Click here to switch to the map view.

The map label for this gene is npr [H]

Identifier: 77748526

GI number: 77748526

Start: 554478

End: 555992

Strand: Reverse

Name: npr [H]

Synonym: XAC0465

Alternate gene names: 77748526

Gene position: 555992-554478 (Counterclockwise)

Preceding gene: 77748527

Following gene: 21241237

Centisome position: 10.74

GC content: 63.56

Gene sequence:

>1515_bases
ATGCCGCTGTGTCGCGCGCGCAATCGTTATTGGGGAACAACGCATCGGCATTGGCCAATCGCGCCGGCCGACGCCTTTAT
CGCACGCGACAGCATCGTCGATGCCGACGGCACCGAACATGTGCGTTTCGATCGCACCTATCAGGGTCTGCCGGTGATCG
GTGGCGACGTGGTCGTGCACTCGCGTCGCGGTGTGATGCGTGAATTGAGCCAGACCATGGACACTACGGTGCGTCCGAGC
CTGCTGCCGGGGATCGATGCGGCAACCGCATTGCGTGTGGCCGGTTCGCACTTCGATGTGGCGCAGGATGCCGCGCCGCG
TGCGAGTCTGGCGCTGTATGCACGCCAAGGCGCGCCGCGCCTGGTGTACGAGGTAATTTACAGCGGCGTCAAACCCGACC
AGACACCGACCGAGATGCATTACATCGTCGATGCGGTGACCCAGCGCATCCTCGAATCCTGGGATACCGTGCATACCGCC
TGTAGCGGCGGCACCAGCGCCGCTGGCACAGGACGTTCGTTGTATGCGGGCAGCGTGACGGTGAACACCACGCGCTGCAG
CAGCACCAGCTACGAACTGACCGATCTCAGTCGCGGCAGCGGTGCGACCTACAACATGCGCAACAGCACCTCCGGCAATG
GCACGCTGGTCACCGATGCCGACAATGCCTGGGGTAGCGGCACCACCGGCGATACGGTCACCGCAGCGGTCGATGCGCAT
TATGGCGTAGCGTTGACCTGGGACTATTACCGCACTACGCATTCGCGCACAGGCATTGCAAACGACGGCGCCGGTGCGCG
AAGCCGGGTGCACTATGGTAGCCGCTACAACAACGCCTTCTGGCAGGACAGCTGTTTCTGCATGACCTTCGGCGATGGCG
ACGGCAGCACGTTCACGCCGCTGGTATCGGTGGATGTGGCCGGCCACGAGATGACCCACGGTGTGACCAGCCGGACCGCC
GCTCTGACCTACTCGGGCGAATCGGGCGGTTTGAATGAGGCCACGTCCGACATCATGGGCACCATGGTGGAATACTCCGC
TGCCAACAGTGCCGAGCCGGGCAATTATCTGATCGGCGAGAAGATCATTCCCAACAACAGCACCGGGACACTGGCGTTGC
GTTACATGTTCAAGCCAAGCCTGGATGGCAAATCGCCCGATTGCTACAGCAGCAGCCTGGGTTCGCTCAATGTGCACTAC
AGCTCGGGCGTGGCCAATCATTTCTACTATCTGCTGGCCGAAGGGGCGGTGGTGCCGAGCGGGTTCGGCTCGGGCACCAG
CTACAATCTGACCGCGACCAGTCTGGTCTGCAGCGGCTCCACGGCGCTCACGGCGATCGGCCGCGTCGCGGCCAGCCGTA
TCTGGTATCGCGCACTGACGGTGTACATGACCTCGTCCACCAACTACGCGGCGGCCCGTCGGGCCACGCTGAGCGCGGCC
ACCGATCTGTACGGCAGCACGTCCACGCAATACCGCGCGGTAGCGGCGGCGTGGAGCGCGGTCTCGGTGAACTGA

Upstream 100 bases:

>100_bases
TTTCTGGAGAGAGTCGTCATGCAATTCCATGTCCTGGGCGCGGCAATCTGCTGCGCGCTCTCGTTTTCTGTTGCCGCAAA
CGCTGCGGATATGTCGGCCA

Downstream 100 bases:

>100_bases
CGGGCGCGTCCCTCGTCATGCCACCAAGGCGTGGCGGGGGGCACATCTGCCATGGCGCCATCCGCGCGCGTATGCTTGGG
TCATTCCTGGGAGGGAACAT

Product: metalloproteinase

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MPLCRARNRYWGTTHRHWPIAPADAFIARDSIVDADGTEHVRFDRTYQGLPVIGGDVVVHSRRGVMRELSQTMDTTVRPS
LLPGIDAATALRVAGSHFDVAQDAAPRASLALYARQGAPRLVYEVIYSGVKPDQTPTEMHYIVDAVTQRILESWDTVHTA
CSGGTSAAGTGRSLYAGSVTVNTTRCSSTSYELTDLSRGSGATYNMRNSTSGNGTLVTDADNAWGSGTTGDTVTAAVDAH
YGVALTWDYYRTTHSRTGIANDGAGARSRVHYGSRYNNAFWQDSCFCMTFGDGDGSTFTPLVSVDVAGHEMTHGVTSRTA
ALTYSGESGGLNEATSDIMGTMVEYSAANSAEPGNYLIGEKIIPNNSTGTLALRYMFKPSLDGKSPDCYSSSLGSLNVHY
SSGVANHFYYLLAEGAVVPSGFGSGTSYNLTATSLVCSGSTALTAIGRVAASRIWYRALTVYMTSSTNYAAARRATLSAA
TDLYGSTSTQYRAVAAAWSAVSVN

Sequences:

>Translated_504_residues
MPLCRARNRYWGTTHRHWPIAPADAFIARDSIVDADGTEHVRFDRTYQGLPVIGGDVVVHSRRGVMRELSQTMDTTVRPS
LLPGIDAATALRVAGSHFDVAQDAAPRASLALYARQGAPRLVYEVIYSGVKPDQTPTEMHYIVDAVTQRILESWDTVHTA
CSGGTSAAGTGRSLYAGSVTVNTTRCSSTSYELTDLSRGSGATYNMRNSTSGNGTLVTDADNAWGSGTTGDTVTAAVDAH
YGVALTWDYYRTTHSRTGIANDGAGARSRVHYGSRYNNAFWQDSCFCMTFGDGDGSTFTPLVSVDVAGHEMTHGVTSRTA
ALTYSGESGGLNEATSDIMGTMVEYSAANSAEPGNYLIGEKIIPNNSTGTLALRYMFKPSLDGKSPDCYSSSLGSLNVHY
SSGVANHFYYLLAEGAVVPSGFGSGTSYNLTATSLVCSGSTALTAIGRVAASRIWYRALTVYMTSSTNYAAARRATLSAA
TDLYGSTSTQYRAVAAAWSAVSVN
>Mature_503_residues
PLCRARNRYWGTTHRHWPIAPADAFIARDSIVDADGTEHVRFDRTYQGLPVIGGDVVVHSRRGVMRELSQTMDTTVRPSL
LPGIDAATALRVAGSHFDVAQDAAPRASLALYARQGAPRLVYEVIYSGVKPDQTPTEMHYIVDAVTQRILESWDTVHTAC
SGGTSAAGTGRSLYAGSVTVNTTRCSSTSYELTDLSRGSGATYNMRNSTSGNGTLVTDADNAWGSGTTGDTVTAAVDAHY
GVALTWDYYRTTHSRTGIANDGAGARSRVHYGSRYNNAFWQDSCFCMTFGDGDGSTFTPLVSVDVAGHEMTHGVTSRTAA
LTYSGESGGLNEATSDIMGTMVEYSAANSAEPGNYLIGEKIIPNNSTGTLALRYMFKPSLDGKSPDCYSSSLGSLNVHYS
SGVANHFYYLLAEGAVVPSGFGSGTSYNLTATSLVCSGSTALTAIGRVAASRIWYRALTVYMTSSTNYAAARRATLSAAT
DLYGSTSTQYRAVAAAWSAVSVN

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 53516; Mature: 53384

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLCRARNRYWGTTHRHWPIAPADAFIARDSIVDADGTEHVRFDRTYQGLPVIGGDVVVH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCEECCCCCCCEEECCCCCCCCEECCCEEEE
SRRGVMRELSQTMDTTVRPSLLPGIDAATALRVAGSHFDVAQDAAPRASLALYARQGAPR
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHEECCCCCCHHHCCCCCCEEEEEECCCCHH
LVYEVIYSGVKPDQTPTEMHYIVDAVTQRILESWDTVHTACSGGTSAAGTGRSLYAGSVT
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEE
VNTTRCSSTSYELTDLSRGSGATYNMRNSTSGNGTLVTDADNAWGSGTTGDTVTAAVDAH
EEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECC
YGVALTWDYYRTTHSRTGIANDGAGARSRVHYGSRYNNAFWQDSCFCMTFGDGDGSTFTP
CCEEEEEHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCEECE
LVSVDVAGHEMTHGVTSRTAALTYSGESGGLNEATSDIMGTMVEYSAANSAEPGNYLIGE
EEEEEECCCHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECC
KIIPNNSTGTLALRYMFKPSLDGKSPDCYSSSLGSLNVHYSSGVANHFYYLLAEGAVVPS
EECCCCCCCEEEEEEEECCCCCCCCCCHHHCCCCCEEEEECCCCHHHEEEEEECCCCCCC
GFGSGTSYNLTATSLVCSGSTALTAIGRVAASRIWYRALTVYMTSSTNYAAARRATLSAA
CCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHH
TDLYGSTSTQYRAVAAAWSAVSVN
HHHCCCCCCHHEEHEEECEEEECC
>Mature Secondary Structure 
PLCRARNRYWGTTHRHWPIAPADAFIARDSIVDADGTEHVRFDRTYQGLPVIGGDVVVH
CCCCCCCCCCCCCCCCCCCCCCHHHHHHCCEECCCCCCCEEECCCCCCCCEECCCEEEE
SRRGVMRELSQTMDTTVRPSLLPGIDAATALRVAGSHFDVAQDAAPRASLALYARQGAPR
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHEECCCCCCHHHCCCCCCEEEEEECCCCHH
LVYEVIYSGVKPDQTPTEMHYIVDAVTQRILESWDTVHTACSGGTSAAGTGRSLYAGSVT
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEE
VNTTRCSSTSYELTDLSRGSGATYNMRNSTSGNGTLVTDADNAWGSGTTGDTVTAAVDAH
EEEEECCCCCEEEEECCCCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECC
YGVALTWDYYRTTHSRTGIANDGAGARSRVHYGSRYNNAFWQDSCFCMTFGDGDGSTFTP
CCEEEEEHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCEECE
LVSVDVAGHEMTHGVTSRTAALTYSGESGGLNEATSDIMGTMVEYSAANSAEPGNYLIGE
EEEEEECCCHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECC
KIIPNNSTGTLALRYMFKPSLDGKSPDCYSSSLGSLNVHYSSGVANHFYYLLAEGAVVPS
EECCCCCCCEEEEEEEECCCCCCCCCCHHHCCCCCEEEEECCCCHHHEEEEEECCCCCCC
GFGSGTSYNLTATSLVCSGSTALTAIGRVAASRIWYRALTVYMTSSTNYAAARRATLSAA
CCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHH
TDLYGSTSTQYRAVAAAWSAVSVN
HHHCCCCCCHHEEHEEECEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2290427; 2127074 [H]