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The map label for this gene is mmuM [H]

Identifier: 21242145

GI number: 21242145

Start: 1602171

End: 1603136

Strand: Direct

Name: mmuM [H]

Synonym: XAC1392

Alternate gene names: 21242145

Gene position: 1602171-1603136 (Clockwise)

Preceding gene: 21242144

Following gene: 77748584

Centisome position: 30.96

GC content: 67.39

Gene sequence:

>966_bases
ATGACGATTCTTCCGCGCCAGCCGCGCGCCAATGCGCCTTTCAGCCAGGCCCTGCAACACGACGGGTATGTGGTGCTGGA
TGGCGCGCTGGCCACCGAGCTGGAGCAGCGCGGCTGCGATCTCAACGATGCGCTGTGGTCGGCGCGCGTGCTGATGGAGC
AGCCGGAGCTGATCTATCAGGTGCATCGCGATTACTTCGCTGCCGGTGCGCAATGCGCGATCACCGCCAGTTATCAGGCC
ACGCCGCTGGGATTTGCCGCACGCGGACTGGATGTTGCGCAAGCGCAGGCGTTGATCGCTCGCAGCGTAGCGCTGGCGAT
GCAGGCGCGTGCCGATCATCTGACGCTGCACCCGCATGCCGCGCCTTTGTGGGTGGCAGGCTCGGTGGGACCGTATGGCG
CGTATCTGGCCGATGGCTCGGAATATCGTGGCGACTACGTGCTGCCGATCGAGCAGTTGATGGACTTTCATCGTCCGCGC
ATCGCGGCGCTGGCTGAGGCTGGCGTGGATCTGCTGGCCTGCGAGACGCTGCCCTCGGCCAGCGAAATCGTGGCCCTGCG
GCAGTTGCTGCAACACGAATTTCCGCAGCTGCATGCCTGGTTTTCCTTCACCTTGCGCGATGCGGCGCATCTGAGCGACG
GCACGCCGCTGGCGCAGGTGGTGCCGGCGCTGGATGCCTGTGCGCAGGTGATCGCGGTGGGCATCAACTGCATTGCGCTG
GATCAGGCGACCGCTGCATTGCACAGCCTGTCGGCGCTGACCGCGCTGCCGCTGGTGGTATACCCGAACTCGGGCGAGCA
CTACGACGCCAGCGACAAGCGCTGGCATGCCGGTCGCGGGGCTGCGCTCACGCTGGCCGACCAGCATGCGCACTGGCTGG
CGGCTGGCGCGCGCTTGATCGGTGGCTGCTGCCGCACCGCACCGCGCGATATCGCCGCGCTGGCGGCCGCGCGTGCGGCG
GAGTGA

Upstream 100 bases:

>100_bases
CGCAGCAGCGCATTGCGTTGTGGTGCGGTATTCCGTTCGTCGCGCTGTGCTATGGCGCCTACGCACTTACCCAATGGCTT
GCGGCCCGGAGACTGTACGC

Downstream 100 bases:

>100_bases
CTCGGCTGACGAACGCGCGCTCACCCCGCGTGTCACACCCGGCCGGCATCGTTGGGATTGCCACCGCAGCATGCAAAGGG
CGAGCCGAAGCCGGGCTTTG

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTILPRQPRANAPFSQALQHDGYVVLDGALATELEQRGCDLNDALWSARVLMEQPELIYQVHRDYFAAGAQCAITASYQA
TPLGFAARGLDVAQAQALIARSVALAMQARADHLTLHPHAAPLWVAGSVGPYGAYLADGSEYRGDYVLPIEQLMDFHRPR
IAALAEAGVDLLACETLPSASEIVALRQLLQHEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACAQVIAVGINCIAL
DQATAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGRGAALTLADQHAHWLAAGARLIGGCCRTAPRDIAALAAARAA
E

Sequences:

>Translated_321_residues
MTILPRQPRANAPFSQALQHDGYVVLDGALATELEQRGCDLNDALWSARVLMEQPELIYQVHRDYFAAGAQCAITASYQA
TPLGFAARGLDVAQAQALIARSVALAMQARADHLTLHPHAAPLWVAGSVGPYGAYLADGSEYRGDYVLPIEQLMDFHRPR
IAALAEAGVDLLACETLPSASEIVALRQLLQHEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACAQVIAVGINCIAL
DQATAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGRGAALTLADQHAHWLAAGARLIGGCCRTAPRDIAALAAARAA
E
>Mature_320_residues
TILPRQPRANAPFSQALQHDGYVVLDGALATELEQRGCDLNDALWSARVLMEQPELIYQVHRDYFAAGAQCAITASYQAT
PLGFAARGLDVAQAQALIARSVALAMQARADHLTLHPHAAPLWVAGSVGPYGAYLADGSEYRGDYVLPIEQLMDFHRPRI
AALAEAGVDLLACETLPSASEIVALRQLLQHEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACAQVIAVGINCIALD
QATAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGRGAALTLADQHAHWLAAGARLIGGCCRTAPRDIAALAAARAAE

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=327, Percent_Identity=24.4648318042813, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786456, Length=306, Percent_Identity=64.7058823529412, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1790450, Length=328, Percent_Identity=27.4390243902439, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17569783, Length=158, Percent_Identity=31.0126582278481, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322966, Length=324, Percent_Identity=28.3950617283951, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324982, Length=320, Percent_Identity=26.5625, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6323983, Length=86, Percent_Identity=41.8604651162791, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20129603, Length=317, Percent_Identity=36.9085173501577, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24585077, Length=289, Percent_Identity=35.6401384083045, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 34212; Mature: 34081

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILPRQPRANAPFSQALQHDGYVVLDGALATELEQRGCDLNDALWSARVLMEQPELIYQ
CCCCCCCCCCCCCHHHHHHCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHH
VHRDYFAAGAQCAITASYQATPLGFAARGLDVAQAQALIARSVALAMQARADHLTLHPHA
HHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
APLWVAGSVGPYGAYLADGSEYRGDYVLPIEQLMDFHRPRIAALAEAGVDLLACETLPSA
CCEEEECCCCCCCCEECCCCCCCCCEEEEHHHHHHHCCCHHHHHHHCCCCEEEECCCCCH
SEIVALRQLLQHEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACAQVIAVGINCIAL
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
DQATAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGRGAALTLADQHAHWLAAGARLI
HHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEECCCCCEEEEECHHHHHHHHHHHHH
GGCCRTAPRDIAALAAARAAE
HHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TILPRQPRANAPFSQALQHDGYVVLDGALATELEQRGCDLNDALWSARVLMEQPELIYQ
CCCCCCCCCCCCHHHHHHCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHH
VHRDYFAAGAQCAITASYQATPLGFAARGLDVAQAQALIARSVALAMQARADHLTLHPHA
HHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
APLWVAGSVGPYGAYLADGSEYRGDYVLPIEQLMDFHRPRIAALAEAGVDLLACETLPSA
CCEEEECCCCCCCCEECCCCCCCCCEEEEHHHHHHHCCCHHHHHHHCCCCEEEECCCCCH
SEIVALRQLLQHEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACAQVIAVGINCIAL
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
DQATAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGRGAALTLADQHAHWLAAGARLI
HHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEECCCCCEEEEECHHHHHHHHHHHHH
GGCCRTAPRDIAALAAARAAE
HHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]