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The map label for this gene is pyrG [H]

Identifier: 23502012

GI number: 23502012

Start: 1112085

End: 1113713

Strand: Reverse

Name: pyrG [H]

Synonym: BR1134

Alternate gene names: 23502012

Gene position: 1113713-1112085 (Counterclockwise)

Preceding gene: 23502013

Following gene: 23502011

Centisome position: 52.84

GC content: 55.62

Gene sequence:

>1629_bases
ATGGCGCGATATGTATTCATCACTGGCGGCGTGGTTTCTTCCCTCGGAAAAGGCATAGCTGCCGCAGCATTGGCTGCACT
CCTTCAGGCACGCGGTTATCGTGTGCGTATCCGTAAACTTGACCCCTATCTGAATGTCGATCCAGGCACAATATCGCCTT
ACCAGCATGGTGAGGTGTTCGTCACTGACGACGGAGCCGAGACAGACCTCGATCTGGGCCATTACGAGCGGTTTACCGGT
CGTCCCGCCAACCAGCAGGATAATATCACGACCGGTCGTATCTACCGCAATATCATCGAAAAGGAACGCCGCGGCGATTA
TCTCGGTGCGACGGTTCAGGTCATTCCTCATGTGACCGACGAGATCAAGAATTTCGTTCTTGAGGGCAATGAGGATTATG
ATTTCGTGCTGTGCGAAATCGGCGGCACGGTTGGCGATATCGAAGCCATGCCGTTTCTGGAAGCCATTCGCCAGCTTGGC
AACGAGTTACCGCGCGGCACGGCGGTTTATATCCACCTGACCCTGATGCCCTATATTCCGGCTGCGGGCGAATTGAAGAC
CAAGCCGACCCAGCATTCGGTCAAGGAACTGCGTTCCATCGGCATTGCACCGGATATTCTTCTGGTGCGTGCCGACCGCG
AAATCCCGGAATCGGAGCGGCGCAAGCTGTCGCTGTTCTGCAATGTCCGTGAAAGCGCGGTCATTCAGGCGCTTGATGTT
GCGACAATCTACGATGTTCCGATCGCCTATCACAAAGAAGGGCTGGATTCGGAAGTCCTGTCCGCATTCGGCATCGATCC
GGCGCCAAAGCCGCGCATGGATCGCTGGGAAGAGGTTTCCCATCGGCTCCACAACCCGGAAGGCGAAGTGACGATTGCCG
TTGTCGGTAAATATACCGGCCTCAAGGATGCCTATAAATCTCTCATCGAGGCGCTGCATCATGGCGGTCTGGCCAATAAG
GTGAAGGTCAATCTCGACTGGATCGAGGCGCAAGTTTTTGAAAGCGAAGACCCGGCTCCATATCTGGAAAAGGTGCATGG
CATTCTGGTGCCGGGCGGCTTTGGTGAGCGTGGTGCTGAAGGCAAGATTCTCGCGGCGAAATTCGCACGCGAGCGCAAGG
TGCCTTATTTCGGTATCTGCTTTGGTATGCAGATGGCCTGCATTGAAGCAGCGCGCAATCTGGTCGGTATCGAAGATGCT
TCCTCAAGCGAGTTTGGCCCAACCAGGGAGCCGGTCGTGGGTCTCATGACCGAATGGCTGAAGGGCAATATGCTTGAAAA
GCGTGCGGCGGCGGGCGATCTTGGCGGTACGATGCGCCTTGGCGCTTATGAAGCGGTGCTGAAGCCCGACTCGAAAATTG
CGCAAATCTACGGCTCGACCGATATCCACGAGCGTCACCGCCATCGTTATGAAGTCAATATCGACTATAAGGACCGTCTC
GAAGCAGCCGGCCTGAATTTCGCTGGCATGTCGCCGGACGGCGTTTTGCCGGAAACGGTCGAATATGCGGATCATCCTTG
GTTTATCGGCGTGCAGTACCATCCGGAACTGAAATCCCGTCCGTTTGAGCCGCATCCGCTTTTTGCATCCTTTATCGAAG
CGGCCATCGAACAGAGCCGTCTGGTCTGA

Upstream 100 bases:

>100_bases
TTGTTCAATGACGGTTGCCGCTCAAGCTTTGGTGAAAAAATGCCCCGAAGTGCATTTTTTTGTGGCGGAATCAATCGGGA
AAGTCTAACGAGATAAGCCC

Downstream 100 bases:

>100_bases
GTTTGAGCGCGCCCTTCGGGGCGCGTTTTGTTTATGCGTCTTGTTTTCGATGACTATGGATGCCAGATACAGCCCATTCT
GGCGTTTATAAATTGAGGTT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MARYVFITGGVVSSLGKGIAAAALAALLQARGYRVRIRKLDPYLNVDPGTISPYQHGEVFVTDDGAETDLDLGHYERFTG
RPANQQDNITTGRIYRNIIEKERRGDYLGATVQVIPHVTDEIKNFVLEGNEDYDFVLCEIGGTVGDIEAMPFLEAIRQLG
NELPRGTAVYIHLTLMPYIPAAGELKTKPTQHSVKELRSIGIAPDILLVRADREIPESERRKLSLFCNVRESAVIQALDV
ATIYDVPIAYHKEGLDSEVLSAFGIDPAPKPRMDRWEEVSHRLHNPEGEVTIAVVGKYTGLKDAYKSLIEALHHGGLANK
VKVNLDWIEAQVFESEDPAPYLEKVHGILVPGGFGERGAEGKILAAKFARERKVPYFGICFGMQMACIEAARNLVGIEDA
SSSEFGPTREPVVGLMTEWLKGNMLEKRAAAGDLGGTMRLGAYEAVLKPDSKIAQIYGSTDIHERHRHRYEVNIDYKDRL
EAAGLNFAGMSPDGVLPETVEYADHPWFIGVQYHPELKSRPFEPHPLFASFIEAAIEQSRLV

Sequences:

>Translated_542_residues
MARYVFITGGVVSSLGKGIAAAALAALLQARGYRVRIRKLDPYLNVDPGTISPYQHGEVFVTDDGAETDLDLGHYERFTG
RPANQQDNITTGRIYRNIIEKERRGDYLGATVQVIPHVTDEIKNFVLEGNEDYDFVLCEIGGTVGDIEAMPFLEAIRQLG
NELPRGTAVYIHLTLMPYIPAAGELKTKPTQHSVKELRSIGIAPDILLVRADREIPESERRKLSLFCNVRESAVIQALDV
ATIYDVPIAYHKEGLDSEVLSAFGIDPAPKPRMDRWEEVSHRLHNPEGEVTIAVVGKYTGLKDAYKSLIEALHHGGLANK
VKVNLDWIEAQVFESEDPAPYLEKVHGILVPGGFGERGAEGKILAAKFARERKVPYFGICFGMQMACIEAARNLVGIEDA
SSSEFGPTREPVVGLMTEWLKGNMLEKRAAAGDLGGTMRLGAYEAVLKPDSKIAQIYGSTDIHERHRHRYEVNIDYKDRL
EAAGLNFAGMSPDGVLPETVEYADHPWFIGVQYHPELKSRPFEPHPLFASFIEAAIEQSRLV
>Mature_541_residues
ARYVFITGGVVSSLGKGIAAAALAALLQARGYRVRIRKLDPYLNVDPGTISPYQHGEVFVTDDGAETDLDLGHYERFTGR
PANQQDNITTGRIYRNIIEKERRGDYLGATVQVIPHVTDEIKNFVLEGNEDYDFVLCEIGGTVGDIEAMPFLEAIRQLGN
ELPRGTAVYIHLTLMPYIPAAGELKTKPTQHSVKELRSIGIAPDILLVRADREIPESERRKLSLFCNVRESAVIQALDVA
TIYDVPIAYHKEGLDSEVLSAFGIDPAPKPRMDRWEEVSHRLHNPEGEVTIAVVGKYTGLKDAYKSLIEALHHGGLANKV
KVNLDWIEAQVFESEDPAPYLEKVHGILVPGGFGERGAEGKILAAKFARERKVPYFGICFGMQMACIEAARNLVGIEDAS
SSEFGPTREPVVGLMTEWLKGNMLEKRAAAGDLGGTMRLGAYEAVLKPDSKIAQIYGSTDIHERHRHRYEVNIDYKDRLE
AAGLNFAGMSPDGVLPETVEYADHPWFIGVQYHPELKSRPFEPHPLFASFIEAAIEQSRLV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=557, Percent_Identity=43.8061041292639, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI28559085, Length=562, Percent_Identity=43.5943060498221, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI28559083, Length=562, Percent_Identity=43.5943060498221, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI221316689, Length=562, Percent_Identity=43.5943060498221, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=57.4349442379182, Blast_Score=598, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=36.1247947454844, Blast_Score=390, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322563, Length=570, Percent_Identity=41.0526315789474, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319432, Length=567, Percent_Identity=39.3298059964727, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=43.9285714285714, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI21357815, Length=506, Percent_Identity=43.2806324110672, Blast_Score=390, Evalue=1e-108,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 60059; Mature: 59928

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARYVFITGGVVSSLGKGIAAAALAALLQARGYRVRIRKLDPYLNVDPGTISPYQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGRPANQQDNITTGRIYRNIIEKERRGDYLGATVQVIPHVTD
EECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EIKNFVLEGNEDYDFVLCEIGGTVGDIEAMPFLEAIRQLGNELPRGTAVYIHLTLMPYIP
HHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCC
AAGELKTKPTQHSVKELRSIGIAPDILLVRADREIPESERRKLSLFCNVRESAVIQALDV
CCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCEEEEEEECHHHHHHHHHHH
ATIYDVPIAYHKEGLDSEVLSAFGIDPAPKPRMDRWEEVSHRLHNPEGEVTIAVVGKYTG
HHHCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCC
LKDAYKSLIEALHHGGLANKVKVNLDWIEAQVFESEDPAPYLEKVHGILVPGGFGERGAE
HHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCCHHHHHHCEEEECCCCCCCCCC
GKILAAKFARERKVPYFGICFGMQMACIEAARNLVGIEDASSSEFGPTREPVVGLMTEWL
CCEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
KGNMLEKRAAAGDLGGTMRLGAYEAVLKPDSKIAQIYGSTDIHERHRHRYEVNIDYKDRL
CCCHHHHHHHCCCCCCCEECCCCHHHCCCCHHHHHHHCCCCHHHHHCCEEEEECCHHHHH
EAAGLNFAGMSPDGVLPETVEYADHPWFIGVQYHPELKSRPFEPHPLFASFIEAAIEQSR
HHCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHC
LV
CC
>Mature Secondary Structure 
ARYVFITGGVVSSLGKGIAAAALAALLQARGYRVRIRKLDPYLNVDPGTISPYQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGRPANQQDNITTGRIYRNIIEKERRGDYLGATVQVIPHVTD
EECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EIKNFVLEGNEDYDFVLCEIGGTVGDIEAMPFLEAIRQLGNELPRGTAVYIHLTLMPYIP
HHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCC
AAGELKTKPTQHSVKELRSIGIAPDILLVRADREIPESERRKLSLFCNVRESAVIQALDV
CCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCEEEEEEECHHHHHHHHHHH
ATIYDVPIAYHKEGLDSEVLSAFGIDPAPKPRMDRWEEVSHRLHNPEGEVTIAVVGKYTG
HHHCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCC
LKDAYKSLIEALHHGGLANKVKVNLDWIEAQVFESEDPAPYLEKVHGILVPGGFGERGAE
HHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCCHHHHHHCEEEECCCCCCCCCC
GKILAAKFARERKVPYFGICFGMQMACIEAARNLVGIEDASSSEFGPTREPVVGLMTEWL
CCEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
KGNMLEKRAAAGDLGGTMRLGAYEAVLKPDSKIAQIYGSTDIHERHRHRYEVNIDYKDRL
CCCHHHHHHHCCCCCCCEECCCCHHHCCCCHHHHHHHCCCCHHHHHCCEEEEECCHHHHH
EAAGLNFAGMSPDGVLPETVEYADHPWFIGVQYHPELKSRPFEPHPLFASFIEAAIEQSR
HHCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHC
LV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA