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The map label for this gene is adk

Identifier: 21672734

GI number: 21672734

Start: 535946

End: 536590

Strand: Direct

Name: adk

Synonym: BUsg469

Alternate gene names: 21672734

Gene position: 535946-536590 (Clockwise)

Preceding gene: 21672733

Following gene: 21672735

Centisome position: 83.55

GC content: 23.57

Gene sequence:

>645_bases
ATGCGTATTATTTTATTAGGTGCTCCAGGTACAGGAAAAGGAACACAAGCAAAATTGATTACAGAAAATTATAATATCCC
CAAAATATCAACAGGAGATATTTTAAGAGAAAATATTCAAAAAAAAAATACAATTGGTAAAAAAATACACAATATTTTAA
AAAATGGAGAATTAGTTTCCAATAGAATTGTATGTAATTTAATAGGAGAAAGAATTCAAAAAAAAGATTGTATTCATGGT
TTTTTATTAGATGGATTTCCAAGAACACAAAAACAAGCTGAATACATATCAAATCTTAAAATAAAAATTGATTATGTTTT
AGAATTAATAGTTCCATACGAATTAATTTTAAAGAGGATATGTGGAAGAAGAGTGCATACTCCATCTGGAAGAATTTATA
ATATCAATTATAATCCTCCTAGGGAAGAAGGAAAAGACGATCTTACTCAAGAAAAATTAACTATCAGAGAAGATGATACA
ATTGAAATTGTTAAAAAAAGACTAGAAAACTACGAAAAAAATTCTTTTTTACTAAATAAATATTATTTAAGAGAAAAAAA
ATTAAAAAAGTTGCAATATTTTAAAATTGATGGAAAACAAAGCATTTATAAAATTCAAAGAGAAATAAAGATGATGTTAA
AATAA

Upstream 100 bases:

>100_bases
AACAAATAAATTAATTTTAGAACAATAAAAATATGATTACTACTTTTTTATAGTAGTAATCTTACTCTTAAAATAATCTT
TTAAACATGAAAAAATAATT

Downstream 100 bases:

>100_bases
AAAATAAAAATTTTTATTTTTGCGTTCTACAGGATTCGAACCTGTGACCTACGGCTTAGAAGGCCGTTGCTCTATCCAGC
TGAGCTAAGAACGCAGATAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGTGKGTQAKLITENYNIPKISTGDILRENIQKKNTIGKKIHNILKNGELVSNRIVCNLIGERIQKKDCIHG
FLLDGFPRTQKQAEYISNLKIKIDYVLELIVPYELILKRICGRRVHTPSGRIYNINYNPPREEGKDDLTQEKLTIREDDT
IEIVKKRLENYEKNSFLLNKYYLREKKLKKLQYFKIDGKQSIYKIQREIKMMLK

Sequences:

>Translated_214_residues
MRIILLGAPGTGKGTQAKLITENYNIPKISTGDILRENIQKKNTIGKKIHNILKNGELVSNRIVCNLIGERIQKKDCIHG
FLLDGFPRTQKQAEYISNLKIKIDYVLELIVPYELILKRICGRRVHTPSGRIYNINYNPPREEGKDDLTQEKLTIREDDT
IEIVKKRLENYEKNSFLLNKYYLREKKLKKLQYFKIDGKQSIYKIQREIKMMLK
>Mature_214_residues
MRIILLGAPGTGKGTQAKLITENYNIPKISTGDILRENIQKKNTIGKKIHNILKNGELVSNRIVCNLIGERIQKKDCIHG
FLLDGFPRTQKQAEYISNLKIKIDYVLELIVPYELILKRICGRRVHTPSGRIYNINYNPPREEGKDDLTQEKLTIREDDT
IEIVKKRLENYEKNSFLLNKYYLREKKLKKLQYFKIDGKQSIYKIQREIKMMLK

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=43.010752688172, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=43.010752688172, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=40.6593406593407, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI310110345, Length=171, Percent_Identity=38.0116959064327, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI53832003, Length=171, Percent_Identity=38.0116959064327, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI8051579, Length=171, Percent_Identity=38.0116959064327, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI53832001, Length=171, Percent_Identity=38.0116959064327, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=29.1208791208791, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4502011, Length=186, Percent_Identity=29.5698924731183, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI28144899, Length=190, Percent_Identity=29.4736842105263, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI28144897, Length=190, Percent_Identity=29.4736842105263, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI237858799, Length=140, Percent_Identity=27.8571428571429, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI21450759, Length=140, Percent_Identity=27.8571428571429, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=49.7652582159624, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=40.3225806451613, Blast_Score=156, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17537943, Length=189, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17567503, Length=191, Percent_Identity=26.1780104712042, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=28.804347826087, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=29.1891891891892, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321018, Length=184, Percent_Identity=43.4782608695652, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320432, Length=187, Percent_Identity=40.1069518716578, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=193, Percent_Identity=27.979274611399, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI22026816, Length=201, Percent_Identity=41.7910447761194, Blast_Score=159, Evalue=9e-40,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=42.8571428571429, Blast_Score=146, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=42.8571428571429, Blast_Score=146, Evalue=9e-36,
Organism=Drosophila melanogaster, GI221459597, Length=193, Percent_Identity=26.9430051813472, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356893, Length=193, Percent_Identity=26.9430051813472, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24663208, Length=130, Percent_Identity=32.3076923076923, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17647141, Length=130, Percent_Identity=32.3076923076923, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BUCAP (Q8K980)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660801.1
- ProteinModelPortal:   Q8K980
- SMR:   Q8K980
- EnsemblBacteria:   EBBUCT00000000443
- GeneID:   1005532
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg469
- GeneTree:   EBGT00050000007800
- HOGENOM:   HBG630208
- OMA:   GILYQRK
- ProtClustDB:   PRK00279
- BioCyc:   BAPH198804:BUSG469-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 25091; Mature: 25091

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGTGKGTQAKLITENYNIPKISTGDILRENIQKKNTIGKKIHNILKNGELVS
CEEEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
NRIVCNLIGERIQKKDCIHGFLLDGFPRTQKQAEYISNLKIKIDYVLELIVPYELILKRI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEHHHHHHHHCCHHHHHHHH
CGRRVHTPSGRIYNINYNPPREEGKDDLTQEKLTIREDDTIEIVKKRLENYEKNSFLLNK
HCCCCCCCCCCEEEECCCCCHHCCCHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHH
YYLREKKLKKLQYFKIDGKQSIYKIQREIKMMLK
HHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGTGKGTQAKLITENYNIPKISTGDILRENIQKKNTIGKKIHNILKNGELVS
CEEEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
NRIVCNLIGERIQKKDCIHGFLLDGFPRTQKQAEYISNLKIKIDYVLELIVPYELILKRI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEHHHHHHHHCCHHHHHHHH
CGRRVHTPSGRIYNINYNPPREEGKDDLTQEKLTIREDDTIEIVKKRLENYEKNSFLLNK
HCCCCCCCCCCEEEECCCCCHHCCCHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCHHHH
YYLREKKLKKLQYFKIDGKQSIYKIQREIKMMLK
HHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438