Click here to switch to the map view.

The map label for this gene is sdaA [H]

Identifier: 21243763

GI number: 21243763

Start: 3551442

End: 3552824

Strand: Direct

Name: sdaA [H]

Synonym: XAC3036

Alternate gene names: 21243763

Gene position: 3551442-3552824 (Clockwise)

Preceding gene: 21243761

Following gene: 77748689

Centisome position: 68.62

GC content: 65.37

Gene sequence:

>1383_bases
ATGGCTGTCAGCACGTTCGACCTGTTCAAGATCGGTATCGGCCCGAGTTCCTCCCACACCGTGGGGCCGATGCGCGCCGC
CGAGCGCTTCGTGCACCGCTGGCTGCTCGATGCCGGGCGCCTGCAGGATGTGGTGCGCATCCGCGCCGAAGTGTTCGGTT
CGCTCGCCCTGACCGGCCGCGGCCATGGCACCGACAAAGCCGTGCTGCTGGGGCTGGAGGGCCATCGCCCCAACGTGATC
GACCCGGACATCATCCCTGCCACGCTGGAGCGCATTCGCGCCAGCAAGCGCATCGCCTTGATGGGCCAGCACGCCATCGT
CTTCGACGAAAAGCGCGACTTGCCGATGAACAAGCGGCAGAAGCTGCCGTACCACACCAACGGCATGCGCTTTACGGCCT
ATGACGCCGACGAAGCGGTCATCGCCACACGCGATTACTATTCGGTCGGTGGCGGCTTTGTCGTCAACCAGGACGACGCG
GCCGACGATCGCATCGTGGCCGACGAAACGCCGCTGCCCTACCCGTTCCTCAGCGGCGACGAACTGCTGGCGCAGTGCGC
GCGCAGCGGCCTGAGCATTGCCGCACTCATGTTCGAAAACGAGAAAAGCTGGCGCAGCGAAGACGAGATCCGTGCTGGCC
TGCGCGAACTGTGGAATGCGATGCAGTCCTGCGTGACGCGCGGCATCCGCGAAGAAGGCACGCTACCGGGCGGCCTGAAT
GTCTCCCGCCGCGCACCTGCGCTGTATCGCGAACTCTCCTCCAAGCCCGAAGCGGCCATGCGCGATCCGTTGACCACGCT
GGATTGGGTCAACCTGTACGCCCTGGCAGTGAACGAAGAAAACGCCGCCGGCGGCCGGGTGGTCACCGCGCCGACCAATG
GCGCGGCCGGCATCATTCCCGCGGTGCTGCATTATTTCGACCGTTTCTGCGCGGGCGCCTCCGAGCAACGCATCTTCGAC
TTCCTGCTCACTGCTGCCGCCATCGGCATCCTCTACAAGGAGAACGCCTCGATTTCCGGCGCCGAAGTCGGCTGCCAGGG
CGAAGTGGGCGTGGCCTGTTCGATGGCCGCAGGCGGCCTGGTTGCCGCGCTTGGCGGCAACCCGGGGCAGATCGAAAACG
CCGCGGAGATCGGCATGGAGCACAACCTCGGCCTGACCTGCGACCCGATCGGCGGGCTGGTACAGATTCCGTGCATCGAA
CGCAACGCCATGGGCGCAGTGAAAGCCATCAACGCCAGCCGCATGGCCATGCGCGGCGACGGCAAGCACAAGGTCTCGCT
GGACAAGGTCATCAAGACCATGCGCGACACCGGTCGCGACATGCAGGACAAGTACAAGGAAACCAGCCGCGGCGGCCTGG
CGGTGAACGTCATCGAATGCTGA

Upstream 100 bases:

>100_bases
GGGTCAGGGGCATCCGCCGGGTTCTCATGCTGCGCTGCAGCCGTGCCGCAACCGCCGAACGACTAGAATAGCCGCCTTTA
CGCTCACCTCTTCGGCACGC

Downstream 100 bases:

>100_bases
GCCACTCGTAGGCGGGGTGCTGATCAACCCAGCGCGCGCAGCGACGAAAGAACCCGCTCCACAGATGCATGCCCTTGCAC
TGCCGTTCTCGTGCACGCGG

Product: L-serine dehydratase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MAVSTFDLFKIGIGPSSSHTVGPMRAAERFVHRWLLDAGRLQDVVRIRAEVFGSLALTGRGHGTDKAVLLGLEGHRPNVI
DPDIIPATLERIRASKRIALMGQHAIVFDEKRDLPMNKRQKLPYHTNGMRFTAYDADEAVIATRDYYSVGGGFVVNQDDA
ADDRIVADETPLPYPFLSGDELLAQCARSGLSIAALMFENEKSWRSEDEIRAGLRELWNAMQSCVTRGIREEGTLPGGLN
VSRRAPALYRELSSKPEAAMRDPLTTLDWVNLYALAVNEENAAGGRVVTAPTNGAAGIIPAVLHYFDRFCAGASEQRIFD
FLLTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGGLVAALGGNPGQIENAAEIGMEHNLGLTCDPIGGLVQIPCIE
RNAMGAVKAINASRMAMRGDGKHKVSLDKVIKTMRDTGRDMQDKYKETSRGGLAVNVIEC

Sequences:

>Translated_460_residues
MAVSTFDLFKIGIGPSSSHTVGPMRAAERFVHRWLLDAGRLQDVVRIRAEVFGSLALTGRGHGTDKAVLLGLEGHRPNVI
DPDIIPATLERIRASKRIALMGQHAIVFDEKRDLPMNKRQKLPYHTNGMRFTAYDADEAVIATRDYYSVGGGFVVNQDDA
ADDRIVADETPLPYPFLSGDELLAQCARSGLSIAALMFENEKSWRSEDEIRAGLRELWNAMQSCVTRGIREEGTLPGGLN
VSRRAPALYRELSSKPEAAMRDPLTTLDWVNLYALAVNEENAAGGRVVTAPTNGAAGIIPAVLHYFDRFCAGASEQRIFD
FLLTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGGLVAALGGNPGQIENAAEIGMEHNLGLTCDPIGGLVQIPCIE
RNAMGAVKAINASRMAMRGDGKHKVSLDKVIKTMRDTGRDMQDKYKETSRGGLAVNVIEC
>Mature_459_residues
AVSTFDLFKIGIGPSSSHTVGPMRAAERFVHRWLLDAGRLQDVVRIRAEVFGSLALTGRGHGTDKAVLLGLEGHRPNVID
PDIIPATLERIRASKRIALMGQHAIVFDEKRDLPMNKRQKLPYHTNGMRFTAYDADEAVIATRDYYSVGGGFVVNQDDAA
DDRIVADETPLPYPFLSGDELLAQCARSGLSIAALMFENEKSWRSEDEIRAGLRELWNAMQSCVTRGIREEGTLPGGLNV
SRRAPALYRELSSKPEAAMRDPLTTLDWVNLYALAVNEENAAGGRVVTAPTNGAAGIIPAVLHYFDRFCAGASEQRIFDF
LLTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGGLVAALGGNPGQIENAAEIGMEHNLGLTCDPIGGLVQIPCIER
NAMGAVKAINASRMAMRGDGKHKVSLDKVIKTMRDTGRDMQDKYKETSRGGLAVNVIEC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=457, Percent_Identity=54.7045951859956, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI48994925, Length=457, Percent_Identity=55.5798687089716, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1789161, Length=462, Percent_Identity=52.8138528138528, Blast_Score=479, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49583; Mature: 49452

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSTFDLFKIGIGPSSSHTVGPMRAAERFVHRWLLDAGRLQDVVRIRAEVFGSLALTGR
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
GHGTDKAVLLGLEGHRPNVIDPDIIPATLERIRASKRIALMGQHAIVFDEKRDLPMNKRQ
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCHHC
KLPYHTNGMRFTAYDADEAVIATRDYYSVGGGFVVNQDDAADDRIVADETPLPYPFLSGD
CCCEECCCEEEEEECCCCEEEEECCCEECCCCEEECCCCCCCCCEEECCCCCCCCCCCCH
ELLAQCARSGLSIAALMFENEKSWRSEDEIRAGLRELWNAMQSCVTRGIREEGTLPGGLN
HHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCC
VSRRAPALYRELSSKPEAAMRDPLTTLDWVNLYALAVNEENAAGGRVVTAPTNGAAGIIP
CCCCCHHHHHHHCCCCCHHHHCCCCHHHHEEEEEEEECCCCCCCCEEEECCCCCCCHHHH
AVLHYFDRFCAGASEQRIFDFLLTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGGL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCCCE
VAALGGNPGQIENAAEIGMEHNLGLTCDPIGGLVQIPCIERNAMGAVKAINASRMAMRGD
EEEECCCCCCCCHHHHCCCCCCCCEEECCCCCEEECCEECCCCCCHHHHCCHHHHEECCC
GKHKVSLDKVIKTMRDTGRDMQDKYKETSRGGLAVNVIEC
CCCEEEHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
AVSTFDLFKIGIGPSSSHTVGPMRAAERFVHRWLLDAGRLQDVVRIRAEVFGSLALTGR
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
GHGTDKAVLLGLEGHRPNVIDPDIIPATLERIRASKRIALMGQHAIVFDEKRDLPMNKRQ
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCHHC
KLPYHTNGMRFTAYDADEAVIATRDYYSVGGGFVVNQDDAADDRIVADETPLPYPFLSGD
CCCEECCCEEEEEECCCCEEEEECCCEECCCCEEECCCCCCCCCEEECCCCCCCCCCCCH
ELLAQCARSGLSIAALMFENEKSWRSEDEIRAGLRELWNAMQSCVTRGIREEGTLPGGLN
HHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCC
VSRRAPALYRELSSKPEAAMRDPLTTLDWVNLYALAVNEENAAGGRVVTAPTNGAAGIIP
CCCCCHHHHHHHCCCCCHHHHCCCCHHHHEEEEEEEECCCCCCCCEEEECCCCCCCHHHH
AVLHYFDRFCAGASEQRIFDFLLTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGGL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCCCE
VAALGGNPGQIENAAEIGMEHNLGLTCDPIGGLVQIPCIERNAMGAVKAINASRMAMRGD
EEEECCCCCCCCHHHHCCCCCCCCEEECCCCCEEECCEECCCCCCHHHHCCHHHHEECCC
GKHKVSLDKVIKTMRDTGRDMQDKYKETSRGGLAVNVIEC
CCCEEEHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]