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The map label for this gene is coaBC [H]

Identifier: 28572561

GI number: 28572561

Start: 445401

End: 446633

Strand: Direct

Name: coaBC [H]

Synonym: TW408

Alternate gene names: 28572561

Gene position: 445401-446633 (Clockwise)

Preceding gene: 28572560

Following gene: 28572562

Centisome position: 48.1

GC content: 47.61

Gene sequence:

>1233_bases
GTGATGCAAAATGCGATCGGGCGCATTTTCTTGGGCGTATGTGGGTCCATCTCAGCATACAAGTCTGTTTATCTTGCCAG
ATTATTCGTAAAAGAGGGCTACGATGTTAGGGTTGGCTTCACCAATGGGGCTTCCCAGTTTGTGACAGGCGAGCCTTTTC
GTGTTTTTACCGGGCATCACGTTCTGAATTTTCCCTGCGATGACCAGAGTCATATTGATATTTCTCGGTGGGCAGACGCC
ATTGTGGTTGCACCGGCAACTGCAAATATTCTTGCTGCCGCCCGGGCGGGTTTGGCAAGCGATATAGTCACTCAGACCAT
TCTCTCCTCTCGTTCTCCCGTATTGTTCGTCCCCTCTATGCATACTGCCATGTGGGAGAATCCCGCAACTCGTGATAACG
TCAATTGTTTGCTGGAGCGTGGTTATCATGTTCTTGGTCCGGTTACTGGTGATCTTAGCAGCGGTGACTGGGGTATTGGG
CGAATGGTGGATCCCTGCGAAATTGTGCAGTATGTTTCACGCAGCCTTTTAAACCATCAGACTGGTAAGCTGTCGGGTAA
AAAGTTTCTAATAACCGCCGGGGGAACAAGGCAGCCAATAGATCCGGTTCGTTATATCGGGAATCGTTCGAGTGGAAAGC
AAGCAATTGCCATAGCTAAAGAAGCGCAGAAGAGGTCTGCTGAGGTGATTCTTATAGCAGCAAATGTCGAGGCGGTTACT
TTGCCAACCGGTATGAGAGTTATTACCGTCGCAACAGCTGAAGAGATGCGGAAGGCCCTGTCCGATAACATTGATACGAG
CGATGTTGTCATAATGGCTGCAGCAGTTTCTGATTTTCAACCAAGAGAGGTTGCGTCACAGAAAATAAAGAGTAATGATG
GCTGGACTTTGCAGCTTATCTCGACCGATGATCTTCTTCGTGAGCTTGCCAGCAATAAATCCCGCCCCAGAGTGCTTGTG
GGGTTTTCTGCTGAAACAGAGGAATCTGCCAATTGCCGTATAGATATCGCTCGACAAAAGCTCCTTAGCAAGGGCTGTGA
CTACATGGTTGTAAATCAAGTTGGTTTTGATGTTGGTTTTGATGTTTCCGATACTGAGGTCAGTTTAATAGATGATAAGC
AGGTCTTTTTCACGGCAAGGGGTAGTAAGGATTACATCGCAAAGCGTATCCTTGATTTCCTCTCCGAGAGAGTGATCGTT
ACATATATTGACCCTCTCGACAGGTCGCTTTAA

Upstream 100 bases:

>100_bases
TTGGGCCACTTGTTTCTGTTGATGCTGATGATAAATCCCTTACAGTCGCAATGCGTGAGATTGCCGAGGATAAACTCGAT
CTTAAGTCTTCTGCAGCCGA

Downstream 100 bases:

>100_bases
AGGTAAGTTGTGATTCTCACATCTGAATCTGTGACAGAAGGGCATCCGGATAAACTGTGTGATCAGATTTCTGATGCAAT
TCTTGATGGTGTTATTTGCA

Product: flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MMQNAIGRIFLGVCGSISAYKSVYLARLFVKEGYDVRVGFTNGASQFVTGEPFRVFTGHHVLNFPCDDQSHIDISRWADA
IVVAPATANILAAARAGLASDIVTQTILSSRSPVLFVPSMHTAMWENPATRDNVNCLLERGYHVLGPVTGDLSSGDWGIG
RMVDPCEIVQYVSRSLLNHQTGKLSGKKFLITAGGTRQPIDPVRYIGNRSSGKQAIAIAKEAQKRSAEVILIAANVEAVT
LPTGMRVITVATAEEMRKALSDNIDTSDVVIMAAAVSDFQPREVASQKIKSNDGWTLQLISTDDLLRELASNKSRPRVLV
GFSAETEESANCRIDIARQKLLSKGCDYMVVNQVGFDVGFDVSDTEVSLIDDKQVFFTARGSKDYIAKRILDFLSERVIV
TYIDPLDRSL

Sequences:

>Translated_410_residues
MMQNAIGRIFLGVCGSISAYKSVYLARLFVKEGYDVRVGFTNGASQFVTGEPFRVFTGHHVLNFPCDDQSHIDISRWADA
IVVAPATANILAAARAGLASDIVTQTILSSRSPVLFVPSMHTAMWENPATRDNVNCLLERGYHVLGPVTGDLSSGDWGIG
RMVDPCEIVQYVSRSLLNHQTGKLSGKKFLITAGGTRQPIDPVRYIGNRSSGKQAIAIAKEAQKRSAEVILIAANVEAVT
LPTGMRVITVATAEEMRKALSDNIDTSDVVIMAAAVSDFQPREVASQKIKSNDGWTLQLISTDDLLRELASNKSRPRVLV
GFSAETEESANCRIDIARQKLLSKGCDYMVVNQVGFDVGFDVSDTEVSLIDDKQVFFTARGSKDYIAKRILDFLSERVIV
TYIDPLDRSL
>Mature_410_residues
MMQNAIGRIFLGVCGSISAYKSVYLARLFVKEGYDVRVGFTNGASQFVTGEPFRVFTGHHVLNFPCDDQSHIDISRWADA
IVVAPATANILAAARAGLASDIVTQTILSSRSPVLFVPSMHTAMWENPATRDNVNCLLERGYHVLGPVTGDLSSGDWGIG
RMVDPCEIVQYVSRSLLNHQTGKLSGKKFLITAGGTRQPIDPVRYIGNRSSGKQAIAIAKEAQKRSAEVILIAANVEAVT
LPTGMRVITVATAEEMRKALSDNIDTSDVVIMAAAVSDFQPREVASQKIKSNDGWTLQLISTDDLLRELASNKSRPRVLV
GFSAETEESANCRIDIARQKLLSKGCDYMVVNQVGFDVGFDVSDTEVSLIDDKQVFFTARGSKDYIAKRILDFLSERVIV
TYIDPLDRSL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI87082301, Length=408, Percent_Identity=35.2941176470588, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17560194, Length=122, Percent_Identity=31.9672131147541, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322762, Length=111, Percent_Identity=35.1351351351351, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24657262, Length=177, Percent_Identity=29.9435028248588, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44784; Mature: 44784

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQNAIGRIFLGVCGSISAYKSVYLARLFVKEGYDVRVGFTNGASQFVTGEPFRVFTGHH
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCE
VLNFPCDDQSHIDISRWADAIVVAPATANILAAARAGLASDIVTQTILSSRSPVLFVPSM
EEECCCCCCCCCCHHHCCCEEEECCCHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCC
HTAMWENPATRDNVNCLLERGYHVLGPVTGDLSSGDWGIGRMVDPCEIVQYVSRSLLNHQ
HHHHCCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
TGKLSGKKFLITAGGTRQPIDPVRYIGNRSSGKQAIAIAKEAQKRSAEVILIAANVEAVT
CCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCEEEEHHHHHCCCCCEEEEEECCEEEE
LPTGMRVITVATAEEMRKALSDNIDTSDVVIMAAAVSDFQPREVASQKIKSNDGWTLQLI
ECCCCEEEEEECHHHHHHHHHCCCCCCCEEEEEEHHCCCCHHHHHHHHHCCCCCEEEEEE
STDDLLRELASNKSRPRVLVGFSAETEESANCRIDIARQKLLSKGCDYMVVNQVGFDVGF
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCCCCC
DVSDTEVSLIDDKQVFFTARGSKDYIAKRILDFLSERVIVTYIDPLDRSL
CCCCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCC
>Mature Secondary Structure
MMQNAIGRIFLGVCGSISAYKSVYLARLFVKEGYDVRVGFTNGASQFVTGEPFRVFTGHH
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCE
VLNFPCDDQSHIDISRWADAIVVAPATANILAAARAGLASDIVTQTILSSRSPVLFVPSM
EEECCCCCCCCCCHHHCCCEEEECCCHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCC
HTAMWENPATRDNVNCLLERGYHVLGPVTGDLSSGDWGIGRMVDPCEIVQYVSRSLLNHQ
HHHHCCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
TGKLSGKKFLITAGGTRQPIDPVRYIGNRSSGKQAIAIAKEAQKRSAEVILIAANVEAVT
CCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCEEEEHHHHHCCCCCEEEEEECCEEEE
LPTGMRVITVATAEEMRKALSDNIDTSDVVIMAAAVSDFQPREVASQKIKSNDGWTLQLI
ECCCCEEEEEECHHHHHHHHHCCCCCCCEEEEEEHHCCCCHHHHHHHHHCCCCCEEEEEE
STDDLLRELASNKSRPRVLVGFSAETEESANCRIDIARQKLLSKGCDYMVVNQVGFDVGF
CHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCCCCC
DVSDTEVSLIDDKQVFFTARGSKDYIAKRILDFLSERVIVTYIDPLDRSL
CCCCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]