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The map label for this gene is fumC [H]

Identifier: 21242293

GI number: 21242293

Start: 1783864

End: 1785267

Strand: Direct

Name: fumC [H]

Synonym: XAC1542

Alternate gene names: 21242293

Gene position: 1783864-1785267 (Clockwise)

Preceding gene: 21242291

Following gene: 21242300

Centisome position: 34.47

GC content: 63.89

Gene sequence:

>1404_bases
ATGAGCGAACGTTTCAGGACCGAACACGACAGCATGGGCGAATTGCAGGTGCCCGCCGACGCGTTGTGGGGCGCGCAGAC
CCAGCGCGCGGTGCAGAATTTCCCGGTGTCCGGGCAGCCGATGCCGCGCGGTTTCATTCGCGCGCTGGGCTTGATCAAGG
CCGCGGCAGCCGGCGTCAACGCCGAGCTTGGATTGCTGCCGAAGTCGATCGGCAAGACCGTGCAGGCCGCTGCATTGCAA
GTGGCCGAGGGCAGCTTCGATGCGCAGTTTCCCATCGATGTGTACCAGACCGGTTCGGGCACCTCGTCCAACATGAATGC
CAATGAGGTGATTGCCACCCTGGCCACGCGTGCCGGCAAGGATGCGGTGCATCCCAACGACCACGTCAATCTGGGCCAGA
GTTCCAACGATGTGGTCCCCACCGCCATTCGCGTGTCGGCATTGCTGGCGGTGCAGGAACATCTGCAACCGGCGCTCAAG
CATCTGCGCAAGACCATCGACAAGCGCGCCAAATCGCTTGATAAGATCGTCAAGACCGGTCGCACGCATTTGATGGACGC
GATGCCGCTCACCTTTGGTCAGGAGTTCGGCGCGTGGTCGGCGCAGCTGAGTTCGGCGCAGGAGCGTATCGACGACGCGC
TCAAGCGCTTGCGACGCTTGCCGCTGGGCGGCACGGCGATCGGGACCGGCATCAATGCCGACCCGCGCTTCGGTGGCAAG
GTCGCCAAGGCCTTGTCCACCCTGAGCGGAGCCAGGTTCGAGAGCGCGGAAAACAAGTTCGAAGGACTCGCCGCGCAGGA
CGATGCGGTGGAGTTGTCTGGCCAACTCAACGCGCTGGCGGTGGCACTGATCAAGATCGCAAACGACTTGCGCTGGATGA
ATGCCGGCCCGTTGGCGGGCCTGGGCGAAATCGAACTGCCGGCGCTGCAGCCTGGCAGCTCGATCATGCCAGGCAAGGTC
AATCCGGTGATTCCCGAAGCCACCGTGATGGCGTGCGCGCAGGTGATCGGCCACCACACTGCCATCACCATCGCCGGGCA
AACCGGCAACTTCCAGTTGAACGTGACGTTGCCGCTGATCGCCTACAACCTGCTGGATTCGATCACCTTGCTGGGCAACG
TTTCGCGCCTGTTGGCCGACACCGCCATTGCCGGTCTGAAGGTGCGTCAGGAGCGCGTCCGCGAGGCGTTGGACCGCAAC
CCCATCTTGGTGACGGCACTGAACCCCATCATCGGTTACGAAAAGGCCGCGGCGATCGCCAAGCGTGCCTACAAGGAGCA
GCGGTCGGTACTGGATGTGGCCAAGGAAGACAGCGGGCTCGGCGAAGCGGAACTGCGGCGATTGCTCGACCCGACGGCAT
TGACACGCGGCGGTATCCATGCCGGCGGCGGTAGCGGGGGCTGA

Upstream 100 bases:

>100_bases
CGCAACGCGGCGTGCGAGTATCGTAGACAGTCTCGCCAGCGTGGGTACGCCCGCCGCCAGCCATCCATCACCACAAATCA
GCAATGTGCGGAGAGTGCAG

Downstream 100 bases:

>100_bases
TCACCGCAGCGCATATGTAGGAGCGCACGTGTGCGCGATGGGGCATTATCGATAACGCCCTGTCGCGGCGCGCTCCTACC
GATTTTGCTGATTTGTCGTC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSERFRTEHDSMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVNAELGLLPKSIGKTVQAAALQ
VAEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGKDAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALK
HLRKTIDKRAKSLDKIVKTGRTHLMDAMPLTFGQEFGAWSAQLSSAQERIDDALKRLRRLPLGGTAIGTGINADPRFGGK
VAKALSTLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKV
NPVIPEATVMACAQVIGHHTAITIAGQTGNFQLNVTLPLIAYNLLDSITLLGNVSRLLADTAIAGLKVRQERVREALDRN
PILVTALNPIIGYEKAAAIAKRAYKEQRSVLDVAKEDSGLGEAELRRLLDPTALTRGGIHAGGGSGG

Sequences:

>Translated_467_residues
MSERFRTEHDSMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVNAELGLLPKSIGKTVQAAALQ
VAEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGKDAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALK
HLRKTIDKRAKSLDKIVKTGRTHLMDAMPLTFGQEFGAWSAQLSSAQERIDDALKRLRRLPLGGTAIGTGINADPRFGGK
VAKALSTLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKV
NPVIPEATVMACAQVIGHHTAITIAGQTGNFQLNVTLPLIAYNLLDSITLLGNVSRLLADTAIAGLKVRQERVREALDRN
PILVTALNPIIGYEKAAAIAKRAYKEQRSVLDVAKEDSGLGEAELRRLLDPTALTRGGIHAGGGSGG
>Mature_466_residues
SERFRTEHDSMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVNAELGLLPKSIGKTVQAAALQV
AEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGKDAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALKH
LRKTIDKRAKSLDKIVKTGRTHLMDAMPLTFGQEFGAWSAQLSSAQERIDDALKRLRRLPLGGTAIGTGINADPRFGGKV
AKALSTLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKVN
PVIPEATVMACAQVIGHHTAITIAGQTGNFQLNVTLPLIAYNLLDSITLLGNVSRLLADTAIAGLKVRQERVREALDRNP
ILVTALNPIIGYEKAAAIAKRAYKEQRSVLDVAKEDSGLGEAELRRLLDPTALTRGGIHAGGGSGG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=455, Percent_Identity=46.5934065934066, Blast_Score=398, Evalue=1e-111,
Organism=Escherichia coli, GI1787896, Length=463, Percent_Identity=46.6522678185745, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI87082375, Length=459, Percent_Identity=39.6514161220044, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1790398, Length=273, Percent_Identity=29.3040293040293, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17553882, Length=456, Percent_Identity=45.1754385964912, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI32565146, Length=321, Percent_Identity=44.2367601246106, Blast_Score=275, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6324993, Length=458, Percent_Identity=46.7248908296943, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321806, Length=272, Percent_Identity=27.5735294117647, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=47.6086956521739, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=46.7532467532467, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=46.7532467532467, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24662684, Length=459, Percent_Identity=45.3159041394335, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=39.6551724137931, Blast_Score=368, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49234; Mature: 49103

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERFRTEHDSMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVN
CCCCCCCCCCCCCCEECCHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AELGLLPKSIGKTVQAAALQVAEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGK
CHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
DAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALKHLRKTIDKRAKSLDKIVKTG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RTHLMDAMPLTFGQEFGAWSAQLSSAQERIDDALKRLRRLPLGGTAIGTGINADPRFGGK
HHHHHHHCCHHHCHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHH
VAKALSTLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAG
HHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
LGEIELPALQPGSSIMPGKVNPVIPEATVMACAQVIGHHTAITIAGQTGNFQLNVTLPLI
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHH
AYNLLDSITLLGNVSRLLADTAIAGLKVRQERVREALDRNPILVTALNPIIGYEKAAAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
KRAYKEQRSVLDVAKEDSGLGEAELRRLLDPTALTRGGIHAGGGSGG
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SERFRTEHDSMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVN
CCCCCCCCCCCCCEECCHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AELGLLPKSIGKTVQAAALQVAEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGK
CHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
DAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALKHLRKTIDKRAKSLDKIVKTG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RTHLMDAMPLTFGQEFGAWSAQLSSAQERIDDALKRLRRLPLGGTAIGTGINADPRFGGK
HHHHHHHCCHHHCHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHH
VAKALSTLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAG
HHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
LGEIELPALQPGSSIMPGKVNPVIPEATVMACAQVIGHHTAITIAGQTGNFQLNVTLPLI
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHH
AYNLLDSITLLGNVSRLLADTAIAGLKVRQERVREALDRNPILVTALNPIIGYEKAAAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
KRAYKEQRSVLDVAKEDSGLGEAELRRLLDPTALTRGGIHAGGGSGG
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]