28572563

Following gene: 28572565

Centisome position: 48.57

GC content: 43.33

Gene sequence:

>960_bases
ATGAAATCTAGTTTACGGATTGTATATGCTGGGACTTCAAGCGTTGCATTGCCAGCGTTGCGTTGCATAAAAACAAGCCA
ACATACTCTGGTTGGAGTTTTAGCAAAGCGTGTTCCGGCAGATCTATGCAGTACGGATTTAAACAATGTTATTTCTGTAC
AGGCGCAGAATTGGCAGATTCCGGTAATAGAGGCACCTATTCTGCGACCCCCTAAAAGCTGTACGAAATCCGCGCTCGCG
AGGTACGAGTTAGCGCGAGAAAAAATACATTCCTTAGCCCCAGATATTGGTGTGATAGTTTCATATGGCGTTCTTCTTGG
CGAAGAAATTCTATCCATTCCCCGCTTTGGATGGATCAATTTACATTTTTCTCTTCTTCCACAGTTTAGGGGCGCTGCAC
CGGTTCAAAGAGCAATTATGAATGGTCTTGATTCGAGCGGTTTCACAATTTTTCGGCTTGAACGGGAATTAGATTCTGGT
GCAATACTTGAAAGTAAAAGATACACTTTTTCACGAAATCTCAACTCAGGTGAGGAGATTTTAAAAATGGCCGAGTATTC
TGCACCTTTTCTTGTTGAAGTGCTGGACTCTCTTGACAGTAAACTTGAAGCTGCCGTGCCACAGAAGGGAAGTGTCACGC
ATGCGCCAAAATTGACTTACAACGAATGCCAAATTGACTGGACGCAGAATTCTGAGAAAATCCTAAGACTTATAAGGGCT
GCCAATCCAGATCCATCTGCGTATTTTTTTGAAAATAATAAGAGAATAAAAGTTATCTCGGCGAAACAACCTTCTGATTG
TTTCGCAAGTTCATTAGCACCCGGTGAGCTTGTTATGCTTGACAAGAAAGTGTTTGTCGGAACGGCAGATCTGCCGGTTG
AACTTGTATTGCTTCATCCGGAGGGTAAAAATAAGATGTCCGGTTACGCATGGTGGTGCGGTTTGCGGACCAGACATTAA

Upstream 100 bases:

>100_bases
TTTAAGGATGTCAATAGAGTGATGGATTTTGTGAAAAAAATGTTGGATTCTTTGCGTGGTAGCTCTATCAAAATTAGATG
TGACGACCCGGAAATTCTCG

Downstream 100 bases:

>100_bases
TCTTGTTTCTCACAACATCACAGCCTTTGATATTGCTTATGTCATAACCGATTACGGTAATTCCTGGGAATTTTTATTTG
CTAAGGTTCACAATTGTTAT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKSSLRIVYAGTSSVALPALRCIKTSQHTLVGVLAKRVPADLCSTDLNNVISVQAQNWQIPVIEAPILRPPKSCTKSALA
RYELAREKIHSLAPDIGVIVSYGVLLGEEILSIPRFGWINLHFSLLPQFRGAAPVQRAIMNGLDSSGFTIFRLERELDSG
AILESKRYTFSRNLNSGEEILKMAEYSAPFLVEVLDSLDSKLEAAVPQKGSVTHAPKLTYNECQIDWTQNSEKILRLIRA
ANPDPSAYFFENNKRIKVISAKQPSDCFASSLAPGELVMLDKKVFVGTADLPVELVLLHPEGKNKMSGYAWWCGLRTRH

Sequences:

>Translated_319_residues
MKSSLRIVYAGTSSVALPALRCIKTSQHTLVGVLAKRVPADLCSTDLNNVISVQAQNWQIPVIEAPILRPPKSCTKSALA
RYELAREKIHSLAPDIGVIVSYGVLLGEEILSIPRFGWINLHFSLLPQFRGAAPVQRAIMNGLDSSGFTIFRLERELDSG
AILESKRYTFSRNLNSGEEILKMAEYSAPFLVEVLDSLDSKLEAAVPQKGSVTHAPKLTYNECQIDWTQNSEKILRLIRA
ANPDPSAYFFENNKRIKVISAKQPSDCFASSLAPGELVMLDKKVFVGTADLPVELVLLHPEGKNKMSGYAWWCGLRTRH
>Mature_319_residues
MKSSLRIVYAGTSSVALPALRCIKTSQHTLVGVLAKRVPADLCSTDLNNVISVQAQNWQIPVIEAPILRPPKSCTKSALA
RYELAREKIHSLAPDIGVIVSYGVLLGEEILSIPRFGWINLHFSLLPQFRGAAPVQRAIMNGLDSSGFTIFRLERELDSG
AILESKRYTFSRNLNSGEEILKMAEYSAPFLVEVLDSLDSKLEAAVPQKGSVTHAPKLTYNECQIDWTQNSEKILRLIRA
ANPDPSAYFFENNKRIKVISAKQPSDCFASSLAPGELVMLDKKVFVGTADLPVELVLLHPEGKNKMSGYAWWCGLRTRH

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI164663775, Length=151, Percent_Identity=35.0993377483444, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1789683, Length=310, Percent_Identity=32.5806451612903, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788589, Length=213, Percent_Identity=26.2910798122066, Blast_Score=74, Evalue=9e-15,
Organism=Drosophila melanogaster, GI45550868, Length=322, Percent_Identity=26.7080745341615, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28571984, Length=264, Percent_Identity=28.4090909090909, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 35305; Mature: 35305

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSLRIVYAGTSSVALPALRCIKTSQHTLVGVLAKRVPADLCSTDLNNVISVQAQNWQI
CCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCEEEEEECCEEE
PVIEAPILRPPKSCTKSALARYELAREKIHSLAPDIGVIVSYGVLLGEEILSIPRFGWIN
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LHFSLLPQFRGAAPVQRAIMNGLDSSGFTIFRLERELDSGAILESKRYTFSRNLNSGEEI
EEHEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCEEECCCEEEECCCCCHHHH
LKMAEYSAPFLVEVLDSLDSKLEAAVPQKGSVTHAPKLTYNECQIDWTQNSEKILRLIRA
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHH
ANPDPSAYFFENNKRIKVISAKQPSDCFASSLAPGELVMLDKKVFVGTADLPVELVLLHP
CCCCCCEEEEECCCEEEEEECCCCHHHHHHCCCCCEEEEEECEEEEECCCCCEEEEEECC
EGKNKMSGYAWWCGLRTRH
CCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MKSSLRIVYAGTSSVALPALRCIKTSQHTLVGVLAKRVPADLCSTDLNNVISVQAQNWQI
CCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCEEEEEECCEEE
PVIEAPILRPPKSCTKSALARYELAREKIHSLAPDIGVIVSYGVLLGEEILSIPRFGWIN
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LHFSLLPQFRGAAPVQRAIMNGLDSSGFTIFRLERELDSGAILESKRYTFSRNLNSGEEI
EEHEECCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCEEECCCEEEECCCCCHHHH
LKMAEYSAPFLVEVLDSLDSKLEAAVPQKGSVTHAPKLTYNECQIDWTQNSEKILRLIRA
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHH
ANPDPSAYFFENNKRIKVISAKQPSDCFASSLAPGELVMLDKKVFVGTADLPVELVLLHP
CCCCCCEEEEECCCEEEEEECCCCHHHHHHCCCCCEEEEEECEEEEECCCCCEEEEEECC
EGKNKMSGYAWWCGLRTRH
CCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA