Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 23097920

GI number: 23097920

Start: 492992

End: 494053

Strand: Reverse

Name: thrC [H]

Synonym: OB0465

Alternate gene names: 23097920

Gene position: 494053-492992 (Counterclockwise)

Preceding gene: 23097921

Following gene: 23097919

Centisome position: 13.61

GC content: 39.08

Gene sequence:

>1062_bases
ATGACCTGGCAAGGTTTATTAAAGGAATATGCGGATTTATTACCAGTCACAGACCAGACACCATCATTAAGTCTAATGGA
AGGAAACACTCCTTTATTGTCTTTTCCAACTTTATCAAAGGAATTAGGAATAGAGTTATATGGAAAATTTGAAGGATTAA
ACCCGACCGGCTCATTTAAAGATAGAGGCATGGTTATGGCAGTTGCAAAAGCAATCGAAGAAGGCAGCAAATCCATTATT
TGTGCTTCTACAGGAAATACTTCAGCTGCAGCTGCTGCCTATGCTGCTAGGGCTGGTATACGTGCAATTATTGTCATCCC
TAAAGGAAAAGTTGCTTTAGGAAAATTAGCTCAAGCCGTCATGTACGGTGCAGAGATTGTTGAGATTGATGGTAATTTTG
ATGAGGCACTGCAAATGGTTCGTAAAATCAGTGAGAAATCAGCCGTTACATTAGTTAACTCTGTTAATCCTTATCGTATT
GACGGACAAAAAACTGCCGCATTTGAAGTTTGCGATCAATTAGGTTCAGCTCCTGATATTCTTGCTATTCCAGTAGGGAA
TGCAGGAAATATTAGTGCATATTGGAAAGGATTTAAAGAATATAACGAAAAACACCAATCGGGACTACCCAAAATGATGG
GATTTGAAGCAGAAGGTGCTGCTGCTATTGTTAAAAATAAAGTTATTGAGCAACCAGAAACAGTAGCTACTGCTATCCGT
ATCGGTAACCCAGCAAGTTGGGAACTTGCCCTAAAAGCAAAAGAAGAATCAAATGGAAGTATTGGGTATGTAACAGATGA
AGAGATTGTAAATGCGTTCAAGCTTTTACCACAAAAAGAAGGTATTTTTGCAGAGCCAGGATCAGCAGCATCTATCGCTG
GTGTTATCCAACAGGTTAAAAGTGGAACTATTCCAAAAGGTAGTAAGGTTGTTGCTGTATTGACAGGGAATGGATTGAAA
GATCCACAAACGGCAATCGATCAACTATCCATTGATCCTGTAAGCTTACCAAACAACGAAAAAGCAGTCATGGACTATCT
TGAAGAGTTGATTACATCATGA

Upstream 100 bases:

>100_bases
CATCTTTGTCTAATTTCCAACATACGTTAGAGAAGTTGAAAAGTTTTGAAGCAGTTATGGAAATCAAAAGCTATTATAAA
GTGGAAGGAGAAGTGATGTA

Downstream 100 bases:

>100_bases
CGCCTTTTGGTATCTCTGTTCCAGCAAGCAGCGGTAATGTGGGCCCTGGTTTTGATTCAACAGGGCTTGCATTAGGCTTA
TACTTACATCTAAATGTAGA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTWQGLLKEYADLLPVTDQTPSLSLMEGNTPLLSFPTLSKELGIELYGKFEGLNPTGSFKDRGMVMAVAKAIEEGSKSII
CASTGNTSAAAAAYAARAGIRAIIVIPKGKVALGKLAQAVMYGAEIVEIDGNFDEALQMVRKISEKSAVTLVNSVNPYRI
DGQKTAAFEVCDQLGSAPDILAIPVGNAGNISAYWKGFKEYNEKHQSGLPKMMGFEAEGAAAIVKNKVIEQPETVATAIR
IGNPASWELALKAKEESNGSIGYVTDEEIVNAFKLLPQKEGIFAEPGSAASIAGVIQQVKSGTIPKGSKVVAVLTGNGLK
DPQTAIDQLSIDPVSLPNNEKAVMDYLEELITS

Sequences:

>Translated_353_residues
MTWQGLLKEYADLLPVTDQTPSLSLMEGNTPLLSFPTLSKELGIELYGKFEGLNPTGSFKDRGMVMAVAKAIEEGSKSII
CASTGNTSAAAAAYAARAGIRAIIVIPKGKVALGKLAQAVMYGAEIVEIDGNFDEALQMVRKISEKSAVTLVNSVNPYRI
DGQKTAAFEVCDQLGSAPDILAIPVGNAGNISAYWKGFKEYNEKHQSGLPKMMGFEAEGAAAIVKNKVIEQPETVATAIR
IGNPASWELALKAKEESNGSIGYVTDEEIVNAFKLLPQKEGIFAEPGSAASIAGVIQQVKSGTIPKGSKVVAVLTGNGLK
DPQTAIDQLSIDPVSLPNNEKAVMDYLEELITS
>Mature_352_residues
TWQGLLKEYADLLPVTDQTPSLSLMEGNTPLLSFPTLSKELGIELYGKFEGLNPTGSFKDRGMVMAVAKAIEEGSKSIIC
ASTGNTSAAAAAYAARAGIRAIIVIPKGKVALGKLAQAVMYGAEIVEIDGNFDEALQMVRKISEKSAVTLVNSVNPYRID
GQKTAAFEVCDQLGSAPDILAIPVGNAGNISAYWKGFKEYNEKHQSGLPKMMGFEAEGAAAIVKNKVIEQPETVATAIRI
GNPASWELALKAKEESNGSIGYVTDEEIVNAFKLLPQKEGIFAEPGSAASIAGVIQQVKSGTIPKGSKVVAVLTGNGLKD
PQTAIDQLSIDPVSLPNNEKAVMDYLEELITS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=304, Percent_Identity=28.9473684210526, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1790207, Length=301, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367138, Length=309, Percent_Identity=24.9190938511327, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322631, Length=316, Percent_Identity=27.2151898734177, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37349; Mature: 37218

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWQGLLKEYADLLPVTDQTPSLSLMEGNTPLLSFPTLSKELGIELYGKFEGLNPTGSFK
CCHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCHHHCCEEEEEEECCCCCCCCCC
DRGMVMAVAKAIEEGSKSIICASTGNTSAAAAAYAARAGIRAIIVIPKGKVALGKLAQAV
CCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
MYGAEIVEIDGNFDEALQMVRKISEKSAVTLVNSVNPYRIDGQKTAAFEVCDQLGSAPDI
HHCCEEEEECCCHHHHHHHHHHHHHHHHEEEEECCCCEEECCCCHHHHHHHHHHCCCCCE
LAIPVGNAGNISAYWKGFKEYNEKHQSGLPKMMGFEAEGAAAIVKNKVIEQPETVATAIR
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCCCHHHHHEEE
IGNPASWELALKAKEESNGSIGYVTDEEIVNAFKLLPQKEGIFAEPGSAASIAGVIQQVK
CCCCCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHH
SGTIPKGSKVVAVLTGNGLKDPQTAIDQLSIDPVSLPNNEKAVMDYLEELITS
CCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TWQGLLKEYADLLPVTDQTPSLSLMEGNTPLLSFPTLSKELGIELYGKFEGLNPTGSFK
CHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCHHHCCEEEEEEECCCCCCCCCC
DRGMVMAVAKAIEEGSKSIICASTGNTSAAAAAYAARAGIRAIIVIPKGKVALGKLAQAV
CCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
MYGAEIVEIDGNFDEALQMVRKISEKSAVTLVNSVNPYRIDGQKTAAFEVCDQLGSAPDI
HHCCEEEEECCCHHHHHHHHHHHHHHHHEEEEECCCCEEECCCCHHHHHHHHHHCCCCCE
LAIPVGNAGNISAYWKGFKEYNEKHQSGLPKMMGFEAEGAAAIVKNKVIEQPETVATAIR
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCCCHHHHHEEE
IGNPASWELALKAKEESNGSIGYVTDEEIVNAFKLLPQKEGIFAEPGSAASIAGVIQQVK
CCCCCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHH
SGTIPKGSKVVAVLTGNGLKDPQTAIDQLSIDPVSLPNNEKAVMDYLEELITS
CCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3098560; 9384377; 3139660 [H]