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The map label for this gene is pms

Identifier: 21241670

GI number: 21241670

Start: 1061898

End: 1062548

Strand: Direct

Name: pms

Synonym: XAC0900

Alternate gene names: 21241670

Gene position: 1061898-1062548 (Clockwise)

Preceding gene: 21241669

Following gene: 21241678

Centisome position: 20.52

GC content: 62.83

Gene sequence:

>651_bases
ATGCTGGGAATCGGCGCCTTCAAACAACGTCTGCCACGCCCGGGCGAAGCACTACCCGGGCGCGAGCAAGCGCTGCCGCT
GCATAACACGCACCTGGTCAACGGCCATCCGTTGCGCGGGGAATTCACTGGTCTGGCCCAGGTGCAATTCGGGCTCGGCT
GTTTCTGGGGCGCGGAACGCAAGTTCTGGAACGTGCCAGGGGTCTACACCACAGCAGTGGGTTACGCCGGCGGGCAGACG
CCGAACGCGACCTATTCGGAAGTGTGTTCCGGGCAGACCGGCCACACCGAAGCGGTGCTGGTGGTGTTCGACGACCATGC
GGTGTCGTTCGCACAATTGCTGCGTACGTTCTGGGAAAGCCACGACCCCACCCAGGGCATGCAGCAAGGTAACGATATGG
GGACGCAATACCGTTCGGCGATTTACTGCACCACGCAGGCGCAGTACGACGCCGCGCTTGCCAGCCGCGATGCGTATCAG
CAACAACTGACCGCAGCCGGTTATGGCGAAATCACCACGGAGATCCGTTTCCCGGCGCCCACGTTCTACTACGCCGAAGA
CGATCACCAGCAATATCTCGCCAAGCACCCCAACGGGTATTGCGGGCTTGGCGGCACGGGAGTGAGCTGCCCGATCGGGC
TGGATGCCTGA

Upstream 100 bases:

>100_bases
AGTAATGCGGCGCGGACGACAGGCGCTGGCCGGGCAGGCTTGAAAGTGGCTCTGGCCGGCGCCATCCAGCAGGCAATCCT
GACGATTGCGGAGCTGCACC

Downstream 100 bases:

>100_bases
CGGAAAGGCGGGCCGGATTGAAACGCTGTCATCCACAAGATCGTGGCAGCGTGCCGATGGCCGACAGTGACCGGCAGCGT
TATCACGATCAGGCACCGCA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MLGIGAFKQRLPRPGEALPGREQALPLHNTHLVNGHPLRGEFTGLAQVQFGLGCFWGAERKFWNVPGVYTTAVGYAGGQT
PNATYSEVCSGQTGHTEAVLVVFDDHAVSFAQLLRTFWESHDPTQGMQQGNDMGTQYRSAIYCTTQAQYDAALASRDAYQ
QQLTAAGYGEITTEIRFPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA

Sequences:

>Translated_216_residues
MLGIGAFKQRLPRPGEALPGREQALPLHNTHLVNGHPLRGEFTGLAQVQFGLGCFWGAERKFWNVPGVYTTAVGYAGGQT
PNATYSEVCSGQTGHTEAVLVVFDDHAVSFAQLLRTFWESHDPTQGMQQGNDMGTQYRSAIYCTTQAQYDAALASRDAYQ
QQLTAAGYGEITTEIRFPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA
>Mature_216_residues
MLGIGAFKQRLPRPGEALPGREQALPLHNTHLVNGHPLRGEFTGLAQVQFGLGCFWGAERKFWNVPGVYTTAVGYAGGQT
PNATYSEVCSGQTGHTEAVLVVFDDHAVSFAQLLRTFWESHDPTQGMQQGNDMGTQYRSAIYCTTQAQYDAALASRDAYQ
QQLTAAGYGEITTEIRFPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=213, Percent_Identity=58.2159624413146, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI208609995, Length=186, Percent_Identity=61.8279569892473, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI208609993, Length=212, Percent_Identity=45.2830188679245, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1790665, Length=191, Percent_Identity=56.5445026178011, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=35.1351351351351, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=35.1851851851852, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24664627, Length=160, Percent_Identity=35, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664631, Length=160, Percent_Identity=35, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=36.1702127659575, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_XANAC (Q8PNY8)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641252.1
- ProteinModelPortal:   Q8PNY8
- SMR:   Q8PNY8
- GeneID:   1154971
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0900
- NMPDR:   fig|190486.1.peg.896
- HOGENOM:   HBG748152
- OMA:   SAIYCTT
- ProtClustDB:   PRK00058
- BioCyc:   XAXO190486:XAC0900-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 23471; Mature: 23471

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: ACT_SITE 54-54

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIGAFKQRLPRPGEALPGREQALPLHNTHLVNGHPLRGEFTGLAQVQFGLGCFWGAER
CCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEECCEEEECCCC
KFWNVPGVYTTAVGYAGGQTPNATYSEVCSGQTGHTEAVLVVFDDHAVSFAQLLRTFWES
CEECCCCHHHHHEECCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHC
HDPTQGMQQGNDMGTQYRSAIYCTTQAQYDAALASRDAYQQQLTAAGYGEITTEIRFPAP
CCCHHHHHCCCHHCHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
TFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA
EEEECCCHHHHHHHHCCCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MLGIGAFKQRLPRPGEALPGREQALPLHNTHLVNGHPLRGEFTGLAQVQFGLGCFWGAER
CCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEECCEEEECCCC
KFWNVPGVYTTAVGYAGGQTPNATYSEVCSGQTGHTEAVLVVFDDHAVSFAQLLRTFWES
CEECCCCHHHHHEECCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHC
HDPTQGMQQGNDMGTQYRSAIYCTTQAQYDAALASRDAYQQQLTAAGYGEITTEIRFPAP
CCCHHHHHCCCHHCHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
TFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA
EEEECCCHHHHHHHHCCCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217