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The map label for this gene is phr [H]

Identifier: 21242230

GI number: 21242230

Start: 1706058

End: 1707512

Strand: Direct

Name: phr [H]

Synonym: XAC1478

Alternate gene names: 21242230

Gene position: 1706058-1707512 (Clockwise)

Preceding gene: 21242229

Following gene: 21242231

Centisome position: 32.96

GC content: 64.6

Gene sequence:

>1455_bases
ATGCTGCGCAGCCTCATTGTTTGCTGCCGAGTTCGTATGTCATACGCCATCGTCTGGTTCCGTCGCGATCTGCGTCTGGA
AGACAACCCGGCCTTGCGCGCCGCACTCGATGCGGGGCATCACCCGATTCCGTTGTACATCGACGCGCCGCACGAAGAGG
GCGAATGGACGCCTGGCGCCGCATCGCGCACCTGGCGGCATCGCTCGCTTGCAGCGCTGGACGGCGCCTTGCGCGCGCTC
GGCAGCGGGCTGGTCATTCGCGTCGGCAACAGCGCGCAGGTGCTGGATGAGGTGATCGCGCAGACCGGTGCGGTGGCGGT
GTACTGGAACCGCAAGTACGAGCCGGCCACCCAGCCGCGCGATGCGCAGATCAAGCGCGATTTGCGCGAGCGCGGCATCG
AGGTGCAGAGCTGCAATTGCGCATTGCTGTTCGAACCGTGGCAGTTGTCCACGCAGCAGGGCGGCCCCTACAAGGTGTTT
ACCCCGTTCTGGCGCAACGCGCTGACGCAGTTGCAATTGCCCGCCGCGATAGGTGCGCCGCGCAGTCTGCCGCCATTGCC
TGCAAGCTTGAAGACCGATGCGCTCGACACGCTGCAATTGGTGCCGGGCCTGCAGTGGGACCAGGGTTTCTGGGAGCACT
GGCAGCCCGGCGAAGCCGGCGCGCACGAAATGCTGGAGATCTTTATCGACGGCGCGTTGTCTGGATATCGCGAAAACCGC
GATCGCCCCGATCGCGTCGGGACCTCGCAACTGTCGCCGCATCTGCACTTCGGCGAAATTGCGCCGTGGCGGATCGCCAA
CACCCTGGAGACGCATCGCACTGCGCGCAATGGCGCAGAAATCGATGCCTATATCCGGCAGCTTGGCTGGCGCGACTTTG
CCTATCACTTGCTGCATCACTTCCCGGACACCACCAACCAGAATCTCAATCCACGCTTTGCAGGATTCGATTGGGCAACG
GTCGATCCGGTTGCATTGCAGGCCTGGCAGCGGGGCCGCACTGGCATTCCGATCGTCGATGCCGGCATGCGCCAGCTCTG
GCATACCGGTTGGATGCACAATCGCGTGCGCATGATCGTCGCCAGTTTTTTGTGCAAGCATCTGCGCATCCACTGGATCG
AAGGCGCGCGCTGGTTCTGGGACACGCTGGTGGATGCGGACCTGGCCAACAACACCCTGGGCTGGCAGTGGGTGGCCGGC
ACCGGCGCCGATGCGGCGCCGTATTTCCGTGTGTTCAATCCGGTCACGCAGGCGGAGAAGTTCGATCCGCAGGCCGCCTA
CATCACGCGCTGGGTACCTGAGCTCGGCAAGCTTGCGGTGAAGGAACGCTTCGCGCCGTGGCTGCATCCGTTGTCGCTGG
CGCGGCTGGCACCGGAGTATCCGCGCACGCCGATCATCGGCCTGGCCGAAGGGCGCGATGCGGCGCTGGCGGCGTATGCG
AAAACGCGCGGCTAG

Upstream 100 bases:

>100_bases
GGCGCACGACTCGGTGGGCAGTTTCGAGTAAGCGCTGTCGTGGAACGGCCGGGTGGTCATCCGCCGCCCGGCATCGCGCC
ATCGTGGCGCCCGCTGGCTT

Downstream 100 bases:

>100_bases
GCGCGCGGCAGGGCGAGCGAGCTCCTGATTGCGTGGTCAGCGGATGCTCGCTTCTGCGCGTTTTCTTCTGCAAGGCTGAG
GCGTTGCACGCGTGTGCTGC

Product: photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MLRSLIVCCRVRMSYAIVWFRRDLRLEDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGAASRTWRHRSLAALDGALRAL
GSGLVIRVGNSAQVLDEVIAQTGAVAVYWNRKYEPATQPRDAQIKRDLRERGIEVQSCNCALLFEPWQLSTQQGGPYKVF
TPFWRNALTQLQLPAAIGAPRSLPPLPASLKTDALDTLQLVPGLQWDQGFWEHWQPGEAGAHEMLEIFIDGALSGYRENR
DRPDRVGTSQLSPHLHFGEIAPWRIANTLETHRTARNGAEIDAYIRQLGWRDFAYHLLHHFPDTTNQNLNPRFAGFDWAT
VDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIVASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAG
TGADAAPYFRVFNPVTQAEKFDPQAAYITRWVPELGKLAVKERFAPWLHPLSLARLAPEYPRTPIIGLAEGRDAALAAYA
KTRG

Sequences:

>Translated_484_residues
MLRSLIVCCRVRMSYAIVWFRRDLRLEDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGAASRTWRHRSLAALDGALRAL
GSGLVIRVGNSAQVLDEVIAQTGAVAVYWNRKYEPATQPRDAQIKRDLRERGIEVQSCNCALLFEPWQLSTQQGGPYKVF
TPFWRNALTQLQLPAAIGAPRSLPPLPASLKTDALDTLQLVPGLQWDQGFWEHWQPGEAGAHEMLEIFIDGALSGYRENR
DRPDRVGTSQLSPHLHFGEIAPWRIANTLETHRTARNGAEIDAYIRQLGWRDFAYHLLHHFPDTTNQNLNPRFAGFDWAT
VDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIVASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAG
TGADAAPYFRVFNPVTQAEKFDPQAAYITRWVPELGKLAVKERFAPWLHPLSLARLAPEYPRTPIIGLAEGRDAALAAYA
KTRG
>Mature_484_residues
MLRSLIVCCRVRMSYAIVWFRRDLRLEDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGAASRTWRHRSLAALDGALRAL
GSGLVIRVGNSAQVLDEVIAQTGAVAVYWNRKYEPATQPRDAQIKRDLRERGIEVQSCNCALLFEPWQLSTQQGGPYKVF
TPFWRNALTQLQLPAAIGAPRSLPPLPASLKTDALDTLQLVPGLQWDQGFWEHWQPGEAGAHEMLEIFIDGALSGYRENR
DRPDRVGTSQLSPHLHFGEIAPWRIANTLETHRTARNGAEIDAYIRQLGWRDFAYHLLHHFPDTTNQNLNPRFAGFDWAT
VDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIVASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAG
TGADAAPYFRVFNPVTQAEKFDPQAAYITRWVPELGKLAVKERFAPWLHPLSLARLAPEYPRTPIIGLAEGRDAALAAYA
KTRG

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=480, Percent_Identity=28.5416666666667, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI4758072, Length=479, Percent_Identity=28.8100208768267, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI188536103, Length=438, Percent_Identity=27.8538812785388, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1786926, Length=487, Percent_Identity=36.5503080082135, Blast_Score=256, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6324962, Length=520, Percent_Identity=29.4230769230769, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17137248, Length=476, Percent_Identity=29.2016806722689, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24585455, Length=476, Percent_Identity=29.2016806722689, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24648152, Length=466, Percent_Identity=26.8240343347639, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54753; Mature: 54753

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSLIVCCRVRMSYAIVWFRRDLRLEDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGA
CHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
ASRTWRHRSLAALDGALRALGSGLVIRVGNSAQVLDEVIAQTGAVAVYWNRKYEPATQPR
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
DAQIKRDLRERGIEVQSCNCALLFEPWQLSTQQGGPYKVFTPFWRNALTQLQLPAAIGAP
HHHHHHHHHHCCCEEECCCEEEEECCCCCCCCCCCCEEEECHHHHHHHHHEECCHHHCCC
RSLPPLPASLKTDALDTLQLVPGLQWDQGFWEHWQPGEAGAHEMLEIFIDGALSGYRENR
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
DRPDRVGTSQLSPHLHFGEIAPWRIANTLETHRTARNGAEIDAYIRQLGWRDFAYHLLHH
CCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FPDTTNQNLNPRFAGFDWATVDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAGTGADAAPYFRVFNPVTQAEK
HHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCHHHHHHH
FDPQAAYITRWVPELGKLAVKERFAPWLHPLSLARLAPEYPRTPIIGLAEGRDAALAAYA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
KTRG
HCCC
>Mature Secondary Structure
MLRSLIVCCRVRMSYAIVWFRRDLRLEDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGA
CHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
ASRTWRHRSLAALDGALRALGSGLVIRVGNSAQVLDEVIAQTGAVAVYWNRKYEPATQPR
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
DAQIKRDLRERGIEVQSCNCALLFEPWQLSTQQGGPYKVFTPFWRNALTQLQLPAAIGAP
HHHHHHHHHHCCCEEECCCEEEEECCCCCCCCCCCCEEEECHHHHHHHHHEECCHHHCCC
RSLPPLPASLKTDALDTLQLVPGLQWDQGFWEHWQPGEAGAHEMLEIFIDGALSGYRENR
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
DRPDRVGTSQLSPHLHFGEIAPWRIANTLETHRTARNGAEIDAYIRQLGWRDFAYHLLHH
CCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FPDTTNQNLNPRFAGFDWATVDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAGTGADAAPYFRVFNPVTQAEK
HHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCHHHHHHH
FDPQAAYITRWVPELGKLAVKERFAPWLHPLSLARLAPEYPRTPIIGLAEGRDAALAAYA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
KTRG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2681164; 11016950 [H]