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The map label for this gene is hemD [H]

Identifier: 27364542

GI number: 27364542

Start: 1121266

End: 1121997

Strand: Reverse

Name: hemD [H]

Synonym: VV1_1121

Alternate gene names: 27364542

Gene position: 1121997-1121266 (Counterclockwise)

Preceding gene: 27364543

Following gene: 27364541

Centisome position: 34.19

GC content: 50.82

Gene sequence:

>732_bases
ATGGCGGTACTGGTAACAAGGCCAGCCGAGCAAGGCCAAGCGCTTTGCCAACTGCTTCAACAAGCTGGAGTCCCTGCACT
CCAGCACCCTCTTATTGATATCGTTGCGAATAGCTCACTCAACACCCTCGCCAACGACCTGAAACAAAGCGATGTGATCA
TCGCAGTGAGTCAACATGCGGTGCAATGCGCCGAACACATCCTCAAAGCACAGCAACAAAACTGGCCGCAAAACGCGCTT
TACCTTGCCGTTGGTCAAAAAACCGCACACTATTTGAGCAAAGTTACCCACCAAGACGTAAACTACCCGACGGTCAGTGA
TAGCGAGCACCTCCTACAACTCCCAGTGTTCAATCGGATAGCAGGAAAACGCGTATTGATTCTGCGCGGTAACGGCGGAC
GAGAACTGATACATCAGGCATTGAGCCAACGAGGGGCTGACGTCCGGTATTGTGAGACCTACCAGAGAGAATTGATCCCC
TTTGATGCGGTAAGCTCTCTCACCTTATGGCGCGATCAGGGAGTCGACACTCTGATTGTCACCAGTGCAGAACAACTCGA
CTACCTCCACGCTCAAATGAGTGATGAGGGTAAATTTTGGTTATATCAACAACGCTTGCTGGTTCCCAGCGAACGTATTG
CTGCCATTGCGACCCAACTTGGCTTTACTCAGGTTTGCAATGTAGGAAGTGCCTCGAACAAAGATTTACTGGCTGCTCTC
CAGCCTAAGTAA

Upstream 100 bases:

>100_bases
CGCGCGCAGGCGGAACAATTAGGCGTGCAATTGGCCAATCAACTGCTGGATGAGGGTGCCAGAGAGATCCTCACCAAGTT
GTACCAAGACCACGAATAAC

Downstream 100 bases:

>100_bases
CACAGGACAAACTCATGACAAGTAAAAAAAATAACGAGCCAAATAAGCCTGAAGAAACAACTTCTCAACCAATAACCTCT
GACGCCTCCACGCCAGAAAC

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MAVLVTRPAEQGQALCQLLQQAGVPALQHPLIDIVANSSLNTLANDLKQSDVIIAVSQHAVQCAEHILKAQQQNWPQNAL
YLAVGQKTAHYLSKVTHQDVNYPTVSDSEHLLQLPVFNRIAGKRVLILRGNGGRELIHQALSQRGADVRYCETYQRELIP
FDAVSSLTLWRDQGVDTLIVTSAEQLDYLHAQMSDEGKFWLYQQRLLVPSERIAAIATQLGFTQVCNVGSASNKDLLAAL
QPK

Sequences:

>Translated_243_residues
MAVLVTRPAEQGQALCQLLQQAGVPALQHPLIDIVANSSLNTLANDLKQSDVIIAVSQHAVQCAEHILKAQQQNWPQNAL
YLAVGQKTAHYLSKVTHQDVNYPTVSDSEHLLQLPVFNRIAGKRVLILRGNGGRELIHQALSQRGADVRYCETYQRELIP
FDAVSSLTLWRDQGVDTLIVTSAEQLDYLHAQMSDEGKFWLYQQRLLVPSERIAAIATQLGFTQVCNVGSASNKDLLAAL
QPK
>Mature_242_residues
AVLVTRPAEQGQALCQLLQQAGVPALQHPLIDIVANSSLNTLANDLKQSDVIIAVSQHAVQCAEHILKAQQQNWPQNALY
LAVGQKTAHYLSKVTHQDVNYPTVSDSEHLLQLPVFNRIAGKRVLILRGNGGRELIHQALSQRGADVRYCETYQRELIPF
DAVSSLTLWRDQGVDTLIVTSAEQLDYLHAQMSDEGKFWLYQQRLLVPSERIAAIATQLGFTQVCNVGSASNKDLLAALQ
PK

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=246, Percent_Identity=42.6829268292683, Blast_Score=171, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 26867; Mature: 26736

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLVTRPAEQGQALCQLLQQAGVPALQHPLIDIVANSSLNTLANDLKQSDVIIAVSQHA
CEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEHHHH
VQCAEHILKAQQQNWPQNALYLAVGQKTAHYLSKVTHQDVNYPTVSDSEHLLQLPVFNRI
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHC
AGKRVLILRGNGGRELIHQALSQRGADVRYCETYQRELIPFDAVSSLTLWRDQGVDTLIV
CCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
TSAEQLDYLHAQMSDEGKFWLYQQRLLVPSERIAAIATQLGFTQVCNVGSASNKDLLAAL
ECHHHHHHHHHHCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEC
QPK
CCC
>Mature Secondary Structure 
AVLVTRPAEQGQALCQLLQQAGVPALQHPLIDIVANSSLNTLANDLKQSDVIIAVSQHA
EEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEHHHH
VQCAEHILKAQQQNWPQNALYLAVGQKTAHYLSKVTHQDVNYPTVSDSEHLLQLPVFNRI
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHC
AGKRVLILRGNGGRELIHQALSQRGADVRYCETYQRELIPFDAVSSLTLWRDQGVDTLIV
CCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
TSAEQLDYLHAQMSDEGKFWLYQQRLLVPSERIAAIATQLGFTQVCNVGSASNKDLLAAL
ECHHHHHHHHHHCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEC
QPK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]