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The map label for this gene is argD [H]

Identifier: 21243249

GI number: 21243249

Start: 2945218

End: 2946714

Strand: Direct

Name: argD [H]

Synonym: XAC2516

Alternate gene names: 21243249

Gene position: 2945218-2946714 (Clockwise)

Preceding gene: 21243237

Following gene: 21243254

Centisome position: 56.91

GC content: 67.27

Gene sequence:

>1497_bases
ATGTCCGTCCTTGCCCCGCTCGCCCCGCTGCGTGCCCATAGCGGCCGCCGCCTGACCGAAGGCCTGGACGACGCGACCAT
CGCGCGGCTGGCCGTCAGCCACCCTGACCTGCAGCAGGCCATCCATGCAGCGGCAGCCGAATACGCGCTGGTGCGCGATG
ACGCCGCCGACCTGCTGGACCTGGACGAAGAGGCGCAGATCGGCGCAGTGCAGGAAGGTTTCATCAATTTCTACGCCGAC
GATGCAGTGACGCCTTACGTGGCACTGGCCGCACGCGGACCATGGGTGGTCACGCTCAAGGGCGCGGTGCTCTACGACGC
CGGCGGCTACGGCATGCTCGGCTTCGGCCATACGCCGGCCGCGGTGCTCGAGGCCATGGCGCGCCCGCAGGTGATGGCGA
ACGTGATGACGCCCAGCCTGGCGCAACGCCGGCTCGATCGCGCCCTGCGTGCCGAGATCGGCCGCAGCCGCGGCGGCTGC
CCGTTCGCACGCTTCATGTGTCTCAATTCCGGCTCCGAAGCGGTGGGCCTGGCCGCCCGCATCGTCGATACCAACGCCAA
GCTGCACACCGACCCCGGCGCGCGGCACGCCGGTGCCACCATCAAGCGCCTGGTGGTCAAGGGCAGCTTCCATGGCCGCA
CCGATCGCCCGGGCCTGTATTCCGATTCCAGTCGCAAGACCTATACCAAATACCTGGCCAGCTATCGCGACGAGGATTCG
GTCATCGCGATCGCCCCGTACGACGTGGCCGCATTGCAACGCGCCTTCGATGAGGCCGCGCGCAATCACTGGTTTATCGA
AGCGGTATTCCTGGAGCCGGTGATGGGCGAAGGCGACCCGGGGCGTGCGTTGCCGGCCGAGTTCTACGCCGCCGCGCGCG
CGCTCACCCGTACCCATGGCAGCCTGTTGCTGGTCGATTCCATCCAGGCCGGGCTGCGCGCGCATGGCGTGCTCTCGGTG
GTGGACTACCCGGGGTTCGAGCAGCTCGACCCGCCGGATCTGGAGACCTATTCCAAGGCGCTCAACGCGGCCCAGTACCC
GCTGTCGGTGCTGGCGGTGACCGAACACGCCGCGCAGGTGTATCGCAAGGGCACCTACGGCAACACCATGACCACCAACC
CACGCGCGCTCGATGTGGCCTGCGCCACGTTGGCCTTGTTCACGCCGCAGGTGCGCGACAACATCCGCATCCGCGGTGCG
CAGGCGATTGCCAAGCTGGAAGCGCTGCAGGCCGAACTCGGCGGCTTGATCACCAAGGTGCAAGGCACCGGCCTGTTGTT
CTCCTGCGAACTTGCACCGCAATTCAAGTGCTACGGCGCCGGTTCCACCGAGGAGTGGTTGCGCCATCGCGGCGTCAACG
TGATCCACGGCGGCGAGAATTCGCTGCGCTTCACTCCGCATTTTGCGATGGATGAAGACGAGCTCGATCTGCTGGTCGGC
TTGATCGCGCGTGCGCTCAAGGAAGGCCCACGCCAGGTGCAGGCCGAGGCGGCCTGA

Upstream 100 bases:

>100_bases
ATCGCCGAAAATATCGTACTTCTTGCCCAGATTCACGCTGCCAAACGCCGATCTTCTGCCGATAATAGGAAGGGAACGCC
ACCTTTGAAGGAGATGCGCC

Downstream 100 bases:

>100_bases
TTCGCTCAACGCGGCATGCCGGCGCGTATGGCGTCGGTGTGCTGCAGATGGCTGATAGGTCTGCTACCAGTTCTCTGCGG
TGTGCCTTGGAACCCTGATC

Product: L-lysine 6-aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSVLAPLAPLRAHSGRRLTEGLDDATIARLAVSHPDLQQAIHAAAAEYALVRDDAADLLDLDEEAQIGAVQEGFINFYAD
DAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPAAVLEAMARPQVMANVMTPSLAQRRLDRALRAEIGRSRGGC
PFARFMCLNSGSEAVGLAARIVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDS
VIAIAPYDVAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARALTRTHGSLLLVDSIQAGLRAHGVLSV
VDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEHAAQVYRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRIRGA
QAIAKLEALQAELGGLITKVQGTGLLFSCELAPQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVG
LIARALKEGPRQVQAEAA

Sequences:

>Translated_498_residues
MSVLAPLAPLRAHSGRRLTEGLDDATIARLAVSHPDLQQAIHAAAAEYALVRDDAADLLDLDEEAQIGAVQEGFINFYAD
DAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPAAVLEAMARPQVMANVMTPSLAQRRLDRALRAEIGRSRGGC
PFARFMCLNSGSEAVGLAARIVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDS
VIAIAPYDVAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARALTRTHGSLLLVDSIQAGLRAHGVLSV
VDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEHAAQVYRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRIRGA
QAIAKLEALQAELGGLITKVQGTGLLFSCELAPQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVG
LIARALKEGPRQVQAEAA
>Mature_497_residues
SVLAPLAPLRAHSGRRLTEGLDDATIARLAVSHPDLQQAIHAAAAEYALVRDDAADLLDLDEEAQIGAVQEGFINFYADD
AVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPAAVLEAMARPQVMANVMTPSLAQRRLDRALRAEIGRSRGGCP
FARFMCLNSGSEAVGLAARIVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDSV
IAIAPYDVAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARALTRTHGSLLLVDSIQAGLRAHGVLSVV
DYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEHAAQVYRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRIRGAQ
AIAKLEALQAELGGLITKVQGTGLLFSCELAPQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVGL
IARALKEGPRQVQAEAA

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=401, Percent_Identity=25.1870324189526, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI284507298, Length=336, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789759, Length=402, Percent_Identity=26.865671641791, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788044, Length=321, Percent_Identity=29.595015576324, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI145693181, Length=408, Percent_Identity=24.5098039215686, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17541228, Length=247, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=26.5060240963855, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 53570; Mature: 53439

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLAPLAPLRAHSGRRLTEGLDDATIARLAVSHPDLQQAIHAAAAEYALVRDDAADLLD
CCCCCCCCHHHHCCCCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHECCCHHHHHC
LDEEAQIGAVQEGFINFYADDAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPA
CCCCCCCCHHHHHHHHEEECCCCCCCEEEECCCCEEEEEECEEEEECCCCCCCCCCCCHH
AVLEAMARPQVMANVMTPSLAQRRLDRALRAEIGRSRGGCPFARFMCLNSGSEAVGLAAR
HHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCCHHEEEEE
IVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDS
EEECCCEEECCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
VIAIAPYDVAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARALTRTHG
EEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SLLLVDSIQAGLRAHGVLSVVDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEHAAQV
CEEEEECHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
YRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRIRGAQAIAKLEALQAELGGLITKV
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCEEEEHHHHHHHHHHHHHHHCHHEEEE
QGTGLLFSCELAPQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVG
ECCCEEEEECCCCCEEEECCCCHHHHHHHCCCEEEECCCCCEEECCCCCCCCHHHHHHHH
LIARALKEGPRQVQAEAA
HHHHHHHCCCHHHHCCCC
>Mature Secondary Structure 
SVLAPLAPLRAHSGRRLTEGLDDATIARLAVSHPDLQQAIHAAAAEYALVRDDAADLLD
CCCCCCCHHHHCCCCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHECCCHHHHHC
LDEEAQIGAVQEGFINFYADDAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPA
CCCCCCCCHHHHHHHHEEECCCCCCCEEEECCCCEEEEEECEEEEECCCCCCCCCCCCHH
AVLEAMARPQVMANVMTPSLAQRRLDRALRAEIGRSRGGCPFARFMCLNSGSEAVGLAAR
HHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCCHHEEEEE
IVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDS
EEECCCEEECCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
VIAIAPYDVAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARALTRTHG
EEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SLLLVDSIQAGLRAHGVLSVVDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEHAAQV
CEEEEECHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
YRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRIRGAQAIAKLEALQAELGGLITKV
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCEEEEHHHHHHHHHHHHHHHCHHEEEE
QGTGLLFSCELAPQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVG
ECCCEEEEECCCCCEEEECCCCHHHHHHHCCCEEEECCCCCEEECCCCCCCCHHHHHHHH
LIARALKEGPRQVQAEAA
HHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]