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The map label for this gene is yadQ [H]

Identifier: 21243552

GI number: 21243552

Start: 3310419

End: 3311804

Strand: Direct

Name: yadQ [H]

Synonym: XAC2825

Alternate gene names: 21243552

Gene position: 3310419-3311804 (Clockwise)

Preceding gene: 21243551

Following gene: 21243553

Centisome position: 63.96

GC content: 67.53

Gene sequence:

>1386_bases
ATGTCTGGTTCCAAACTCCCCCCGCGTCGCTTGCGGCCGCTGTTGTCCAGCGAAGGCTGGCGTCGTCGCGCTGCACTGTG
GGGCGGCGCGATTGCGGTGGCGCTGGTGGCGATCGTCTTCGCAAAGGCCAGCGACGCGGCCTTCCATCTTTTTCAACGCA
TTACCGCGCACTCGATCTGGTGGGCGCTGCTGCTGACGCCGGGCATCTTCGCCCTGCTTGCCTGGCTCACCTCCGGTGCG
CTGCGGCCCACGCGCGGCAGCGGCATCCCGCAGGTGATTGCCGCGCTGGAACACCCCGACCCGGCATTTCGCGACAGCAA
CCTCTCGTTGCGCGTGTCGGTCGGCAAGCTCGCGCTGACCACCTTGTCGCTGCTCGGCGGCGCATCGGTAGGACGCGAAG
GACCCACCGTGCATGTCGGCGCCAGCCTGATGCATGTGTTCGGGCGCTGGTTCGGTTTTCGCGGCCCACGCGAGCTCTCG
CATTTTCTGCTCGCCGGCGGCGCCGCCGGTATCGCGGCCGCGTTCAATACGCCGCTAGCGGGTGTGGTATTCGCGATCGA
AGAACTGAGCGGGCGTTTCGAGCACCGCTTTTCCGGCACCTTGCTCACCGCGGTGATCGTTGGCGGGGTGGTGTCGCTAG
GCCTGCTGGGCAGCTACACCTATTTCGGCAAGGTGGCGGTGGCCTTGCCCTTGGGCCAGGCCTGGTTGGCGATCGCCTTG
TGCGGCAGCGTGGCCGGGTTACTCGGTGGCCTCTTCGCGCGGATGGTGCTGGCCAGCGTCAGCGGCAAACCGCGCTGGCT
GGGTGCGCTGCGCCAACGGCATCCGGTGCTGCTGGCCGCGCTGTGCGGCGTTGCCCTGGTCGGGCTGGCGCTGGTGTTCG
GGCAAGGCGCGTTCGGTACCGGCTACGACCAGGCGCGCAGCCTGGTGCAGGGGCATGCGGTGGTCGGCCACGAGTTCGGC
ATGATGAAACTCATCGCCAATCTGGTCTCGTATCTGGCCGGCATTCCAGGTGGCCTGTTTTCGCCGGCGCTGGCAGTGGG
TGCCGGCATCGGTCACAACCTCTCGGTGCTGATGCCCAGCGTGGATCCACGCACCTTCGTGCTGCTGGGCATGTGCGCCT
ATCTCACCGGCGTGACCCAGGCGCCGCTGACCTCGGCGGTGATTTCGCTGGAGCTCACCGACACCAACCAGATGCTGCTG
CCGATCCTGGCCACCGTGCTGATTGCGCGCGCAGTCTCCGGGCTAGTCTGCAAGACGCCGATCTATCGTGGCCTGGCAGA
GCAATTGCTGGCCGTGCCGGCGCCCGCTGCAGAGCGCGCGTCGACGTCGCAGCGCCAGACCTCGGCTGGAAACAGCGGCC
AGGACGACGCTCCCCCACGAACATGA

Upstream 100 bases:

>100_bases
CGCGGCTCCAAGTCGCCGCCGCATACCTCATGTTGGCGACAGCGCAGGAATGTGGGTCGCTGTCGACACCGCTGCGGCCC
AGCAGTGCGACAATGACGGA

Downstream 100 bases:

>100_bases
GCTGCCGCACCGCTCGCCAGCGGTGCAGCACGGTAGACCCCCTCCTCATCGTGCTGCTTCCCGAGGTTGCGTATGCGCGC
AATGCACTTCGAGCGTTTTG

Product: chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSGSKLPPRRLRPLLSSEGWRRRAALWGGAIAVALVAIVFAKASDAAFHLFQRITAHSIWWALLLTPGIFALLAWLTSGA
LRPTRGSGIPQVIAALEHPDPAFRDSNLSLRVSVGKLALTTLSLLGGASVGREGPTVHVGASLMHVFGRWFGFRGPRELS
HFLLAGGAAGIAAAFNTPLAGVVFAIEELSGRFEHRFSGTLLTAVIVGGVVSLGLLGSYTYFGKVAVALPLGQAWLAIAL
CGSVAGLLGGLFARMVLASVSGKPRWLGALRQRHPVLLAALCGVALVGLALVFGQGAFGTGYDQARSLVQGHAVVGHEFG
MMKLIANLVSYLAGIPGGLFSPALAVGAGIGHNLSVLMPSVDPRTFVLLGMCAYLTGVTQAPLTSAVISLELTDTNQMLL
PILATVLIARAVSGLVCKTPIYRGLAEQLLAVPAPAAERASTSQRQTSAGNSGQDDAPPRT

Sequences:

>Translated_461_residues
MSGSKLPPRRLRPLLSSEGWRRRAALWGGAIAVALVAIVFAKASDAAFHLFQRITAHSIWWALLLTPGIFALLAWLTSGA
LRPTRGSGIPQVIAALEHPDPAFRDSNLSLRVSVGKLALTTLSLLGGASVGREGPTVHVGASLMHVFGRWFGFRGPRELS
HFLLAGGAAGIAAAFNTPLAGVVFAIEELSGRFEHRFSGTLLTAVIVGGVVSLGLLGSYTYFGKVAVALPLGQAWLAIAL
CGSVAGLLGGLFARMVLASVSGKPRWLGALRQRHPVLLAALCGVALVGLALVFGQGAFGTGYDQARSLVQGHAVVGHEFG
MMKLIANLVSYLAGIPGGLFSPALAVGAGIGHNLSVLMPSVDPRTFVLLGMCAYLTGVTQAPLTSAVISLELTDTNQMLL
PILATVLIARAVSGLVCKTPIYRGLAEQLLAVPAPAAERASTSQRQTSAGNSGQDDAPPRT
>Mature_460_residues
SGSKLPPRRLRPLLSSEGWRRRAALWGGAIAVALVAIVFAKASDAAFHLFQRITAHSIWWALLLTPGIFALLAWLTSGAL
RPTRGSGIPQVIAALEHPDPAFRDSNLSLRVSVGKLALTTLSLLGGASVGREGPTVHVGASLMHVFGRWFGFRGPRELSH
FLLAGGAAGIAAAFNTPLAGVVFAIEELSGRFEHRFSGTLLTAVIVGGVVSLGLLGSYTYFGKVAVALPLGQAWLAIALC
GSVAGLLGGLFARMVLASVSGKPRWLGALRQRHPVLLAALCGVALVGLALVFGQGAFGTGYDQARSLVQGHAVVGHEFGM
MKLIANLVSYLAGIPGGLFSPALAVGAGIGHNLSVLMPSVDPRTFVLLGMCAYLTGVTQAPLTSAVISLELTDTNQMLLP
ILATVLIARAVSGLVCKTPIYRGLAEQLLAVPAPAAERASTSQRQTSAGNSGQDDAPPRT

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=381, Percent_Identity=30.1837270341207, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87081943, Length=382, Percent_Identity=27.2251308900524, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71996455, Length=431, Percent_Identity=26.4501160092807, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71996452, Length=431, Percent_Identity=26.4501160092807, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532615, Length=398, Percent_Identity=24.3718592964824, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322500, Length=415, Percent_Identity=25.5421686746988, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 47830; Mature: 47699

Theoretical pI: Translated: 11.08; Mature: 11.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCCCHHHHCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGSKLPPRRLRPLLSSEGWRRRAALWGGAIAVALVAIVFAKASDAAFHLFQRITAHSIW
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH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HHHHHHHHHHHCCCCCHHHHCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA