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The map label for this gene is ykfD [H]

Identifier: 21242144

GI number: 21242144

Start: 1600777

End: 1602174

Strand: Direct

Name: ykfD [H]

Synonym: XAC1391

Alternate gene names: 21242144

Gene position: 1600777-1602174 (Clockwise)

Preceding gene: 21242124

Following gene: 21242145

Centisome position: 30.93

GC content: 64.88

Gene sequence:

>1398_bases
ATGCCCGAGCCGTCGTCCGCCACCGCACCGCAGTTCCAGCGCAGCATGCAGGTGCGCCATCTGGTGATGCTGTCGCTGGG
CGGGGTGATCGGCACCGGCCTGTTCTTCAACACTGGGTACATCATTGCCAGCACCGGCGCGCTGGGCACGGTACTGGCGT
ATCTGATCGGCGCACTGGTGGTGTACCTGGTGATGCAATGCCTGGGCGAGCTGGCGGTGGCGATGCCGCAAACCGGTGCG
TTTCATGTGTATGCCGCGCGCTACCTCGGCCCGGCGACCGGCTATGTGGTGGCGTGGTTGTATTGGTTGACCTGGACGGT
GGCATTGGGTTCGAGCCTGACGGCCGCAGCGTTCTGCATGCAGTACTGGTTTCCGCACAGCCTGGCGTGGCCGTGGTGTC
TGCTGTTCTGCGCGCTGATCTTCGGCCTGAATACAGTTTCGGCGCGCTGGTTTGCCGAAGGCGAGTTCTGGTTTTCGTTG
ATCAAGGTGATCACCATCCTGGTGTTCATCGTGCTTGGCGGCGCGGCGGTGATCGGTCTGTTGCCACTGGCCGACGGTTC
GCCCGCACCCGGGCTGCGCCATCTGCGCGCCAACGGCTGGTTCGCGCACGGTACGCTCCCGATCTTGATGACGATGGTGG
CGGTGAATTTCGCATTTTCCGGCACCGAGTTGATCGGCGTGGCGGCCGGCGAAACCGCACAGCCTGCACGCGCGATTCCG
CTGGCAATCCGCACAACGCTGGTGCGGCTGGTGGTGCTGTTCGTCGGCACGGTGCTGGTGCTGGCGGCGCTGCTGCCTGC
CAGACGAGCGGCCGTGGAAACCAGCCCGTTCGTGCGCGCCTTCGAGCTGTTGGGCATTCCATATGCAGCCGACATCTTGA
ATGCGGTGATCCTCACCGCGATCCTGTCGGCGGCCAATTCCGGGCTGTATGCGGCCGCGCGCATGCTGTGGTCGTTGGCC
AATGAAGGCACGTTGCCGAGCGGCCTGGCGCGCTTGACCGGCCGCGGCATCCCGTTGCGTGCCGTGTCGCTGAGCATGCT
GGGCGGCTTGCTGGCGCTGCTCACCGGCGTGTATGCGCCCGAAACGGTGTTCGTTGCGATCTCGGCAGTCTCGGGCTTCG
CCGTCGTGGTGGTGTGGCTGAGCATTTGCGCCGCGCATTACCGCTTCCGTCGCCAATGGCTGCGCGATGGCGCTGCGCTG
GAAACGCTGGCGTATCGCGCGCCGTGGTACCCGTGGACCCCGATTCTGGGCTTTTCGCTGTGTCTGCTCGCCTGCATCGG
GTTGGCATTCGATCCGCAGCAGCGCATTGCGTTGTGGTGCGGTATTCCGTTCGTCGCGCTGTGCTATGGCGCCTACGCAC
TTACCCAATGGCTTGCGGCCCGGAGACTGTACGCATGA

Upstream 100 bases:

>100_bases
GCGCCAGTGAGCGGTAGGTCCTGCATCACAACTCGACTGCGCGCGGCTGTGCCCGTCTGCATGCACGTGGCAGGATGGAG
TCCCCCGACCATTCGCCCCC

Downstream 100 bases:

>100_bases
CGATTCTTCCGCGCCAGCCGCGCGCCAATGCGCCTTTCAGCCAGGCCCTGCAACACGACGGGTATGTGGTGCTGGATGGC
GCGCTGGCCACCGAGCTGGA

Product: S-methylmethionine transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MPEPSSATAPQFQRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALVVYLVMQCLGELAVAMPQTGA
FHVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCMQYWFPHSLAWPWCLLFCALIFGLNTVSARWFAEGEFWFSL
IKVITILVFIVLGGAAVIGLLPLADGSPAPGLRHLRANGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETAQPARAIP
LAIRTTLVRLVVLFVGTVLVLAALLPARRAAVETSPFVRAFELLGIPYAADILNAVILTAILSAANSGLYAAARMLWSLA
NEGTLPSGLARLTGRGIPLRAVSLSMLGGLLALLTGVYAPETVFVAISAVSGFAVVVVWLSICAAHYRFRRQWLRDGAAL
ETLAYRAPWYPWTPILGFSLCLLACIGLAFDPQQRIALWCGIPFVALCYGAYALTQWLAARRLYA

Sequences:

>Translated_465_residues
MPEPSSATAPQFQRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALVVYLVMQCLGELAVAMPQTGA
FHVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCMQYWFPHSLAWPWCLLFCALIFGLNTVSARWFAEGEFWFSL
IKVITILVFIVLGGAAVIGLLPLADGSPAPGLRHLRANGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETAQPARAIP
LAIRTTLVRLVVLFVGTVLVLAALLPARRAAVETSPFVRAFELLGIPYAADILNAVILTAILSAANSGLYAAARMLWSLA
NEGTLPSGLARLTGRGIPLRAVSLSMLGGLLALLTGVYAPETVFVAISAVSGFAVVVVWLSICAAHYRFRRQWLRDGAAL
ETLAYRAPWYPWTPILGFSLCLLACIGLAFDPQQRIALWCGIPFVALCYGAYALTQWLAARRLYA
>Mature_464_residues
PEPSSATAPQFQRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALVVYLVMQCLGELAVAMPQTGAF
HVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCMQYWFPHSLAWPWCLLFCALIFGLNTVSARWFAEGEFWFSLI
KVITILVFIVLGGAAVIGLLPLADGSPAPGLRHLRANGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETAQPARAIPL
AIRTTLVRLVVLFVGTVLVLAALLPARRAAVETSPFVRAFELLGIPYAADILNAVILTAILSAANSGLYAAARMLWSLAN
EGTLPSGLARLTGRGIPLRAVSLSMLGGLLALLTGVYAPETVFVAISAVSGFAVVVVWLSICAAHYRFRRQWLRDGAALE
TLAYRAPWYPWTPILGFSLCLLACIGLAFDPQQRIALWCGIPFVALCYGAYALTQWLAARRLYA

Specific function: Transporter for the intake of S-methylmethionine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=389, Percent_Identity=23.1362467866324, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI115648022, Length=389, Percent_Identity=23.1362467866324, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=72.1739130434783, Blast_Score=687, Evalue=0.0,
Organism=Escherichia coli, GI1788480, Length=470, Percent_Identity=37.2340425531915, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI48994972, Length=466, Percent_Identity=33.6909871244635, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1786302, Length=415, Percent_Identity=35.421686746988, Blast_Score=254, Evalue=9e-69,
Organism=Escherichia coli, GI1786789, Length=422, Percent_Identity=34.8341232227488, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1786602, Length=458, Percent_Identity=34.7161572052402, Blast_Score=238, Evalue=9e-64,
Organism=Escherichia coli, GI87081915, Length=429, Percent_Identity=33.5664335664336, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1790653, Length=395, Percent_Identity=32.1518987341772, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1789017, Length=454, Percent_Identity=32.15859030837, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17532491, Length=429, Percent_Identity=21.9114219114219, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=344, Percent_Identity=21.8023255813953, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=430, Percent_Identity=30.6976744186047, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324553, Length=410, Percent_Identity=33.6585365853659, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320717, Length=427, Percent_Identity=30.6791569086651, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324061, Length=427, Percent_Identity=29.9765807962529, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321629, Length=428, Percent_Identity=30.3738317757009, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=428, Percent_Identity=31.7757009345794, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324990, Length=474, Percent_Identity=29.1139240506329, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321053, Length=419, Percent_Identity=29.8329355608592, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319824, Length=417, Percent_Identity=29.4964028776978, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319543, Length=427, Percent_Identity=29.2740046838407, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319542, Length=434, Percent_Identity=28.5714285714286, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=440, Percent_Identity=27.5, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=429, Percent_Identity=29.3706293706294, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322967, Length=428, Percent_Identity=29.2056074766355, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324924, Length=437, Percent_Identity=29.0617848970252, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324981, Length=432, Percent_Identity=30.5555555555556, Blast_Score=156, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6319608, Length=435, Percent_Identity=22.7586206896552, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=545, Percent_Identity=21.4678899082569, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49868; Mature: 49737

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPSSATAPQFQRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
VYLVMQCLGELAVAMPQTGAFHVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCM
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QYWFPHSLAWPWCLLFCALIFGLNTVSARWFAEGEFWFSLIKVITILVFIVLGGAAVIGL
HHHCCCCCHHHHHHHHHHHHHCCCHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLADGSPAPGLRHLRANGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETAQPARAIP
HCCCCCCCCCCHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
LAIRTTLVRLVVLFVGTVLVLAALLPARRAAVETSPFVRAFELLGIPYAADILNAVILTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHH
ILSAANSGLYAAARMLWSLANEGTLPSGLARLTGRGIPLRAVSLSMLGGLLALLTGVYAP
HHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
ETVFVAISAVSGFAVVVVWLSICAAHYRFRRQWLRDGAALETLAYRAPWYPWTPILGFSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHH
CLLACIGLAFDPQQRIALWCGIPFVALCYGAYALTQWLAARRLYA
HHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PEPSSATAPQFQRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
VYLVMQCLGELAVAMPQTGAFHVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCM
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QYWFPHSLAWPWCLLFCALIFGLNTVSARWFAEGEFWFSLIKVITILVFIVLGGAAVIGL
HHHCCCCCHHHHHHHHHHHHHCCCHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLADGSPAPGLRHLRANGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETAQPARAIP
HCCCCCCCCCCHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
LAIRTTLVRLVVLFVGTVLVLAALLPARRAAVETSPFVRAFELLGIPYAADILNAVILTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHH
ILSAANSGLYAAARMLWSLANEGTLPSGLARLTGRGIPLRAVSLSMLGGLLALLTGVYAP
HHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
ETVFVAISAVSGFAVVVVWLSICAAHYRFRRQWLRDGAALETLAYRAPWYPWTPILGFSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHH
CLLACIGLAFDPQQRIALWCGIPFVALCYGAYALTQWLAARRLYA
HHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684 [H]