Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 23099426

GI number: 23099426

Start: 1999014

End: 2000189

Strand: Reverse

Name: hemN [H]

Synonym: OB1971

Alternate gene names: 23099426

Gene position: 2000189-1999014 (Counterclockwise)

Preceding gene: 23099427

Following gene: 23099425

Centisome position: 55.09

GC content: 33.33

Gene sequence:

>1176_bases
TTGGATTCAATAAAAGCAGTATATATACACATTCCATTTTGTAAACAAATATGTCATTACTGCAATTTTGTTAAATATTT
TTATATGGAAAACAAAGCTGACGATTATATTGAAGCGCTAATCCATGAGATAGATTGCACTGTAATTGGATATAATGTTC
ATGTGGATACCATTTATATGGGTGGAGGTACACCTACCGCTTTAAATATACAACAACTCAAAAAACTATTTAATTTTTTA
GGTAGAAAATTTAATTTAGAATCTTGTAAAGAGTTTACGATTGAAATAAATCCCGGTGACATCGATCATGAAAAAGCTCA
GCTACTTTCTTCGTATGGGGTTAACAGAGTTTCATTTGGTGTACAAGTAATGGACGATGACATGCTACGAAAAATTGGAA
GAATGCATTGTGTAAAAGACGTCTATGAAACAGTAGACTTATTAACCAAAAATGATTTTCGAAATATTAGTCTCGATTTA
ATCTATGCATTACCAAACCAAACAGTAGAACACTTTGAAAAAACATTACACGATGCGCTTCAATTTGGATTACCACATTA
TTCAACCTATGCATTGCAAATTGAACCGAAGACAGTGTTTTTCCATAAGCAGAATAAAGGTCAGCTACAGCGCCCTCCAG
AAGATGCAGAAGTGGAAATGTATCGGATATTACAACACGAGATGAAAAAACGTGGCATAAGGCAGTATGAAATAAGTAAT
TTTGCAAAACCAGGATATGAAAGTAAACATAATCTTACTTATTGGAATAATGATTATTATTACGGTTTTGGTGCAGGTGC
GCATGGATACATTCCAGGTAAGCGTACTTCCAATAGTAAGCCACTTGGTACATATATGCGTGCTGCTAAAGAAGAAGGAA
GTGCAATTGACGAAATCGAAGAAATCACTAAAAAAGATCAAATTGAAGAAGAGCTATTTTTGCAACTACGTAAAACATCT
GGAATTGATAAGAAGATGTTTGAGCAAAAATACGGGGTATCTCTTGAGCAATTGTATGAAAAAGAATTACAGGATTTATT
AGAACAAGGTTTACTAAGATTGATAGATGGGAATTACCGTTTAACGGATAGAGGAATGCTATTGGGGGATCAAGTATTTT
CCAAATTCTTAATGCTACAATCTGCTGGTGATAAAATTATTCAATTGGAAAGCTAA

Upstream 100 bases:

>100_bases
ATGGATGATAACTAAAAAGAAACTTGTATAAATAGATAGAGGGGGGACTGATAGAGTAATATCTATCAGTTTTCCTTTTT
ATTAGAAGGGTCGATTAATT

Downstream 100 bases:

>100_bases
ACTGTTTGACAAAGAAAAAGGGATTTGATAATTTATTTATAGAATTAGCACTCAATAATCAAGAGTGCTAACAGAGGTGA
TCATCATGTTAACTGAAAGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MDSIKAVYIHIPFCKQICHYCNFVKYFYMENKADDYIEALIHEIDCTVIGYNVHVDTIYMGGGTPTALNIQQLKKLFNFL
GRKFNLESCKEFTIEINPGDIDHEKAQLLSSYGVNRVSFGVQVMDDDMLRKIGRMHCVKDVYETVDLLTKNDFRNISLDL
IYALPNQTVEHFEKTLHDALQFGLPHYSTYALQIEPKTVFFHKQNKGQLQRPPEDAEVEMYRILQHEMKKRGIRQYEISN
FAKPGYESKHNLTYWNNDYYYGFGAGAHGYIPGKRTSNSKPLGTYMRAAKEEGSAIDEIEEITKKDQIEEELFLQLRKTS
GIDKKMFEQKYGVSLEQLYEKELQDLLEQGLLRLIDGNYRLTDRGMLLGDQVFSKFLMLQSAGDKIIQLES

Sequences:

>Translated_391_residues
MDSIKAVYIHIPFCKQICHYCNFVKYFYMENKADDYIEALIHEIDCTVIGYNVHVDTIYMGGGTPTALNIQQLKKLFNFL
GRKFNLESCKEFTIEINPGDIDHEKAQLLSSYGVNRVSFGVQVMDDDMLRKIGRMHCVKDVYETVDLLTKNDFRNISLDL
IYALPNQTVEHFEKTLHDALQFGLPHYSTYALQIEPKTVFFHKQNKGQLQRPPEDAEVEMYRILQHEMKKRGIRQYEISN
FAKPGYESKHNLTYWNNDYYYGFGAGAHGYIPGKRTSNSKPLGTYMRAAKEEGSAIDEIEEITKKDQIEEELFLQLRKTS
GIDKKMFEQKYGVSLEQLYEKELQDLLEQGLLRLIDGNYRLTDRGMLLGDQVFSKFLMLQSAGDKIIQLES
>Mature_391_residues
MDSIKAVYIHIPFCKQICHYCNFVKYFYMENKADDYIEALIHEIDCTVIGYNVHVDTIYMGGGTPTALNIQQLKKLFNFL
GRKFNLESCKEFTIEINPGDIDHEKAQLLSSYGVNRVSFGVQVMDDDMLRKIGRMHCVKDVYETVDLLTKNDFRNISLDL
IYALPNQTVEHFEKTLHDALQFGLPHYSTYALQIEPKTVFFHKQNKGQLQRPPEDAEVEMYRILQHEMKKRGIRQYEISN
FAKPGYESKHNLTYWNNDYYYGFGAGAHGYIPGKRTSNSKPLGTYMRAAKEEGSAIDEIEEITKKDQIEEELFLQLRKTS
GIDKKMFEQKYGVSLEQLYEKELQDLLEQGLLRLIDGNYRLTDRGMLLGDQVFSKFLMLQSAGDKIIQLES

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=373, Percent_Identity=30.5630026809651, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1789325, Length=385, Percent_Identity=29.8701298701299, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87082341, Length=380, Percent_Identity=25.2631578947368, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 45416; Mature: 45416

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSIKAVYIHIPFCKQICHYCNFVKYFYMENKADDYIEALIHEIDCTVIGYNVHVDTIYM
CCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEEEEEEEEE
GGGTPTALNIQQLKKLFNFLGRKFNLESCKEFTIEINPGDIDHEKAQLLSSYGVNRVSFG
CCCCCCEECHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEC
VQVMDDDMLRKIGRMHCVKDVYETVDLLTKNDFRNISLDLIYALPNQTVEHFEKTLHDAL
EEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
QFGLPHYSTYALQIEPKTVFFHKQNKGQLQRPPEDAEVEMYRILQHEMKKRGIRQYEISN
HHCCCCCEEEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEHHHH
FAKPGYESKHNLTYWNNDYYYGFGAGAHGYIPGKRTSNSKPLGTYMRAAKEEGSAIDEIE
CCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHH
EITKKDQIEEELFLQLRKTSGIDKKMFEQKYGVSLEQLYEKELQDLLEQGLLRLIDGNYR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
LTDRGMLLGDQVFSKFLMLQSAGDKIIQLES
EECCCCCHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MDSIKAVYIHIPFCKQICHYCNFVKYFYMENKADDYIEALIHEIDCTVIGYNVHVDTIYM
CCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEEEEEEEEE
GGGTPTALNIQQLKKLFNFLGRKFNLESCKEFTIEINPGDIDHEKAQLLSSYGVNRVSFG
CCCCCCEECHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEC
VQVMDDDMLRKIGRMHCVKDVYETVDLLTKNDFRNISLDLIYALPNQTVEHFEKTLHDAL
EEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
QFGLPHYSTYALQIEPKTVFFHKQNKGQLQRPPEDAEVEMYRILQHEMKKRGIRQYEISN
HHCCCCCEEEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEHHHH
FAKPGYESKHNLTYWNNDYYYGFGAGAHGYIPGKRTSNSKPLGTYMRAAKEEGSAIDEIE
CCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHH
EITKKDQIEEELFLQLRKTSGIDKKMFEQKYGVSLEQLYEKELQDLLEQGLLRLIDGNYR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
LTDRGMLLGDQVFSKFLMLQSAGDKIIQLES
EECCCCCHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]