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The map label for this gene is hrcA

Identifier: 23099425

GI number: 23099425

Start: 1997900

End: 1998928

Strand: Reverse

Name: hrcA

Synonym: OB1970

Alternate gene names: 23099425

Gene position: 1998928-1997900 (Counterclockwise)

Preceding gene: 23099426

Following gene: 23099424

Centisome position: 55.06

GC content: 35.37

Gene sequence:

>1029_bases
ATGTTAACTGAAAGGCAACTGATCATTTTACAAGTCATTATTGATGATTTTATTGAAACTGCACATCCCATTGGGTCTCG
TGCATTATCAAAAAGCGAATACCTTCCGTATAGTGCAGCAACTATCCGGAATGAAATGGCTGACCTAGAGGATTTAGGTT
TTCTTGAAAAAACCCATACTTCATCAGGTAGAATTCCTTCAGAAAAGGGTTATCGTTATTATGTAGACCACCTTATAGGT
CCTATGAATCAACACGAAGCGGGAATATTACGTAAGTATACTGACGGAGAGTTTTTTGAATTTGAACAAGTAGTACAAAT
GACTGCAGAAGTATTATCTGAACTAACAAATTACACTTCGATAATCTTAGGGCCAGAAATGTTTGAAGCTACGTTAAAAC
AAATTCAAGTACTAACATTATCCGATCATACCGCTGTAGCAATTCTAGTAACCAGTACAGGTCATGTAGAGCACCGTTCG
TTTGCCCTACCTGAAGGTATAGCTTCTTCAGATTTAGAGAAGTTAGTGAACATTTTAAATGATCGTTTAAAAGGCGTGCC
GATTATTCGATTAGGAGAAGTTATTTCTACTGAAGTCGCACAACTAATGCATCGTTATATGGATGATTTTGAAGCTTCCT
TTGATTTACTTCGAGCATTCTTTATGAACGAACACCCAGTTAAGTTGTATTTCGGTGGGAAATCAAACATCTTAATGCAG
CCTGAGTTTAACGATGTAGATAAAATTCGATCATTTTATGCCTTAATCGAACAAGAAGATGAAATAGCAAATCTCTTGAA
AAATACGCATCAAGGTATTAAAGTATCGATTGGTAATGAAAATAAAGTTGAGGCGATTAAAGATTTAAGTCTCATAACTG
CATCTTATCATGTAGGAGATAATCTTATGGGTACAATTGCATTATTAGGGCCAACAAGAATGGAATACAAAAAAGTAATT
TCATTAATGAAGGGAATTTCCGATGAAATGACCAACACGTTAGATAGGTGGTATAAGGGAGATTCTTAA

Upstream 100 bases:

>100_bases
CAATTGGAAAGCTAAACTGTTTGACAAAGAAAAAGGGATTTGATAATTTATTTATAGAATTAGCACTCAATAATCAAGAG
TGCTAACAGAGGTGATCATC

Downstream 100 bases:

>100_bases
CTTAAGTTCTTAATAGAACGTCTTGGTTTTCTAAATAGTGCAATCATGATATAGTCAATGATGGAAATTGAAAGCGAGGT
GCCACTAAAATTGAACGAAA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLTERQLIILQVIIDDFIETAHPIGSRALSKSEYLPYSAATIRNEMADLEDLGFLEKTHTSSGRIPSEKGYRYYVDHLIG
PMNQHEAGILRKYTDGEFFEFEQVVQMTAEVLSELTNYTSIILGPEMFEATLKQIQVLTLSDHTAVAILVTSTGHVEHRS
FALPEGIASSDLEKLVNILNDRLKGVPIIRLGEVISTEVAQLMHRYMDDFEASFDLLRAFFMNEHPVKLYFGGKSNILMQ
PEFNDVDKIRSFYALIEQEDEIANLLKNTHQGIKVSIGNENKVEAIKDLSLITASYHVGDNLMGTIALLGPTRMEYKKVI
SLMKGISDEMTNTLDRWYKGDS

Sequences:

>Translated_342_residues
MLTERQLIILQVIIDDFIETAHPIGSRALSKSEYLPYSAATIRNEMADLEDLGFLEKTHTSSGRIPSEKGYRYYVDHLIG
PMNQHEAGILRKYTDGEFFEFEQVVQMTAEVLSELTNYTSIILGPEMFEATLKQIQVLTLSDHTAVAILVTSTGHVEHRS
FALPEGIASSDLEKLVNILNDRLKGVPIIRLGEVISTEVAQLMHRYMDDFEASFDLLRAFFMNEHPVKLYFGGKSNILMQ
PEFNDVDKIRSFYALIEQEDEIANLLKNTHQGIKVSIGNENKVEAIKDLSLITASYHVGDNLMGTIALLGPTRMEYKKVI
SLMKGISDEMTNTLDRWYKGDS
>Mature_342_residues
MLTERQLIILQVIIDDFIETAHPIGSRALSKSEYLPYSAATIRNEMADLEDLGFLEKTHTSSGRIPSEKGYRYYVDHLIG
PMNQHEAGILRKYTDGEFFEFEQVVQMTAEVLSELTNYTSIILGPEMFEATLKQIQVLTLSDHTAVAILVTSTGHVEHRS
FALPEGIASSDLEKLVNILNDRLKGVPIIRLGEVISTEVAQLMHRYMDDFEASFDLLRAFFMNEHPVKLYFGGKSNILMQ
PEFNDVDKIRSFYALIEQEDEIANLLKNTHQGIKVSIGNENKVEAIKDLSLITASYHVGDNLMGTIALLGPTRMEYKKVI
SLMKGISDEMTNTLDRWYKGDS

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_OCEIH (Q8EPW3)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692891.1
- ProteinModelPortal:   Q8EPW3
- SMR:   Q8EPW3
- GeneID:   1018447
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1970
- NMPDR:   fig|221109.1.peg.1970
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   OIHE221109:OB1970-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 38659; Mature: 38659

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTERQLIILQVIIDDFIETAHPIGSRALSKSEYLPYSAATIRNEMADLEDLGFLEKTHT
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCC
SSGRIPSEKGYRYYVDHLIGPMNQHEAGILRKYTDGEFFEFEQVVQMTAEVLSELTNYTS
CCCCCCCCCCCCEEHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHE
IILGPEMFEATLKQIQVLTLSDHTAVAILVTSTGHVEHRSFALPEGIASSDLEKLVNILN
EEECHHHHHHHHHHEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
DRLKGVPIIRLGEVISTEVAQLMHRYMDDFEASFDLLRAFFMNEHPVKLYFGGKSNILMQ
HHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEC
PEFNDVDKIRSFYALIEQEDEIANLLKNTHQGIKVSIGNENKVEAIKDLSLITASYHVGD
CCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC
NLMGTIALLGPTRMEYKKVISLMKGISDEMTNTLDRWYKGDS
CHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTERQLIILQVIIDDFIETAHPIGSRALSKSEYLPYSAATIRNEMADLEDLGFLEKTHT
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCC
SSGRIPSEKGYRYYVDHLIGPMNQHEAGILRKYTDGEFFEFEQVVQMTAEVLSELTNYTS
CCCCCCCCCCCCEEHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHE
IILGPEMFEATLKQIQVLTLSDHTAVAILVTSTGHVEHRSFALPEGIASSDLEKLVNILN
EEECHHHHHHHHHHEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
DRLKGVPIIRLGEVISTEVAQLMHRYMDDFEASFDLLRAFFMNEHPVKLYFGGKSNILMQ
HHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEC
PEFNDVDKIRSFYALIEQEDEIANLLKNTHQGIKVSIGNENKVEAIKDLSLITASYHVGD
CCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC
NLMGTIALLGPTRMEYKKVISLMKGISDEMTNTLDRWYKGDS
CHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376