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The map label for this gene is adk

Identifier: 28572386

GI number: 28572386

Start: 254348

End: 254908

Strand: Direct

Name: adk

Synonym: TW226

Alternate gene names: 28572386

Gene position: 254348-254908 (Clockwise)

Preceding gene: 28572385

Following gene: 28572387

Centisome position: 27.47

GC content: 48.13

Gene sequence:

>561_bases
ATGCGGGCTATAATGGTCGGCCCTCCGGGGTCTGGAAAAGGTACCCAGTGTGGTCTTATTCAGAGCAGACTTGGTATATC
TGTCATCGCAACCGGTGATGTGTTTCGTGAACGCATGAAAACTGATATGGCACTAAGGGACATTGTGTCATCAGGTGGTT
ATGTTTCTGATTCGACGACCAATCGCATTGTAGAGGACTGCCTTGACAAGGAGGATGTGTCCTCCGGGTTTGTCCTTGAT
GGGTATCCACGAACCCTGCAACAGCTGGACTTTCTAGAGGGCTTTTTAAAACGACGTGCCCTTACGCTGGATGCCGTCTT
TAGCTTGGAGGTTGCGACAGATCTCCTAATTGAGAGGCTGCGTGCCCGATCAAAGGAGTCTGGCCGTACTGACGACAGAG
ATTCTGTGATTGCTCGTAGATTGGAAATCTATACCGAAATGACCTTGCCGATTATCGATGCCTGCGAAGAAAAGGGACTG
CTTCACAGGATAGATGCTTCCAAGGGTATAGAGGAAGTTTTTCAGTCCATCAAAGATGTATTTGACAGGGTGACAATTTA
A

Upstream 100 bases:

>100_bases
GGACCTCTGTGCTGATTATGGTTGGTGTTGGCCTGGATACCGTAAAACAGATTGATGCGCAAATGCAACAGAGGCATTAC
AGGGGCTTGTTGACAGCCTA

Downstream 100 bases:

>100_bases
AAGTGAATACCGAGTATTTGCACGTTTTGTGGTTTAACCCCGATACTGATTGTGAGCCCCGTTTTTATGACGTGCATCAC
CCGCTCATTCCTGCCACATC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MRAIMVGPPGSGKGTQCGLIQSRLGISVIATGDVFRERMKTDMALRDIVSSGGYVSDSTTNRIVEDCLDKEDVSSGFVLD
GYPRTLQQLDFLEGFLKRRALTLDAVFSLEVATDLLIERLRARSKESGRTDDRDSVIARRLEIYTEMTLPIIDACEEKGL
LHRIDASKGIEEVFQSIKDVFDRVTI

Sequences:

>Translated_186_residues
MRAIMVGPPGSGKGTQCGLIQSRLGISVIATGDVFRERMKTDMALRDIVSSGGYVSDSTTNRIVEDCLDKEDVSSGFVLD
GYPRTLQQLDFLEGFLKRRALTLDAVFSLEVATDLLIERLRARSKESGRTDDRDSVIARRLEIYTEMTLPIIDACEEKGL
LHRIDASKGIEEVFQSIKDVFDRVTI
>Mature_186_residues
MRAIMVGPPGSGKGTQCGLIQSRLGISVIATGDVFRERMKTDMALRDIVSSGGYVSDSTTNRIVEDCLDKEDVSSGFVLD
GYPRTLQQLDFLEGFLKRRALTLDAVFSLEVATDLLIERLRARSKESGRTDDRDSVIARRLEIYTEMTLPIIDACEEKGL
LHRIDASKGIEEVFQSIKDVFDRVTI

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=216, Percent_Identity=29.6296296296296, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI7524346, Length=216, Percent_Identity=29.6296296296296, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI4502011, Length=179, Percent_Identity=32.9608938547486, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI7706497, Length=193, Percent_Identity=31.6062176165803, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI28144897, Length=190, Percent_Identity=32.6315789473684, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI28144899, Length=190, Percent_Identity=32.6315789473684, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI209915597, Length=182, Percent_Identity=31.3186813186813, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI310110345, Length=218, Percent_Identity=26.1467889908257, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI53832003, Length=218, Percent_Identity=26.1467889908257, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI8051579, Length=218, Percent_Identity=26.1467889908257, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI53832001, Length=218, Percent_Identity=26.1467889908257, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI19923437, Length=192, Percent_Identity=27.0833333333333, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1786680, Length=209, Percent_Identity=30.1435406698565, Blast_Score=95, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17552384, Length=216, Percent_Identity=31.9444444444444, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17567503, Length=188, Percent_Identity=34.0425531914894, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=30.9782608695652, Blast_Score=96, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=29.7297297297297, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25147457, Length=188, Percent_Identity=26.063829787234, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=30.1435406698565, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322828, Length=185, Percent_Identity=24.8648648648649, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321018, Length=190, Percent_Identity=27.3684210526316, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=31.7757009345794, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221459597, Length=186, Percent_Identity=32.258064516129, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356893, Length=186, Percent_Identity=32.258064516129, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24663208, Length=188, Percent_Identity=29.7872340425532, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17647141, Length=188, Percent_Identity=29.7872340425532, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17737899, Length=192, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24645822, Length=192, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24582962, Length=170, Percent_Identity=28.2352941176471, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_TROW8 (Q83I60)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789166.1
- ProteinModelPortal:   Q83I60
- SMR:   Q83I60
- STRING:   Q83I60
- GeneID:   1064518
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW226
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   CLSK229581
- BioCyc:   TWHI218496:TW0211-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20692; Mature: 20692

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAIMVGPPGSGKGTQCGLIQSRLGISVIATGDVFRERMKTDMALRDIVSSGGYVSDSTT
CCEEEECCCCCCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
NRIVEDCLDKEDVSSGFVLDGYPRTLQQLDFLEGFLKRRALTLDAVFSLEVATDLLIERL
HHHHHHHCCHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RARSKESGRTDDRDSVIARRLEIYTEMTLPIIDACEEKGLLHRIDASKGIEEVFQSIKDV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHH
FDRVTI
HHHCCC
>Mature Secondary Structure
MRAIMVGPPGSGKGTQCGLIQSRLGISVIATGDVFRERMKTDMALRDIVSSGGYVSDSTT
CCEEEECCCCCCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
NRIVEDCLDKEDVSSGFVLDGYPRTLQQLDFLEGFLKRRALTLDAVFSLEVATDLLIERL
HHHHHHHCCHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RARSKESGRTDDRDSVIARRLEIYTEMTLPIIDACEEKGLLHRIDASKGIEEVFQSIKDV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHH
FDRVTI
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174