Click here to switch to the map view.

The map label for this gene is rmrA [H]

Identifier: 21243208

GI number: 21243208

Start: 2881059

End: 2882261

Strand: Reverse

Name: rmrA [H]

Synonym: XAC2475

Alternate gene names: 21243208

Gene position: 2882261-2881059 (Counterclockwise)

Preceding gene: 21243209

Following gene: 21243207

Centisome position: 55.69

GC content: 67.0

Gene sequence:

>1203_bases
TTGAGCAACCACGACCATCAGTCCAATGACGGCCAGTCCTCGGCCACGGATGCGCAGGGCGCAGGCGCGCGCGGCGAGCA
GGAGCCGCCCAAACCCTCGCCGTTGAAGAACCCCAAGGTGAAGTGGACGCTGATCCTGGTCGGGGTGCTGGTGCTGATCC
TGCTGGTGGTGTGGGTGGCCTATTACCTGATCAAGGGCCGCTACATGCAGGACACCAACAACGCCTATCTGCAGGCCGAT
TCGGTGGCCGTGGCACCGCGCGTCAGCGGCTACGTGACCAAGGTGCTGGTGAGCGACAACCAGATCGTGGAGGCTGGCCA
GCCGCTGCTGCAGATCGACGACCGCACCTACCAGGCCACGCTGCAGCAGGCCGAAGCCGCCATTGCCGCACGCCAGGCCG
ATATCGTCGCGGCCACCGCCAATGTCTCCGCACAGGAATCGGCGCTGCTGCAGGCGCGCACCCAGGTCACCGCAGCTGCT
GCCAGCCTCAAGTTCGCCCAGGCCGAAGTGAAGCGCTTCGCGCCGTTGGCCGCCTCCGGTGCAGACACCCACGAACATCA
GGAAAGCCTGCAGCACGATCTGGCACGCGCACGCGCCCAGTACGACGCCGCGCAGGCGCAGGCCAAGGCCGGCGAGAGCC
AGATCCAGGCCAGCCGCGCGCAACTGGAACAGGCACAGGCCGGCGTGAAACAGGCCACCGCCGATGCCGACCAGGCGCGC
GTGGCGGTGGAAGACACCCGTCTGACCAGCCGTATCCACGGCCGGGTTGGCGACAAGACCGTGCAGGTGGGCCAGTTCCT
CGGCGCCGGCACCCGCACCATGACCATCGTGCCGCAGGAATCGCTGTATCTGGTTGCCAATTTCAAGGAAACCCAGGTCG
GCCTGATGCGTCCCGGCCAGCCGGCCGAGATCGAGGTCGATGCGCTTTCGGGCGTAAAACTGCACGGCAAAGTCGAGAGC
CTGTCGCCGGGCACCGGCTCGCAGTTCGCGTTGCTGCCGCCGGAAAATGCCACCGGCAATTTCACCAAGGTGGTCCAGCG
CGTGCCGGTGCGCATCCGTGTGCTGGCCGGTGACGAGGCGCGCAAGGTGCTGGTGCCGGGCATGTCGGTGGAAGTCACTG
TCGACACGCGCTCGGCCAAGGACGCCAAGCAGCGTGCCGAACAAGAATCCGACCGCGTGCAGGAGCAGGAGCGCGCGCGA
TGA

Upstream 100 bases:

>100_bases
CCGGGCAGTTCAAATAATTGTATGGTTGCGCCGCCACTGCCGACGCCGCCGAGACGGCCGCTGCCTGGCGCGCCTCGCCC
ATCACACAGGACGCATCCTT

Downstream 100 bases:

>100_bases
GTGCAGCGGCCGCCACCGGCCCGCGTGCCGGCGGCAGCGCCCAGCGCGAGAAGGCCGAGCCGGGCGCCTGGCTGGCGGTG
CTGGCCGGCACCATCGGCTC

Product: transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSNHDHQSNDGQSSATDAQGAGARGEQEPPKPSPLKNPKVKWTLILVGVLVLILLVVWVAYYLIKGRYMQDTNNAYLQAD
SVAVAPRVSGYVTKVLVSDNQIVEAGQPLLQIDDRTYQATLQQAEAAIAARQADIVAATANVSAQESALLQARTQVTAAA
ASLKFAQAEVKRFAPLAASGADTHEHQESLQHDLARARAQYDAAQAQAKAGESQIQASRAQLEQAQAGVKQATADADQAR
VAVEDTRLTSRIHGRVGDKTVQVGQFLGAGTRTMTIVPQESLYLVANFKETQVGLMRPGQPAEIEVDALSGVKLHGKVES
LSPGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGDEARKVLVPGMSVEVTVDTRSAKDAKQRAEQESDRVQEQERAR

Sequences:

>Translated_400_residues
MSNHDHQSNDGQSSATDAQGAGARGEQEPPKPSPLKNPKVKWTLILVGVLVLILLVVWVAYYLIKGRYMQDTNNAYLQAD
SVAVAPRVSGYVTKVLVSDNQIVEAGQPLLQIDDRTYQATLQQAEAAIAARQADIVAATANVSAQESALLQARTQVTAAA
ASLKFAQAEVKRFAPLAASGADTHEHQESLQHDLARARAQYDAAQAQAKAGESQIQASRAQLEQAQAGVKQATADADQAR
VAVEDTRLTSRIHGRVGDKTVQVGQFLGAGTRTMTIVPQESLYLVANFKETQVGLMRPGQPAEIEVDALSGVKLHGKVES
LSPGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGDEARKVLVPGMSVEVTVDTRSAKDAKQRAEQESDRVQEQERAR
>Mature_399_residues
SNHDHQSNDGQSSATDAQGAGARGEQEPPKPSPLKNPKVKWTLILVGVLVLILLVVWVAYYLIKGRYMQDTNNAYLQADS
VAVAPRVSGYVTKVLVSDNQIVEAGQPLLQIDDRTYQATLQQAEAAIAARQADIVAATANVSAQESALLQARTQVTAAAA
SLKFAQAEVKRFAPLAASGADTHEHQESLQHDLARARAQYDAAQAQAKAGESQIQASRAQLEQAQAGVKQATADADQARV
AVEDTRLTSRIHGRVGDKTVQVGQFLGAGTRTMTIVPQESLYLVANFKETQVGLMRPGQPAEIEVDALSGVKLHGKVESL
SPGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGDEARKVLVPGMSVEVTVDTRSAKDAKQRAEQESDRVQEQERAR

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=357, Percent_Identity=34.1736694677871, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1788711, Length=338, Percent_Identity=30.4733727810651, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1790519, Length=291, Percent_Identity=34.020618556701, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1789637, Length=350, Percent_Identity=27.4285714285714, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081951, Length=333, Percent_Identity=25.2252252252252, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790024, Length=300, Percent_Identity=26.3333333333333, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789900, Length=310, Percent_Identity=25.1612903225806, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790012, Length=300, Percent_Identity=26.3333333333333, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42906; Mature: 42774

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHDHQSNDGQSSATDAQGAGARGEQEPPKPSPLKNPKVKWTLILVGVLVLILLVVWVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
YYLIKGRYMQDTNNAYLQADSVAVAPRVSGYVTKVLVSDNQIVEAGQPLLQIDDRTYQAT
HHHHCCCEEECCCCCEEEECCEEECCCCCCEEEEEEECCCCEECCCCCEEEECCHHHHHH
LQQAEAAIAARQADIVAATANVSAQESALLQARTQVTAAAASLKFAQAEVKRFAPLAASG
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ADTHEHQESLQHDLARARAQYDAAQAQAKAGESQIQASRAQLEQAQAGVKQATADADQAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHE
VAVEDTRLTSRIHGRVGDKTVQVGQFLGAGTRTMTIVPQESLYLVANFKETQVGLMRPGQ
EEEHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCEEECCCCCC
PAEIEVDALSGVKLHGKVESLSPGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGDEA
CCEEEEEECCCEEEECEECCCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEEECCCC
RKVLVPGMSVEVTVDTRSAKDAKQRAEQESDRVQEQERAR
CEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNHDHQSNDGQSSATDAQGAGARGEQEPPKPSPLKNPKVKWTLILVGVLVLILLVVWVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
YYLIKGRYMQDTNNAYLQADSVAVAPRVSGYVTKVLVSDNQIVEAGQPLLQIDDRTYQAT
HHHHCCCEEECCCCCEEEECCEEECCCCCCEEEEEEECCCCEECCCCCEEEECCHHHHHH
LQQAEAAIAARQADIVAATANVSAQESALLQARTQVTAAAASLKFAQAEVKRFAPLAASG
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ADTHEHQESLQHDLARARAQYDAAQAQAKAGESQIQASRAQLEQAQAGVKQATADADQAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHE
VAVEDTRLTSRIHGRVGDKTVQVGQFLGAGTRTMTIVPQESLYLVANFKETQVGLMRPGQ
EEEHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCEEECCCCCC
PAEIEVDALSGVKLHGKVESLSPGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGDEA
CCEEEEEECCCEEEECEECCCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEEECCCC
RKVLVPGMSVEVTVDTRSAKDAKQRAEQESDRVQEQERAR
CEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]