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The map label for this gene is hemK [H]

Identifier: 21241678

GI number: 21241678

Start: 1069474

End: 1070334

Strand: Direct

Name: hemK [H]

Synonym: XAC0908

Alternate gene names: 21241678

Gene position: 1069474-1070334 (Clockwise)

Preceding gene: 21241670

Following gene: 21241679

Centisome position: 20.66

GC content: 69.69

Gene sequence:

>861_bases
ATGTCCGACGATCTCGCCGCCATTCCCGCCGATCAGCTGCTTCGCCGCGCCGACGGGCGGATCGAACGCTGCGATGCCGA
GGCACTGCTGCTGCACGCGCTGGGCCGCGATCGCGGCTGGTTGTTCATGCACGGGCGCGATGCGGTGCCTCTATCGATCG
CGCAGGCCTTCGATGCCTTGGTGCAGCGCCGTGAGGCCGGCGAGCCGGTGGCCTATTTGACCGGCTCACGCGGATTCTGG
ACGCTGGACCTGGCGGTCTCGCCGGCCACGCTGATCCCGCGCGCCGATACCGAAGCGCTGGTCGAGCTTGCGCTGGAGCG
CCTGGACACCCTGCCAGGCCGTCGTGTCGCCGATCTGGGGACCGGCAGTGGCGCGATTGCGCTGGCCATCGCCAGCGAAC
GTCCGCAGGCGCAGGTGATCGCCACCGATGCGAGCGCTGCGGCGTTGGCCATGGCCCAACGCAACGCCGACAGCCACAGC
TTGCGCAATGTCGAGTGCCGCCTGGGCGGCTGGTTCGCGCCCTTGGCTGGCGAGACCTTTGACCTGATCGCCAGCAACCC
GCCGTATATCGCCGCGCACGACTCGCACCTGCAGCAGGGCGATCTTCGCTACGAACCGGCCAGTGCGCTGGCCTCCGGCA
GCGACGGGCTGGACGATATCCGCCTGATCGTGGCCGATGCGCCTGCGCATCTGCTGCCGGGCGGCTGGTTGCTGCTCGAA
CATGGCTGGGACCAGGGGGCAGCGGTGGCCGAACTGCTGGTTGCGCGCGGTTTCGCTGCGGTGGCCACGCATCAGGATCT
GGAGCAGCGCGATCGGGTGACCTTGGGGCGCTGGTTGCCAGCTGCGGGCCAGGGCGGCTGA

Upstream 100 bases:

>100_bases
GTCTTTGGCTATCGACTCGTCAGATGGCATCTGGCGCAATCGCGGTGCACGCCATCGTCGATAATGGTCAGCCGATGTTG
CGTGTAGGTGAACAGCCCGT

Downstream 100 bases:

>100_bases
GCAACTGCCCGCGCGCTATTGTCGGGAGACGAGGGCCGCGCGTTCCGAAGCGGAGTACGTGCGTTCGATAGAGCGGTTGC
GCGCATCGAGTGCGCTCGCC

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: M.XfaHemK2P [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSDDLAAIPADQLLRRADGRIERCDAEALLLHALGRDRGWLFMHGRDAVPLSIAQAFDALVQRREAGEPVAYLTGSRGFW
TLDLAVSPATLIPRADTEALVELALERLDTLPGRRVADLGTGSGAIALAIASERPQAQVIATDASAAALAMAQRNADSHS
LRNVECRLGGWFAPLAGETFDLIASNPPYIAAHDSHLQQGDLRYEPASALASGSDGLDDIRLIVADAPAHLLPGGWLLLE
HGWDQGAAVAELLVARGFAAVATHQDLEQRDRVTLGRWLPAAGQGG

Sequences:

>Translated_286_residues
MSDDLAAIPADQLLRRADGRIERCDAEALLLHALGRDRGWLFMHGRDAVPLSIAQAFDALVQRREAGEPVAYLTGSRGFW
TLDLAVSPATLIPRADTEALVELALERLDTLPGRRVADLGTGSGAIALAIASERPQAQVIATDASAAALAMAQRNADSHS
LRNVECRLGGWFAPLAGETFDLIASNPPYIAAHDSHLQQGDLRYEPASALASGSDGLDDIRLIVADAPAHLLPGGWLLLE
HGWDQGAAVAELLVARGFAAVATHQDLEQRDRVTLGRWLPAAGQGG
>Mature_285_residues
SDDLAAIPADQLLRRADGRIERCDAEALLLHALGRDRGWLFMHGRDAVPLSIAQAFDALVQRREAGEPVAYLTGSRGFWT
LDLAVSPATLIPRADTEALVELALERLDTLPGRRVADLGTGSGAIALAIASERPQAQVIATDASAAALAMAQRNADSHSL
RNVECRLGGWFAPLAGETFDLIASNPPYIAAHDSHLQQGDLRYEPASALASGSDGLDDIRLIVADAPAHLLPGGWLLLEH
GWDQGAAVAELLVARGFAAVATHQDLEQRDRVTLGRWLPAAGQGG

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=273, Percent_Identity=32.2344322344322, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1787463, Length=256, Percent_Identity=50.390625, Blast_Score=245, Evalue=2e-66,
Organism=Escherichia coli, GI87082085, Length=184, Percent_Identity=36.4130434782609, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24582226, Length=229, Percent_Identity=31.0043668122271, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 30346; Mature: 30214

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDLAAIPADQLLRRADGRIERCDAEALLLHALGRDRGWLFMHGRDAVPLSIAQAFDAL
CCCCCCCCCHHHHHHHHCCCEECCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
VQRREAGEPVAYLTGSRGFWTLDLAVSPATLIPRADTEALVELALERLDTLPGRRVADLG
HHHHHCCCCEEEEECCCCEEEEEEEECCCEECCCCCHHHHHHHHHHHHHCCCCCEEEECC
TGSGAIALAIASERPQAQVIATDASAAALAMAQRNADSHSLRNVECRLGGWFAPLAGETF
CCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHCCCCCCCCCEEEEEECCEECCCCCCCE
DLIASNPPYIAAHDSHLQQGDLRYEPASALASGSDGLDDIRLIVADAPAHLLPGGWLLLE
EEEECCCCEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEE
HGWDQGAAVAELLVARGFAAVATHQDLEQRDRVTLGRWLPAAGQGG
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCEEHHHCCCCCCCCC
>Mature Secondary Structure 
SDDLAAIPADQLLRRADGRIERCDAEALLLHALGRDRGWLFMHGRDAVPLSIAQAFDAL
CCCCCCCCHHHHHHHHCCCEECCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
VQRREAGEPVAYLTGSRGFWTLDLAVSPATLIPRADTEALVELALERLDTLPGRRVADLG
HHHHHCCCCEEEEECCCCEEEEEEEECCCEECCCCCHHHHHHHHHHHHHCCCCCEEEECC
TGSGAIALAIASERPQAQVIATDASAAALAMAQRNADSHSLRNVECRLGGWFAPLAGETF
CCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHCCCCCCCCCEEEEEECCEECCCCCCCE
DLIASNPPYIAAHDSHLQQGDLRYEPASALASGSDGLDDIRLIVADAPAHLLPGGWLLLE
EEEECCCCEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEE
HGWDQGAAVAELLVARGFAAVATHQDLEQRDRVTLGRWLPAAGQGG
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]