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The map label for this gene is serC

Identifier: 21242398

GI number: 21242398

Start: 1899326

End: 1900411

Strand: Direct

Name: serC

Synonym: XAC1648

Alternate gene names: 21242398

Gene position: 1899326-1900411 (Clockwise)

Preceding gene: 21242395

Following gene: 21242399

Centisome position: 36.7

GC content: 64.55

Gene sequence:

>1086_bases
ATGACACGCGCGTTCAATTTCAGTGCCGGCCCCGCGACATTGCCGGAATCGGTCCTGCGCCAGGCGCAGGCAGAGATGGT
GGAGTGGAACGGCGTTGGCGCCTCGATCGTGGAAATCAGCCACCGCAGCGCCGATTTCATGGCGGTGGCCGCTGCCGCCG
AAGCCGATCTGCGCAGTTTGTTGTCGATTCCCGACGACTATGCGGTGCTGTTCACCGCCGGTGGCGCCACCACCATCCAG
GCGCTGCTGCCGCTGAATTTCGCCGCGCCCGGCCAGGCGGCCGACTACGTGATCACCGGGCATTGGGGCAAGACCGCGAT
CAAGCAGGCGGCCACATATGTGGATGCGCGCATCGCCGCCGACGCGCAGGCCGATGGCTTCGTCGACATTCCCGCTGCGG
CCAGCTGGACCTTGTCGCCGCATTCGGCCTACGTGCACATCACCGCCAACGAAACCATCCATGGCGTCGAATTTCGCGAC
ACGCCGGACGTGGGCACGCTGCCGTTGTTTGCCGACTTCAGTTCGTCGATCGCCTCCGAGCCGCTGGATATTTCGCGCTA
CGGCCTGATCTACGCCGGCGCACAGAAGAATCTTGGTCCGGTCGGCATTTCGGTGGTGATCGTGCGGCGCGATCTGCTGG
AACGTGCCGGGCAACCGCGTGCGGACATCTTCAATTACGCCTCGCAGGTCGCGCGCGATTCGATGCTCAACACCCCGCCG
ACCTGGAACTGGTATCTGCTCGGGCTGACCGTGAAGTGGATGCTGGAGCAGGGCGGAGTGCAGGAGTTTGCGCGCCGCAA
TGCAGAGAAGGCCGCGCTGGTGTACGGCGCCATCGATGGTTCCGGCGGCTTCTATCGCAACCTGATCAAACCGGCAGTGC
GTTCGCGCATGAACATCCCGTTCTTTCTGCCGGACGAGCGGCTGGATGCGCTGTTCGTCAGCGAATCCAAGGCAGCCGGG
CTGCTCGCGTTGAAGGGTCACAAGGCAGTCGGTGGCATTCGGGCGTCGCTGTACAACGCGATGCCGGTGGCGGGCGCGCA
AGCGCTGGCCGCGTTCATGCACGACTTCCAGCAGCGTCACGGCTGA

Upstream 100 bases:

>100_bases
ACGTCAGGCTCAGTCAAAAGGATGCAGCTGCAACTTTTTTGTCCGCTGCCAAGCCCGATGCGCTGCGGCATACTAGAAGG
CTAGCTCGACAAGGTATGCC

Downstream 100 bases:

>100_bases
GTCTTCATCTACCTGCGGCGTCTGCCGCGCAGGCGCATGCGCTGCCAGCGCACATGCGCCGCCATTTTAGGAATGCCCAG
CAATGGCCCCCAAGTCCAAC

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTRAFNFSAGPATLPESVLRQAQAEMVEWNGVGASIVEISHRSADFMAVAAAAEADLRSLLSIPDDYAVLFTAGGATTIQ
ALLPLNFAAPGQAADYVITGHWGKTAIKQAATYVDARIAADAQADGFVDIPAAASWTLSPHSAYVHITANETIHGVEFRD
TPDVGTLPLFADFSSSIASEPLDISRYGLIYAGAQKNLGPVGISVVIVRRDLLERAGQPRADIFNYASQVARDSMLNTPP
TWNWYLLGLTVKWMLEQGGVQEFARRNAEKAALVYGAIDGSGGFYRNLIKPAVRSRMNIPFFLPDERLDALFVSESKAAG
LLALKGHKAVGGIRASLYNAMPVAGAQALAAFMHDFQQRHG

Sequences:

>Translated_361_residues
MTRAFNFSAGPATLPESVLRQAQAEMVEWNGVGASIVEISHRSADFMAVAAAAEADLRSLLSIPDDYAVLFTAGGATTIQ
ALLPLNFAAPGQAADYVITGHWGKTAIKQAATYVDARIAADAQADGFVDIPAAASWTLSPHSAYVHITANETIHGVEFRD
TPDVGTLPLFADFSSSIASEPLDISRYGLIYAGAQKNLGPVGISVVIVRRDLLERAGQPRADIFNYASQVARDSMLNTPP
TWNWYLLGLTVKWMLEQGGVQEFARRNAEKAALVYGAIDGSGGFYRNLIKPAVRSRMNIPFFLPDERLDALFVSESKAAG
LLALKGHKAVGGIRASLYNAMPVAGAQALAAFMHDFQQRHG
>Mature_360_residues
TRAFNFSAGPATLPESVLRQAQAEMVEWNGVGASIVEISHRSADFMAVAAAAEADLRSLLSIPDDYAVLFTAGGATTIQA
LLPLNFAAPGQAADYVITGHWGKTAIKQAATYVDARIAADAQADGFVDIPAAASWTLSPHSAYVHITANETIHGVEFRDT
PDVGTLPLFADFSSSIASEPLDISRYGLIYAGAQKNLGPVGISVVIVRRDLLERAGQPRADIFNYASQVARDSMLNTPPT
WNWYLLGLTVKWMLEQGGVQEFARRNAEKAALVYGAIDGSGGFYRNLIKPAVRSRMNIPFFLPDERLDALFVSESKAAGL
LALKGHKAVGGIRASLYNAMPVAGAQALAAFMHDFQQRHG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=364, Percent_Identity=41.2087912087912, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI10863955, Length=360, Percent_Identity=37.2222222222222, Blast_Score=255, Evalue=5e-68,
Organism=Escherichia coli, GI1787136, Length=363, Percent_Identity=50.6887052341598, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17506897, Length=363, Percent_Identity=38.5674931129477, Blast_Score=294, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=35.3246753246753, Blast_Score=232, Evalue=6e-62,
Organism=Drosophila melanogaster, GI21356589, Length=363, Percent_Identity=43.5261707988981, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_XANAC (Q8PLY7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641980.1
- ProteinModelPortal:   Q8PLY7
- SMR:   Q8PLY7
- GeneID:   1155719
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1648
- NMPDR:   fig|190486.1.peg.1624
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   XAXO190486:XAC1648-MONOMER
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 38680; Mature: 38549

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 102-102 BINDING 152-152 BINDING 172-172 BINDING 195-195

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAFNFSAGPATLPESVLRQAQAEMVEWNGVGASIVEISHRSADFMAVAAAAEADLRSL
CCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
LSIPDDYAVLFTAGGATTIQALLPLNFAAPGQAADYVITGHWGKTAIKQAATYVDARIAA
HCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
DAQADGFVDIPAAASWTLSPHSAYVHITANETIHGVEFRDTPDVGTLPLFADFSSSIASE
CCCCCCCEECCCCCEEEECCCCEEEEEEECCEEECEECCCCCCCCCCEEHHHHHHHHCCC
PLDISRYGLIYAGAQKNLGPVGISVVIVRRDLLERAGQPRADIFNYASQVARDSMLNTPP
CCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
TWNWYLLGLTVKWMLEQGGVQEFARRNAEKAALVYGAIDGSGGFYRNLIKPAVRSRMNIP
CCCEEEEEEEHEEHHHHCCHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCC
FFLPDERLDALFVSESKAAGLLALKGHKAVGGIRASLYNAMPVAGAQALAAFMHDFQQRH
EECCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
G
C
>Mature Secondary Structure 
TRAFNFSAGPATLPESVLRQAQAEMVEWNGVGASIVEISHRSADFMAVAAAAEADLRSL
CEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
LSIPDDYAVLFTAGGATTIQALLPLNFAAPGQAADYVITGHWGKTAIKQAATYVDARIAA
HCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
DAQADGFVDIPAAASWTLSPHSAYVHITANETIHGVEFRDTPDVGTLPLFADFSSSIASE
CCCCCCCEECCCCCEEEECCCCEEEEEEECCEEECEECCCCCCCCCCEEHHHHHHHHCCC
PLDISRYGLIYAGAQKNLGPVGISVVIVRRDLLERAGQPRADIFNYASQVARDSMLNTPP
CCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
TWNWYLLGLTVKWMLEQGGVQEFARRNAEKAALVYGAIDGSGGFYRNLIKPAVRSRMNIP
CCCEEEEEEEHEEHHHHCCHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCC
FFLPDERLDALFVSESKAAGLLALKGHKAVGGIRASLYNAMPVAGAQALAAFMHDFQQRH
EECCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217