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The map label for this gene is acdA [H]

Identifier: 23100465

GI number: 23100465

Start: 3118917

End: 3120056

Strand: Reverse

Name: acdA [H]

Synonym: OB3010

Alternate gene names: 23100465

Gene position: 3120056-3118917 (Counterclockwise)

Preceding gene: 23100466

Following gene: 23100464

Centisome position: 85.94

GC content: 40.44

Gene sequence:

>1140_bases
ATGAATTTTCAATTAACAGAAGAACAAGAAATGCTGCGTAAAATGGTCCGCGATTTTGCGGAAAAAGAAGTTGCACCTAC
AGCATCTGAGCGTGATGAGGAAGAACGCTTTGACCGTTCTATCTTTGATCAAATGGCACAGTTAGGTTTAACCGGTATCC
CGTGGCCAGAAGAATATGGTGGGATTGGTTCGGATTATTTGAGCTACGTTATTGCGGTAGAAGAACTTTCTCGTGTATGT
GCATCTACAGGAGTAACATTGTCAGCTCATTTATCTTTAGCAAGCTGGCCGATATTTAAATATGGAACAGAAGATCAAAA
GAAAAATTTCTTGCAACGATTAGCCACAGGTGAAGCATTAGGGGCCTATGCTTTATCTGAGCCAGGAGCTGGAAGTGACG
TTGTATCCATGAAAACCACAGCAAGAAGAGACGGTGAAGATTTTGTCATTAATGGGAATAAGGTATGGATTACCAATGGT
GGCGTAGCTGATATTTATATTGTATTTGCGAAAACTGACACGGATGCAAATCATAAAGGAATTAGTGCATTTATTATTGA
AAAAGGTACAGAAGGATTCAGGTTTGGGAAAAAGGAGAAAAAGCTCGGCATTCGTTCATCACCGACCACCGAATTAATTT
TTGAAAACTGTCGAATTCCTAAATCGAACTTACTTGGTAATGAAGGAGAAGGATTTAAAATTGCCATGACTACATTAGAT
GGAGGAAGAAATGGCATTGCTGCACAAGCTGTAGGTATTGCGCAAGGCGCATTGGATGCTGCTTCGGATTATGCCAAAGA
ACGCCAGCAATTTGGTAAGCCGATTGCTGAAAATCAAGGAATCTCTTTTAAACTAGCAGATATGGCAACAGAGATAGAGG
CAGCCCGTCTATTAACTTATCAAGCAGCTTGGCTGGAATCAGCTGGTTTACCGTATGGTAAAGCTTCTGCCATGTCGAAG
TTATTTGCTGGAGATGTGGCAATGAAAAGTACTGTAGAAGCAGTTCAAGTATTTGGTGGCTATGGATATACCAAAGATTA
TCCAGTAGAAAGATATATGCGCGATGCTAAAATCACGCAAATTTATGAAGGAACAAATGAGGTACAACGGCTGGTGATCG
GTAGAATGGTAACTAAATAA

Upstream 100 bases:

>100_bases
TCCGGGATGCAAAAGTTACAGAAATATACGAAGGTACCAATGAAATTCAGCATATTGTAATTGCAAAACATCTACTAAAT
GATGAAGGGATGCATGGTTA

Downstream 100 bases:

>100_bases
TGACAGAATTAAAGTAAGGAAAGGAGGACCTCATAAAAATGGCAGAAGATCGAATTCTTTCATCGGTCAAGGATCAGCAA
CTTGTTAGTAAGCGACGTAA

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNFQLTEEQEMLRKMVRDFAEKEVAPTASERDEEERFDRSIFDQMAQLGLTGIPWPEEYGGIGSDYLSYVIAVEELSRVC
ASTGVTLSAHLSLASWPIFKYGTEDQKKNFLQRLATGEALGAYALSEPGAGSDVVSMKTTARRDGEDFVINGNKVWITNG
GVADIYIVFAKTDTDANHKGISAFIIEKGTEGFRFGKKEKKLGIRSSPTTELIFENCRIPKSNLLGNEGEGFKIAMTTLD
GGRNGIAAQAVGIAQGALDAASDYAKERQQFGKPIAENQGISFKLADMATEIEAARLLTYQAAWLESAGLPYGKASAMSK
LFAGDVAMKSTVEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTNEVQRLVIGRMVTK

Sequences:

>Translated_379_residues
MNFQLTEEQEMLRKMVRDFAEKEVAPTASERDEEERFDRSIFDQMAQLGLTGIPWPEEYGGIGSDYLSYVIAVEELSRVC
ASTGVTLSAHLSLASWPIFKYGTEDQKKNFLQRLATGEALGAYALSEPGAGSDVVSMKTTARRDGEDFVINGNKVWITNG
GVADIYIVFAKTDTDANHKGISAFIIEKGTEGFRFGKKEKKLGIRSSPTTELIFENCRIPKSNLLGNEGEGFKIAMTTLD
GGRNGIAAQAVGIAQGALDAASDYAKERQQFGKPIAENQGISFKLADMATEIEAARLLTYQAAWLESAGLPYGKASAMSK
LFAGDVAMKSTVEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTNEVQRLVIGRMVTK
>Mature_379_residues
MNFQLTEEQEMLRKMVRDFAEKEVAPTASERDEEERFDRSIFDQMAQLGLTGIPWPEEYGGIGSDYLSYVIAVEELSRVC
ASTGVTLSAHLSLASWPIFKYGTEDQKKNFLQRLATGEALGAYALSEPGAGSDVVSMKTTARRDGEDFVINGNKVWITNG
GVADIYIVFAKTDTDANHKGISAFIIEKGTEGFRFGKKEKKLGIRSSPTTELIFENCRIPKSNLLGNEGEGFKIAMTTLD
GGRNGIAAQAVGIAQGALDAASDYAKERQQFGKPIAENQGISFKLADMATEIEAARLLTYQAAWLESAGLPYGKASAMSK
LFAGDVAMKSTVEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTNEVQRLVIGRMVTK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=51.8817204301075, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=43.6997319034853, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=43.2, Blast_Score=308, Evalue=4e-84,
Organism=Homo sapiens, GI7656849, Length=372, Percent_Identity=41.9354838709677, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=41.2698412698413, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=41.2698412698413, Blast_Score=305, Evalue=4e-83,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=43.768115942029, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI21361497, Length=350, Percent_Identity=41.1428571428571, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=35.6382978723404, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI4557235, Length=384, Percent_Identity=38.0208333333333, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI76496475, Length=384, Percent_Identity=38.0208333333333, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=32.2751322751323, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=31.9559228650138, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI48976061, Length=326, Percent_Identity=31.5950920245399, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI211971008, Length=295, Percent_Identity=32.5423728813559, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI38505218, Length=391, Percent_Identity=27.3657289002558, Blast_Score=125, Evalue=4e-29,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=31.8537859007833, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=28.9473684210526, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI87082384, Length=266, Percent_Identity=26.6917293233083, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081702, Length=341, Percent_Identity=25.5131964809384, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=43.5828877005348, Blast_Score=333, Evalue=7e-92,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=41.2868632707775, Blast_Score=318, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=42.7440633245383, Blast_Score=310, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=42.3684210526316, Blast_Score=310, Evalue=8e-85,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=43.0446194225722, Blast_Score=304, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=41.994750656168, Blast_Score=297, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=40.2116402116402, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI71990804, Length=302, Percent_Identity=44.7019867549669, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71985184, Length=380, Percent_Identity=37.6315789473684, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=33.42175066313, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=43.0434782608696, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI71985192, Length=306, Percent_Identity=38.562091503268, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17551932, Length=376, Percent_Identity=32.7127659574468, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17505929, Length=374, Percent_Identity=32.3529411764706, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71982178, Length=269, Percent_Identity=33.8289962825279, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=31.5352697095436, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=29.2096219931272, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17531913, Length=193, Percent_Identity=30.0518134715026, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI86563383, Length=306, Percent_Identity=26.797385620915, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=306, Percent_Identity=26.797385620915, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=51.4666666666667, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=45.8666666666667, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=41.8666666666667, Blast_Score=324, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=42.9708222811671, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=41.2073490813648, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI281363737, Length=386, Percent_Identity=36.2694300518135, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=31.1345646437995, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI45550141, Length=314, Percent_Identity=26.1146496815287, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221473076, Length=314, Percent_Identity=26.1146496815287, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41519; Mature: 41519

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQLTEEQEMLRKMVRDFAEKEVAPTASERDEEERFDRSIFDQMAQLGLTGIPWPEEYG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLSYVIAVEELSRVCASTGVTLSAHLSLASWPIFKYGTEDQKKNFLQRLATGEAL
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCEECCCCHHHHHHHHHHHCCHHH
GAYALSEPGAGSDVVSMKTTARRDGEDFVINGNKVWITNGGVADIYIVFAKTDTDANHKG
HHHCCCCCCCCCCEEEEHHHHCCCCCEEEEECCEEEEECCCCEEEEEEEEECCCCCCCCC
ISAFIIEKGTEGFRFGKKEKKLGIRSSPTTELIFENCRIPKSNLLGNEGEGFKIAMTTLD
EEEEEEECCCCCCCCCCHHHCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCEEEEEEEEC
GGRNGIAAQAVGIAQGALDAASDYAKERQQFGKPIAENQGISFKLADMATEIEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
QAAWLESAGLPYGKASAMSKLFAGDVAMKSTVEAVQVFGGYGYTKDYPVERYMRDAKITQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTNEVQRLVIGRMVTK
HHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFQLTEEQEMLRKMVRDFAEKEVAPTASERDEEERFDRSIFDQMAQLGLTGIPWPEEYG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLSYVIAVEELSRVCASTGVTLSAHLSLASWPIFKYGTEDQKKNFLQRLATGEAL
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCEECCCCHHHHHHHHHHHCCHHH
GAYALSEPGAGSDVVSMKTTARRDGEDFVINGNKVWITNGGVADIYIVFAKTDTDANHKG
HHHCCCCCCCCCCEEEEHHHHCCCCCEEEEECCEEEEECCCCEEEEEEEEECCCCCCCCC
ISAFIIEKGTEGFRFGKKEKKLGIRSSPTTELIFENCRIPKSNLLGNEGEGFKIAMTTLD
EEEEEEECCCCCCCCCCHHHCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCEEEEEEEEC
GGRNGIAAQAVGIAQGALDAASDYAKERQQFGKPIAENQGISFKLADMATEIEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
QAAWLESAGLPYGKASAMSKLFAGDVAMKSTVEAVQVFGGYGYTKDYPVERYMRDAKITQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTNEVQRLVIGRMVTK
HHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]