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The map label for this gene is hemC [H]

Identifier: 27364543

GI number: 27364543

Start: 1121999

End: 1122937

Strand: Reverse

Name: hemC [H]

Synonym: VV1_1122

Alternate gene names: 27364543

Gene position: 1122937-1121999 (Counterclockwise)

Preceding gene: 27364545

Following gene: 27364542

Centisome position: 34.22

GC content: 54.1

Gene sequence:

>939_bases
ATGACACACTCAACGCCAATCCGAATCGCAACACGCAAAAGCCCCCTCGCTCTATGGCAAGCCTACTACGTAAAAGACGC
GCTACAAAAAGCCCATCCGGGCTTGGAAGTCGAGCTGGTGACCATGGTGACCAAAGGTGACGTGATTCTTGATACCCCTC
TTGCCAAAGTGGGTGGCAAAGGCCTTTTTGTCAAAGAGCTCGAAGTGGCAATGCTGGAAGGGCGTGCAGACCTCGCCGTT
CACTCGATGAAAGACGTGCCAGTGGATTTCCCAGAAGGTTTAGGTTTGGTGACGATTTGTGAGCGTGAAGATCCTCGCGA
TGCCTTTGTCTCAAACACCTACCATCATGTTGATGAACTGCCTCAAGGCGCGGTTGTCGGCACTTGTAGCTTGCGTCGTC
AATGTCAATTGAAAGCCTATCGCCCAGATTTGGTGATCAAAGAACTGCGCGGCAACGTCGGCACTCGTTTAAGCAAACTC
GATGCAGGTGAATACGACGCGATCATTCTCGCGGCCGCTGGCTTGAAACGTCTTGAGCTGGAAGAGCGCATCCGCAGCTT
TATTGAGCCAGAACAATCGCTCCCAGCCGTCGGCCAAGGTGCCGTGGGCATTGAATGTCGTACTAACGATGAGCGTATTC
TCAAACTTCTCGAACCGTTGAACCACGCCGATACGGCCGATCGCGTCAAATGCGAACGCGCCATGAACCTCACCTTAGAA
GGCGGCTGCCAAGTGCCAATCGGTAGCTATGCGCTGCTTGAGGGCGATGAGATCTGGCTCCGTGCGTTGGTGGGCGAGCC
AGATGGCAGCGAAATCGTCCGTGGTGAAATTCGTGGCCCTCGCGCGCAGGCGGAACAATTAGGCGTGCAATTGGCCAATC
AACTGCTGGATGAGGGTGCCAGAGAGATCCTCACCAAGTTGTACCAAGACCACGAATAA

Upstream 100 bases:

>100_bases
CGTTAACCCTAGCATCAGTTCCACCAACTAACAGTAAGACTTTAGCAGTGAGAGTGGTAGGATTAGCCCAAATCAGAACG
TTCAAGATATTGGGAAGACA

Downstream 100 bases:

>100_bases
CATGGCGGTACTGGTAACAAGGCCAGCCGAGCAAGGCCAAGCGCTTTGCCAACTGCTTCAACAAGCTGGAGTCCCTGCAC
TCCAGCACCCTCTTATTGAT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTHSTPIRIATRKSPLALWQAYYVKDALQKAHPGLEVELVTMVTKGDVILDTPLAKVGGKGLFVKELEVAMLEGRADLAV
HSMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYHHVDELPQGAVVGTCSLRRQCQLKAYRPDLVIKELRGNVGTRLSKL
DAGEYDAIILAAAGLKRLELEERIRSFIEPEQSLPAVGQGAVGIECRTNDERILKLLEPLNHADTADRVKCERAMNLTLE
GGCQVPIGSYALLEGDEIWLRALVGEPDGSEIVRGEIRGPRAQAEQLGVQLANQLLDEGAREILTKLYQDHE

Sequences:

>Translated_312_residues
MTHSTPIRIATRKSPLALWQAYYVKDALQKAHPGLEVELVTMVTKGDVILDTPLAKVGGKGLFVKELEVAMLEGRADLAV
HSMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYHHVDELPQGAVVGTCSLRRQCQLKAYRPDLVIKELRGNVGTRLSKL
DAGEYDAIILAAAGLKRLELEERIRSFIEPEQSLPAVGQGAVGIECRTNDERILKLLEPLNHADTADRVKCERAMNLTLE
GGCQVPIGSYALLEGDEIWLRALVGEPDGSEIVRGEIRGPRAQAEQLGVQLANQLLDEGAREILTKLYQDHE
>Mature_311_residues
THSTPIRIATRKSPLALWQAYYVKDALQKAHPGLEVELVTMVTKGDVILDTPLAKVGGKGLFVKELEVAMLEGRADLAVH
SMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYHHVDELPQGAVVGTCSLRRQCQLKAYRPDLVIKELRGNVGTRLSKLD
AGEYDAIILAAAGLKRLELEERIRSFIEPEQSLPAVGQGAVGIECRTNDERILKLLEPLNHADTADRVKCERAMNLTLEG
GCQVPIGSYALLEGDEIWLRALVGEPDGSEIVRGEIRGPRAQAEQLGVQLANQLLDEGAREILTKLYQDHE

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=334, Percent_Identity=41.0179640718563, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI66933009, Length=334, Percent_Identity=41.0179640718563, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI48994974, Length=303, Percent_Identity=74.5874587458746, Blast_Score=454, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=38.871473354232, Blast_Score=195, Evalue=8e-51,
Organism=Drosophila melanogaster, GI20130425, Length=257, Percent_Identity=43.1906614785992, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34328; Mature: 34197

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSTPIRIATRKSPLALWQAYYVKDALQKAHPGLEVELVTMVTKGDVILDTPLAKVGGK
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEECCHHHHCCC
GLFVKELEVAMLEGRADLAVHSMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYHHVDEL
CEEHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHCCHHHHHHHC
PQGAVVGTCSLRRQCQLKAYRPDLVIKELRGNVGTRLSKLDAGEYDAIILAAAGLKRLEL
CCCCEEEEHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHCCCCCCCEEEEEECCCHHHHH
EERIRSFIEPEQSLPAVGQGAVGIECRTNDERILKLLEPLNHADTADRVKCERAMNLTLE
HHHHHHHHCCHHCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEC
GGCQVPIGSYALLEGDEIWLRALVGEPDGSEIVRGEIRGPRAQAEQLGVQLANQLLDEGA
CCCCCCCCCEEEECCCCEEEEEEECCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
REILTKLYQDHE
HHHHHHHHHCCC
>Mature Secondary Structure 
THSTPIRIATRKSPLALWQAYYVKDALQKAHPGLEVELVTMVTKGDVILDTPLAKVGGK
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEECCHHHHCCC
GLFVKELEVAMLEGRADLAVHSMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYHHVDEL
CEEHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHCCHHHHHHHC
PQGAVVGTCSLRRQCQLKAYRPDLVIKELRGNVGTRLSKLDAGEYDAIILAAAGLKRLEL
CCCCEEEEHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHCCCCCCCEEEEEECCCHHHHH
EERIRSFIEPEQSLPAVGQGAVGIECRTNDERILKLLEPLNHADTADRVKCERAMNLTLE
HHHHHHHHCCHHCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEC
GGCQVPIGSYALLEGDEIWLRALVGEPDGSEIVRGEIRGPRAQAEQLGVQLANQLLDEGA
CCCCCCCCCEEEECCCCEEEEEEECCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
REILTKLYQDHE
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA