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The map label for this gene is upp

Identifier: 21243254

GI number: 21243254

Start: 2953345

End: 2953977

Strand: Direct

Name: upp

Synonym: XAC2521

Alternate gene names: 21243254

Gene position: 2953345-2953977 (Clockwise)

Preceding gene: 21243249

Following gene: 21243261

Centisome position: 57.06

GC content: 65.88

Gene sequence:

>633_bases
ATGAAAATCGTCGAAGTCCGCCACCCCCTCGTCCAGCACAAGATCGGCCTGCTGCGCGATGCCGCCTTGAGCACCAAGGG
CTTCCGCGAACTGGTTACCGAACTGGGCACGCTGCTGGCCTACGAGGCCACCGCCAACCTGGACACCGAATCGCACACCC
AGCCGGGCTGGGCCGGCCCGGTGACGGTGCAGCGCATTGCCGGCGCAAAGATCACCTTGGTACCGATCCTGCGCGCCGGT
CTGGGCATGCTGCCCGGCGTACTGGCACTGATTCCTGCCGCACGCGTGAGCGTGGTCGGTCTGCAGCGCGATGAAGAGAC
CCTGCAACCGGTGCCCTATTTCGAACGCCTCACTGGCCGCCTGGAAGAACGCGACGCACTGATCCTGGATCCGATGCTGG
CCACCGGCGGCACCCTGATCGCCACCATCGACATGCTCAAGCGCGCGGGCGCACGGCGCATCAAAGGCATCTTTCTGGTC
GCTGCGCCGGAAGGCCTGAAGGCGCTGGAAGCGGCGCACCCGGATGTCGAGGTCTATACCGCGGCCATCGACGACCACCT
CAACGACAAGGGCTACATCCTGCCCGGCCTGGGCGATGCAGGCGACCGGATCTTTGGGACGCGGCTGGAGTAA

Upstream 100 bases:

>100_bases
TTTCACTGACATGACATATGCATCGGCGATCACACCCGAAATGTGGCGACACACCGCGCGGCTGCGGCACACTGTGCCTC
TCTCCCGCCTGCCCCCACCC

Downstream 100 bases:

>100_bases
GTTTAAGCCCCTCTCCCCCGGGAGAGGGGTTGGGGTGAGGGTACGGCATGCCAGTGTTCTTGCTGCCGCCCTACCCTCAT
CCGGCGCTACGCGCCACCTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHTQPGWAGPVTVQRIAGAKITLVPILRAG
LGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLV
AAPEGLKALEAAHPDVEVYTAAIDDHLNDKGYILPGLGDAGDRIFGTRLE

Sequences:

>Translated_210_residues
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHTQPGWAGPVTVQRIAGAKITLVPILRAG
LGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLV
AAPEGLKALEAAHPDVEVYTAAIDDHLNDKGYILPGLGDAGDRIFGTRLE
>Mature_210_residues
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHTQPGWAGPVTVQRIAGAKITLVPILRAG
LGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLV
AAPEGLKALEAAHPDVEVYTAAIDDHLNDKGYILPGLGDAGDRIFGTRLE

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=207, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI57863312, Length=207, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=66.3461538461538, Blast_Score=294, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17539892, Length=205, Percent_Identity=25.8536585365854, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=205, Percent_Identity=25.8536585365854, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=158, Percent_Identity=36.7088607594937, Blast_Score=105, Evalue=4e-24,
Organism=Drosophila melanogaster, GI45550449, Length=146, Percent_Identity=31.5068493150685, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573516, Length=146, Percent_Identity=31.5068493150685, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573514, Length=146, Percent_Identity=31.5068493150685, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573512, Length=146, Percent_Identity=31.5068493150685, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_XANAC (P59001)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642836.1
- ProteinModelPortal:   P59001
- SMR:   P59001
- GeneID:   1156592
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2521
- NMPDR:   fig|190486.1.peg.2480
- HOGENOM:   HBG326432
- OMA:   VYVLDPM
- ProtClustDB:   PRK00129
- BioCyc:   XAXO190486:XAC2521-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22580; Mature: 22580

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHTQPGWAGP
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VTVQRIAGAKITLVPILRAGLGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGR
HHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHCCCCCHHHHHHCC
LEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLVAAPEGLKALEAAHPDVEVYT
HHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHCCEEEEEECCCCHHHHHHCCCCCEEEE
AAIDDHLNDKGYILPGLGDAGDRIFGTRLE
EEHHHCCCCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHTQPGWAGP
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VTVQRIAGAKITLVPILRAGLGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGR
HHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHCCCCCHHHHHHCC
LEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLVAAPEGLKALEAAHPDVEVYT
HHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHCCEEEEEECCCCHHHHHHCCCCCEEEE
AAIDDHLNDKGYILPGLGDAGDRIFGTRLE
EEHHHCCCCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217