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The map label for this gene is treA

Identifier: 77748541

GI number: 77748541

Start: 708731

End: 710404

Strand: Reverse

Name: treA

Synonym: XAC0604

Alternate gene names: 77748541

Gene position: 710404-708731 (Counterclockwise)

Preceding gene: 21241376

Following gene: 21241374

Centisome position: 13.73

GC content: 66.91

Gene sequence:

>1674_bases
ATGAGTTCTGCCGCGCCCCCGTGCTGCACGTCGCTGCTTGGCCTGTCGCTGAGCATGTTTGTTGCGCCGGGCACGCTGAC
CGCCGCGCCGCTGGACGCTCCGGTCGTCAATGCGCCGGCGCCCACGCCGCCCACGCCCGACCTGGCCTACCCGGAACTGT
TTCAGGCCGTGCAGCGCGGTGAGTTGTTCGATGACCAGAAGCACTTTGTCGACTTCCTGCCGCTGCGCGACCCGGCGCTG
ATCAACGCCGACTATCTGGCCCAGCACGATCACCCCGGCTTCGATCTGCGCAAGTTCGTGGACGCCAATTTCGAAGAATC
GCCGCCGGTGCAGACCGATGCGATCCGCCAGGACACCGCGCTGCGCGAGCACATCGACCTGCTGTGGCCCAAGCTGGTGC
GCAGCCAGAACCACGTGCCGCCGCACAGCAGCCTGCTGGCGCTGCCGCATCCGTATGTGGTGCCGGGCGGACGCTTCCGC
GAGGTGTATTACTGGGATTCCTACTTCACCATGCTGGGCCTGGTGAAGAGCGGCGAAACCACGCTCAGCCGCCAGATGCT
GGACAACTTTGCCTACCTGATCGACACCTACGGGCATATTCCCAACGGCAACCGCACCTACTACCTCAGCCGCTCGCAGC
CGCCGTTCTTCTCCTACATGGTGGAGCTGCAGGCCGGCGTGGAAGGCGAGGCGGTATATCAGCGCTACCTGCCGCAGCTG
CAAAAGGAATATGCCTACTGGATGCAGGGCAGCGATGACCTGCAGCCCGGCCAGGCCGCGCGCCACGTGGTGCGTCTGGC
CGATGGCAGCGTGCTCAACCGCTATTGGGACGAGCGCGACACCCCGCGCCCGGAAGCCTGGCTGCACGACACCCGCACCG
CCGCAGAAGTGACCGACCGCCCGGCCGCCGAGGTCTACCGCGACCTGCGTGCCGGCGCCGAAAGTGGCTGGGACTACACC
AGCCGCTGGCTGGCCGACGGCCAGAACCTGCGCACCATCCGTACCACTGCCATCCTCCCGATCGACCTCAACAGCCTGCT
CTACCACCTGGAGCGCACGCTGGCGCTGGCCTGCGCGCAACCTGGCGCGGAGTGCACCCGCGATTACGCCGCACTTGCAC
AGCAGCGCAAGCAGGCCATCGACGCGCATCTGTGGAATACCGCCGGCTACTACGCCGACTACGACTGGCAGACGCGTACG
CTGAGCAACCAGGTCACCGCCGCTGCGCTATACCCGCTGTTTGCCGGCCTGGCCTCGGACGATCACGCCAAGCGCACCGC
CAGCACCGTGCGTAAAACGCTACTGCGTCCGGGCGGACTGGCCACCACCGCAGTGAAGACCGGTCAGCAGTGGGATGAGC
CCAACGGCTGGGCGCCGCTGCAATGGGTGGCTGTGGATGGCCTGCGGCGCTACGGCGAAGACGCGCTGGCACGCACCATT
GGCGAACGTTTTCTGGCTCAAGTGCAGGCGCTGTTCGCACGCGAGCACAAGCTGGTCGAAAAGTACGGCCTGGAAACCGA
TGCGGCCGGCGGCGGCGGTGGCGAGTACGCGCTGCAGGACGGCTTCGGCTGGACCAACGGCGTCACCTTGATGCTGCTGA
ACCTGTATCCGGGCAAGGACACCAAAGCCGCACCCGCCAAGCGGGTGCGCAAGCCCGAGGCGGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
CCCCGTGCGAAGCCCGTCGGCGTGCCGGCAGCTCGCTCGGTCCCGCCCGCCACACCGGTCGTTTACCATGCCCTACGCCA
CTGCCCGTTCTGGAGATGTC

Downstream 100 bases:

>100_bases
GGACGGTGCCGCTGCTGCGCAGTGCGTGGCGGCAGCAGGGTCGGATCATCGGCGTTGGATGTCGGGCGGTGCACATCTTC
GATGCGCAGCACAGCCGTTG

Product: trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDAPVVNAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPAL
INADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFR
EVYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQL
QKEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVTDRPAAEVYRDLRAGAESGWDYT
SRWLADGQNLRTIRTTAILPIDLNSLLYHLERTLALACAQPGAECTRDYAALAQQRKQAIDAHLWNTAGYYADYDWQTRT
LSNQVTAAALYPLFAGLASDDHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTI
GERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKDTKAAPAKRVRKPEAAAR

Sequences:

>Translated_557_residues
MSSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDAPVVNAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPAL
INADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFR
EVYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQL
QKEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVTDRPAAEVYRDLRAGAESGWDYT
SRWLADGQNLRTIRTTAILPIDLNSLLYHLERTLALACAQPGAECTRDYAALAQQRKQAIDAHLWNTAGYYADYDWQTRT
LSNQVTAAALYPLFAGLASDDHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTI
GERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKDTKAAPAKRVRKPEAAAR
>Mature_556_residues
SSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDAPVVNAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPALI
NADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFRE
VYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQLQ
KEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVTDRPAAEVYRDLRAGAESGWDYTS
RWLADGQNLRTIRTTAILPIDLNSLLYHLERTLALACAQPGAECTRDYAALAQQRKQAIDAHLWNTAGYYADYDWQTRTL
SNQVTAAALYPLFAGLASDDHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTIG
ERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKDTKAAPAKRVRKPEAAAR

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family

Homologues:

Organism=Homo sapiens, GI116284412, Length=547, Percent_Identity=34.7349177330896, Blast_Score=252, Evalue=8e-67,
Organism=Escherichia coli, GI1787447, Length=552, Percent_Identity=52.536231884058, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1789936, Length=519, Percent_Identity=51.252408477842, Blast_Score=495, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17542196, Length=537, Percent_Identity=31.6573556797021, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI25148109, Length=534, Percent_Identity=31.2734082397004, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25141398, Length=545, Percent_Identity=31.1926605504587, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17565078, Length=510, Percent_Identity=31.1764705882353, Blast_Score=231, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI71987755, Length=424, Percent_Identity=27.8301886792453, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319473, Length=451, Percent_Identity=29.7117516629712, Blast_Score=153, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6320204, Length=452, Percent_Identity=28.0973451327434, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24656680, Length=587, Percent_Identity=31.175468483816, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24656675, Length=587, Percent_Identity=31.175468483816, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24656661, Length=524, Percent_Identity=31.6793893129771, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17933716, Length=524, Percent_Identity=31.6793893129771, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24656670, Length=524, Percent_Identity=31.6793893129771, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24656685, Length=474, Percent_Identity=32.2784810126582, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI22024178, Length=539, Percent_Identity=29.3135435992579, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI45551104, Length=381, Percent_Identity=30.1837270341207, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28573474, Length=313, Percent_Identity=28.4345047923323, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TREA_XANAC (Q8PPT1)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640957.2
- ProteinModelPortal:   Q8PPT1
- SMR:   Q8PPT1
- GeneID:   1154675
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0604
- NMPDR:   fig|190486.1.peg.601
- HOGENOM:   HBG485982
- OMA:   NRYWDAS
- ProtClustDB:   PRK13272
- BioCyc:   XAXO190486:XAC0604-MONOMER
- BRENDA:   3.2.1.28
- HAMAP:   MF_01060
- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232
- PANTHER:   PTHR23403
- PRINTS:   PR00744

Pfam domain/function: PF01204 Trehalase; SSF48208 Glyco_trans_6hp

EC number: =3.2.1.28

Molecular weight: Translated: 62112; Mature: 61981

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00927 TREHALASE_1; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDAPVVNAPAPTPPTPDLAYPELFQAVQRG
CCCCCCHHHHHHHHHHHHHEECCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
ELFDDQKHFVDFLPLRDPALINADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTA
CCCCCHHHHHHHCCCCCCCEECHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHH
LREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFREVYYWDSYFTMLGLVKSGET
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEECCCCCEEEEEEEHHHHHHHHHHHCCCH
TLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
QKEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVTDR
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHCCHHHHHHCCC
PAAEVYRDLRAGAESGWDYTSRWLADGQNLRTIRTTAILPIDLNSLLYHLERTLALACAQ
CHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEEEEEECHHHHHHHHHHHHHHHHCC
PGAECTRDYAALAQQRKQAIDAHLWNTAGYYADYDWQTRTLSNQVTAAALYPLFAGLASD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
DHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTI
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEEECCCCC
TKAAPAKRVRKPEAAAR
CCCCCHHHHCCCHHCCC
>Mature Secondary Structure 
SSAAPPCCTSLLGLSLSMFVAPGTLTAAPLDAPVVNAPAPTPPTPDLAYPELFQAVQRG
CCCCCHHHHHHHHHHHHHEECCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
ELFDDQKHFVDFLPLRDPALINADYLAQHDHPGFDLRKFVDANFEESPPVQTDAIRQDTA
CCCCCHHHHHHHCCCCCCCEECHHHHHCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHH
LREHIDLLWPKLVRSQNHVPPHSSLLALPHPYVVPGGRFREVYYWDSYFTMLGLVKSGET
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEECCCCCEEEEEEEHHHHHHHHHHHCCCH
TLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPFFSYMVELQAGVEGEAVYQRYLPQL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
QKEYAYWMQGSDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEVTDR
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHCCHHHHHHCCC
PAAEVYRDLRAGAESGWDYTSRWLADGQNLRTIRTTAILPIDLNSLLYHLERTLALACAQ
CHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEEEEEECHHHHHHHHHHHHHHHHCC
PGAECTRDYAALAQQRKQAIDAHLWNTAGYYADYDWQTRTLSNQVTAAALYPLFAGLASD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
DHAKRTASTVRKTLLRPGGLATTAVKTGQQWDEPNGWAPLQWVAVDGLRRYGEDALARTI
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GERFLAQVQALFAREHKLVEKYGLETDAAGGGGGEYALQDGFGWTNGVTLMLLNLYPGKD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEEECCCCC
TKAAPAKRVRKPEAAAR
CCCCCHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217