Click here to switch to the map view.

The map label for this gene is dsbD [H]

Identifier: 27364648

GI number: 27364648

Start: 1230924

End: 1232705

Strand: Reverse

Name: dsbD [H]

Synonym: VV1_1247

Alternate gene names: 27364648

Gene position: 1232705-1230924 (Counterclockwise)

Preceding gene: 27364649

Following gene: 27364647

Centisome position: 37.56

GC content: 49.89

Gene sequence:

>1782_bases
ATGCGCGCATTATTGACTTTCTTTGTTGCTGGATTGCTTGTGCTTTCCTCACCCGCCATGGCGCTGTTTGGCAATAACCA
AAACAGCAGTTTTGCTTCTGGCTCGAATGATTTTGTGCCTGTTGATCAGGCTTTTCCTTTTAACTATTTCCAGCAAGATC
ACCGCATCACCCTAGACTGGCAAGTCAAAGAGGGTTACTACCTCTATCAACAGCGTCTTTCATTTAGCGCAGAAAACGTT
GTATTGGGTGACATTCAAATGGAAAACGGTCAGCCCTACCGTGATGAATTTTTTGGTGATGTGAATATTTATACCAACCC
ATTGTTCGTTAACATCCCAATGCAAGACTGGCAGCCGGGTGCAAAATTGATCGTACAATACCAAGGCTGTGCCAAAGCGG
GCTTTTGCTATCCACCTGAAACACGAGTGATCGACATTACCTCGTTTACCAATGGTGACATGGCACCAGCAACAATGCCG
ACACAGACCGCCAACCCTCTCGATACATCAACGCCTCAACCTCTGACCCAGCAAGATCAGTTGGCTTCGGGCTTAGCGGA
TAACTGGTGGACGCCACTGCTGTTTTTGGCACTGGGTGTTGGCTTGGCCTTTACCCCTTGCGTATTGCCGATGTACCCGA
TTCTGACCAGCATCGTATTAGGCAGCGGTAAACTGAGTCAGCGACGCGCGCTTGGGCTCTCTCTGGTCTATGTTCAAGGC
ATGGCATTGACCTATACCTTACTGGGTCTGGTTGTCGCTTCCGCTGGCTTACAGTTCCAAGCCGCCATGCAGCACCCTTA
TGTGTTGATCGGCCTGAGTATTCTTTTTGTCACCTTAGCGCTCTCGATGTTTGGGGTGTACACCTTACAACTGCCTAGCA
GCGTACAAACTTGGCTGAACAATTTGAGCAATAAGCAGCAAGGGGGCAGCAGTGCAGGTGTTTTTGCCATGGGTGCCATT
TCCGGTTTGGTGTGCTCGCCTTGTACCACCGCCCCACTTTCTGGGGCACTGCTGTACGTGGCACAAAGTGGTGATCTCTT
AACGGGGGGCGTTGCGCTGTATGCCTTAGCCATGGGCATGGGTATCCCTTTAATTTTAGTCGCGGTGTTTGGAAATAAAC
TGCTCCCCAAAGCGGGCGGTTGGATGGATCGCGTTAAAACGCTGTTTGGTTTTGTATTGCTGGCAGCGCCAATCTTCCTA
TTGGAGCGCATCCTTCCTGAAATGTGGTCAACCGCGCTGTGGTCTGCCTTGGGTATCGCGGCGTTTGGCTGGCTTTACCA
TGTGAAAAATAGTTTGGAGTTTGGTGGTTGGAAGCAAAGCGCGGTGGGCATCATTGCCGTGCTGGGTCTGTTTGCGTCCG
CTCAGCCTGCCCTCAATTATTGGTTTACTGACAGCTCTCAACAGACTCAAACCAGTGAAGTGAGCTTTATTAAAATCCGC
AACGTCGAAGAGCTTCAACAACAATTGGCGTTAGCCAAGCAAGCCAAAAAACCTGTAATGCTCGACTTTTATGCCGATTG
GTGTGTGGCGTGTAAAGAGTTCGAGAAATACACTTTCCACGACCCAGCCGTGGCAGCTCAACTCAAACAATTTGTGTTGC
TTCAAGCCGACGTGACGCGTAACCAAGCACAGGACATTGAGCTGCTACAGGCCCAACAAGTGCTCGGCCTACCAACGATC
GATTTTTGGGATGCGCAAGGTAATCCGGTTTCAAACGCTCGACTCACTGGCTTTATGCAAGCGGCGCCTTTCTTGGAGCA
TATTCAACGAATTTCCAACTAA

Upstream 100 bases:

>100_bases
AATTTTCTGCACATAACCTTCCTATCGCTGAAACTTTCTGCACCGTTTCTGGGTCTGATTGGGTTAGACTAACTCCATTC
ACTCCCATATTTTGTTCACT

Downstream 100 bases:

>100_bases
CCGATTCAAACGCCAGCAAACCTTGCTGGCGTTTTTTCTTACCACATTCTCACCTTCACAACGGAGGTATATGCAAACTC
TCTAATAAAAGTCGATTTAC

Product: thiol:disulfide interchange protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MRALLTFFVAGLLVLSSPAMALFGNNQNSSFASGSNDFVPVDQAFPFNYFQQDHRITLDWQVKEGYYLYQQRLSFSAENV
VLGDIQMENGQPYRDEFFGDVNIYTNPLFVNIPMQDWQPGAKLIVQYQGCAKAGFCYPPETRVIDITSFTNGDMAPATMP
TQTANPLDTSTPQPLTQQDQLASGLADNWWTPLLFLALGVGLAFTPCVLPMYPILTSIVLGSGKLSQRRALGLSLVYVQG
MALTYTLLGLVVASAGLQFQAAMQHPYVLIGLSILFVTLALSMFGVYTLQLPSSVQTWLNNLSNKQQGGSSAGVFAMGAI
SGLVCSPCTTAPLSGALLYVAQSGDLLTGGVALYALAMGMGIPLILVAVFGNKLLPKAGGWMDRVKTLFGFVLLAAPIFL
LERILPEMWSTALWSALGIAAFGWLYHVKNSLEFGGWKQSAVGIIAVLGLFASAQPALNYWFTDSSQQTQTSEVSFIKIR
NVEELQQQLALAKQAKKPVMLDFYADWCVACKEFEKYTFHDPAVAAQLKQFVLLQADVTRNQAQDIELLQAQQVLGLPTI
DFWDAQGNPVSNARLTGFMQAAPFLEHIQRISN

Sequences:

>Translated_593_residues
MRALLTFFVAGLLVLSSPAMALFGNNQNSSFASGSNDFVPVDQAFPFNYFQQDHRITLDWQVKEGYYLYQQRLSFSAENV
VLGDIQMENGQPYRDEFFGDVNIYTNPLFVNIPMQDWQPGAKLIVQYQGCAKAGFCYPPETRVIDITSFTNGDMAPATMP
TQTANPLDTSTPQPLTQQDQLASGLADNWWTPLLFLALGVGLAFTPCVLPMYPILTSIVLGSGKLSQRRALGLSLVYVQG
MALTYTLLGLVVASAGLQFQAAMQHPYVLIGLSILFVTLALSMFGVYTLQLPSSVQTWLNNLSNKQQGGSSAGVFAMGAI
SGLVCSPCTTAPLSGALLYVAQSGDLLTGGVALYALAMGMGIPLILVAVFGNKLLPKAGGWMDRVKTLFGFVLLAAPIFL
LERILPEMWSTALWSALGIAAFGWLYHVKNSLEFGGWKQSAVGIIAVLGLFASAQPALNYWFTDSSQQTQTSEVSFIKIR
NVEELQQQLALAKQAKKPVMLDFYADWCVACKEFEKYTFHDPAVAAQLKQFVLLQADVTRNQAQDIELLQAQQVLGLPTI
DFWDAQGNPVSNARLTGFMQAAPFLEHIQRISN
>Mature_593_residues
MRALLTFFVAGLLVLSSPAMALFGNNQNSSFASGSNDFVPVDQAFPFNYFQQDHRITLDWQVKEGYYLYQQRLSFSAENV
VLGDIQMENGQPYRDEFFGDVNIYTNPLFVNIPMQDWQPGAKLIVQYQGCAKAGFCYPPETRVIDITSFTNGDMAPATMP
TQTANPLDTSTPQPLTQQDQLASGLADNWWTPLLFLALGVGLAFTPCVLPMYPILTSIVLGSGKLSQRRALGLSLVYVQG
MALTYTLLGLVVASAGLQFQAAMQHPYVLIGLSILFVTLALSMFGVYTLQLPSSVQTWLNNLSNKQQGGSSAGVFAMGAI
SGLVCSPCTTAPLSGALLYVAQSGDLLTGGVALYALAMGMGIPLILVAVFGNKLLPKAGGWMDRVKTLFGFVLLAAPIFL
LERILPEMWSTALWSALGIAAFGWLYHVKNSLEFGGWKQSAVGIIAVLGLFASAQPALNYWFTDSSQQTQTSEVSFIKIR
NVEELQQQLALAKQAKKPVMLDFYADWCVACKEFEKYTFHDPAVAAQLKQFVLLQADVTRNQAQDIELLQAQQVLGLPTI
DFWDAQGNPVSNARLTGFMQAAPFLEHIQRISN

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=560, Percent_Identity=52.5, Blast_Score=565, Evalue=1e-162,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 64816; Mature: 64816

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALLTFFVAGLLVLSSPAMALFGNNQNSSFASGSNDFVPVDQAFPFNYFQQDHRITLDW
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCHHHCCCCEEEEEE
QVKEGYYLYQQRLSFSAENVVLGDIQMENGQPYRDEFFGDVNIYTNPLFVNIPMQDWQPG
EECCCHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHCCCCEEEECCEEEECCHHCCCCC
AKLIVQYQGCAKAGFCYPPETRVIDITSFTNGDMAPATMPTQTANPLDTSTPQPLTQQDQ
CEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LASGLADNWWTPLLFLALGVGLAFTPCVLPMYPILTSIVLGSGKLSQRRALGLSLVYVQG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCEEEEHHHH
MALTYTLLGLVVASAGLQFQAAMQHPYVLIGLSILFVTLALSMFGVYTLQLPSSVQTWLN
HHHHHHHHHHHHHHCCCCEEHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHH
NLSNKQQGGSSAGVFAMGAISGLVCSPCTTAPLSGALLYVAQSGDLLTGGVALYALAMGM
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEHHHHHHHHHHHC
GIPLILVAVFGNKLLPKAGGWMDRVKTLFGFVLLAAPIFLLERILPEMWSTALWSALGIA
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGWLYHVKNSLEFGGWKQSAVGIIAVLGLFASAQPALNYWFTDSSQQTQTSEVSFIKIR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEEC
NVEELQQQLALAKQAKKPVMLDFYADWCVACKEFEKYTFHDPAVAAQLKQFVLLQADVTR
CHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
NQAQDIELLQAQQVLGLPTIDFWDAQGNPVSNARLTGFMQAAPFLEHIQRISN
CHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRALLTFFVAGLLVLSSPAMALFGNNQNSSFASGSNDFVPVDQAFPFNYFQQDHRITLDW
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCHHHCCCCEEEEEE
QVKEGYYLYQQRLSFSAENVVLGDIQMENGQPYRDEFFGDVNIYTNPLFVNIPMQDWQPG
EECCCHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHCCCCEEEECCEEEECCHHCCCCC
AKLIVQYQGCAKAGFCYPPETRVIDITSFTNGDMAPATMPTQTANPLDTSTPQPLTQQDQ
CEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LASGLADNWWTPLLFLALGVGLAFTPCVLPMYPILTSIVLGSGKLSQRRALGLSLVYVQG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCEEEEHHHH
MALTYTLLGLVVASAGLQFQAAMQHPYVLIGLSILFVTLALSMFGVYTLQLPSSVQTWLN
HHHHHHHHHHHHHHCCCCEEHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHH
NLSNKQQGGSSAGVFAMGAISGLVCSPCTTAPLSGALLYVAQSGDLLTGGVALYALAMGM
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEHHHHHHHHHHHC
GIPLILVAVFGNKLLPKAGGWMDRVKTLFGFVLLAAPIFLLERILPEMWSTALWSALGIA
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGWLYHVKNSLEFGGWKQSAVGIIAVLGLFASAQPALNYWFTDSSQQTQTSEVSFIKIR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEEC
NVEELQQQLALAKQAKKPVMLDFYADWCVACKEFEKYTFHDPAVAAQLKQFVLLQADVTR
CHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
NQAQDIELLQAQQVLGLPTIDFWDAQGNPVSNARLTGFMQAAPFLEHIQRISN
CHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA