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The map label for this gene is cysK [H]

Identifier: 21244066

GI number: 21244066

Start: 3936660

End: 3937619

Strand: Direct

Name: cysK [H]

Synonym: XAC3341

Alternate gene names: 21244066

Gene position: 3936660-3937619 (Clockwise)

Preceding gene: 21244065

Following gene: 21244067

Centisome position: 76.06

GC content: 67.92

Gene sequence:

>960_bases
ATGGCCCTGTACGACAACATTCTCGACACCATCGGCCGCACCCCGGTGGTCAAGCTCCAACGCCTCGCCCCGGATAACGT
GACCTTGTACGTCAAGGTCGAATCGTTCAATCCCGGCGGCTCGGTCAAGGACCGGCTGGCGCTGGCGATCATCCTGGACG
CCGAACAGCGCGGCCTGCTCAAGCCCGGCGACACCATCGTCGAAGCCACCTCCGGCAACACCGGCGTGGCACTGGCCATG
GTGGCCGCAGCACGCGGCTACAAGTTCGTCGCCACCATGGTGGAAACCTTCTCCATCGAACGCCGCAAGCTGATGCGTGC
CTATGGCGCCAAGGTCATCCTGACGCCGGCTGCCGAGCGCGGCAGCGGCATGGTGCGCAAAGCGAAGGAGCTGGCCGAAC
AGCACGGCTGGTTCCTGGCCAGCCAGTTCGCCAATCCGGCCAACCCGGCCTACCACCGCAACACCACCGCTGCCGAGATC
CTGCGCGATTTCGCCGGCCACCGGCTGGACCATTTCGTCACCGGCTGGGGCACCGGCGGCACCCTCACCGGCGTGGGCGA
GGTCCTGAGCGTTGCGCGCCCGGAAGTGCGCATCACCGCCTCGGAGCCGGCTGGCGCCGCCTTGCTGCAAGGCCAGGACT
GGAAACCGCACAAGATCCAGGGCTGGACCCCGGACTTCATACCCGAGGTGCTCAACCGCGAGGTCGCCCATGAGGTGCTG
AGCGTGGAAGACACCGACGCCATCACCGTGGCGCGGCGCCTGGCCGCCGAAGAAGGCATCTTCACCGGCATCTCCGGCGG
TGCCACCGTCGCCACCGCGCTGCGCGTGGCAGAAGGCGCGGTGCCTGGCGCCGTCATCCTGGCGATGCTGCCCGACACTG
GCGAGCGCTACTTCTCGACCCCGCTCTTCGCCGACATCAACGAAGGCTCCGACGACGACTGGCTGGCCGGGCTGCCCTGA

Upstream 100 bases:

>100_bases
TTCGGCAGCGCGCCGCTGAGCGCCTCGCCGCCGCACTCACCCGGCGCAACGCCCCACACGCCCACACTGGCCCACGCAGC
CTGATTCCGACGGAGACCCC

Downstream 100 bases:

>100_bases
TCGGGCGCAGTTGATGACCAGACCTGAAGCCGCGCAATGCGCGGCTTTTTGGCCACGGCTGAACAGTGTATTTGCGCCGG
AAGACGCCGCGTCGCGGCGG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MALYDNILDTIGRTPVVKLQRLAPDNVTLYVKVESFNPGGSVKDRLALAIILDAEQRGLLKPGDTIVEATSGNTGVALAM
VAAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEI
LRDFAGHRLDHFVTGWGTGGTLTGVGEVLSVARPEVRITASEPAGAALLQGQDWKPHKIQGWTPDFIPEVLNREVAHEVL
SVEDTDAITVARRLAAEEGIFTGISGGATVATALRVAEGAVPGAVILAMLPDTGERYFSTPLFADINEGSDDDWLAGLP

Sequences:

>Translated_319_residues
MALYDNILDTIGRTPVVKLQRLAPDNVTLYVKVESFNPGGSVKDRLALAIILDAEQRGLLKPGDTIVEATSGNTGVALAM
VAAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEI
LRDFAGHRLDHFVTGWGTGGTLTGVGEVLSVARPEVRITASEPAGAALLQGQDWKPHKIQGWTPDFIPEVLNREVAHEVL
SVEDTDAITVARRLAAEEGIFTGISGGATVATALRVAEGAVPGAVILAMLPDTGERYFSTPLFADINEGSDDDWLAGLP
>Mature_318_residues
ALYDNILDTIGRTPVVKLQRLAPDNVTLYVKVESFNPGGSVKDRLALAIILDAEQRGLLKPGDTIVEATSGNTGVALAMV
AAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEIL
RDFAGHRLDHFVTGWGTGGTLTGVGEVLSVARPEVRITASEPAGAALLQGQDWKPHKIQGWTPDFIPEVLNREVAHEVLS
VEDTDAITVARRLAAEEGIFTGISGGATVATALRVAEGAVPGAVILAMLPDTGERYFSTPLFADINEGSDDDWLAGLP

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=309, Percent_Identity=39.4822006472492, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI295821200, Length=309, Percent_Identity=39.4822006472492, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI4557415, Length=309, Percent_Identity=39.4822006472492, Blast_Score=205, Evalue=4e-53,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=44.7811447811448, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=47.1698113207547, Blast_Score=228, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=42.8104575163399, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17562970, Length=318, Percent_Identity=41.5094339622642, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI115535073, Length=312, Percent_Identity=44.5512820512821, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=41.8367346938776, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=41.3907284768212, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=330, Percent_Identity=35.7575757575758, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32566672, Length=232, Percent_Identity=39.6551724137931, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=33.5365853658537, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17539800, Length=335, Percent_Identity=24.4776119402985, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71996324, Length=326, Percent_Identity=25.7668711656442, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561716, Length=108, Percent_Identity=39.8148148148148, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=333, Percent_Identity=32.1321321321321, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=31.3253012048193, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=38.4615384615385, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=38.4615384615385, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34086; Mature: 33955

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYDNILDTIGRTPVVKLQRLAPDNVTLYVKVESFNPGGSVKDRLALAIILDAEQRGLL
CCHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEEECCCCCCCHHHHEEEEEEEECCCCCCC
KPGDTIVEATSGNTGVALAMVAAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAER
CCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
GSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEILRDFAGHRLDHFVTGWGTGG
CCHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEECCCCCC
TLTGVGEVLSVARPEVRITASEPAGAALLQGQDWKPHKIQGWTPDFIPEVLNREVAHEVL
CHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SVEDTDAITVARRLAAEEGIFTGISGGATVATALRVAEGAVPGAVILAMLPDTGERYFST
CCCCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCC
PLFADINEGSDDDWLAGLP
CCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
ALYDNILDTIGRTPVVKLQRLAPDNVTLYVKVESFNPGGSVKDRLALAIILDAEQRGLL
CHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEEECCCCCCCHHHHEEEEEEEECCCCCCC
KPGDTIVEATSGNTGVALAMVAAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAER
CCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
GSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEILRDFAGHRLDHFVTGWGTGG
CCHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEECCCCCC
TLTGVGEVLSVARPEVRITASEPAGAALLQGQDWKPHKIQGWTPDFIPEVLNREVAHEVL
CHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SVEDTDAITVARRLAAEEGIFTGISGGATVATALRVAEGAVPGAVILAMLPDTGERYFST
CCCCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCC
PLFADINEGSDDDWLAGLP
CCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA