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The map label for this gene is 23097681

Identifier: 23097681

GI number: 23097681

Start: 247709

End: 248683

Strand: Direct

Name: 23097681

Synonym: OB0226

Alternate gene names: NA

Gene position: 247709-248683 (Clockwise)

Preceding gene: 23097680

Following gene: 23097682

Centisome position: 6.82

GC content: 40.21

Gene sequence:

>975_bases
ATGAAAGCAACAGCAAAGGCGCATACAAATATCGCATTGATAAAATATTGGGGAAAGCGAAATGAACCAATTATATTACC
AACAAATAGTAACCTATCTCTTACGTTAGATGGGTTTTCTACTGTAACGACCGTCCATTTTCAAGAAGAATTAAGTTCCG
ATGAGTTTTTCTTGAATGATAGGCTTGTAGAAGACGCAGCAAGCCAACGTGTAACAGGATTCTTAGATAAGGTCAGAGCA
ATGGCGGGTAAAGAAATGTATGCTCGAATTCATTCTTTAAACCATGTTCCGACTGCGGCAGGATTTGCATCCTCAGCTTC
AGGTTTTGCTGCATTAGCTGCAGCTAGCACAAAAGCCATAGGGTTAGAATTAAATGATACGGAATTATCTATATTAACAA
GACAAGGTTCCGGCTCAGCGTGTCGCTCTATCTATGGTGGCTTTGTCGAATGGCAGATGGGTGAAAAAGAAGACGGTTCT
GATTCTTATGCAGTACCTATTGCTTCAAAGGATCATTGGGACATCCGTGTAGCTGCTGTAGTCCTTTCTGCTACGGAGAA
GAAAGTATCAAGTCGAGATGGAATGAGAAGAACTGTGGAAACATCTCCTTTCTATGATGGCTGGTTAAAACAAACACCGA
AGGATTTAGAGGAAATAAAGACGGCAATTCATGATAAAGACTTTGAAAAGACAGGAAGTATTGCGGAAGCGAATTGTATG
AGAATGCATGCAACAACATTAGGCGCAAATCCTCCTTTTACGTATTGGCAAGACACAACGATGCGTGTCATGCAAAATGT
ACAACAGATGAGAGAAGAAGGAATTCCTGCTTACTTTACCATTGATGCTGGCCCAAATGTTAAAGTGTTATATTTACCAA
AAGATGAGTCGAAAGTGAAGCAAAGACTTGAACAGATTATGGGTGTCGAGGATGTAATCGTTAGTAAGCCAGGAAAAGGA
ATAAGCTATTTGTAG

Upstream 100 bases:

>100_bases
TTAGCTGATAAACTTCGTAAATTCGGTGCTAATTCAGTTTGGCCATTTGTATTGAAGAAGCAAAGTAAGTCTTAAACGAG
AAGATTGAAGGAGTAATTCA

Downstream 100 bases:

>100_bases
GGGTTGGAAAAGTTGAGTAAGAGACAATTGACCGTTAAAGTGCCAGGCAAACTAATGATTGCTGGAGAGTTCGCTGTATT
AGAACCTTATCAAAAACTTG

Product: mevalonate diphosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase; GHMP Kinase Domain-Containing Protein; Phosphomevalonate Kinase; Ghmp Kinase

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKATAKAHTNIALIKYWGKRNEPIILPTNSNLSLTLDGFSTVTTVHFQEELSSDEFFLNDRLVEDAASQRVTGFLDKVRA
MAGKEMYARIHSLNHVPTAAGFASSASGFAALAAASTKAIGLELNDTELSILTRQGSGSACRSIYGGFVEWQMGEKEDGS
DSYAVPIASKDHWDIRVAAVVLSATEKKVSSRDGMRRTVETSPFYDGWLKQTPKDLEEIKTAIHDKDFEKTGSIAEANCM
RMHATTLGANPPFTYWQDTTMRVMQNVQQMREEGIPAYFTIDAGPNVKVLYLPKDESKVKQRLEQIMGVEDVIVSKPGKG
ISYL

Sequences:

>Translated_324_residues
MKATAKAHTNIALIKYWGKRNEPIILPTNSNLSLTLDGFSTVTTVHFQEELSSDEFFLNDRLVEDAASQRVTGFLDKVRA
MAGKEMYARIHSLNHVPTAAGFASSASGFAALAAASTKAIGLELNDTELSILTRQGSGSACRSIYGGFVEWQMGEKEDGS
DSYAVPIASKDHWDIRVAAVVLSATEKKVSSRDGMRRTVETSPFYDGWLKQTPKDLEEIKTAIHDKDFEKTGSIAEANCM
RMHATTLGANPPFTYWQDTTMRVMQNVQQMREEGIPAYFTIDAGPNVKVLYLPKDESKVKQRLEQIMGVEDVIVSKPGKG
ISYL
>Mature_324_residues
MKATAKAHTNIALIKYWGKRNEPIILPTNSNLSLTLDGFSTVTTVHFQEELSSDEFFLNDRLVEDAASQRVTGFLDKVRA
MAGKEMYARIHSLNHVPTAAGFASSASGFAALAAASTKAIGLELNDTELSILTRQGSGSACRSIYGGFVEWQMGEKEDGS
DSYAVPIASKDHWDIRVAAVVLSATEKKVSSRDGMRRTVETSPFYDGWLKQTPKDLEEIKTAIHDKDFEKTGSIAEANCM
RMHATTLGANPPFTYWQDTTMRVMQNVQQMREEGIPAYFTIDAGPNVKVLYLPKDESKVKQRLEQIMGVEDVIVSKPGKG
ISYL

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=309, Percent_Identity=38.8349514563107, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17537201, Length=334, Percent_Identity=31.1377245508982, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17537203, Length=197, Percent_Identity=34.5177664974619, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324371, Length=326, Percent_Identity=38.6503067484663, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28571205, Length=303, Percent_Identity=38.2838283828383, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 35755; Mature: 35755

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKATAKAHTNIALIKYWGKRNEPIILPTNSNLSLTLDGFSTVTTVHFQEELSSDEFFLND
CCCCCCCCCCEEEEEEECCCCCCEEEECCCCCEEEECCCCEEEEEEEHHHCCCCCEEEHH
RLVEDAASQRVTGFLDKVRAMAGKEMYARIHSLNHVPTAAGFASSASGFAALAAASTKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCEEE
GLELNDTELSILTRQGSGSACRSIYGGFVEWQMGEKEDGSDSYAVPIASKDHWDIRVAAV
EEEECCCEEEEEEECCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEEHE
VLSATEKKVSSRDGMRRTVETSPFYDGWLKQTPKDLEEIKTAIHDKDFEKTGSIAEANCM
EHHHHHHHHHHCCCCHHCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCHHHCCCCCHHHHE
RMHATTLGANPPFTYWQDTTMRVMQNVQQMREEGIPAYFTIDAGPNVKVLYLPKDESKVK
EEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCHHHHH
QRLEQIMGVEDVIVSKPGKGISYL
HHHHHHCCHHHHEECCCCCCCCCC
>Mature Secondary Structure
MKATAKAHTNIALIKYWGKRNEPIILPTNSNLSLTLDGFSTVTTVHFQEELSSDEFFLND
CCCCCCCCCCEEEEEEECCCCCCEEEECCCCCEEEECCCCEEEEEEEHHHCCCCCEEEHH
RLVEDAASQRVTGFLDKVRAMAGKEMYARIHSLNHVPTAAGFASSASGFAALAAASTKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCEEE
GLELNDTELSILTRQGSGSACRSIYGGFVEWQMGEKEDGSDSYAVPIASKDHWDIRVAAV
EEEECCCEEEEEEECCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEEHE
VLSATEKKVSSRDGMRRTVETSPFYDGWLKQTPKDLEEIKTAIHDKDFEKTGSIAEANCM
EHHHHHHHHHHCCCCHHCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCHHHCCCCCHHHHE
RMHATTLGANPPFTYWQDTTMRVMQNVQQMREEGIPAYFTIDAGPNVKVLYLPKDESKVK
EEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCHHHHH
QRLEQIMGVEDVIVSKPGKGISYL
HHHHHHCCHHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA