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The map label for this gene is tdh [C]

Identifier: 21243553

GI number: 21243553

Start: 3311871

End: 3312941

Strand: Direct

Name: tdh [C]

Synonym: XAC2826

Alternate gene names: 21243553

Gene position: 3311871-3312941 (Clockwise)

Preceding gene: 21243552

Following gene: 21243556

Centisome position: 63.99

GC content: 64.99

Gene sequence:

>1071_bases
TTGCGTATGCGCGCAATGCACTTCGAGCGTTTTGAACAGGTTCCGGAAATTCTGCAGCTCCCCGACCCGACGCCAAGCGA
TGACGGCGTGGTGATCAAGGTGGCAGCCACCGGCATCTGCCGCAGCGATTGGCACGGCTGGATGGGGCACGATCCGGACA
TCGCATTGCCGCACGTACCGGGACATGAGTTCGCCGGCGAAGTGGTCGCCATGGGAAAACGCATCTCGGGCTTTGCGATC
GGCACCCGGGTCACCGTGCCGTTCGTGTCAGGGTGCGGGCGCTGCGCGCAGTGCCATGGCGGCAATCAGCACGTGTGCTC
GAACCAGTTCCAGCCCGGCTTCACCGCATGGGGATCGTTCGCCGAATATGTCGCGATCGATTTTGCCGAGACGAATCTGG
TCAGACTGCCGGAAAGCATCGACGATGCGACGGCGGCAAGCCTGGGATGCCGGTTTGCCACCTCGTTCCGGGCCGTGGTC
GATCAGGCCAGAACCGGCCCAGGGGAATGGGTCGTGGTCCATGGCTGCGGCGGCGTCGGGCTTTCGGCAGTGATGATCGC
AGCGGCGCTGGGGGCGCAGGTGGTTGCGGTGGACATCTTCGACGACAAGCTGGCGTTCGCCGTCGAATGCGGCGCGGTCG
CAACGGTCAACGCGTCGAAAGCGGCCGACACGGTGGAGGCGATTCGCGAGATCACCAAGGGCGGCGCGCACGTTTCCATC
GATGCGCTCGGCAGCCCCGCGACCTGTTTCAACTCCATCAGCAACCTGCGGCGGCGCGGCCGTCATGTCCAGGTGGGACT
GATGCTGGGCGAACACGCCACGCCCAGGATCCCGATGGCGCAGGTGATCGGCCACGAACTGGAGATCTACGGCAGCCACG
GGATGCAGGCGTGGCGGTACGATGCCATGTTGGCGATGATCCAGGCCGGGAAGATCGCACCTCAACGGCTCATCGGCAAA
AGAGTGGGCCTGGACGAGGCCATTGCGGTGCTGACCGGCATGGACGCTACGCGCGACCTCGGCATCAGCGTCATCGATCG
CTTCCAGCCCGTATCGCCGCCGGCATCCTAG

Upstream 100 bases:

>100_bases
CAGCGGCCAGGACGACGCTCCCCCACGAACATGAGCTGCCGCACCGCTCGCCAGCGGTGCAGCACGGTAGACCCCCTCCT
CATCGTGCTGCTTCCCGAGG

Downstream 100 bases:

>100_bases
GCACCTGGTGGCACACCTTGATGGGCCGGACAGGCGCGTAAACGACCGGCCTGCACAACGAAAAACGCGGCGCAAGCGCC
GCGTTCCGGTGTCGCGAAGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MRMRAMHFERFEQVPEILQLPDPTPSDDGVVIKVAATGICRSDWHGWMGHDPDIALPHVPGHEFAGEVVAMGKRISGFAI
GTRVTVPFVSGCGRCAQCHGGNQHVCSNQFQPGFTAWGSFAEYVAIDFAETNLVRLPESIDDATAASLGCRFATSFRAVV
DQARTGPGEWVVVHGCGGVGLSAVMIAAALGAQVVAVDIFDDKLAFAVECGAVATVNASKAADTVEAIREITKGGAHVSI
DALGSPATCFNSISNLRRRGRHVQVGLMLGEHATPRIPMAQVIGHELEIYGSHGMQAWRYDAMLAMIQAGKIAPQRLIGK
RVGLDEAIAVLTGMDATRDLGISVIDRFQPVSPPAS

Sequences:

>Translated_356_residues
MRMRAMHFERFEQVPEILQLPDPTPSDDGVVIKVAATGICRSDWHGWMGHDPDIALPHVPGHEFAGEVVAMGKRISGFAI
GTRVTVPFVSGCGRCAQCHGGNQHVCSNQFQPGFTAWGSFAEYVAIDFAETNLVRLPESIDDATAASLGCRFATSFRAVV
DQARTGPGEWVVVHGCGGVGLSAVMIAAALGAQVVAVDIFDDKLAFAVECGAVATVNASKAADTVEAIREITKGGAHVSI
DALGSPATCFNSISNLRRRGRHVQVGLMLGEHATPRIPMAQVIGHELEIYGSHGMQAWRYDAMLAMIQAGKIAPQRLIGK
RVGLDEAIAVLTGMDATRDLGISVIDRFQPVSPPAS
>Mature_356_residues
MRMRAMHFERFEQVPEILQLPDPTPSDDGVVIKVAATGICRSDWHGWMGHDPDIALPHVPGHEFAGEVVAMGKRISGFAI
GTRVTVPFVSGCGRCAQCHGGNQHVCSNQFQPGFTAWGSFAEYVAIDFAETNLVRLPESIDDATAASLGCRFATSFRAVV
DQARTGPGEWVVVHGCGGVGLSAVMIAAALGAQVVAVDIFDDKLAFAVECGAVATVNASKAADTVEAIREITKGGAHVSI
DALGSPATCFNSISNLRRRGRHVQVGLMLGEHATPRIPMAQVIGHELEIYGSHGMQAWRYDAMLAMIQAGKIAPQRLIGK
RVGLDEAIAVLTGMDATRDLGISVIDRFQPVSPPAS

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=252, Percent_Identity=31.3492063492063, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI34577061, Length=252, Percent_Identity=31.7460317460317, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4501929, Length=331, Percent_Identity=28.0966767371601, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI71565154, Length=244, Percent_Identity=27.8688524590164, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI156523966, Length=254, Percent_Identity=29.9212598425197, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501939, Length=254, Percent_Identity=29.9212598425197, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI71743840, Length=266, Percent_Identity=26.6917293233083, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI262073058, Length=266, Percent_Identity=26.6917293233083, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI71565152, Length=251, Percent_Identity=28.6852589641434, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194239674, Length=337, Percent_Identity=28.1899109792285, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI13236495, Length=337, Percent_Identity=28.1899109792285, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI194239676, Length=223, Percent_Identity=30.9417040358744, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790045, Length=350, Percent_Identity=30.2857142857143, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082125, Length=327, Percent_Identity=28.4403669724771, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787863, Length=322, Percent_Identity=29.5031055900621, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI226510992, Length=274, Percent_Identity=34.6715328467153, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788073, Length=323, Percent_Identity=28.7925696594427, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786825, Length=287, Percent_Identity=29.616724738676, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87081918, Length=326, Percent_Identity=30.0613496932515, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788075, Length=326, Percent_Identity=26.0736196319018, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786552, Length=293, Percent_Identity=26.6211604095563, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786518, Length=287, Percent_Identity=26.4808362369338, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790718, Length=319, Percent_Identity=26.3322884012539, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788407, Length=271, Percent_Identity=27.6752767527675, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=267, Percent_Identity=32.2097378277154, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17562582, Length=267, Percent_Identity=32.5842696629214, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562584, Length=334, Percent_Identity=29.6407185628743, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71997431, Length=224, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=224, Percent_Identity=29.0178571428571, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=206, Percent_Identity=29.126213592233, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=333, Percent_Identity=27.9279279279279, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=331, Percent_Identity=27.7945619335347, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=331, Percent_Identity=29.3051359516616, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=335, Percent_Identity=30.1492537313433, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=269, Percent_Identity=30.1115241635688, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323961, Length=270, Percent_Identity=32.5925925925926, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6320033, Length=290, Percent_Identity=28.6206896551724, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=337, Percent_Identity=28.486646884273, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=337, Percent_Identity=28.486646884273, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323980, Length=224, Percent_Identity=33.4821428571429, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=358, Percent_Identity=25.6983240223464, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=202, Percent_Identity=31.6831683168317, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737897, Length=327, Percent_Identity=26.9113149847095, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17737895, Length=301, Percent_Identity=25.2491694352159, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137530, Length=319, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37792; Mature: 37792

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMRAMHFERFEQVPEILQLPDPTPSDDGVVIKVAATGICRSDWHGWMGHDPDIALPHVP
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHCCCCCCCCCCCEECCCCC
GHEFAGEVVAMGKRISGFAIGTRVTVPFVSGCGRCAQCHGGNQHVCSNQFQPGFTAWGSF
CHHHHHHHHHHCCCCCCEEECCEEEEHHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHH
AEYVAIDFAETNLVRLPESIDDATAASLGCRFATSFRAVVDQARTGPGEWVVVHGCGGVG
HHHEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCH
LSAVMIAAALGAQVVAVDIFDDKLAFAVECGAVATVNASKAADTVEAIREITKGGAHVSI
HHHHHHHHHHCCEEEEEEEECCCEEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCEEEE
DALGSPATCFNSISNLRRRGRHVQVGLMLGEHATPRIPMAQVIGHELEIYGSHGMQAWRY
ECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCCEEEEEECCCCCHHHH
DAMLAMIQAGKIAPQRLIGKRVGLDEAIAVLTGMDATRDLGISVIDRFQPVSPPAS
HHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCHHHCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRMRAMHFERFEQVPEILQLPDPTPSDDGVVIKVAATGICRSDWHGWMGHDPDIALPHVP
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHCCCCCCCCCCCEECCCCC
GHEFAGEVVAMGKRISGFAIGTRVTVPFVSGCGRCAQCHGGNQHVCSNQFQPGFTAWGSF
CHHHHHHHHHHCCCCCCEEECCEEEEHHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHH
AEYVAIDFAETNLVRLPESIDDATAASLGCRFATSFRAVVDQARTGPGEWVVVHGCGGVG
HHHEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCH
LSAVMIAAALGAQVVAVDIFDDKLAFAVECGAVATVNASKAADTVEAIREITKGGAHVSI
HHHHHHHHHHCCEEEEEEEECCCEEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCEEEE
DALGSPATCFNSISNLRRRGRHVQVGLMLGEHATPRIPMAQVIGHELEIYGSHGMQAWRY
ECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCCEEEEEECCCCCHHHH
DAMLAMIQAGKIAPQRLIGKRVGLDEAIAVLTGMDATRDLGISVIDRFQPVSPPAS
HHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCHHHCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]