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The map label for this gene is mvaA [H]

Identifier: 23097679

GI number: 23097679

Start: 245429

End: 246718

Strand: Direct

Name: mvaA [H]

Synonym: OB0224

Alternate gene names: 23097679

Gene position: 245429-246718 (Clockwise)

Preceding gene: 23097675

Following gene: 23097680

Centisome position: 6.76

GC content: 40.7

Gene sequence:

>1290_bases
ATGAAATCTTCTAGAATTCCAGGTTTTTATAATATGTCTGTAGATCAAAGACGTAAATTATTAAAGGATAATTATGATCT
AACAGATGAGCAGATGAGCAACCTGACAGATAATCCGTCACTTTCTTTAGACAAAGCGGATAACATGATAGAGAATGTTA
TTGGAACATTTGAACTCCCGTTAGGTATGGGGTTGAACTTTGTCATAAACGGGAACGAGTATACCGTACCTATGGCAATT
GAAGAAGCTTCTGTCGTAGCGTCTGCCAGTCATATAGCAAAAATTGTTAGAAGTGCTGGTGGATTTGAAGCGGAGTCTAG
GGAAAGATTAATGATAGGGCAGATACAAGTAGTAGGATGTTCTAACTTTCATGAAGCAAAGCAAGATCTACTTGATCAAA
AAGATACTTTAATGAACGCGGCTAATGATGCCTATCCGAGTATTGTTAAGCGCGGTGGTGGGACAAGAGATCTTGATGTT
CGTATCTTAAATGAAGATGCAAATTCAACATACTCTCAAATGCTTGTTATGCATATATATGTCGATACTTGCGATGCAAT
GGGGGCGAATATGATCAACACAATGGCAGAAGCCATCGCTCCTATTGTTGAAGAAATAACTGGCGGAAAAGTTTACCTTC
GAATTTTGTCTAACTACGCTGATCGAAGTTTAGCAAGCGCCAAGTGTGTTATTCCTCCTCATCTTTTAGCGACTGGTGAT
TTCACTGGTGAAGAAGTTAGAGACGGTGTTATACATGCATATGAATTTGCAGCTTCTGATCCATATCGAGCTGTGACCCA
TAACAAAGGTATCATGAACGGCATAGATCCAATTGTGATAGCCACGGGGAATGATTGGCGTGCTGTTGAAGCAGGTGCTC
ATGCATATGCGGCCAAGGACGGTCAATATGGATCAATGACTAGATGGTCTAGAGATGAAGCAGGCAATTTAGTTGGTGAA
ATAGAATTACCAATGTCTGTTGGAATTGTAGGGGGAGCTACGAGGGTACACCCATTAGCTGAGCTCTCTCTTTCTATAAT
GAATATTGAATCTGCAGCTGAATTGGCGGAAGTTATCGTTTCTGTTGGGTTAGCGCAGAATCTCGGTGCTTTGAAAGCTT
TAGCAACCGACGGAATACAAAAAGGGCATATGGCTCTTCATTCCCGTTCTGTTGCAATTGCTGGAGGGGCTTCAGGGGAG
ATGATTGATGTGATAGCAAAGAAATTAATAGATCAAAAAGAAATCCGTGTCGGAAAAGCTAAAGAATTGGTGGAACAGTA
TAAACAATGA

Upstream 100 bases:

>100_bases
CATTATAATTCGTGTTATAATTTACGTAGTTTAAATTGGGAAACGATCCATTAAAATATTTAGTTCAATGAATTTCAACA
GATTAAAGGATGAGCGAGGA

Downstream 100 bases:

>100_bases
GTTTAGAAAAAGTAACAGCCTCAGAGAAAACAGCTATTGGTGTAGCTCATAGTAAACTTATTTTAATTGGAGAGCACGCA
GTTGTACACGGACAACCAGC

Product: hydroxymethylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKSSRIPGFYNMSVDQRRKLLKDNYDLTDEQMSNLTDNPSLSLDKADNMIENVIGTFELPLGMGLNFVINGNEYTVPMAI
EEASVVASASHIAKIVRSAGGFEAESRERLMIGQIQVVGCSNFHEAKQDLLDQKDTLMNAANDAYPSIVKRGGGTRDLDV
RILNEDANSTYSQMLVMHIYVDTCDAMGANMINTMAEAIAPIVEEITGGKVYLRILSNYADRSLASAKCVIPPHLLATGD
FTGEEVRDGVIHAYEFAASDPYRAVTHNKGIMNGIDPIVIATGNDWRAVEAGAHAYAAKDGQYGSMTRWSRDEAGNLVGE
IELPMSVGIVGGATRVHPLAELSLSIMNIESAAELAEVIVSVGLAQNLGALKALATDGIQKGHMALHSRSVAIAGGASGE
MIDVIAKKLIDQKEIRVGKAKELVEQYKQ

Sequences:

>Translated_429_residues
MKSSRIPGFYNMSVDQRRKLLKDNYDLTDEQMSNLTDNPSLSLDKADNMIENVIGTFELPLGMGLNFVINGNEYTVPMAI
EEASVVASASHIAKIVRSAGGFEAESRERLMIGQIQVVGCSNFHEAKQDLLDQKDTLMNAANDAYPSIVKRGGGTRDLDV
RILNEDANSTYSQMLVMHIYVDTCDAMGANMINTMAEAIAPIVEEITGGKVYLRILSNYADRSLASAKCVIPPHLLATGD
FTGEEVRDGVIHAYEFAASDPYRAVTHNKGIMNGIDPIVIATGNDWRAVEAGAHAYAAKDGQYGSMTRWSRDEAGNLVGE
IELPMSVGIVGGATRVHPLAELSLSIMNIESAAELAEVIVSVGLAQNLGALKALATDGIQKGHMALHSRSVAIAGGASGE
MIDVIAKKLIDQKEIRVGKAKELVEQYKQ
>Mature_429_residues
MKSSRIPGFYNMSVDQRRKLLKDNYDLTDEQMSNLTDNPSLSLDKADNMIENVIGTFELPLGMGLNFVINGNEYTVPMAI
EEASVVASASHIAKIVRSAGGFEAESRERLMIGQIQVVGCSNFHEAKQDLLDQKDTLMNAANDAYPSIVKRGGGTRDLDV
RILNEDANSTYSQMLVMHIYVDTCDAMGANMINTMAEAIAPIVEEITGGKVYLRILSNYADRSLASAKCVIPPHLLATGD
FTGEEVRDGVIHAYEFAASDPYRAVTHNKGIMNGIDPIVIATGNDWRAVEAGAHAYAAKDGQYGSMTRWSRDEAGNLVGE
IELPMSVGIVGGATRVHPLAELSLSIMNIESAAELAEVIVSVGLAQNLGALKALATDGIQKGHMALHSRSVAIAGGASGE
MIDVIAKKLIDQKEIRVGKAKELVEQYKQ

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 46259; Mature: 46259

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSRIPGFYNMSVDQRRKLLKDNYDLTDEQMSNLTDNPSLSLDKADNMIENVIGTFELP
CCCCCCCCEECCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCEECC
LGMGLNFVINGNEYTVPMAIEEASVVASASHIAKIVRSAGGFEAESRERLMIGQIQVVGC
CCCCCEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEC
SNFHEAKQDLLDQKDTLMNAANDAYPSIVKRGGGTRDLDVRILNEDANSTYSQMLVMHIY
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHE
VDTCDAMGANMINTMAEAIAPIVEEITGGKVYLRILSNYADRSLASAKCVIPPHLLATGD
EHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCEEECCC
FTGEEVRDGVIHAYEFAASDPYRAVTHNKGIMNGIDPIVIATGNDWRAVEAGAHAYAAKD
CCHHHHHCCHHEEHHHCCCCCCHHHHCCCCCCCCCCCEEEEECCCCEEECCCCHHEECCC
GQYGSMTRWSRDEAGNLVGEIELPMSVGIVGGATRVHPLAELSLSIMNIESAAELAEVIV
CCCCCCCCCCCHHHCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVGLAQNLGALKALATDGIQKGHMALHSRSVAIAGGASGEMIDVIAKKLIDQKEIRVGKA
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCHHHHCCCHH
KELVEQYKQ
HHHHHHHCC
>Mature Secondary Structure
MKSSRIPGFYNMSVDQRRKLLKDNYDLTDEQMSNLTDNPSLSLDKADNMIENVIGTFELP
CCCCCCCCEECCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCEECC
LGMGLNFVINGNEYTVPMAIEEASVVASASHIAKIVRSAGGFEAESRERLMIGQIQVVGC
CCCCCEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEC
SNFHEAKQDLLDQKDTLMNAANDAYPSIVKRGGGTRDLDVRILNEDANSTYSQMLVMHIY
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHE
VDTCDAMGANMINTMAEAIAPIVEEITGGKVYLRILSNYADRSLASAKCVIPPHLLATGD
EHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCEEECCC
FTGEEVRDGVIHAYEFAASDPYRAVTHNKGIMNGIDPIVIATGNDWRAVEAGAHAYAAKD
CCHHHHHCCHHEEHHHCCCCCCHHHHCCCCCCCCCCCEEEEECCCCEEECCCCHHEECCC
GQYGSMTRWSRDEAGNLVGEIELPMSVGIVGGATRVHPLAELSLSIMNIESAAELAEVIV
CCCCCCCCCCCHHHCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVGLAQNLGALKALATDGIQKGHMALHSRSVAIAGGASGEMIDVIAKKLIDQKEIRVGKA
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCHHHHCCCHH
KELVEQYKQ
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]