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The map label for this gene is gcp

Identifier: 28572332

GI number: 28572332

Start: 209856

End: 211061

Strand: Direct

Name: gcp

Synonym: TW170

Alternate gene names: 28572332

Gene position: 209856-211061 (Clockwise)

Preceding gene: 28572331

Following gene: 28572333

Centisome position: 22.66

GC content: 46.68

Gene sequence:

>1206_bases
GTGTCTATTATCCTCGGAATCGAAACATCTTGCGATGAAACAGGTGTTGGCATAGTGTCTGGTTCAACTGTTCTTGCAAA
TGAGGTTGCCTCATCAAGCTTACGCCATAAACCTTTTGGCGGTGTTATCCCCGAAATAGCTGCTCGGGCGCATCTTGAGT
ATTTGCCAAATTTGCTTGAATTGGCGCTTGAGACGGCACAGCTCTGTATTAAAGATATTGATGGTATAGCTGTTACCGCA
GGCCCTGGACTTGTTACCAGTCTTTCTGTTGGCGTTTCTGCGGCCAAGGCTTTGGGATTATCTACGGGGACGCCTGTTTA
TGGTGTAAATCATCTTGTTGGACATGCCGTATCGGCTTTTCTGGATGATTACACTAATGATGGCCTTGGTGTTATTCACC
GCAGGGACAGTATCGGATCTAATGGAATTGAGAATGACGCCAGTTCGACACACTCACATACGCATACAACGCAGGTAAAC
AGACATTCAAACCTGTGTGTCTATACACCTCCCCGGCGTGTTTTACGAGATGTTTGTAAGTATATGCATGTCAGAGATTC
AGTTGTTTTGCTTGCATCAGGTGGGCATTCCTGTCTGTTGAAAATACATAACAATAAGATATCGCTTTTAGGTGAGACAC
TGGATGATGCAGCCGGTGAGGCGTTTGACAAAATCGCAAGACTTATGGGCCTTCAGTATCCCGGAGGTCCTGCGATTGAG
ATGCTTGCCAGTTCGGGTAACCCCAATGCCGTGGAGTTTCCAAGGGCGCTGTTGACGCATTTTGAAGAACACAACAGGTA
TAGTTTTTCTTTTTCAGGGTTGAAAACCGCGGTTGGTAGGGTTGTTGAAAGAATAAAGAGTAATCCAGCCCATTCGATAC
CCAAGATAGAAGATATTGCTGCAAGTTTTCAGGAAGCCGTTGCAGATGTTTTGACAGCAAAAACTGTAGCGGCTGCCTTG
GCCAGTGATGTGGATCTAATAGTTATGGGTGGTGGGGTAGCTGCAAATAATCGCATTAGAGAGATGCTTTGCGAAAGAGC
GAAAATCCACGGCTTGGACGTAAAGATCCCACCTATTGCGCTGTGCACCGATAATGGTGCAATGATTGCCGCCGCTGGCT
CGTGGCTTATGCAGCTGGGATACAATCCGAGTCATTCAAGGTTTTCGCCCGTATCGATTATGCCGCTAACCCAGATGGTT
GTGTGA

Upstream 100 bases:

>100_bases
CAGCTATTGGAATGTATAAAAAACACGGTTTTGTTACCCTGGGTCGGCGACCAAAGTACTATAACGGCGTTGATGCAATA
ACTATGAAGAAAGAGTTATA

Downstream 100 bases:

>100_bases
CAATTTGCGTCTCTTCTTCCACTTAATAGCGCTTGACTGTTATTCAGCACTGCAAGTGGGATTGTTGGGTATCCACAATC
CCAAGTGTTAATGGTCTCAA

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSIILGIETSCDETGVGIVSGSTVLANEVASSSLRHKPFGGVIPEIAARAHLEYLPNLLELALETAQLCIKDIDGIAVTA
GPGLVTSLSVGVSAAKALGLSTGTPVYGVNHLVGHAVSAFLDDYTNDGLGVIHRRDSIGSNGIENDASSTHSHTHTTQVN
RHSNLCVYTPPRRVLRDVCKYMHVRDSVVLLASGGHSCLLKIHNNKISLLGETLDDAAGEAFDKIARLMGLQYPGGPAIE
MLASSGNPNAVEFPRALLTHFEEHNRYSFSFSGLKTAVGRVVERIKSNPAHSIPKIEDIAASFQEAVADVLTAKTVAAAL
ASDVDLIVMGGGVAANNRIREMLCERAKIHGLDVKIPPIALCTDNGAMIAAAGSWLMQLGYNPSHSRFSPVSIMPLTQMV
V

Sequences:

>Translated_401_residues
MSIILGIETSCDETGVGIVSGSTVLANEVASSSLRHKPFGGVIPEIAARAHLEYLPNLLELALETAQLCIKDIDGIAVTA
GPGLVTSLSVGVSAAKALGLSTGTPVYGVNHLVGHAVSAFLDDYTNDGLGVIHRRDSIGSNGIENDASSTHSHTHTTQVN
RHSNLCVYTPPRRVLRDVCKYMHVRDSVVLLASGGHSCLLKIHNNKISLLGETLDDAAGEAFDKIARLMGLQYPGGPAIE
MLASSGNPNAVEFPRALLTHFEEHNRYSFSFSGLKTAVGRVVERIKSNPAHSIPKIEDIAASFQEAVADVLTAKTVAAAL
ASDVDLIVMGGGVAANNRIREMLCERAKIHGLDVKIPPIALCTDNGAMIAAAGSWLMQLGYNPSHSRFSPVSIMPLTQMV
V
>Mature_400_residues
SIILGIETSCDETGVGIVSGSTVLANEVASSSLRHKPFGGVIPEIAARAHLEYLPNLLELALETAQLCIKDIDGIAVTAG
PGLVTSLSVGVSAAKALGLSTGTPVYGVNHLVGHAVSAFLDDYTNDGLGVIHRRDSIGSNGIENDASSTHSHTHTTQVNR
HSNLCVYTPPRRVLRDVCKYMHVRDSVVLLASGGHSCLLKIHNNKISLLGETLDDAAGEAFDKIARLMGLQYPGGPAIEM
LASSGNPNAVEFPRALLTHFEEHNRYSFSFSGLKTAVGRVVERIKSNPAHSIPKIEDIAASFQEAVADVLTAKTVAAALA
SDVDLIVMGGGVAANNRIREMLCERAKIHGLDVKIPPIALCTDNGAMIAAAGSWLMQLGYNPSHSRFSPVSIMPLTQMVV

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=415, Percent_Identity=29.1566265060241, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI8923380, Length=214, Percent_Identity=30.3738317757009, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789445, Length=187, Percent_Identity=42.2459893048128, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17557464, Length=388, Percent_Identity=26.5463917525773, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71995670, Length=203, Percent_Identity=28.0788177339901, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322891, Length=219, Percent_Identity=27.8538812785388, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI20129063, Length=398, Percent_Identity=32.1608040201005, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21357207, Length=115, Percent_Identity=39.1304347826087, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_TROW8 (Q83I95)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789112.1
- ProteinModelPortal:   Q83I95
- SMR:   Q83I95
- STRING:   Q83I95
- GeneID:   1064464
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW170
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PLYGVNH
- ProtClustDB:   PRK09604
- BioCyc:   TWHI218496:TW0157-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 42364; Mature: 42233

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIILGIETSCDETGVGIVSGSTVLANEVASSSLRHKPFGGVIPEIAARAHLEYLPNLLE
CEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LALETAQLCIKDIDGIAVTAGPGLVTSLSVGVSAAKALGLSTGTPVYGVNHLVGHAVSAF
HHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LDDYTNDGLGVIHRRDSIGSNGIENDASSTHSHTHTTQVNRHSNLCVYTPPRRVLRDVCK
HHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHH
YMHVRDSVVLLASGGHSCLLKIHNNKISLLGETLDDAAGEAFDKIARLMGLQYPGGPAIE
HHHCCCCEEEEECCCCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
MLASSGNPNAVEFPRALLTHFEEHNRYSFSFSGLKTAVGRVVERIKSNPAHSIPKIEDIA
HEECCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
ASFQEAVADVLTAKTVAAALASDVDLIVMGGGVAANNRIREMLCERAKIHGLDVKIPPIA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCEE
LCTDNGAMIAAAGSWLMQLGYNPSHSRFSPVSIMPLTQMVV
EECCCCCEEEEHHHHHHHCCCCCCCCCCCCEEECCHHHHCC
>Mature Secondary Structure 
SIILGIETSCDETGVGIVSGSTVLANEVASSSLRHKPFGGVIPEIAARAHLEYLPNLLE
EEEEEECCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LALETAQLCIKDIDGIAVTAGPGLVTSLSVGVSAAKALGLSTGTPVYGVNHLVGHAVSAF
HHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LDDYTNDGLGVIHRRDSIGSNGIENDASSTHSHTHTTQVNRHSNLCVYTPPRRVLRDVCK
HHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHH
YMHVRDSVVLLASGGHSCLLKIHNNKISLLGETLDDAAGEAFDKIARLMGLQYPGGPAIE
HHHCCCCEEEEECCCCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
MLASSGNPNAVEFPRALLTHFEEHNRYSFSFSGLKTAVGRVVERIKSNPAHSIPKIEDIA
HEECCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
ASFQEAVADVLTAKTVAAALASDVDLIVMGGGVAANNRIREMLCERAKIHGLDVKIPPIA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCEE
LCTDNGAMIAAAGSWLMQLGYNPSHSRFSPVSIMPLTQMVV
EECCCCCEEEEHHHHHHHCCCCCCCCCCCCEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174