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The map label for this gene is mvk [H]

Identifier: 23097680

GI number: 23097680

Start: 246715

End: 247683

Strand: Direct

Name: mvk [H]

Synonym: OB0225

Alternate gene names: 23097680

Gene position: 246715-247683 (Clockwise)

Preceding gene: 23097679

Following gene: 23097681

Centisome position: 6.8

GC content: 41.28

Gene sequence:

>969_bases
ATGAGTTTAGAAAAAGTAACAGCCTCAGAGAAAACAGCTATTGGTGTAGCTCATAGTAAACTTATTTTAATTGGAGAGCA
CGCAGTTGTACACGGACAACCAGCGATTGCAATTCCATTTCCTTTAATAGGTGTAGAAACCGTTATTGAGTACGTCCCTG
GTACGGTGAAAGTGGACAGCTCTTTTTATCATGGGCCATTACATCATGCTCCTGACTATCTTCAGGGTATAGCTAATTGT
GTTGATGAAACACTTGCATATCTTGAGATTCCTAATGAGGACTTGTTGATCCGTATTAATTCCTCGATCCCACCAGGAAA
AGGTCTTGGTTCTAGTGCTTCAGTAGCGATATCTGTGATACGCTCTTTGTTTGATTATGCAGATCGTTCCTATACGACAG
AAGAACTACTGCGTCTAGCGAATGTGGCAGAAACCTATGCTCACGGTGATCCAAGCGGATTAGACACGCTTACGATCACA
TCTAATTTACCTGTATGGTTTGAAAAGGACCATCCGGTTGATTATATCGAGCTTGGAGAAGATCTTCATTTTATTGTCGC
TGATTCTGGTCGAGTTGGGGATACAAGAACCTCGGTTGAATCTGTAGCCCAATTGTTAAGAATGGCTCCAAAACGTATAC
ACGCGAAGATAGAACGAATCGGAGAGCTAACACACCATGCAAAAGACGCATTGGAAAAAGCAAGTAAGCAATTTTTAGGA
CAATTGCTGAATGAAGCGCAAAAAGAACTTGAAGCTCTTGGTGTTAGTGATGCCGGATTAAACAAATTAATTCATCTTGC
ACGTGAAGAGGGAGCTTTAGGTGCGAAGCTAACTGGCGGTGGAAATGGTGGGTGCATAATTGCATTAGCGCAAAATGAGG
TGCACTCAAAACAATTAGCTGATAAACTTCGTAAATTCGGTGCTAATTCAGTTTGGCCATTTGTATTGAAGAAGCAAAGT
AAGTCTTAA

Upstream 100 bases:

>100_bases
GGGCTTCAGGGGAGATGATTGATGTGATAGCAAAGAAATTAATAGATCAAAAAGAAATCCGTGTCGGAAAAGCTAAAGAA
TTGGTGGAACAGTATAAACA

Downstream 100 bases:

>100_bases
ACGAGAAGATTGAAGGAGTAATTCAATGAAAGCAACAGCAAAGGCGCATACAAATATCGCATTGATAAAATATTGGGGAA
AGCGAAATGAACCAATTATA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSLEKVTASEKTAIGVAHSKLILIGEHAVVHGQPAIAIPFPLIGVETVIEYVPGTVKVDSSFYHGPLHHAPDYLQGIANC
VDETLAYLEIPNEDLLIRINSSIPPGKGLGSSASVAISVIRSLFDYADRSYTTEELLRLANVAETYAHGDPSGLDTLTIT
SNLPVWFEKDHPVDYIELGEDLHFIVADSGRVGDTRTSVESVAQLLRMAPKRIHAKIERIGELTHHAKDALEKASKQFLG
QLLNEAQKELEALGVSDAGLNKLIHLAREEGALGAKLTGGGNGGCIIALAQNEVHSKQLADKLRKFGANSVWPFVLKKQS
KS

Sequences:

>Translated_322_residues
MSLEKVTASEKTAIGVAHSKLILIGEHAVVHGQPAIAIPFPLIGVETVIEYVPGTVKVDSSFYHGPLHHAPDYLQGIANC
VDETLAYLEIPNEDLLIRINSSIPPGKGLGSSASVAISVIRSLFDYADRSYTTEELLRLANVAETYAHGDPSGLDTLTIT
SNLPVWFEKDHPVDYIELGEDLHFIVADSGRVGDTRTSVESVAQLLRMAPKRIHAKIERIGELTHHAKDALEKASKQFLG
QLLNEAQKELEALGVSDAGLNKLIHLAREEGALGAKLTGGGNGGCIIALAQNEVHSKQLADKLRKFGANSVWPFVLKKQS
KS
>Mature_321_residues
SLEKVTASEKTAIGVAHSKLILIGEHAVVHGQPAIAIPFPLIGVETVIEYVPGTVKVDSSFYHGPLHHAPDYLQGIANCV
DETLAYLEIPNEDLLIRINSSIPPGKGLGSSASVAISVIRSLFDYADRSYTTEELLRLANVAETYAHGDPSGLDTLTITS
NLPVWFEKDHPVDYIELGEDLHFIVADSGRVGDTRTSVESVAQLLRMAPKRIHAKIERIGELTHHAKDALEKASKQFLGQ
LLNEAQKELEALGVSDAGLNKLIHLAREEGALGAKLTGGGNGGCIIALAQNEVHSKQLADKLRKFGANSVWPFVLKKQSK
S

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 34742; Mature: 34611

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEKVTASEKTAIGVAHSKLILIGEHAVVHGQPAIAIPFPLIGVETVIEYVPGTVKVDS
CCCCHHCCCCHHEEEEEECEEEEEECCEEEECCCCEECCCCHHHHHHHHHHCCCCEEECC
SFYHGPLHHAPDYLQGIANCVDETLAYLEIPNEDLLIRINSSIPPGKGLGSSASVAISVI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
RSLFDYADRSYTTEELLRLANVAETYAHGDPSGLDTLTITSNLPVWFEKDHPVDYIELGE
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCHHCCCC
DLHFIVADSGRVGDTRTSVESVAQLLRMAPKRIHAKIERIGELTHHAKDALEKASKQFLG
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLLNEAQKELEALGVSDAGLNKLIHLAREEGALGAKLTGGGNGGCIIALAQNEVHSKQLA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCHHHHHHHH
DKLRKFGANSVWPFVLKKQSKS
HHHHHHCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
SLEKVTASEKTAIGVAHSKLILIGEHAVVHGQPAIAIPFPLIGVETVIEYVPGTVKVDS
CCCHHCCCCHHEEEEEECEEEEEECCEEEECCCCEECCCCHHHHHHHHHHCCCCEEECC
SFYHGPLHHAPDYLQGIANCVDETLAYLEIPNEDLLIRINSSIPPGKGLGSSASVAISVI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
RSLFDYADRSYTTEELLRLANVAETYAHGDPSGLDTLTITSNLPVWFEKDHPVDYIELGE
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCHHCCCC
DLHFIVADSGRVGDTRTSVESVAQLLRMAPKRIHAKIERIGELTHHAKDALEKASKQFLG
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLLNEAQKELEALGVSDAGLNKLIHLAREEGALGAKLTGGGNGGCIIALAQNEVHSKQLA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCHHHHHHHH
DKLRKFGANSVWPFVLKKQSKS
HHHHHHCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA