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The map label for this gene is rmrB [H]

Identifier: 21243207

GI number: 21243207

Start: 2879476

End: 2881062

Strand: Reverse

Name: rmrB [H]

Synonym: XAC2474

Alternate gene names: 21243207

Gene position: 2881062-2879476 (Counterclockwise)

Preceding gene: 21243208

Following gene: 21243206

Centisome position: 55.67

GC content: 65.41

Gene sequence:

>1587_bases
ATGAGTGCAGCGGCCGCCACCGGCCCGCGTGCCGGCGGCAGCGCCCAGCGCGAGAAGGCCGAGCCGGGCGCCTGGCTGGC
GGTGCTGGCCGGCACCATCGGCTCGTTCATGGCGACGCTGGATATTTCCATCGTCAATGCCGCGCTGCCCACCATCCAGG
GCGAGGTCGGCGCCAGCGGCACCGAAGGTACCTGGATTTCCACCGCCTACCTGGTGGCCGAGATCATCATGATCCCGCTG
ACCGGCTGGTTCGTGCGCACGCTGGGCCTGCGCAATTTCCTGCTGATCTGTGCGGTGATGTTCACCGCGTTCTCGGTGGT
GTGCGGGCTGTCGACGTCGCTGTCGATGATGATCATCGGCCGCGTCGGACAAGGCCTGGCCGGCGGCGCCTTGATTCCGA
CCGCGCTGACCATCGTCGCCACGCGGTTGCCGCCCAGCCAGCAGACCATGGGCACCGCCTTGTTTGGCATGACCGTGATC
ATGGGTCCGGTGATCGGCCCGCTGCTCGGCGGCTGGCTGACCGAAAACGTCAGCTGGCACTACGCGTTTTTCATCAACGT
GCCGATCTGCGTTGGCCTGGTCGCGTTGCTGCTGCTCGGTCTCAAACACGAAAAGGGCGACTGGGCAGGCCTGCTCAACG
CCGATTGGCTGGGCATCTACGGCTTGACCGCGGGTCTGGGCGGGCTGACCGTGGTGCTGGAAGAAGGCCAGCGCGAGCGC
TGGTTCGAGTCCAGCGAGATCAATACCCTGAGCCTGATTGCGTTGAGCGGATTCATTGCGCTGGTGATCAGCCAGTTCCG
GCGGCGCCCTCCGGTGATCCGCCTGTCGCTGCTGCTGCAGCGCAGCTTCGGCGCGGTCTTCATCATGGTCATGGCGGTGG
GCATGATCCTGTTCGGCGTCATGTACATGATTCCGCAGTTCCTGGCAGTGATCTCCGGCTACAACACCGAGCAGGCCGGA
TACGTGCTGCTGCTGTCCGGCCTGCCGACCGTGTTGCTGATGCCGATGATGCCCAAGCTGCTGGAAACGGTGGACGTGCG
CATCTTGGTCATTGCCGGGCTGATCTGCTTTGCCGCTGCCTGTTTCGTCAATCTGTCGCTCACTGCCGACACCGTGGGCA
CGCACTTCGTCGCCGGGCAGCTGCTGCAGGGCTGCGGCCTGGCGTTGGCGATGATGTCGCTCAACCAGGCGGCGATTTCG
TCGGTGCCGCCGGAACTGGCAGGCGATGCCTCGGGCCTGTTCAATGCCGGCCGCAACCTGGGCGGCTCGGTCGGGCTGGC
GCTGATCTCCACCTTTCAGGAGCGCCGCATGACCTTCCACACCGAAACCATCGGCAGTTCGATCACCGCCAACGCCAGCC
GTGCGCAGGAGGCGCTGGCCGGCCTGACCGCACAGATGCAGGGCAGTGCCGGCGGCGAGGCGGCGGCCCGCTCGATCGCC
CAGTTCGCCCGCGTCGTGCAACAGCAGGCCCTGGTGATGACCTATAGCGATCTGTTCTGGATCTTCGGCGTGATCGTGGT
CTGCACGATTCCGCTGGCCTTTTTGCTCAAGCCGTTACCCAAGGGGGCGCACCTTGCAATGCACTGA

Upstream 100 bases:

>100_bases
GCATGTCGGTGGAAGTCACTGTCGACACGCGCTCGGCCAAGGACGCCAAGCAGCGTGCCGAACAAGAATCCGACCGCGTG
CAGGAGCAGGAGCGCGCGCG

Downstream 100 bases:

>100_bases
TTCCATGCGCCTGATCCGCATGCCGCTGGCTGCGGCGTTGAGTACGCTGCTGCTTGGCGGCTGCATGCTCGGCCCCAACT
ACACCAAGCCGCCAGCGGTT

Product: transport protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSAAAATGPRAGGSAQREKAEPGAWLAVLAGTIGSFMATLDISIVNAALPTIQGEVGASGTEGTWISTAYLVAEIIMIPL
TGWFVRTLGLRNFLLICAVMFTAFSVVCGLSTSLSMMIIGRVGQGLAGGALIPTALTIVATRLPPSQQTMGTALFGMTVI
MGPVIGPLLGGWLTENVSWHYAFFINVPICVGLVALLLLGLKHEKGDWAGLLNADWLGIYGLTAGLGGLTVVLEEGQRER
WFESSEINTLSLIALSGFIALVISQFRRRPPVIRLSLLLQRSFGAVFIMVMAVGMILFGVMYMIPQFLAVISGYNTEQAG
YVLLLSGLPTVLLMPMMPKLLETVDVRILVIAGLICFAAACFVNLSLTADTVGTHFVAGQLLQGCGLALAMMSLNQAAIS
SVPPELAGDASGLFNAGRNLGGSVGLALISTFQERRMTFHTETIGSSITANASRAQEALAGLTAQMQGSAGGEAAARSIA
QFARVVQQQALVMTYSDLFWIFGVIVVCTIPLAFLLKPLPKGAHLAMH

Sequences:

>Translated_528_residues
MSAAAATGPRAGGSAQREKAEPGAWLAVLAGTIGSFMATLDISIVNAALPTIQGEVGASGTEGTWISTAYLVAEIIMIPL
TGWFVRTLGLRNFLLICAVMFTAFSVVCGLSTSLSMMIIGRVGQGLAGGALIPTALTIVATRLPPSQQTMGTALFGMTVI
MGPVIGPLLGGWLTENVSWHYAFFINVPICVGLVALLLLGLKHEKGDWAGLLNADWLGIYGLTAGLGGLTVVLEEGQRER
WFESSEINTLSLIALSGFIALVISQFRRRPPVIRLSLLLQRSFGAVFIMVMAVGMILFGVMYMIPQFLAVISGYNTEQAG
YVLLLSGLPTVLLMPMMPKLLETVDVRILVIAGLICFAAACFVNLSLTADTVGTHFVAGQLLQGCGLALAMMSLNQAAIS
SVPPELAGDASGLFNAGRNLGGSVGLALISTFQERRMTFHTETIGSSITANASRAQEALAGLTAQMQGSAGGEAAARSIA
QFARVVQQQALVMTYSDLFWIFGVIVVCTIPLAFLLKPLPKGAHLAMH
>Mature_527_residues
SAAAATGPRAGGSAQREKAEPGAWLAVLAGTIGSFMATLDISIVNAALPTIQGEVGASGTEGTWISTAYLVAEIIMIPLT
GWFVRTLGLRNFLLICAVMFTAFSVVCGLSTSLSMMIIGRVGQGLAGGALIPTALTIVATRLPPSQQTMGTALFGMTVIM
GPVIGPLLGGWLTENVSWHYAFFINVPICVGLVALLLLGLKHEKGDWAGLLNADWLGIYGLTAGLGGLTVVLEEGQRERW
FESSEINTLSLIALSGFIALVISQFRRRPPVIRLSLLLQRSFGAVFIMVMAVGMILFGVMYMIPQFLAVISGYNTEQAGY
VLLLSGLPTVLLMPMMPKLLETVDVRILVIAGLICFAAACFVNLSLTADTVGTHFVAGQLLQGCGLALAMMSLNQAAISS
VPPELAGDASGLFNAGRNLGGSVGLALISTFQERRMTFHTETIGSSITANASRAQEALAGLTAQMQGSAGGEAAARSIAQ
FARVVQQQALVMTYSDLFWIFGVIVVCTIPLAFLLKPLPKGAHLAMH

Specific function: Translocase that confers resistance to substances of high hydrophobicity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=508, Percent_Identity=32.0866141732283, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1788710, Length=497, Percent_Identity=30.5835010060362, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1790195, Length=352, Percent_Identity=28.6931818181818, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87081983, Length=427, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788392, Length=411, Percent_Identity=25.3041362530414, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322958, Length=203, Percent_Identity=26.6009852216749, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321663, Length=149, Percent_Identity=29.5302013422819, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=167, Percent_Identity=26.9461077844311, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55483; Mature: 55351

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAAATGPRAGGSAQREKAEPGAWLAVLAGTIGSFMATLDISIVNAALPTIQGEVGASG
CCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TEGTWISTAYLVAEIIMIPLTGWFVRTLGLRNFLLICAVMFTAFSVVCGLSTSLSMMIIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RVGQGLAGGALIPTALTIVATRLPPSQQTMGTALFGMTVIMGPVIGPLLGGWLTENVSWH
HHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YAFFINVPICVGLVALLLLGLKHEKGDWAGLLNADWLGIYGLTAGLGGLTVVLEEGQRER
EEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHH
WFESSEINTLSLIALSGFIALVISQFRRRPPVIRLSLLLQRSFGAVFIMVMAVGMILFGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYMIPQFLAVISGYNTEQAGYVLLLSGLPTVLLMPMMPKLLETVDVRILVIAGLICFAAA
HHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CFVNLSLTADTVGTHFVAGQLLQGCGLALAMMSLNQAAISSVPPELAGDASGLFNAGRNL
HHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHCCCC
GGSVGLALISTFQERRMTFHTETIGSSITANASRAQEALAGLTAQMQGSAGGEAAARSIA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QFARVVQQQALVMTYSDLFWIFGVIVVCTIPLAFLLKPLPKGAHLAMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SAAAATGPRAGGSAQREKAEPGAWLAVLAGTIGSFMATLDISIVNAALPTIQGEVGASG
CCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TEGTWISTAYLVAEIIMIPLTGWFVRTLGLRNFLLICAVMFTAFSVVCGLSTSLSMMIIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RVGQGLAGGALIPTALTIVATRLPPSQQTMGTALFGMTVIMGPVIGPLLGGWLTENVSWH
HHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YAFFINVPICVGLVALLLLGLKHEKGDWAGLLNADWLGIYGLTAGLGGLTVVLEEGQRER
EEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHH
WFESSEINTLSLIALSGFIALVISQFRRRPPVIRLSLLLQRSFGAVFIMVMAVGMILFGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYMIPQFLAVISGYNTEQAGYVLLLSGLPTVLLMPMMPKLLETVDVRILVIAGLICFAAA
HHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CFVNLSLTADTVGTHFVAGQLLQGCGLALAMMSLNQAAISSVPPELAGDASGLFNAGRNL
HHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHCCCC
GGSVGLALISTFQERRMTFHTETIGSSITANASRAQEALAGLTAQMQGSAGGEAAARSIA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QFARVVQQQALVMTYSDLFWIFGVIVVCTIPLAFLLKPLPKGAHLAMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]