Click here to switch to the map view.

The map label for this gene is trpE [H]

Identifier: 28572537

GI number: 28572537

Start: 416640

End: 418070

Strand: Direct

Name: trpE [H]

Synonym: TW384

Alternate gene names: 28572537

Gene position: 416640-418070 (Clockwise)

Preceding gene: 28572527

Following gene: 28572538

Centisome position: 45.0

GC content: 43.89

Gene sequence:

>1431_bases
GTGGAAGAAGATCGGGGTGTTTTTTGGGTGGATTACCCCGTTGACCTCTCCGAGGATTTTGCTGACAGTTGTTTCCGATA
CCTCTTTGAAGCCCTTTTTTACGATTCGGAGAATTGCTTTTGGCTGGATGATGCACGACCACTGCAAAACCGACGACGCA
GTGCGATTGGCTCTGGTCCGTCGGTGAGTCTTCGATCTGGGAGCTGTCTTGATCCGACTGATGTGGAGTCTTTTTTCTCA
AAGCTCTTGGATTGTGACCCACAGCCTTGGCCATTAGGCTTTGTTGGGTGGATTGATTACGAAGTTGGCGCATGTCTATT
GGGTGTAAATTATCCAACACAGCAAGATGCTCCTGCTACAGGTCAAACTAATTTATCCTCGTGGATTTGCTGCAACCGCG
CGATATGTATTGACTACAGAATGGGATTGCTGAAAATTATCAGTTTTTCCAAAAATACTGTTGATGCAAAAGAATGGGTA
AATAGGGCTTCAACTCTGGTTGAGAAGCTCTTGATGAAAGGTTCAATAGACCGAGAAGATTATATCCCGCAGGCTAAATC
AAGGCATTTAGCAAACTCAAAACTCATGCCAAGAAATAGTTTTGCTTCAGGGTTGCAGTGGCTTCATACCGATCAACAAT
ATTTGCAACTTATTCACAGAGTTCTGGAAAAAATCATGCGTGGAGATGTTTACCAAATTTGTCTGGCTAACAGACTTACG
ATCAGGAACTCCGGTAACAGGTCACCATTTTCTGCCTTTTGGGCCCTTAGACAGAAAAGTCCAACACAGTACTGTGCCTA
TATCAAAATCGGACCGCGCCACTTTGTTAGCTCTTCCCCAGAGCTTTTTCTGGCATTATCTGACAATATTCTTGTCACAG
AACCGATCAAGGGAACACGCCCAAGGGGTAGGTCTCCTTCCGAGGATTCATATCTGATATCGGAGCTTAAAACTTCTGAA
AAAGAGAAAGCCGAAAACCTTATGATTGTCGATCTAATGCGCAATGATTTTAGTAAAATCTGCTCTTCGGTTGAAGTTGA
TTATATGTATAGGGTCAGAACATATAAGGGTTTGCATCAGCTTGTATCGAGAGTAAGCGGTATCTTGCGCCCAGGACGTG
GATTTTTTGATATTTTGTGTGCAACATTTCCAGCAGGATCAGTGACCGGAGCACCTAAAATCGCAGCCGTCAAGTCTATA
TATGATTTGGAAAGGGCAAGAAGGGGAGTTTATTCAGGTGCATTCGGTTATATATCGGGCGATGGAAAGAATATCTGTTT
TGCGATGTCTATTAGATCAGCAGTTTTTTGCAATGGAGAAGTCAGTATTGGTAGTGGAGGGGGAGTGGTGTTTGATAGCG
ATCCGGAGTTTGAACTTGCCGAGACTAAACTGAAGGTAGCGGCAATGATTGATGCGATTTTGGGTAGGTAG

Upstream 100 bases:

>100_bases
GCTATCCCAATTAGGAGCAGTGGGTTAATGCTACTTATAACCTCAAGGAAGGTATGCACGAAGTCGAACACCTACTAAAG
TTTAGTAAATGGAGACAATT

Downstream 100 bases:

>100_bases
ATACTTTTCATGAAAACCTATAACCGGTTCATCCAAGAACATGCATGCGTTACGTGCCTTAGATACATTGTGTGAGAATA
TGGAATACAATTTTCGTGCC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MEEDRGVFWVDYPVDLSEDFADSCFRYLFEALFYDSENCFWLDDARPLQNRRRSAIGSGPSVSLRSGSCLDPTDVESFFS
KLLDCDPQPWPLGFVGWIDYEVGACLLGVNYPTQQDAPATGQTNLSSWICCNRAICIDYRMGLLKIISFSKNTVDAKEWV
NRASTLVEKLLMKGSIDREDYIPQAKSRHLANSKLMPRNSFASGLQWLHTDQQYLQLIHRVLEKIMRGDVYQICLANRLT
IRNSGNRSPFSAFWALRQKSPTQYCAYIKIGPRHFVSSSPELFLALSDNILVTEPIKGTRPRGRSPSEDSYLISELKTSE
KEKAENLMIVDLMRNDFSKICSSVEVDYMYRVRTYKGLHQLVSRVSGILRPGRGFFDILCATFPAGSVTGAPKIAAVKSI
YDLERARRGVYSGAFGYISGDGKNICFAMSIRSAVFCNGEVSIGSGGGVVFDSDPEFELAETKLKVAAMIDAILGR

Sequences:

>Translated_476_residues
MEEDRGVFWVDYPVDLSEDFADSCFRYLFEALFYDSENCFWLDDARPLQNRRRSAIGSGPSVSLRSGSCLDPTDVESFFS
KLLDCDPQPWPLGFVGWIDYEVGACLLGVNYPTQQDAPATGQTNLSSWICCNRAICIDYRMGLLKIISFSKNTVDAKEWV
NRASTLVEKLLMKGSIDREDYIPQAKSRHLANSKLMPRNSFASGLQWLHTDQQYLQLIHRVLEKIMRGDVYQICLANRLT
IRNSGNRSPFSAFWALRQKSPTQYCAYIKIGPRHFVSSSPELFLALSDNILVTEPIKGTRPRGRSPSEDSYLISELKTSE
KEKAENLMIVDLMRNDFSKICSSVEVDYMYRVRTYKGLHQLVSRVSGILRPGRGFFDILCATFPAGSVTGAPKIAAVKSI
YDLERARRGVYSGAFGYISGDGKNICFAMSIRSAVFCNGEVSIGSGGGVVFDSDPEFELAETKLKVAAMIDAILGR
>Mature_476_residues
MEEDRGVFWVDYPVDLSEDFADSCFRYLFEALFYDSENCFWLDDARPLQNRRRSAIGSGPSVSLRSGSCLDPTDVESFFS
KLLDCDPQPWPLGFVGWIDYEVGACLLGVNYPTQQDAPATGQTNLSSWICCNRAICIDYRMGLLKIISFSKNTVDAKEWV
NRASTLVEKLLMKGSIDREDYIPQAKSRHLANSKLMPRNSFASGLQWLHTDQQYLQLIHRVLEKIMRGDVYQICLANRLT
IRNSGNRSPFSAFWALRQKSPTQYCAYIKIGPRHFVSSSPELFLALSDNILVTEPIKGTRPRGRSPSEDSYLISELKTSE
KEKAENLMIVDLMRNDFSKICSSVEVDYMYRVRTYKGLHQLVSRVSGILRPGRGFFDILCATFPAGSVTGAPKIAAVKSI
YDLERARRGVYSGAFGYISGDGKNICFAMSIRSAVFCNGEVSIGSGGGVVFDSDPEFELAETKLKVAAMIDAILGR

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=293, Percent_Identity=36.1774744027304, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1787518, Length=277, Percent_Identity=35.0180505415162, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87082077, Length=266, Percent_Identity=25.9398496240602, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786809, Length=197, Percent_Identity=24.8730964467005, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=448, Percent_Identity=29.9107142857143, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6324361, Length=414, Percent_Identity=26.8115942028986, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 53346; Mature: 53346

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEDRGVFWVDYPVDLSEDFADSCFRYLFEALFYDSENCFWLDDARPLQNRRRSAIGSGP
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCC
SVSLRSGSCLDPTDVESFFSKLLDCDPQPWPLGFVGWIDYEVGACLLGVNYPTQQDAPAT
CEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCC
GQTNLSSWICCNRAICIDYRMGLLKIISFSKNTVDAKEWVNRASTLVEKLLMKGSIDRED
CCCCCCHHHHCCCEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
YIPQAKSRHLANSKLMPRNSFASGLQWLHTDQQYLQLIHRVLEKIMRGDVYQICLANRLT
CCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHHCCEE
IRNSGNRSPFSAFWALRQKSPTQYCAYIKIGPRHFVSSSPELFLALSDNILVTEPIKGTR
EECCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHCCCCCEEEEEECCEEEECCCCCCC
PRGRSPSEDSYLISELKTSEKEKAENLMIVDLMRNDFSKICSSVEVDYMYRVRTYKGLHQ
CCCCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LVSRVSGILRPGRGFFDILCATFPAGSVTGAPKIAAVKSIYDLERARRGVYSGAFGYISG
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEC
DGKNICFAMSIRSAVFCNGEVSIGSGGGVVFDSDPEFELAETKLKVAAMIDAILGR
CCCCEEEEEEECCEEEECCEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEEDRGVFWVDYPVDLSEDFADSCFRYLFEALFYDSENCFWLDDARPLQNRRRSAIGSGP
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCC
SVSLRSGSCLDPTDVESFFSKLLDCDPQPWPLGFVGWIDYEVGACLLGVNYPTQQDAPAT
CEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCC
GQTNLSSWICCNRAICIDYRMGLLKIISFSKNTVDAKEWVNRASTLVEKLLMKGSIDRED
CCCCCCHHHHCCCEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
YIPQAKSRHLANSKLMPRNSFASGLQWLHTDQQYLQLIHRVLEKIMRGDVYQICLANRLT
CCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHHCCEE
IRNSGNRSPFSAFWALRQKSPTQYCAYIKIGPRHFVSSSPELFLALSDNILVTEPIKGTR
EECCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHCCCCCEEEEEECCEEEECCCCCCC
PRGRSPSEDSYLISELKTSEKEKAENLMIVDLMRNDFSKICSSVEVDYMYRVRTYKGLHQ
CCCCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LVSRVSGILRPGRGFFDILCATFPAGSVTGAPKIAAVKSIYDLERARRGVYSGAFGYISG
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEC
DGKNICFAMSIRSAVFCNGEVSIGSGGGVVFDSDPEFELAETKLKVAAMIDAILGR
CCCCEEEEEEECCEEEECCEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]