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The map label for this gene is ribA [H]

Identifier: 21244516

GI number: 21244516

Start: 4460548

End: 4461681

Strand: Direct

Name: ribA [H]

Synonym: XAC3792

Alternate gene names: 21244516

Gene position: 4460548-4461681 (Clockwise)

Preceding gene: 21244514

Following gene: 21244517

Centisome position: 86.18

GC content: 70.28

Gene sequence:

>1134_bases
ATGAGCAGCCCCCTCCCCTCCCCCAGCACACAGGCCTTCGGCGATCCGGCGGCGATTCGCTGTGAGCGCGCCGCTTCCGA
ACTGCGTGCCGGGCGCCCGGTCTTGCTGACGGCGGCGAATGGGCAGGCGCGTGCGGTGCTGGCGCTGGATAGCAGCACGG
CACAGTCGTATGCGGCGTTCGCCCGTGCCGCACGGGGCCGCCACTATCTCTTTGTGACGCCCACTCGCGCCCAGGTGCTG
GGGCTGAGCGCGCCGCAGGGTGCGCGCGTGGGCTTGATCGATCACAGCTACGACCAGCTCGCCGCGTTGGCCTACCTGCG
CGACACCCCGGTGCCTGCGCAGTGGACGGCCGGCGATGCGCTGGATGCCGGCGGCGTGGAGATCGCGCGGCTTGGCCTGC
TGCTGCCGGCGTTGCTGGCGGTGGAGCTGCGCGATGTGCACGACCATGCCGCGTTCGCCGGCTGCCAGTCGCTGGCGCTG
GACGATTTGCTGCGCGGCTGTGCCACCTCCGCGGCTGCCGGCTACGAGCTGGTGACCCGCACCCCGGTGCCGCTGCGCGG
CCTGGGCATGAGTGAGTTCGTGGTGTTTCGCGGCGGTGTGGCGCAGCGCGATCAGGTGGCGATCGTGGTCGGCCAGCCGG
ACCTGGGCACTGCCGTCCCGGTGCGCGTGCATTCGTCGTGCCTCACCGGCGACCTGTTCGGCTCGCTCAAATGCGATTGC
GGCGACCAGCTGCGGCACGGCCTGGCCAAGTTGAAGGAGCTCGGTGGCGGCGTCCTGCTGTATCTGGACCAGGAAGGTCG
CGGCACCGGCATCGCCGCCAAGATGCGCGCCTACGGCTATCAGCATGCGGGCCTGGACACCATCGACGCCGATGCGCAAT
TGGGCTTTGGTCCGGACGAGCGCCGCTACGGCAGTGCGGTGGCGATGTTGCGCGGGCTGGGCATCGGCCGGATCCGGTTG
TTGACCAACAACCCGGCCAAGGCCGAGCGCCTGCGCGCGGCCGGCATCGTGGTCGAAGACCGCATCGCGATCACCGGCGA
CATCACCGCCGAAAACGAGCAGTACCTGCGCACCAAGGCCGCACGCGCCGGCCACGCGCTGGATGTGGATGCGTTGATCC
TGGCCGCGCAATAA

Upstream 100 bases:

>100_bases
CCTGTCGCCAGGCGCGCGACAATGGGCAGAGACGATCACGCAATGACCGCGGCGGCGTCCGCCTTGAAGCGGCCGTGGCA
ATCCCCATCTGGAGTCGTGC

Downstream 100 bases:

>100_bases
CGCGCCCGGCGCCGGGTGCGCCTGCACTGGGCAGCCGGCTATGCTTGCGCATCGCTTCTGCAGGCCCGCCTCGTGCACGA
CGCTCCACCGCCGCACCCCG

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MSSPLPSPSTQAFGDPAAIRCERAASELRAGRPVLLTAANGQARAVLALDSSTAQSYAAFARAARGRHYLFVTPTRAQVL
GLSAPQGARVGLIDHSYDQLAALAYLRDTPVPAQWTAGDALDAGGVEIARLGLLLPALLAVELRDVHDHAAFAGCQSLAL
DDLLRGCATSAAAGYELVTRTPVPLRGLGMSEFVVFRGGVAQRDQVAIVVGQPDLGTAVPVRVHSSCLTGDLFGSLKCDC
GDQLRHGLAKLKELGGGVLLYLDQEGRGTGIAAKMRAYGYQHAGLDTIDADAQLGFGPDERRYGSAVAMLRGLGIGRIRL
LTNNPAKAERLRAAGIVVEDRIAITGDITAENEQYLRTKAARAGHALDVDALILAAQ

Sequences:

>Translated_377_residues
MSSPLPSPSTQAFGDPAAIRCERAASELRAGRPVLLTAANGQARAVLALDSSTAQSYAAFARAARGRHYLFVTPTRAQVL
GLSAPQGARVGLIDHSYDQLAALAYLRDTPVPAQWTAGDALDAGGVEIARLGLLLPALLAVELRDVHDHAAFAGCQSLAL
DDLLRGCATSAAAGYELVTRTPVPLRGLGMSEFVVFRGGVAQRDQVAIVVGQPDLGTAVPVRVHSSCLTGDLFGSLKCDC
GDQLRHGLAKLKELGGGVLLYLDQEGRGTGIAAKMRAYGYQHAGLDTIDADAQLGFGPDERRYGSAVAMLRGLGIGRIRL
LTNNPAKAERLRAAGIVVEDRIAITGDITAENEQYLRTKAARAGHALDVDALILAAQ
>Mature_376_residues
SSPLPSPSTQAFGDPAAIRCERAASELRAGRPVLLTAANGQARAVLALDSSTAQSYAAFARAARGRHYLFVTPTRAQVLG
LSAPQGARVGLIDHSYDQLAALAYLRDTPVPAQWTAGDALDAGGVEIARLGLLLPALLAVELRDVHDHAAFAGCQSLALD
DLLRGCATSAAAGYELVTRTPVPLRGLGMSEFVVFRGGVAQRDQVAIVVGQPDLGTAVPVRVHSSCLTGDLFGSLKCDCG
DQLRHGLAKLKELGGGVLLYLDQEGRGTGIAAKMRAYGYQHAGLDTIDADAQLGFGPDERRYGSAVAMLRGLGIGRIRLL
TNNPAKAERLRAAGIVVEDRIAITGDITAENEQYLRTKAARAGHALDVDALILAAQ

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=189, Percent_Identity=44.4444444444444, Blast_Score=154, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6319438, Length=168, Percent_Identity=37.5, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 39491; Mature: 39359

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPLPSPSTQAFGDPAAIRCERAASELRAGRPVLLTAANGQARAVLALDSSTAQSYAAF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCHHHHHHH
ARAARGRHYLFVTPTRAQVLGLSAPQGARVGLIDHSYDQLAALAYLRDTPVPAQWTAGDA
HHHHCCCEEEEEECCHHEEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC
LDAGGVEIARLGLLLPALLAVELRDVHDHAAFAGCQSLALDDLLRGCATSAAAGYELVTR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
TPVPLRGLGMSEFVVFRGGVAQRDQVAIVVGQPDLGTAVPVRVHSSCLTGDLFGSLKCDC
CCCCCCCCCCHHEEEEECCCCCCCCEEEEECCCCCCCCCEEEECCCHHCCHHCCCEECCC
GDQLRHGLAKLKELGGGVLLYLDQEGRGTGIAAKMRAYGYQHAGLDTIDADAQLGFGPDE
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCEECCCCCCCCCCCH
RRYGSAVAMLRGLGIGRIRLLTNNPAKAERLRAAGIVVEDRIAITGDITAENEQYLRTKA
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCEEEECCEEEEECEECCCHHHHHHHH
ARAGHALDVDALILAAQ
HHCCCCCCCEEEEEECC
>Mature Secondary Structure 
SSPLPSPSTQAFGDPAAIRCERAASELRAGRPVLLTAANGQARAVLALDSSTAQSYAAF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCHHHHHHH
ARAARGRHYLFVTPTRAQVLGLSAPQGARVGLIDHSYDQLAALAYLRDTPVPAQWTAGDA
HHHHCCCEEEEEECCHHEEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC
LDAGGVEIARLGLLLPALLAVELRDVHDHAAFAGCQSLALDDLLRGCATSAAAGYELVTR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
TPVPLRGLGMSEFVVFRGGVAQRDQVAIVVGQPDLGTAVPVRVHSSCLTGDLFGSLKCDC
CCCCCCCCCCHHEEEEECCCCCCCCEEEEECCCCCCCCCEEEECCCHHCCHHCCCEECCC
GDQLRHGLAKLKELGGGVLLYLDQEGRGTGIAAKMRAYGYQHAGLDTIDADAQLGFGPDE
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCEECCCCCCCCCCCH
RRYGSAVAMLRGLGIGRIRLLTNNPAKAERLRAAGIVVEDRIAITGDITAENEQYLRTKA
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCEEEECCEEEEECEECCCHHHHHHHH
ARAGHALDVDALILAAQ
HHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]