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The map label for this gene is htpG

Identifier: 21243261

GI number: 21243261

Start: 2960605

End: 2962509

Strand: Direct

Name: htpG

Synonym: XAC2528

Alternate gene names: 21243261

Gene position: 2960605-2962509 (Clockwise)

Preceding gene: 21243254

Following gene: 21243262

Centisome position: 57.2

GC content: 62.31

Gene sequence:

>1905_bases
ATGACCGTTGAAACCGATAAGCAGACGCTCGGCTTCCAGACCGAGGTCAAGCAGCTGCTGCAGCTGATGATCCATTCGTT
GTACTCGAACAAGGAAATCTTCCTGCGCGAGCTGGTCTCCAATGCCGCCGACGCCGCCGACAAGCTGCGCTTCGAAGCCC
TGGTCAAGCCCGAGCTGCTGGAAGGCAGCGGCGAGCTGCGCATCCGCGTCGACTACGACAAGGACGCGCGCACCGTCACC
ATCGACGACAACGGCATCGGCATGAGCCGCGAGGATGCGGTCTCGCACCTGGGCACCATCGCCAAGTCCGGCACCGCCGA
TTTCCTCAAGCACCTCAGCGGCGACCAGAAGAAGGACGCCAACCTGATCGGCCAGTTCGGCGTGGGCTTCTATAGCGCGT
TCATCGTCGCCGACCAGGTGGACGTGTATTCGCGCCGCGCCGGCCTTCCGGCCAGCGAAGGCGTTCACTGGTCCTCGCGT
GGCGAAGGCGAATTCGAAATCGCCAGCGTCGACAAGCCCGAGCGCGGCACCCGCATCGTGCTGCACCTGAAGGAAGGCGA
AGAATCGTTCGCCGATGGCTGGACGCTGCGCGGCATCCTCAAGAAATACTCCGACCACATCGGCCTGCCGATCGAGATGC
GCAAGGAGCATTACGGCGAAGCCGCCGACAAGCCGGCAGAGCCGGAGTGGGAAGCGGTCAACCGCGCCAGCGCCTTGTGG
ACGCGCCCCAAGTCCGAGATCAAGGACGAGGAATACCAGGAGTTCTATAAACACGTCGCGCACGACGCGGGCAACCCGTT
GGCGTGGAGCCACAACAAGGTCGAAGGCAAGCTGGAATACACCTCGCTGCTGTTCGTGCCCGGCCGCGCGCCGTTCGACC
TGTACCACCGCGATTCGGCCAAGGGCCTGAAGCTGTACGTGCAGCGCGTTTTCATCATGGACCAGGCCGAGCAGTTCCTG
CCGCTGTACCTGCGTTTCATCAAGGGTGTGGTGGATTCGTCGGACCTGTCGCTCAATGTTTCGCGCGAAATCCTGCAATC
CGGCCCGGTGGTCGATTCGATGAAGTCGGCGCTGACCAAGCGCTCGCTGGACATGCTGGAGAAGCTGGCCAAGGACAAGC
CGGACGACTACGCCACGTTCTGGCGCAACTTCGGCCAGGCATTGAAGGAAGGCCCGGCCGAGGATTACGCCAACCGCGAA
AAGATCGCCGGCCTGCTGCGCTTCTCCTCCACGCACGACACCACCGGCGCGCAGAGCGTGGGCCTGGCCGACTACGTAGG
TCGTTTGGCCGACGGCCAGGACAAGCTGTACTACCTCACTGGCGAAAGCTATGCGCAGATCAAGGACAGCCCGCATCTTG
AGGTGTTCCGCAAGAAGGGCATCGAAGTGCTGCTGCTCACCGATCGCATCGACGAATGGCTGATGAGCTATCTCACCGAA
TTCGACGGCAAGTCGTTCGTGGACGTGGCACGCGGCGACCTGGACCTGGGCAAGCTGGATTCGGAAGAAGACAAGAAGGC
GCAGGAAGAAGTCGCCAAATCCAAGGAAGGCCTGGCCTCGCGCATCAAGGCAGCGCTAGGCGACGACGTGGCCGAATTAC
GCGTCTCGCACCGCCTGACCGACTCCCCCGCGATCCTGGCGATCGGCCAAGGCGACCTGGGCCTGCAGATGCGCCAGCTG
CTGGAAGCCAGCGGCCAGGCGGTGCCGGAAAGCAAGCCGGTGTTCGAATTCAACCCCACCCATCCGCTGATCGAAAAGCT
GGATGCGGAGCAGGATATGGATCGCTTCGGCGACCTGAGCCGTGTGTTGTTCGATCAGGCGGCGCTGGCTGCAGGCGATA
GCCTGAAGGATCCTGCGGCCTATGTGCGGCGGTTGAATAAGTTGTTGTTGGAGTTATCTGCTTAA

Upstream 100 bases:

>100_bases
CGGCACATTCGCGCAGGCCCGCCTTGAAAAATCGGTAGACGGCCGCATCCCCAGGCCATCGGCCGCGTTGCGGCCTGGAC
CACCACGGAGCACGACCCCA

Downstream 100 bases:

>100_bases
TCTTAATCAGCAGCGGTGATATGCAAACAAAGACCGGCCTGATGGCCGGTCTTTGTATTTGAGTATCTTCATGGGCCTTT
AAAAATCATCTGTCTCGCCA

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MTVETDKQTLGFQTEVKQLLQLMIHSLYSNKEIFLRELVSNAADAADKLRFEALVKPELLEGSGELRIRVDYDKDARTVT
IDDNGIGMSREDAVSHLGTIAKSGTADFLKHLSGDQKKDANLIGQFGVGFYSAFIVADQVDVYSRRAGLPASEGVHWSSR
GEGEFEIASVDKPERGTRIVLHLKEGEESFADGWTLRGILKKYSDHIGLPIEMRKEHYGEAADKPAEPEWEAVNRASALW
TRPKSEIKDEEYQEFYKHVAHDAGNPLAWSHNKVEGKLEYTSLLFVPGRAPFDLYHRDSAKGLKLYVQRVFIMDQAEQFL
PLYLRFIKGVVDSSDLSLNVSREILQSGPVVDSMKSALTKRSLDMLEKLAKDKPDDYATFWRNFGQALKEGPAEDYANRE
KIAGLLRFSSTHDTTGAQSVGLADYVGRLADGQDKLYYLTGESYAQIKDSPHLEVFRKKGIEVLLLTDRIDEWLMSYLTE
FDGKSFVDVARGDLDLGKLDSEEDKKAQEEVAKSKEGLASRIKAALGDDVAELRVSHRLTDSPAILAIGQGDLGLQMRQL
LEASGQAVPESKPVFEFNPTHPLIEKLDAEQDMDRFGDLSRVLFDQAALAAGDSLKDPAAYVRRLNKLLLELSA

Sequences:

>Translated_634_residues
MTVETDKQTLGFQTEVKQLLQLMIHSLYSNKEIFLRELVSNAADAADKLRFEALVKPELLEGSGELRIRVDYDKDARTVT
IDDNGIGMSREDAVSHLGTIAKSGTADFLKHLSGDQKKDANLIGQFGVGFYSAFIVADQVDVYSRRAGLPASEGVHWSSR
GEGEFEIASVDKPERGTRIVLHLKEGEESFADGWTLRGILKKYSDHIGLPIEMRKEHYGEAADKPAEPEWEAVNRASALW
TRPKSEIKDEEYQEFYKHVAHDAGNPLAWSHNKVEGKLEYTSLLFVPGRAPFDLYHRDSAKGLKLYVQRVFIMDQAEQFL
PLYLRFIKGVVDSSDLSLNVSREILQSGPVVDSMKSALTKRSLDMLEKLAKDKPDDYATFWRNFGQALKEGPAEDYANRE
KIAGLLRFSSTHDTTGAQSVGLADYVGRLADGQDKLYYLTGESYAQIKDSPHLEVFRKKGIEVLLLTDRIDEWLMSYLTE
FDGKSFVDVARGDLDLGKLDSEEDKKAQEEVAKSKEGLASRIKAALGDDVAELRVSHRLTDSPAILAIGQGDLGLQMRQL
LEASGQAVPESKPVFEFNPTHPLIEKLDAEQDMDRFGDLSRVLFDQAALAAGDSLKDPAAYVRRLNKLLLELSA
>Mature_633_residues
TVETDKQTLGFQTEVKQLLQLMIHSLYSNKEIFLRELVSNAADAADKLRFEALVKPELLEGSGELRIRVDYDKDARTVTI
DDNGIGMSREDAVSHLGTIAKSGTADFLKHLSGDQKKDANLIGQFGVGFYSAFIVADQVDVYSRRAGLPASEGVHWSSRG
EGEFEIASVDKPERGTRIVLHLKEGEESFADGWTLRGILKKYSDHIGLPIEMRKEHYGEAADKPAEPEWEAVNRASALWT
RPKSEIKDEEYQEFYKHVAHDAGNPLAWSHNKVEGKLEYTSLLFVPGRAPFDLYHRDSAKGLKLYVQRVFIMDQAEQFLP
LYLRFIKGVVDSSDLSLNVSREILQSGPVVDSMKSALTKRSLDMLEKLAKDKPDDYATFWRNFGQALKEGPAEDYANREK
IAGLLRFSSTHDTTGAQSVGLADYVGRLADGQDKLYYLTGESYAQIKDSPHLEVFRKKGIEVLLLTDRIDEWLMSYLTEF
DGKSFVDVARGDLDLGKLDSEEDKKAQEEVAKSKEGLASRIKAALGDDVAELRVSHRLTDSPAILAIGQGDLGLQMRQLL
EASGQAVPESKPVFEFNPTHPLIEKLDAEQDMDRFGDLSRVLFDQAALAAGDSLKDPAAYVRRLNKLLLELSA

Specific function: Molecular chaperone. Has ATPase activity

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family

Homologues:

Organism=Homo sapiens, GI4507677, Length=680, Percent_Identity=37.5, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI20149594, Length=682, Percent_Identity=36.5102639296188, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI155722983, Length=633, Percent_Identity=35.2290679304897, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI154146191, Length=410, Percent_Identity=38.0487804878049, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI153792590, Length=410, Percent_Identity=38.0487804878049, Blast_Score=267, Evalue=3e-71,
Organism=Escherichia coli, GI1786679, Length=624, Percent_Identity=59.2948717948718, Blast_Score=773, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559162, Length=668, Percent_Identity=38.1736526946108, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17542208, Length=668, Percent_Identity=35.7784431137725, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI115535205, Length=644, Percent_Identity=33.8509316770186, Blast_Score=331, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI115535167, Length=427, Percent_Identity=36.2997658079625, Blast_Score=268, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6323840, Length=676, Percent_Identity=37.2781065088757, Blast_Score=426, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6325016, Length=209, Percent_Identity=41.1483253588517, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI17647529, Length=685, Percent_Identity=38.5401459854015, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21357739, Length=678, Percent_Identity=36.1356932153392, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24586016, Length=648, Percent_Identity=33.9506172839506, Blast_Score=359, Evalue=3e-99,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): HTPG_XANAC (Q8PJK3)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642843.1
- ProteinModelPortal:   Q8PJK3
- GeneID:   1156599
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2528
- NMPDR:   fig|190486.1.peg.2487
- HOGENOM:   HBG631012
- OMA:   AIYYITA
- ProtClustDB:   PRK05218
- BioCyc:   XAXO190486:XAC2528-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00505
- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.30.565.10
- PANTHER:   PTHR11528
- PIRSF:   PIRSF002583
- PRINTS:   PR00775
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 70783; Mature: 70651

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVETDKQTLGFQTEVKQLLQLMIHSLYSNKEIFLRELVSNAADAADKLRFEALVKPELL
CCCCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
EGSGELRIRVDYDKDARTVTIDDNGIGMSREDAVSHLGTIAKSGTADFLKHLSGDQKKDA
CCCCCEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCH
NLIGQFGVGFYSAFIVADQVDVYSRRAGLPASEGVHWSSRGEGEFEIASVDKPERGTRIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEE
LHLKEGEESFADGWTLRGILKKYSDHIGLPIEMRKEHYGEAADKPAEPEWEAVNRASALW
EEEECCCHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
TRPKSEIKDEEYQEFYKHVAHDAGNPLAWSHNKVEGKLEYTSLLFVPGRAPFDLYHRDSA
CCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHCCCCC
KGLKLYVQRVFIMDQAEQFLPLYLRFIKGVVDSSDLSLNVSREILQSGPVVDSMKSALTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCHHHHHHHHHH
RSLDMLEKLAKDKPDDYATFWRNFGQALKEGPAEDYANREKIAGLLRFSSTHDTTGAQSV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCC
GLADYVGRLADGQDKLYYLTGESYAQIKDSPHLEVFRKKGIEVLLLTDRIDEWLMSYLTE
CHHHHHHHHCCCCCCEEEEECCCHHHCCCCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHH
FDGKSFVDVARGDLDLGKLDSEEDKKAQEEVAKSKEGLASRIKAALGDDVAELRVSHRLT
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
DSPAILAIGQGDLGLQMRQLLEASGQAVPESKPVFEFNPTHPLIEKLDAEQDMDRFGDLS
CCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHCCHHHHHHHHHHH
RVLFDQAALAAGDSLKDPAAYVRRLNKLLLELSA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVETDKQTLGFQTEVKQLLQLMIHSLYSNKEIFLRELVSNAADAADKLRFEALVKPELL
CCCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
EGSGELRIRVDYDKDARTVTIDDNGIGMSREDAVSHLGTIAKSGTADFLKHLSGDQKKDA
CCCCCEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCH
NLIGQFGVGFYSAFIVADQVDVYSRRAGLPASEGVHWSSRGEGEFEIASVDKPERGTRIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEE
LHLKEGEESFADGWTLRGILKKYSDHIGLPIEMRKEHYGEAADKPAEPEWEAVNRASALW
EEEECCCHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
TRPKSEIKDEEYQEFYKHVAHDAGNPLAWSHNKVEGKLEYTSLLFVPGRAPFDLYHRDSA
CCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHCCCCC
KGLKLYVQRVFIMDQAEQFLPLYLRFIKGVVDSSDLSLNVSREILQSGPVVDSMKSALTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCHHHHHHHHHH
RSLDMLEKLAKDKPDDYATFWRNFGQALKEGPAEDYANREKIAGLLRFSSTHDTTGAQSV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCC
GLADYVGRLADGQDKLYYLTGESYAQIKDSPHLEVFRKKGIEVLLLTDRIDEWLMSYLTE
CHHHHHHHHCCCCCCEEEEECCCHHHCCCCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHH
FDGKSFVDVARGDLDLGKLDSEEDKKAQEEVAKSKEGLASRIKAALGDDVAELRVSHRLT
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
DSPAILAIGQGDLGLQMRQLLEASGQAVPESKPVFEFNPTHPLIEKLDAEQDMDRFGDLS
CCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHCCHHHHHHHHHHH
RVLFDQAALAAGDSLKDPAAYVRRLNKLLLELSA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217