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The map label for this gene is cysG [H]

Identifier: 21244065

GI number: 21244065

Start: 3935372

End: 3936643

Strand: Direct

Name: cysG [H]

Synonym: XAC3340

Alternate gene names: 21244065

Gene position: 3935372-3936643 (Clockwise)

Preceding gene: 21244061

Following gene: 21244066

Centisome position: 76.04

GC content: 71.46

Gene sequence:

>1272_bases
ATGAAGTCATTTCCGACGGCTATAAGCCGGCGTTACGGTCTGGCCCTCCCCCAACGATGCTGCCGAACCGTGACTCCTGC
GTTCCCGCTGCTTGCCGACCTGCGTGGCCGTGCCGTCCTGGTGGTCGGCGGCGGCGCCGACGCCGAGCGCGCCACTGGCC
AGTTGCTGCAGGCCGGTGCGCTGCCGCTGGTCGGCGCGCCCGAGCTCACGGCGCAGTTGCGGCACTGGGCGCAGGCAGGC
CGGCTGCGCTGGTTGGCCGGTCGGTTCGACCCGGCATGGCTGGCGCAGTCCGACCAACCGCTATGGCTCACCATCGCCGC
CAGCGAATCGGCAGCGCTCAACGACGCCCTGCGCCAAGCAGCAAGTGCCCATCGGCTGCTGACCCACGCCGCAGCGCCTG
CGGCGTCCGCAACGGTTCCTGCGCGCTCCACAGGACCGCGCAGCGCGATCGGCACGCTGGCGCCCGGCAACGTGAGCCTG
GTCGGCGCCGGCCCCGGCGATCCGGGCCTGCTCACCCGGCATGCGCTGCGCGCACTGCGTCAGGCCGAGGTGGTGCTGCA
CGACCGCCTGGTCAGCCCGCAGATCCTGCGCCTGGCTCGGCACGGCGCGCACCTCATCGAGGTCGGCAAGTCGGCGCAAG
GCCATAGCACCCGGCAGGAACAGATTCACGGCCTGATGCTGGAACACGCCCGGGCCGGTCGCCGCGTGGTACGGCTGAAG
GGCGGCGACCCATTCGTGTTCGGCCGCGGCGGCGAAGAGCTGGAATTCCTGCGCGCGCACGGCATCGGCTTCCAGGTGAT
TCCCGGCATCACCGCCGCCATCGCCTGCGCCGCCTATGCCGGCATTCCGCTCACCCACCGCGACCATGCGCAATCGCTGC
GGCTGATCACCGCGCACTGCAAGGATTCGCTGGACACGCTGGATTGGCAGGCGCTTGGCCAGGAACGCCAGACCCTGGCG
TTCTACATGGGCGTGGCCGGTCTGGACGCCATCCAGCAACGTCTGCTGCAGGCCGGCCGCGCACCCACCACCCCGTTCGC
GCTGGTCGAAAACGGCTCGCGCCCGCAGCAACGGGTAATCACCGGTACGCTCGCCAGCCTGGCCGCCAGCGCCCGGCAGC
ACGCCGTGACCGCACCGGCGCTGCTGATCCTGGGCGAGGTAACGGCACTGGCGCAGACGCTGCATTGGTTCGGCAGCGCG
CCGCTGAGCGCCTCGCCGCCGCACTCACCCGGCGCAACGCCCCACACGCCCACACTGGCCCACGCAGCCTGA

Upstream 100 bases:

>100_bases
GTCATGGCTTATATCCAAAAAAGCGCGAGGCGCTACAAGGGATTCGACTGTAGAGGAGTTCTGCGGGCCAGCTTATAACC
GAACGCTATTTTTAGGATGT

Downstream 100 bases:

>100_bases
TTCCGACGGAGACCCCATGGCCCTGTACGACAACATTCTCGACACCATCGGCCGCACCCCGGTGGTCAAGCTCCAACGCC
TCGCCCCGGATAACGTGACC

Product: siroheme synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKSFPTAISRRYGLALPQRCCRTVTPAFPLLADLRGRAVLVVGGGADAERATGQLLQAGALPLVGAPELTAQLRHWAQAG
RLRWLAGRFDPAWLAQSDQPLWLTIAASESAALNDALRQAASAHRLLTHAAAPAASATVPARSTGPRSAIGTLAPGNVSL
VGAGPGDPGLLTRHALRALRQAEVVLHDRLVSPQILRLARHGAHLIEVGKSAQGHSTRQEQIHGLMLEHARAGRRVVRLK
GGDPFVFGRGGEELEFLRAHGIGFQVIPGITAAIACAAYAGIPLTHRDHAQSLRLITAHCKDSLDTLDWQALGQERQTLA
FYMGVAGLDAIQQRLLQAGRAPTTPFALVENGSRPQQRVITGTLASLAASARQHAVTAPALLILGEVTALAQTLHWFGSA
PLSASPPHSPGATPHTPTLAHAA

Sequences:

>Translated_423_residues
MKSFPTAISRRYGLALPQRCCRTVTPAFPLLADLRGRAVLVVGGGADAERATGQLLQAGALPLVGAPELTAQLRHWAQAG
RLRWLAGRFDPAWLAQSDQPLWLTIAASESAALNDALRQAASAHRLLTHAAAPAASATVPARSTGPRSAIGTLAPGNVSL
VGAGPGDPGLLTRHALRALRQAEVVLHDRLVSPQILRLARHGAHLIEVGKSAQGHSTRQEQIHGLMLEHARAGRRVVRLK
GGDPFVFGRGGEELEFLRAHGIGFQVIPGITAAIACAAYAGIPLTHRDHAQSLRLITAHCKDSLDTLDWQALGQERQTLA
FYMGVAGLDAIQQRLLQAGRAPTTPFALVENGSRPQQRVITGTLASLAASARQHAVTAPALLILGEVTALAQTLHWFGSA
PLSASPPHSPGATPHTPTLAHAA
>Mature_423_residues
MKSFPTAISRRYGLALPQRCCRTVTPAFPLLADLRGRAVLVVGGGADAERATGQLLQAGALPLVGAPELTAQLRHWAQAG
RLRWLAGRFDPAWLAQSDQPLWLTIAASESAALNDALRQAASAHRLLTHAAAPAASATVPARSTGPRSAIGTLAPGNVSL
VGAGPGDPGLLTRHALRALRQAEVVLHDRLVSPQILRLARHGAHLIEVGKSAQGHSTRQEQIHGLMLEHARAGRRVVRLK
GGDPFVFGRGGEELEFLRAHGIGFQVIPGITAAIACAAYAGIPLTHRDHAQSLRLITAHCKDSLDTLDWQALGQERQTLA
FYMGVAGLDAIQQRLLQAGRAPTTPFALVENGSRPQQRVITGTLASLAASARQHAVTAPALLILGEVTALAQTLHWFGSA
PLSASPPHSPGATPHTPTLAHAA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=244, Percent_Identity=54.0983606557377, Blast_Score=258, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6322922, Length=239, Percent_Identity=34.7280334728033, Blast_Score=126, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 44501; Mature: 44501

Theoretical pI: Translated: 11.44; Mature: 11.44

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFPTAISRRYGLALPQRCCRTVTPAFPLLADLRGRAVLVVGGGADAERATGQLLQAGA
CCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
LPLVGAPELTAQLRHWAQAGRLRWLAGRFDPAWLAQSDQPLWLTIAASESAALNDALRQA
CCCCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
ASAHRLLTHAAAPAASATVPARSTGPRSAIGTLAPGNVSLVGAGPGDPGLLTRHALRALR
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHH
QAEVVLHDRLVSPQILRLARHGAHLIEVGKSAQGHSTRQEQIHGLMLEHARAGRRVVRLK
HHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
GGDPFVFGRGGEELEFLRAHGIGFQVIPGITAAIACAAYAGIPLTHRDHAQSLRLITAHC
CCCEEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KDSLDTLDWQALGQERQTLAFYMGVAGLDAIQQRLLQAGRAPTTPFALVENGSRPQQRVI
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHH
TGTLASLAASARQHAVTAPALLILGEVTALAQTLHWFGSAPLSASPPHSPGATPHTPTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
HAA
CCC
>Mature Secondary Structure
MKSFPTAISRRYGLALPQRCCRTVTPAFPLLADLRGRAVLVVGGGADAERATGQLLQAGA
CCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
LPLVGAPELTAQLRHWAQAGRLRWLAGRFDPAWLAQSDQPLWLTIAASESAALNDALRQA
CCCCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
ASAHRLLTHAAAPAASATVPARSTGPRSAIGTLAPGNVSLVGAGPGDPGLLTRHALRALR
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHH
QAEVVLHDRLVSPQILRLARHGAHLIEVGKSAQGHSTRQEQIHGLMLEHARAGRRVVRLK
HHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
GGDPFVFGRGGEELEFLRAHGIGFQVIPGITAAIACAAYAGIPLTHRDHAQSLRLITAHC
CCCEEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KDSLDTLDWQALGQERQTLAFYMGVAGLDAIQQRLLQAGRAPTTPFALVENGSRPQQRVI
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHH
TGTLASLAASARQHAVTAPALLILGEVTALAQTLHWFGSAPLSASPPHSPGATPHTPTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
HAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA