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The map label for this gene is kdsA [H]

Identifier: 23502011

GI number: 23502011

Start: 1111146

End: 1111979

Strand: Reverse

Name: kdsA [H]

Synonym: BR1133

Alternate gene names: 23502011

Gene position: 1111979-1111146 (Counterclockwise)

Preceding gene: 23502012

Following gene: 23502010

Centisome position: 52.76

GC content: 57.07

Gene sequence:

>834_bases
ATGGTGACTGCCAATTCCACGGTTAAAGTCGGTAACGTCACGTTTTCCAACAGCGCGCCTTTGGCGCTGATCGCTGGCCC
TTGCCAGATGGAAACGCGCGACCATGCCTTTGAAATGGCGGGTCACCTGAAGGAAATGACCGATAAGCTGGGTATTGGCC
TTGTTTACAAGTCCAGCTTCGATAAGGCCAACCGCACTTCGCTGAAGGCCGCGCGCGGCATCGGTCTTGAAAAGGCGCTG
GAAGTGTTCAGCGATCTCAAGAAGGAATATGGTTTTCCCGTTCTGACCGATATCCATACCGAAGAGCAGTGTGCGGCTGT
CGCTCCGGTTGTCGATGTGCTTCAGATCCCGGCATTTCTTTGCCGCCAGACCGATCTCCTGATTGCCGCCGCCAGAACTG
GCCGTGTGGTGAATGTGAAGAAAGGCCAGTTTCTTGCGCCTTGGGACATGAAGAATGTTCTTGCCAAGATCACCGAGAGC
GGCAATCCGAATGTTCTGGCCACGGAGCGCGGCGTGTCGTTCGGCTATAATACGCTTGTTTCGGATATGCGCGCATTGCC
AATCATGGCTGGCCTTGGTGCGCCGGTGATTTTTGATGCGACTCACTCCGTCCAGCAGCCGGGCGGGCAGGGCGGTTCTA
CGGGTGGGCAGCGTGAATTCGTCGAAACGCTGGCGCGTGCCGCAGTTGCAGTGGGCGTGGCGGGCCTCTTCATCGAAACC
CACGAAGATCCCGATAATGCTCCGTCCGACGGCCCCAACATGGTGCCGATCGACAAGATGCCGGCGCTTCTGGAAAAGCT
GATGGCATTCGATCGCATTGCCAAGGCGCTGTAA

Upstream 100 bases:

>100_bases
AGCGCGCCCTTCGGGGCGCGTTTTGTTTATGCGTCTTGTTTTCGATGACTATGGATGCCAGATACAGCCCATTCTGGCGT
TTATAAATTGAGGTTCCGCT

Downstream 100 bases:

>100_bases
GCCTGGAAAGTGCATGAGACTGGCGGGGATTTTCCCCGCCTTTTGTTTGATTACATCTTTATTTTCACCGCATTTGTCAC
ACGCCGGATGTTTCCATTTG

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MVTANSTVKVGNVTFSNSAPLALIAGPCQMETRDHAFEMAGHLKEMTDKLGIGLVYKSSFDKANRTSLKAARGIGLEKAL
EVFSDLKKEYGFPVLTDIHTEEQCAAVAPVVDVLQIPAFLCRQTDLLIAAARTGRVVNVKKGQFLAPWDMKNVLAKITES
GNPNVLATERGVSFGYNTLVSDMRALPIMAGLGAPVIFDATHSVQQPGGQGGSTGGQREFVETLARAAVAVGVAGLFIET
HEDPDNAPSDGPNMVPIDKMPALLEKLMAFDRIAKAL

Sequences:

>Translated_277_residues
MVTANSTVKVGNVTFSNSAPLALIAGPCQMETRDHAFEMAGHLKEMTDKLGIGLVYKSSFDKANRTSLKAARGIGLEKAL
EVFSDLKKEYGFPVLTDIHTEEQCAAVAPVVDVLQIPAFLCRQTDLLIAAARTGRVVNVKKGQFLAPWDMKNVLAKITES
GNPNVLATERGVSFGYNTLVSDMRALPIMAGLGAPVIFDATHSVQQPGGQGGSTGGQREFVETLARAAVAVGVAGLFIET
HEDPDNAPSDGPNMVPIDKMPALLEKLMAFDRIAKAL
>Mature_277_residues
MVTANSTVKVGNVTFSNSAPLALIAGPCQMETRDHAFEMAGHLKEMTDKLGIGLVYKSSFDKANRTSLKAARGIGLEKAL
EVFSDLKKEYGFPVLTDIHTEEQCAAVAPVVDVLQIPAFLCRQTDLLIAAARTGRVVNVKKGQFLAPWDMKNVLAKITES
GNPNVLATERGVSFGYNTLVSDMRALPIMAGLGAPVIFDATHSVQQPGGQGGSTGGQREFVETLARAAVAVGVAGLFIET
HEDPDNAPSDGPNMVPIDKMPALLEKLMAFDRIAKAL

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=275, Percent_Identity=45.0909090909091, Blast_Score=253, Evalue=1e-68,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 29479; Mature: 29479

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTANSTVKVGNVTFSNSAPLALIAGPCQMETRDHAFEMAGHLKEMTDKLGIGLVYKSSF
CCCCCCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCC
DKANRTSLKAARGIGLEKALEVFSDLKKEYGFPVLTDIHTEEQCAAVAPVVDVLQIPAFL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
CRQTDLLIAAARTGRVVNVKKGQFLAPWDMKNVLAKITESGNPNVLATERGVSFGYNTLV
HCCHHHEEEEECCCCEEEECCCCEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
SDMRALPIMAGLGAPVIFDATHSVQQPGGQGGSTGGQREFVETLARAAVAVGVAGLFIET
HHHHHHHHHHCCCCCEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEE
HEDPDNAPSDGPNMVPIDKMPALLEKLMAFDRIAKAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVTANSTVKVGNVTFSNSAPLALIAGPCQMETRDHAFEMAGHLKEMTDKLGIGLVYKSSF
CCCCCCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCC
DKANRTSLKAARGIGLEKALEVFSDLKKEYGFPVLTDIHTEEQCAAVAPVVDVLQIPAFL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
CRQTDLLIAAARTGRVVNVKKGQFLAPWDMKNVLAKITESGNPNVLATERGVSFGYNTLV
HCCHHHEEEEECCCCEEEECCCCEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
SDMRALPIMAGLGAPVIFDATHSVQQPGGQGGSTGGQREFVETLARAAVAVGVAGLFIET
HHHHHHHHHHCCCCCEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEE
HEDPDNAPSDGPNMVPIDKMPALLEKLMAFDRIAKAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA