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The map label for this gene is panC

Identifier: 21672477

GI number: 21672477

Start: 213798

End: 214655

Strand: Reverse

Name: panC

Synonym: BUsg190

Alternate gene names: 21672477

Gene position: 214655-213798 (Counterclockwise)

Preceding gene: 21672478

Following gene: 21672475

Centisome position: 33.46

GC content: 23.19

Gene sequence:

>858_bases
ATGAATATTATAAAAAATATCAACCTACTAGAAAAAAAAATAAAAGAACTAAAAAAAAAGAATAAAATAATTGGATTAGT
ACCAACAATGGGAAATTTACATGATGGTCACATAAAATTAATTTTATTAGCAAAAAAAAATGTAGATATTGTAATAGTAA
GCATTTTTATTAATCCTATGCAATTTGAAGATCTATTGGATCTTAAAAAATATCCCAAAACTTTTGAACAAGATTGTTGT
ATTTTAAAACAAGAAAAAGTTGAAATTCTTTTTTGTCCGGATGTAAATGAAATGTATCCTCTTGGATTAAAAAATCACAC
ATATATTGATGTACCTAAATTATCTAAAATTATAGAAGGAAAGGTACGTCCTGGACATTTTATAGGCGTAACAACAATAG
TTTGTAAGTTATTTAACTTAATACAACCAAATTTTTCTTTCTTTGGAGAAAAAGATTATCAACAACTATTAATTATAAAA
AAATTAGTAAAAGAATTAAATTATCCTATAAAAATTATTAGTTTACCTATAATAAGATTAAAAAACGGATTAGCTTTTAG
CTCTCGTAACAAGCACCTGAGCGATCTAGCACAACAAAAAGCATCTTACTTATATCAAGCTATAAAACAAACTTGTAATT
TTATTAAAAACAACAATGGGAAAAACATTAAAAAAAATATTCATACATCACGTAAATATCTTATAAAAAAAGGATTTTAT
ATTGATATATTTAATGCGTATGATTCCAAAACACTTGATCCTATATCTAAAGACAGCAAAAATATTATTATAATAGCATC
AGTTTGGTTAGGAAAAATTCGATTAATTGACAATAAAAAAATAATACTAAGAGATTAA

Upstream 100 bases:

>100_bases
CAATGGAAGCATTCAAAATGCTATTAAACAATATATCAATGAAGTTAAAAATGGAAATTTCCCCAGTGAAAAATATAGTT
TTTAAATTTTTGGAATGATC

Downstream 100 bases:

>100_bases
AAAAATTTTTATTTTTTAAAAATCACTTTTCCTATATATGGTAAATATCGATAAGATTGAGCATAATCTATTCCATATCC
AACCATAAATTCATCAGGTA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNIIKNINLLEKKIKELKKKNKIIGLVPTMGNLHDGHIKLILLAKKNVDIVIVSIFINPMQFEDLLDLKKYPKTFEQDCC
ILKQEKVEILFCPDVNEMYPLGLKNHTYIDVPKLSKIIEGKVRPGHFIGVTTIVCKLFNLIQPNFSFFGEKDYQQLLIIK
KLVKELNYPIKIISLPIIRLKNGLAFSSRNKHLSDLAQQKASYLYQAIKQTCNFIKNNNGKNIKKNIHTSRKYLIKKGFY
IDIFNAYDSKTLDPISKDSKNIIIIASVWLGKIRLIDNKKIILRD

Sequences:

>Translated_285_residues
MNIIKNINLLEKKIKELKKKNKIIGLVPTMGNLHDGHIKLILLAKKNVDIVIVSIFINPMQFEDLLDLKKYPKTFEQDCC
ILKQEKVEILFCPDVNEMYPLGLKNHTYIDVPKLSKIIEGKVRPGHFIGVTTIVCKLFNLIQPNFSFFGEKDYQQLLIIK
KLVKELNYPIKIISLPIIRLKNGLAFSSRNKHLSDLAQQKASYLYQAIKQTCNFIKNNNGKNIKKNIHTSRKYLIKKGFY
IDIFNAYDSKTLDPISKDSKNIIIIASVWLGKIRLIDNKKIILRD
>Mature_285_residues
MNIIKNINLLEKKIKELKKKNKIIGLVPTMGNLHDGHIKLILLAKKNVDIVIVSIFINPMQFEDLLDLKKYPKTFEQDCC
ILKQEKVEILFCPDVNEMYPLGLKNHTYIDVPKLSKIIEGKVRPGHFIGVTTIVCKLFNLIQPNFSFFGEKDYQQLLIIK
KLVKELNYPIKIISLPIIRLKNGLAFSSRNKHLSDLAQQKASYLYQAIKQTCNFIKNNNGKNIKKNIHTSRKYLIKKGFY
IDIFNAYDSKTLDPISKDSKNIIIIASVWLGKIRLIDNKKIILRD

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=283, Percent_Identity=45.9363957597173, Blast_Score=280, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6322046, Length=298, Percent_Identity=34.5637583892617, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_BUCAP (Q8K9U7)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660544.1
- ProteinModelPortal:   Q8K9U7
- SMR:   Q8K9U7
- EnsemblBacteria:   EBBUCT00000000301
- GeneID:   1005387
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg190
- GeneTree:   EBGT00050000007772
- HOGENOM:   HBG428839
- OMA:   DEAHDAK
- ProtClustDB:   PRK00380
- BioCyc:   BAPH198804:BUSG190-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32966; Mature: 32966

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIKNINLLEKKIKELKKKNKIIGLVPTMGNLHDGHIKLILLAKKNVDIVIVSIFINPM
CCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEECCCCEEEEEEEECCH
QFEDLLDLKKYPKTFEQDCCILKQEKVEILFCPDVNEMYPLGLKNHTYIDVPKLSKIIEG
HHHHHHHHHHCCCHHHHHHHHEECCCEEEEECCCCCCCCCCCCCCCEEECCHHHHHHHCC
KVRPGHFIGVTTIVCKLFNLIQPNFSFFGEKDYQQLLIIKKLVKELNYPIKIISLPIIRL
CCCCCCEEHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEE
KNGLAFSSRNKHLSDLAQQKASYLYQAIKQTCNFIKNNNGKNIKKNIHTSRKYLIKKGFY
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCE
IDIFNAYDSKTLDPISKDSKNIIIIASVWLGKIRLIDNKKIILRD
EEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCEEEEEC
>Mature Secondary Structure
MNIIKNINLLEKKIKELKKKNKIIGLVPTMGNLHDGHIKLILLAKKNVDIVIVSIFINPM
CCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEECCCCEEEEEEEECCH
QFEDLLDLKKYPKTFEQDCCILKQEKVEILFCPDVNEMYPLGLKNHTYIDVPKLSKIIEG
HHHHHHHHHHCCCHHHHHHHHEECCCEEEEECCCCCCCCCCCCCCCEEECCHHHHHHHCC
KVRPGHFIGVTTIVCKLFNLIQPNFSFFGEKDYQQLLIIKKLVKELNYPIKIISLPIIRL
CCCCCCEEHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEE
KNGLAFSSRNKHLSDLAQQKASYLYQAIKQTCNFIKNNNGKNIKKNIHTSRKYLIKKGFY
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCE
IDIFNAYDSKTLDPISKDSKNIIIIASVWLGKIRLIDNKKIILRD
EEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438