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The map label for this gene is hom [H]

Identifier: 23097921

GI number: 23097921

Start: 494053

End: 495351

Strand: Reverse

Name: hom [H]

Synonym: OB0466

Alternate gene names: 23097921

Gene position: 495351-494053 (Counterclockwise)

Preceding gene: 23097923

Following gene: 23097920

Centisome position: 13.64

GC content: 37.11

Gene sequence:

>1299_bases
ATGAAAGAGAAAGTGTCTGTTGGTTTATTAGGTTTAGGAGTTGTTGGGTCTGGTGTTATTCAATTAATTAATGACCACCG
TGAAAAATTAACTCATCAACTTGGTTGTGAAGTAGAAGTATCGAAAGTGTTAGTAAAAAATTTAGATAAAACAAGAAATA
TACATATTAATGGTGATTTGCTCACGACAAATCCAAGTGATGTATTAGATCATCCATCAATTGACATTATAGTAGAAGTA
ATGGGTGGCATTGATCAAGCAAAAGAATATATTTTACGTGCTTTTAATAATAAAAAACATGTCGTATCCGCCAATAAAGA
CTTAGTCGCTCTGCATGGACCTGAGCTTCAAGAAGCTGCTACCAAAAATCGTTGCGACTTCTATTATGAGGCAAGCGTTG
CTGGAGGCATTCCAATTCTAAGAGGTATTTCGGAAGGATTGTCTACGGACCATATTCAACGTGTTATGGGGATTGTGAAT
GGTACTACAAACTATATCCTAACTAAAATGGATGAAGAAGGAATGAGTTACGAAGACGCTCTATTAGAAGCGCAACGGTT
AGGATTTGCAGAAGCAGACCCTACTTCAGATGTTGACGGATTAGACGCTGCTCGAAAAATGGCCATCCTTGGTCGACTTG
CTTTCTCGACTCCTGTTGAATTAAGCGATGTAGAAGTAAACGGTATTCGAGGGATTGAATTAGAAGATTTACGTTACGGA
AAACAACTCGGTTATACAATGAAACTTATTGGTTTTGCGAACTTTAACGATCAAGAGCTGGAAGTAAATGTACAACCTAC
ACTCTTATCAAAAAACCACCCATTATCTAGTGTGAAGAACGAATATAATGCAGTTTATGTATATGGCGAGGCTGTAGGTG
AAACCATGTTTTATGGACCTGGGGCCGGTAGTTTGCCTACTGCTACAGCAATACTATCTGATGTCAGTGCAGCGATAAAA
GGATTACGTCTTGGTGTATCCGGCAGTCAATCAAATGAAATGCAGTTCACTAAAACGTTAACCCCAATTAATAAGCGACA
TAGCCAGTATTATATTAGGCTCTGTGTAAAGGATGAATCTGGAGTTCTTTCTAAAATATCATCATTATTCCATGAACAAG
ATATAAGCTTCCAACGTATCGTACAAACACCTGTTAATGATTATGAAGCAGCTGAAATTGTTGTTGTAACTCATGATACA
TCTTTGTCTAATTTCCAACATACGTTAGAGAAGTTGAAAAGTTTTGAAGCAGTTATGGAAATCAAAAGCTATTATAAAGT
GGAAGGAGAAGTGATGTAA

Upstream 100 bases:

>100_bases
TAACACAATATTTATTTGTTAATTTCAAATAATTCACTATTGCCATACATTAGTTTTCGTGTTTAAATGTATTCAATATA
CATCGCAGAGGGGTGAAAGT

Downstream 100 bases:

>100_bases
TGACCTGGCAAGGTTTATTAAAGGAATATGCGGATTTATTACCAGTCACAGACCAGACACCATCATTAAGTCTAATGGAA
GGAAACACTCCTTTATTGTC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKEKVSVGLLGLGVVGSGVIQLINDHREKLTHQLGCEVEVSKVLVKNLDKTRNIHINGDLLTTNPSDVLDHPSIDIIVEV
MGGIDQAKEYILRAFNNKKHVVSANKDLVALHGPELQEAATKNRCDFYYEASVAGGIPILRGISEGLSTDHIQRVMGIVN
GTTNYILTKMDEEGMSYEDALLEAQRLGFAEADPTSDVDGLDAARKMAILGRLAFSTPVELSDVEVNGIRGIELEDLRYG
KQLGYTMKLIGFANFNDQELEVNVQPTLLSKNHPLSSVKNEYNAVYVYGEAVGETMFYGPGAGSLPTATAILSDVSAAIK
GLRLGVSGSQSNEMQFTKTLTPINKRHSQYYIRLCVKDESGVLSKISSLFHEQDISFQRIVQTPVNDYEAAEIVVVTHDT
SLSNFQHTLEKLKSFEAVMEIKSYYKVEGEVM

Sequences:

>Translated_432_residues
MKEKVSVGLLGLGVVGSGVIQLINDHREKLTHQLGCEVEVSKVLVKNLDKTRNIHINGDLLTTNPSDVLDHPSIDIIVEV
MGGIDQAKEYILRAFNNKKHVVSANKDLVALHGPELQEAATKNRCDFYYEASVAGGIPILRGISEGLSTDHIQRVMGIVN
GTTNYILTKMDEEGMSYEDALLEAQRLGFAEADPTSDVDGLDAARKMAILGRLAFSTPVELSDVEVNGIRGIELEDLRYG
KQLGYTMKLIGFANFNDQELEVNVQPTLLSKNHPLSSVKNEYNAVYVYGEAVGETMFYGPGAGSLPTATAILSDVSAAIK
GLRLGVSGSQSNEMQFTKTLTPINKRHSQYYIRLCVKDESGVLSKISSLFHEQDISFQRIVQTPVNDYEAAEIVVVTHDT
SLSNFQHTLEKLKSFEAVMEIKSYYKVEGEVM
>Mature_432_residues
MKEKVSVGLLGLGVVGSGVIQLINDHREKLTHQLGCEVEVSKVLVKNLDKTRNIHINGDLLTTNPSDVLDHPSIDIIVEV
MGGIDQAKEYILRAFNNKKHVVSANKDLVALHGPELQEAATKNRCDFYYEASVAGGIPILRGISEGLSTDHIQRVMGIVN
GTTNYILTKMDEEGMSYEDALLEAQRLGFAEADPTSDVDGLDAARKMAILGRLAFSTPVELSDVEVNGIRGIELEDLRYG
KQLGYTMKLIGFANFNDQELEVNVQPTLLSKNHPLSSVKNEYNAVYVYGEAVGETMFYGPGAGSLPTATAILSDVSAAIK
GLRLGVSGSQSNEMQFTKTLTPINKRHSQYYIRLCVKDESGVLSKISSLFHEQDISFQRIVQTPVNDYEAAEIVVVTHDT
SLSNFQHTLEKLKSFEAVMEIKSYYKVEGEVM

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=277, Percent_Identity=29.6028880866426, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790376, Length=364, Percent_Identity=24.4505494505494, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=227, Percent_Identity=25.5506607929515, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47488; Mature: 47488

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKVSVGLLGLGVVGSGVIQLINDHREKLTHQLGCEVEVSKVLVKNLDKTRNIHINGDL
CCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCE
LTTNPSDVLDHPSIDIIVEVMGGIDQAKEYILRAFNNKKHVVSANKDLVALHGPELQEAA
EECCCHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCHHHHH
TKNRCDFYYEASVAGGIPILRGISEGLSTDHIQRVMGIVNGTTNYILTKMDEEGMSYEDA
CCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LLEAQRLGFAEADPTSDVDGLDAARKMAILGRLAFSTPVELSDVEVNGIRGIELEDLRYG
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCEEECCCCCCCHHHHHHH
KQLGYTMKLIGFANFNDQELEVNVQPTLLSKNHPLSSVKNEYNAVYVYGEAVGETMFYGP
HHCCCEEEEEEECCCCCCEEEEEECEEEECCCCCHHHHCCCCCEEEEEECCCCCEEEECC
GAGSLPTATAILSDVSAAIKGLRLGVSGSQSNEMQFTKTLTPINKRHSQYYIRLCVKDES
CCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEHHHCCHHHCCCEEEEEEEEECCC
GVLSKISSLFHEQDISFQRIVQTPVNDYEAAEIVVVTHDTSLSNFQHTLEKLKSFEAVME
CHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
IKSYYKVEGEVM
HHHHHHCCCCCC
>Mature Secondary Structure
MKEKVSVGLLGLGVVGSGVIQLINDHREKLTHQLGCEVEVSKVLVKNLDKTRNIHINGDL
CCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCE
LTTNPSDVLDHPSIDIIVEVMGGIDQAKEYILRAFNNKKHVVSANKDLVALHGPELQEAA
EECCCHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCHHHHH
TKNRCDFYYEASVAGGIPILRGISEGLSTDHIQRVMGIVNGTTNYILTKMDEEGMSYEDA
CCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LLEAQRLGFAEADPTSDVDGLDAARKMAILGRLAFSTPVELSDVEVNGIRGIELEDLRYG
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCEEECCCCCCCHHHHHHH
KQLGYTMKLIGFANFNDQELEVNVQPTLLSKNHPLSSVKNEYNAVYVYGEAVGETMFYGP
HHCCCEEEEEEECCCCCCEEEEEECEEEECCCCCHHHHCCCCCEEEEEECCCCCEEEECC
GAGSLPTATAILSDVSAAIKGLRLGVSGSQSNEMQFTKTLTPINKRHSQYYIRLCVKDES
CCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEHHHCCHHHCCCEEEEEEEEECCC
GVLSKISSLFHEQDISFQRIVQTPVNDYEAAEIVVVTHDTSLSNFQHTLEKLKSFEAVME
CHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
IKSYYKVEGEVM
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]