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The map label for this gene is tdk

Identifier: 23100454

GI number: 23100454

Start: 3107655

End: 3108278

Strand: Reverse

Name: tdk

Synonym: OB2999

Alternate gene names: 23100454

Gene position: 3108278-3107655 (Counterclockwise)

Preceding gene: 23100455

Following gene: 23100453

Centisome position: 85.62

GC content: 37.66

Gene sequence:

>624_bases
ATGTATGTAATGAAACAAAATGGCTGGGTAGAATTAATTTGTGGAAGTATGTTTTCTGGGAAATCAGAAGAATTAATTCG
TCGTGTACGTCGTGCGACATATGCCCATATTAACGTAAGAGTATATAAACCAGCAATCGATGACCGCTATGATGATAAAG
CAATTGTGTCACATGATGGGACTTCCACAATGGCACGCCCAATTCACGATGCTGTAGAAATATTAGAAGATGTGGATAAC
AATGTAGAAATTGTTGGTATTGATGAAGTACAATTTTTTGATAATAATGTCGTAGATGTAATAGAGGAGCTTGCTGATCG
TGGTATTCGCGTAATTGTAGCAGGTCTTGATTTAGATTTTCGTGGAGAACCTTTTGAACCTGTGCCGAAGATTATGGCAT
TAGCAGAATCCGTAACAAAATTAAATGCAATTTGTCCTATATGTGGTTCACCTGCAAGTCGCACACAACGACTTATTGAC
GGTAAGCCAGCTTCGTATAACGATCCTATCATTTTGGTTGGTGCTTCTGAATCCTATGAACCAAGATGCAGACATCATCA
TGAAGTTCCTTTTCGTCCAGAAAATAATTTTGCAACGAAATCTTGGGATGCATTAAAAAGTTAA

Upstream 100 bases:

>100_bases
GGATGTGGTGGCTTCGATGGTTTTCTATTCCGAAGTGATTATTTCAACGACTTTTGAGCACAGTCTGGTGCGGAGGAATA
TCTTGAGAGGGGATCTTCAC

Downstream 100 bases:

>100_bases
TAGAAAAAATAAGAATGGATAGTTAAGTAATGAGAAAACTTATACTATCCTTTTTACATACTGGTTTATCCTAGGTGGTC
AATTGACCCAAGGACTCCCA

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MYVMKQNGWVELICGSMFSGKSEELIRRVRRATYAHINVRVYKPAIDDRYDDKAIVSHDGTSTMARPIHDAVEILEDVDN
NVEIVGIDEVQFFDNNVVDVIEELADRGIRVIVAGLDLDFRGEPFEPVPKIMALAESVTKLNAICPICGSPASRTQRLID
GKPASYNDPIILVGASESYEPRCRHHHEVPFRPENNFATKSWDALKS

Sequences:

>Translated_207_residues
MYVMKQNGWVELICGSMFSGKSEELIRRVRRATYAHINVRVYKPAIDDRYDDKAIVSHDGTSTMARPIHDAVEILEDVDN
NVEIVGIDEVQFFDNNVVDVIEELADRGIRVIVAGLDLDFRGEPFEPVPKIMALAESVTKLNAICPICGSPASRTQRLID
GKPASYNDPIILVGASESYEPRCRHHHEVPFRPENNFATKSWDALKS
>Mature_207_residues
MYVMKQNGWVELICGSMFSGKSEELIRRVRRATYAHINVRVYKPAIDDRYDDKAIVSHDGTSTMARPIHDAVEILEDVDN
NVEIVGIDEVQFFDNNVVDVIEELADRGIRVIVAGLDLDFRGEPFEPVPKIMALAESVTKLNAICPICGSPASRTQRLID
GKPASYNDPIILVGASESYEPRCRHHHEVPFRPENNFATKSWDALKS

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Homo sapiens, GI164698438, Length=183, Percent_Identity=38.2513661202186, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI1787490, Length=180, Percent_Identity=28.3333333333333, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17543396, Length=183, Percent_Identity=31.6939890710383, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_OCEIH (Q8EM59)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693921.1
- ProteinModelPortal:   Q8EM59
- SMR:   Q8EM59
- GeneID:   1016723
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2999
- NMPDR:   fig|221109.1.peg.3001
- HOGENOM:   HBG522108
- OMA:   NEIRSTP
- ProtClustDB:   PRK04296
- BioCyc:   OIHE221109:OB2999-MONOMER
- BRENDA:   2.7.1.21
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 23269; Mature: 23269

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVMKQNGWVELICGSMFSGKSEELIRRVRRATYAHINVRVYKPAIDDRYDDKAIVSHDG
CEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCEEEECCC
TSTMARPIHDAVEILEDVDNNVEIVGIDEVQFFDNNVVDVIEELADRGIRVIVAGLDLDF
CHHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHCCCEEEEEEECCCCC
RGEPFEPVPKIMALAESVTKLNAICPICGSPASRTQRLIDGKPASYNDPIILVGASESYE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCC
PRCRHHHEVPFRPENNFATKSWDALKS
CHHHCCCCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MYVMKQNGWVELICGSMFSGKSEELIRRVRRATYAHINVRVYKPAIDDRYDDKAIVSHDG
CEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCEEEECCC
TSTMARPIHDAVEILEDVDNNVEIVGIDEVQFFDNNVVDVIEELADRGIRVIVAGLDLDF
CHHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHCCCEEEEEEECCCCC
RGEPFEPVPKIMALAESVTKLNAICPICGSPASRTQRLIDGKPASYNDPIILVGASESYE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCC
PRCRHHHEVPFRPENNFATKSWDALKS
CHHHCCCCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376