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The map label for this gene is truD

Identifier: 21242472

GI number: 21242472

Start: 1983853

End: 1984962

Strand: Direct

Name: truD

Synonym: XAC1723

Alternate gene names: 21242472

Gene position: 1983853-1984962 (Clockwise)

Preceding gene: 21242471

Following gene: 21242474

Centisome position: 38.33

GC content: 66.67

Gene sequence:

>1110_bases
ATGAGCGAGACCTCTTTGCTGCCGCGTGCGCATGGCGCCGCGGTGCTCAGCGCGGCGATGCGCAGCACCCCGGACGATTT
TCAGGTCGACGAGCTGCCGGCATTCGAACCCTCCGGCGAAGGCGAGCATCTGCTGCTCACCGTGCGCAAGCGTGGCCAGA
ACACGGCCTATATCGCCAAAAAGCTCGCGCACTGGGCCGGCATCGCCGAGATGGGCGTCAGCTATGCGGGTCTGAAAGAT
CGCCATGCAGTGACCACCCAGCGCTTCAGCGTGCATCTGCCCAGGCGCATCGCGCCGGATATCGCCGCGCTGGATGATAC
GCAGATGCAGGTGGTCGAGAGCAGTTGGCACAATCGCAAGCTGCAGCGCGGTGCGCTGCATGGGAACCGCTTCGTGCTGA
CGCTGCGCCAGGTGCAGGGCGAGCGCGATGCGATCGAGCAGCGGCTGCAGGCGATTGCTGCGCGTGGCATCCCCAATTGG
TTCGGCGAACAACGTTTCGGTCGCGATGGCGGAAATGTGGCGGCTGCGCTGGCGATGTTCGGTCATGTGCAAGCTGACGA
CGGAACCTTGCTGCCGGCGCCCACATCCAGGCGGCGGCTACGCCACGATCAGCGCTCGATGTTGCTGTCGGCAGCGCGCT
CGGCCTTGTTCAATCGCGTGCTCGGCGCACGCGTGGCGCAGGGGAGTTGGGATGGCGCACTGGAGGGCGAGGCGTGGATG
CTGGACGGCTCGCGCAGCGTCTTCGGCCCGGAGCCGTGGAGCGAGGCCTTGGCCGAGCGACTGGCGCGTTTCGATATCCA
TCCCAGTGGCCCGTTGTGGGGCGCTGGCCAGTTGCGCTCGACCGACCAAGCGGCAGCGGTGGAGCAGGGCGCATTGTCCG
ACCCGCCATCCATCGCATTGCGCCAAGGCCTGGAAGCTGCGGGATTGAAGCAGGAACGCCGCGCCCTGCGCTTGCGTCCG
CACGGTCTGGAGTATCAATGGCTGGAGCCGCAGACCCTGCAGCTCGCCTTCGCGCTGCCGCCCGGTTGCTATGCCACCGC
AGTGCTGTGGGAATTGGGAGATGTCGCCGACGCCGGTCGCTTCAACGTCGACGTACGCGCCGATGCGTGA

Upstream 100 bases:

>100_bases
CGCTTGGCGCCGGAGCGGCGCCGATGCTGCCCGATGCAATCACCGCGCCGAACCACCCGGCGCACAGCGCGCCACCTCCG
GCGCGAAGGCGAACCACACC

Downstream 100 bases:

>100_bases
TCGCGTGCGGGTGCTGGTCGATCTGCGCGGGACAGCATGTGACGGCCCAATCTTGCTGTGCGCGCAGGAGCGGCCTTGGC
GGTCGCTGAGGCGATAGTGG

Product: tRNA pseudouridine synthase D

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSETSLLPRAHGAAVLSAAMRSTPDDFQVDELPAFEPSGEGEHLLLTVRKRGQNTAYIAKKLAHWAGIAEMGVSYAGLKD
RHAVTTQRFSVHLPRRIAPDIAALDDTQMQVVESSWHNRKLQRGALHGNRFVLTLRQVQGERDAIEQRLQAIAARGIPNW
FGEQRFGRDGGNVAAALAMFGHVQADDGTLLPAPTSRRRLRHDQRSMLLSAARSALFNRVLGARVAQGSWDGALEGEAWM
LDGSRSVFGPEPWSEALAERLARFDIHPSGPLWGAGQLRSTDQAAAVEQGALSDPPSIALRQGLEAAGLKQERRALRLRP
HGLEYQWLEPQTLQLAFALPPGCYATAVLWELGDVADAGRFNVDVRADA

Sequences:

>Translated_369_residues
MSETSLLPRAHGAAVLSAAMRSTPDDFQVDELPAFEPSGEGEHLLLTVRKRGQNTAYIAKKLAHWAGIAEMGVSYAGLKD
RHAVTTQRFSVHLPRRIAPDIAALDDTQMQVVESSWHNRKLQRGALHGNRFVLTLRQVQGERDAIEQRLQAIAARGIPNW
FGEQRFGRDGGNVAAALAMFGHVQADDGTLLPAPTSRRRLRHDQRSMLLSAARSALFNRVLGARVAQGSWDGALEGEAWM
LDGSRSVFGPEPWSEALAERLARFDIHPSGPLWGAGQLRSTDQAAAVEQGALSDPPSIALRQGLEAAGLKQERRALRLRP
HGLEYQWLEPQTLQLAFALPPGCYATAVLWELGDVADAGRFNVDVRADA
>Mature_368_residues
SETSLLPRAHGAAVLSAAMRSTPDDFQVDELPAFEPSGEGEHLLLTVRKRGQNTAYIAKKLAHWAGIAEMGVSYAGLKDR
HAVTTQRFSVHLPRRIAPDIAALDDTQMQVVESSWHNRKLQRGALHGNRFVLTLRQVQGERDAIEQRLQAIAARGIPNWF
GEQRFGRDGGNVAAALAMFGHVQADDGTLLPAPTSRRRLRHDQRSMLLSAARSALFNRVLGARVAQGSWDGALEGEAWML
DGSRSVFGPEPWSEALAERLARFDIHPSGPLWGAGQLRSTDQAAAVEQGALSDPPSIALRQGLEAAGLKQERRALRLRPH
GLEYQWLEPQTLQLAFALPPGCYATAVLWELGDVADAGRFNVDVRADA

Specific function: Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain

Homologues:

Organism=Escherichia coli, GI1789102, Length=358, Percent_Identity=37.1508379888268, Blast_Score=202, Evalue=3e-53,
Organism=Drosophila melanogaster, GI21355799, Length=148, Percent_Identity=32.4324324324324, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRUD_XANAC (Q8PLR6)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642054.1
- ProteinModelPortal:   Q8PLR6
- SMR:   Q8PLR6
- GeneID:   1155794
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1723
- NMPDR:   fig|190486.1.peg.1698
- HOGENOM:   HBG541221
- OMA:   ALTRQWF
- ProtClustDB:   PRK00984
- BioCyc:   XAXO190486:XAC1723-MONOMER
- HAMAP:   MF_01082
- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760
- PANTHER:   PTHR13326

Pfam domain/function: PF01142 TruD; SSF55120 PsdUridine_synth_cat_dom

EC number: NA

Molecular weight: Translated: 40357; Mature: 40226

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS50984 TRUD; PS01268 UPF0024

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETSLLPRAHGAAVLSAAMRSTPDDFQVDELPAFEPSGEGEHLLLTVRKRGQNTAYIAK
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHH
KLAHWAGIAEMGVSYAGLKDRHAVTTQRFSVHLPRRIAPDIAALDDTQMQVVESSWHNRK
HHHHHHHHHHHCCHHCCCCCCHHHHHHHHEEECCHHHCCCHHHCCCHHHHHHHHHHHHHH
LQRGALHGNRFVLTLRQVQGERDAIEQRLQAIAARGIPNWFGEQRFGRDGGNVAAALAMF
HHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHH
GHVQADDGTLLPAPTSRRRLRHDQRSMLLSAARSALFNRVLGARVAQGSWDGALEGEAWM
HCEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LDGSRSVFGPEPWSEALAERLARFDIHPSGPLWGAGQLRSTDQAAAVEQGALSDPPSIAL
EECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHH
RQGLEAAGLKQERRALRLRPHGLEYQWLEPQTLQLAFALPPGCYATAVLWELGDVADAGR
HCCCHHCCCHHHHHHHHCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCC
FNVDVRADA
EEEEEEECC
>Mature Secondary Structure 
SETSLLPRAHGAAVLSAAMRSTPDDFQVDELPAFEPSGEGEHLLLTVRKRGQNTAYIAK
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHH
KLAHWAGIAEMGVSYAGLKDRHAVTTQRFSVHLPRRIAPDIAALDDTQMQVVESSWHNRK
HHHHHHHHHHHCCHHCCCCCCHHHHHHHHEEECCHHHCCCHHHCCCHHHHHHHHHHHHHH
LQRGALHGNRFVLTLRQVQGERDAIEQRLQAIAARGIPNWFGEQRFGRDGGNVAAALAMF
HHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHH
GHVQADDGTLLPAPTSRRRLRHDQRSMLLSAARSALFNRVLGARVAQGSWDGALEGEAWM
HCEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LDGSRSVFGPEPWSEALAERLARFDIHPSGPLWGAGQLRSTDQAAAVEQGALSDPPSIAL
EECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHH
RQGLEAAGLKQERRALRLRPHGLEYQWLEPQTLQLAFALPPGCYATAVLWELGDVADAGR
HCCCHHCCCHHHHHHHHCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCC
FNVDVRADA
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217