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The map label for this gene is trpB

Identifier: 21243444

GI number: 21243444

Start: 3177394

End: 3178611

Strand: Reverse

Name: trpB

Synonym: XAC2717

Alternate gene names: 21243444

Gene position: 3178611-3177394 (Counterclockwise)

Preceding gene: 21243446

Following gene: 21243443

Centisome position: 61.42

GC content: 64.86

Gene sequence:

>1218_bases
ATGTCGGCCCAGCCCATCAGTGACTTTTACGCCTATCCGGATGCTGCCGGCCACTTCGGCCAGTTCGGTGGCCGTTTCGT
CGCCGAAACCTTGATCGGCCCGCTGCAGGAACTGTCCGCCGCCTACGATCAGGCACGGCAAGATCCGAGTTTCATCGCCG
AATACGACAAGGACCTCAAGCATTACGTCGGCCGGCCCAGCCCGATCTACCACGCTGAACGGCTCAGCCGTGAAGTGGGT
GGGGCGCAGATCCTGCTCAAGCGCGAAGACCTCAACCATACCGGCGCGCACAAGATCAACAACACCATCGGCCAGGCCCT
GCTGGCCAGCCGCATGGGCAAGACCCGCATCATCGCCGAGACCGGCGCCGGCCAGCACGGCGTCGCCAGTGCCACCGTGG
CGGCACGCCTGGGCCTGGAATGCGTGGTCTACATGGGCGCCACCGATATCGAGCGGCAGAAGATCAACGTCTACCGCATG
AAGTTGCTCGGCGCCACGGTGATCCCGGTGACCTCCGGCTCTGCCACGCTCAAGGACGCGCTCAACGAAGCCATGCGCGA
CTGGGTGACCAACGTGCGCGACACCTTCTACATCATCGGCACCGTGGCTGGCCCGGACCCATACCCGCGCATGGTGCGCG
ACTTCAACGCCATTGTCGGCCGCGAGGCGCGCGAACAGATGTTGCAGGACTATGGCCGGCTGCCGGATGCGATCAGTGCC
TGCGTGGGCGGCGGCAGCAACGCGATCGGTTTGTTCCATGCCTTCCTCAATGATCCGGGCGTCAAGATCTATGGCGCCGA
AGCGGCCGGCGATGGCATCGCCACTGGCCGCCATGCCGCCTCCATCGCCGCCGGGCGCCCGGGCGTGCTGCACGGCAATC
GCACCTATGTGATCTGCGACGACGACGGCCAGATCACCGAGACCCATTCGATTTCCGCTGGCCTGGATTACCCCGGTGTA
GGCCCGGAGCATTCGTTTCTCTCGGACAGCGGTCGCGCGGTGTATCAGGGCATCACCGACGACGAGGCGATGGCCGCCTT
CCATCTGCTGGCGCATACCGAAGGCATTCTTGCCGCGCTCGAGTCCAGCCATGCGGTGGCGCAGTCGATCAAGCTTGCGC
GCGAGCTGCCCAGGGATGCCTTGGTGCTATGCAATCTGTCGGGGCGTGGCGATAAGGATGTGCACACCATCGCGGCGCGC
GAGGGGATCGCTCTTTAG

Upstream 100 bases:

>100_bases
ATTCCAGGTCACAGGTTGCAGCAATCTTATCGATTTATCCCATGCCGCGGCTGCGCTAGAGTGATGCCTCTCGTATGACG
CATTGCTGCAGAGGATTTTC

Downstream 100 bases:

>100_bases
GAGTGGCGGCGGCGACTTCTCTATCCGGATGCAGGGACGCGGCGATGATCGAAGGAATGCTCCAGTTGGTGGCCGAGGTG
CTGTTGCAGGCCTTGGCCGA

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSAQPISDFYAYPDAAGHFGQFGGRFVAETLIGPLQELSAAYDQARQDPSFIAEYDKDLKHYVGRPSPIYHAERLSREVG
GAQILLKREDLNHTGAHKINNTIGQALLASRMGKTRIIAETGAGQHGVASATVAARLGLECVVYMGATDIERQKINVYRM
KLLGATVIPVTSGSATLKDALNEAMRDWVTNVRDTFYIIGTVAGPDPYPRMVRDFNAIVGREAREQMLQDYGRLPDAISA
CVGGGSNAIGLFHAFLNDPGVKIYGAEAAGDGIATGRHAASIAAGRPGVLHGNRTYVICDDDGQITETHSISAGLDYPGV
GPEHSFLSDSGRAVYQGITDDEAMAAFHLLAHTEGILAALESSHAVAQSIKLARELPRDALVLCNLSGRGDKDVHTIAAR
EGIAL

Sequences:

>Translated_405_residues
MSAQPISDFYAYPDAAGHFGQFGGRFVAETLIGPLQELSAAYDQARQDPSFIAEYDKDLKHYVGRPSPIYHAERLSREVG
GAQILLKREDLNHTGAHKINNTIGQALLASRMGKTRIIAETGAGQHGVASATVAARLGLECVVYMGATDIERQKINVYRM
KLLGATVIPVTSGSATLKDALNEAMRDWVTNVRDTFYIIGTVAGPDPYPRMVRDFNAIVGREAREQMLQDYGRLPDAISA
CVGGGSNAIGLFHAFLNDPGVKIYGAEAAGDGIATGRHAASIAAGRPGVLHGNRTYVICDDDGQITETHSISAGLDYPGV
GPEHSFLSDSGRAVYQGITDDEAMAAFHLLAHTEGILAALESSHAVAQSIKLARELPRDALVLCNLSGRGDKDVHTIAAR
EGIAL
>Mature_404_residues
SAQPISDFYAYPDAAGHFGQFGGRFVAETLIGPLQELSAAYDQARQDPSFIAEYDKDLKHYVGRPSPIYHAERLSREVGG
AQILLKREDLNHTGAHKINNTIGQALLASRMGKTRIIAETGAGQHGVASATVAARLGLECVVYMGATDIERQKINVYRMK
LLGATVIPVTSGSATLKDALNEAMRDWVTNVRDTFYIIGTVAGPDPYPRMVRDFNAIVGREAREQMLQDYGRLPDAISAC
VGGGSNAIGLFHAFLNDPGVKIYGAEAAGDGIATGRHAASIAAGRPGVLHGNRTYVICDDDGQITETHSISAGLDYPGVG
PEHSFLSDSGRAVYQGITDDEAMAAFHLLAHTEGILAALESSHAVAQSIKLARELPRDALVLCNLSGRGDKDVHTIAARE
GIAL

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=381, Percent_Identity=53.8057742782152, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321412, Length=381, Percent_Identity=54.3307086614173, Blast_Score=446, Evalue=1e-126,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_XANAC (Q8PJ28)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643026.1
- ProteinModelPortal:   Q8PJ28
- SMR:   Q8PJ28
- GeneID:   1156788
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2717
- NMPDR:   fig|190486.1.peg.2670
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- ProtClustDB:   PRK04346
- BioCyc:   XAXO190486:XAC2717-MONOMER
- BRENDA:   4.2.1.20
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 43193; Mature: 43062

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQPISDFYAYPDAAGHFGQFGGRFVAETLIGPLQELSAAYDQARQDPSFIAEYDKDLK
CCCCCCHHHHCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
HYVGRPSPIYHAERLSREVGGAQILLKREDLNHTGAHKINNTIGQALLASRMGKTRIIAE
HHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
TGAGQHGVASATVAARLGLECVVYMGATDIERQKINVYRMKLLGATVIPVTSGSATLKDA
CCCCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHH
LNEAMRDWVTNVRDTFYIIGTVAGPDPYPRMVRDFNAIVGREAREQMLQDYGRLPDAISA
HHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHH
CVGGGSNAIGLFHAFLNDPGVKIYGAEAAGDGIATGRHAASIAAGRPGVLHGNRTYVICD
HHCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHCCCCCCEEECCEEEEEEC
DDGQITETHSISAGLDYPGVGPEHSFLSDSGRAVYQGITDDEAMAAFHLLAHTEGILAAL
CCCCEEECCCCCCCCCCCCCCCCCCHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
ESSHAVAQSIKLARELPRDALVLCNLSGRGDKDVHTIAAREGIAL
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SAQPISDFYAYPDAAGHFGQFGGRFVAETLIGPLQELSAAYDQARQDPSFIAEYDKDLK
CCCCCHHHHCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
HYVGRPSPIYHAERLSREVGGAQILLKREDLNHTGAHKINNTIGQALLASRMGKTRIIAE
HHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEE
TGAGQHGVASATVAARLGLECVVYMGATDIERQKINVYRMKLLGATVIPVTSGSATLKDA
CCCCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHH
LNEAMRDWVTNVRDTFYIIGTVAGPDPYPRMVRDFNAIVGREAREQMLQDYGRLPDAISA
HHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHH
CVGGGSNAIGLFHAFLNDPGVKIYGAEAAGDGIATGRHAASIAAGRPGVLHGNRTYVICD
HHCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHCCCCCCEEECCEEEEEEC
DDGQITETHSISAGLDYPGVGPEHSFLSDSGRAVYQGITDDEAMAAFHLLAHTEGILAAL
CCCCEEECCCCCCCCCCCCCCCCCCHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
ESSHAVAQSIKLARELPRDALVLCNLSGRGDKDVHTIAAREGIAL
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217